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ENOPH1 Gene

protein-coding   GIFtS: 57
GCID: GC04P083351

Enolase-Phosphatase 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Enolase-Phosphatase 11 2     MASA Homolog2 3
Acireductone Synthase1 2     EC 3.1.3.773 8
Enolase-Phosphatase E11 2     E12
2,3-Diketo-5-Methylthio-1-Phosphopentane Phosphatase2 3     MST1452
MASA2 3     mtnC2

External Ids:    HGNC: 245991   Entrez Gene: 584782   Ensembl: ENSG000001452937   UniProtKB: Q9UHY73   

Export aliases for ENOPH1 gene to outside databases

Previous GC identifers: GC04P083570 GC04P079093


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ENOPH1 Gene:
ENOPH1 (enolase-phosphatase 1) is a protein-coding gene. Diseases associated with ENOPH1 include primary biliary cirrhosis, and papilloma. GO annotations related to this gene include magnesium ion binding and acireductone synthase activity.

UniProtKB/Swiss-Prot: ENOPH_HUMAN, Q9UHY7
Function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate
(DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is
then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ENOPH1 gene promoter:
         E2F-4   E2F-3a   HFH-3   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidENOPH1 promoter sequence
   Search Chromatin IP Primers for ENOPH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ENOPH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.22   Ensembl cytogenetic band:  4q21.22   HGNC cytogenetic band: 4q21.3

ENOPH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENOPH1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P083351:  view genomic region     (about GC identifiers)

Start:
83,351,715 bp from pter      End:
83,382,244 bp from pter
Size:
30,530 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ENOPH_HUMAN, Q9UHY7 (See protein sequence)
Recommended Name: Enolase-phosphatase E1  
Size: 261 amino acids; 28933 Da
Cofactor: Binds 1 magnesium ion per subunit
Subunit: Monomer
Sequence caution: Sequence=AAQ13671.1; Type=Frameshift; Positions=235;
2 PDB 3D structures from and Proteopedia for ENOPH1:
1YNS (3D)        1ZS9 (3D)    
Secondary accessions: Q7Z4C5 Q9BVC2
Alternative splicing: 2 isoforms:  Q9UHY7-1   Q9UHY7-2   

Explore the universe of human proteins at neXtProt for ENOPH1: NX_Q9UHY7

Explore proteomics data for ENOPH1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ENOPH1 (Q9UHY7) (see all 10)
     LLDIEGT  IGHKVES  NILFLTDV  SSGSVEAQ 


    See ENOPH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067027.1  
    ENSEMBL proteins: 
     ENSP00000273920   ENSP00000422005   ENSP00000427209  
    Reactome Protein details: Q9UHY7

    ENOPH1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for ENOPH1
    OriGene Custom Protein Services for ENOPH1
    GenScript Custom Purified and Recombinant Proteins Services for ENOPH1
    Novus Biologicals ENOPH1 Proteins
    Novus Biologicals ENOPH1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ENOPH1
    Cloud-Clone Corp. Proteins for ENOPH1

    ENOPH1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for ENOPH1
    Cloud-Clone Corp. Antibodies for ENOPH1
    ThermoFisher Antibodies for ENOPH1
    LSBio Antibodies in human, mouse, rat for ENOPH1

    ENOPH1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ENOPH1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ENOPH1
    Cloud-Clone Corp. CLIAs for ENOPH1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR006439 HAD-SF_hydro_IA
     IPR023214 HAD-like_dom
     IPR027511 ENOPH1_eukaryotes
     IPR023943 Enolase-ppase_E1

    Graphical View of Domain Structure for InterPro Entry Q9UHY7

    ProtoNet protein and cluster: Q9UHY7

    UniProtKB/Swiss-Prot: ENOPH_HUMAN, Q9UHY7
    Similarity: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family


    ENOPH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENOPH_HUMAN, Q9UHY7
    Function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate
    (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is
    then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)
    Catalytic activity: 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one
    + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.771 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0016787hydrolase activity ----
    GO:0043874acireductone synthase activity TAS--
         
    ENOPH1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ENOPH1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ENOPH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ENOPH1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ENOPH1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ENOPH1:
    hsa-mir-484 (MIRT042153), hsa-mir-375 (MIRT019743), hsa-mir-92a-3p (MIRT049352)

