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Aliases for ENOPH1 Gene

Aliases for ENOPH1 Gene

  • Enolase-Phosphatase 1 2 3
  • 2,3-Diketo-5-Methylthio-1-Phosphopentane Phosphatase 3 4
  • Enolase-Phosphatase E1 2 3
  • Acireductone Synthase 2 3
  • EC 3.1.3.77 4 63
  • MASA 3 4
  • MASA Homolog 4
  • MST145 3
  • MtnC 3
  • E1 3

External Ids for ENOPH1 Gene

Previous GeneCards Identifiers for ENOPH1 Gene

  • GC04P083570
  • GC04P083351
  • GC04P079093

Summaries for ENOPH1 Gene

GeneCards Summary for ENOPH1 Gene

ENOPH1 (Enolase-Phosphatase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of amino acids and derivatives. GO annotations related to this gene include magnesium ion binding and acireductone synthase activity.

UniProtKB/Swiss-Prot for ENOPH1 Gene

  • Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENOPH1 Gene

Genomics for ENOPH1 Gene

Regulatory Elements for ENOPH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ENOPH1 Gene

Start:
82,430,562 bp from pter
End:
82,461,092 bp from pter
Size:
30,531 bases
Orientation:
Plus strand

Genomic View for ENOPH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENOPH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENOPH1 Gene

Proteins for ENOPH1 Gene

  • Protein details for ENOPH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHY7-ENOPH_HUMAN
    Recommended name:
    Enolase-phosphatase E1
    Protein Accession:
    Q9UHY7
    Secondary Accessions:
    • Q7Z4C5
    • Q9BVC2

    Protein attributes for ENOPH1 Gene

    Size:
    261 amino acids
    Molecular mass:
    28933 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAQ13671.1; Type=Frameshift; Positions=235; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ENOPH1 Gene

    Alternative splice isoforms for ENOPH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENOPH1 Gene

Proteomics data for ENOPH1 Gene at MOPED

Post-translational modifications for ENOPH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENOPH1 Gene

Domains for ENOPH1 Gene

Protein Domains for ENOPH1 Gene

Suggested Antigen Peptide Sequences for ENOPH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHY7

UniProtKB/Swiss-Prot:

ENOPH_HUMAN :
  • Q9UHY7
Family:
  • Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
genes like me logo Genes that share domains with ENOPH1: view

No data available for Gene Families for ENOPH1 Gene

Function for ENOPH1 Gene

Molecular function for ENOPH1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate.
UniProtKB/Swiss-Prot Function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).

Enzyme Numbers (IUBMB) for ENOPH1 Gene

Gene Ontology (GO) - Molecular Function for ENOPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0016787 hydrolase activity --
GO:0043874 acireductone synthase activity TAS --
genes like me logo Genes that share ontologies with ENOPH1: view

Animal Model Products

CRISPR Products

miRNA for ENOPH1 Gene

miRTarBase miRNAs that target ENOPH1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENOPH1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ENOPH1 Gene

Localization for ENOPH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENOPH1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENOPH1 Gene COMPARTMENTS Subcellular localization image for ENOPH1 gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ENOPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ENOPH1: view

Pathways for ENOPH1 Gene

genes like me logo Genes that share pathways with ENOPH1: view

Pathways by source for ENOPH1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9UHY7-ENOPH_HUMAN

  • Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.
  • Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.

Gene Ontology (GO) - Biological Process for ENOPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0006595 polyamine metabolic process TAS --
GO:0008152 metabolic process --
GO:0016311 dephosphorylation TAS --
GO:0019509 L-methionine biosynthetic process from methylthioadenosine TAS --
genes like me logo Genes that share ontologies with ENOPH1: view

Compounds for ENOPH1 Gene

(3) HMDB Compounds for ENOPH1 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(1) Drugbank Compounds for ENOPH1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2-OXOHEPTYLPHOSPHONIC ACID
target

(3) Novoseek inferred chemical compound relationships for ENOPH1 Gene

Compound -log(P) Hits PubMed IDs
cysteine 48.4 4
pyruvate 25 2
atp 15.8 2
genes like me logo Genes that share compounds with ENOPH1: view

Transcripts for ENOPH1 Gene

Unigene Clusters for ENOPH1 Gene

Enolase-phosphatase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENOPH1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENOPH1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - - - - -
SP7: -
SP8: - - - - -
SP9: - - - - - - - - - - - -
SP10:

Relevant External Links for ENOPH1 Gene

GeneLoc Exon Structure for
ENOPH1
ECgene alternative splicing isoforms for
ENOPH1

Expression for ENOPH1 Gene

mRNA expression in normal human tissues for ENOPH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENOPH1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ENOPH1 Gene

SOURCE GeneReport for Unigene cluster for ENOPH1 Gene Hs.18442

genes like me logo Genes that share expressions with ENOPH1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ENOPH1 Gene

Orthologs for ENOPH1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ENOPH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENOPH1 35
  • 99.74 (n)
  • 100 (a)
ENOPH1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ENOPH1 35
  • 89.27 (n)
  • 92.34 (a)
ENOPH1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENOPH1 35
  • 92.31 (n)
  • 95.73 (a)
ENOPH1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Enoph1 35
  • 85.34 (n)
  • 94.55 (a)
Enoph1 16
Enoph1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ENOPH1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENOPH1 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Enoph1 35
  • 85.47 (n)
  • 93.77 (a)
chicken
(Gallus gallus)
Aves ENOPH1 35
  • 72.8 (n)
  • 78.54 (a)
ENOPH1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENOPH1 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13590 35
tropical clawed frog
(Silurana tropicalis)
Amphibia enoph1 35
  • 69.65 (n)
  • 68.48 (a)
zebrafish
(Danio rerio)
Actinopterygii enoph1 35
  • 65.24 (n)
  • 62.65 (a)
enoph1 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta ENOPH_ANOGA 35
  • 56.24 (n)
  • 51.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12173 35
  • 52.79 (n)
  • 43.35 (a)
CG12173 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F58H1.3 35
  • 51.18 (n)
  • 44.81 (a)
F58H1.3 36
  • 44 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTR4 36
  • 35 (a)
OneToOne
UTR4 38
rice
(Oryza sativa)
Liliopsida Os01g0101200 35
  • 51.9 (n)
  • 49.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for ENOPH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENOPH1 Gene

ENSEMBL:
Gene Tree for ENOPH1 (if available)
TreeFam:
Gene Tree for ENOPH1 (if available)

Paralogs for ENOPH1 Gene

Pseudogenes.org Pseudogenes for ENOPH1 Gene

genes like me logo Genes that share paralogs with ENOPH1: view

No data available for Paralogs for ENOPH1 Gene

Variants for ENOPH1 Gene

Sequence variations from dbSNP and Humsavar for ENOPH1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1113576 -- 82,447,827(+) TTATT(C/T)GTTAC intron-variant
rs1878493 -- 82,438,420(+) AGGCC(A/C)TGGCA intron-variant
rs1878494 -- 82,441,039(+) ATTCT(A/G)ATACC intron-variant
rs1980187 -- 82,457,719(-) AACTA(A/C)CTACC intron-variant
rs2056183 -- 82,455,556(-) tgatc(C/T)gccca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENOPH1 Gene

Variant ID Type Subtype PubMed ID
nsv829988 CNV Loss 17160897
nsv829989 CNV Loss 17160897

Relevant External Links for ENOPH1 Gene

HapMap Linkage Disequilibrium report
ENOPH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENOPH1 Gene

Disorders for ENOPH1 Gene

No disorders were found for ENOPH1 Gene.

No data available for UniProtKB/Swiss-Prot for ENOPH1 Gene

Publications for ENOPH1 Gene

  1. Crystal structure of human E1 enzyme and its complex with a substrate analog reveals the mechanism of its phosphatase/enolase activity. (PMID: 15843022) Wang H. … Rao Z. (J. Mol. Biol. 2005) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ENOPH1 Gene

Sources for ENOPH1 Gene

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