    Block miRNA regulation of human, mouse, rat ENOPH1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ENOPH1:
    hsa-miR-3163 hsa-miR-1323 hsa-miR-548o hsa-miR-340 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidENOPH1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ENOPH1
    Predesigned siRNA for gene silencing in human, mouse, rat ENOPH1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ENOPH1

    Clone
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    OriGene clones in human, mouse for ENOPH1 (see all 7)
    OriGene ORF clones in mouse, rat for ENOPH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ENOPH1 (NM_021204)
    Sino Biological Human cDNA Clone for ENOPH1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENOPH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENOPH1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ENOPH1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ENOPH1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENOPH1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ENOPH_HUMAN, Q9UHY7: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    nucleus2
    endoplasmic reticulum1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    ENOPH1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ENOPH1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism of amino acids and derivatives
    Methionine salvage pathway0.00
    Metabolism of polyamines0.00
    Metabolism of amino acids and derivatives
    S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I0.00
    2Sulfur amino acid metabolism
    Sulfur amino acid metabolism0.35
    Cysteine and methionine metabolism0.35
    3Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ENOPH1
        S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I


    1 Reactome Pathway for ENOPH1
        Methionine salvage pathway


    1 Kegg Pathway  (Kegg details for ENOPH1):
        Cysteine and methionine metabolism

    UniProtKB/Swiss-Prot: ENOPH_HUMAN, Q9UHY7
    Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from
    S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6
    Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from
    S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6


    ENOPH1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ENOPH1: 

              Amino Acid Metabolism I in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ENOPH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ENOPH1 (Q9UHY72, 3 ENSP000002739204) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS27P426772, 3, ENSP000003575554MINT-8269318 I2D: score=4 STRING: ENSP00000357555
    RAB10P610262, 3, ENSP000002647104MINT-8267731 I2D: score=2 STRING: ENSP00000264710
    ADI1Q9BV573, ENSP000003336664I2D: score=1 STRING: ENSP00000333666
    APIPQ96GX93, ENSP000002783594I2D: score=1 STRING: ENSP00000278359
    VBP1P617583, ENSP000002864284I2D: score=1 STRING: ENSP00000286428
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0006595polyamine metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0016311dephosphorylation TAS--
    GO:0019509L-methionine salvage from methylthioadenosine TAS--

    ENOPH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ENOPH1 (ENOPH)

    3 HMDB Compounds for ENOPH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for ENOPH1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-OXOHEPTYLPHOSPHONIC ACID-- --target--10592235

    3 Novoseek inferred chemical compound relationships for ENOPH1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 48.4 4 8321287 (1), 11890701 (1), 1515036 (1), 20164921 (1)
    pyruvate 25 3 8344439 (1), 9007715 (1)
    atp 15.8 3 1649632 (1), 20448897 (1)



    ENOPH1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ENOPH1 gene: 
    NM_021204.3  

    Unigene Cluster for ENOPH1:

    Enolase-phosphatase 1
    Hs.18442  [show with all ESTs]
    Unigene Representative Sequence: NM_021204
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273920(uc003hmv.3 uc003hmx.3) ENST00000509635 ENST00000505846

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ENOPH1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ENOPH1:
    hsa-miR-3163 hsa-miR-1323 hsa-miR-548o hsa-miR-340 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidENOPH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ENOPH1
    Predesigned siRNA for gene silencing in human, mouse, rat ENOPH1
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    OriGene clones in human, mouse for ENOPH1 (see all 7)
    OriGene ORF clones in mouse, rat for ENOPH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ENOPH1 (NM_021204)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENOPH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENOPH1
    Primer
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    OriGene qPCR primer pairs and template standards for ENOPH1
    OriGene qSTAR qPCR primer pairs in human, mouse for ENOPH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ENOPH1
      QuantiTect SYBR Green Assays in human, mouse, rat ENOPH1
      QuantiFast Probe-based Assays in human, mouse, rat ENOPH1

    Additional mRNA sequence: 

    AF087881.1 AF113125.1 AF177286.1 AK022656.1 AL110167.1 BC001317.1 BC065815.1 CR457141.1 

    23 DOTS entries:

    DT.95215271  DT.99955049  DT.121220779  DT.75136185  DT.91759671  DT.100645207  DT.100815443  DT.121220876 
    DT.91759674  DT.100815445  DT.95215269  DT.95215272  DT.100815444  DT.121220687  DT.121220706  DT.121220710 
    DT.121220861  DT.121220899  DT.121220932  DT.91976208  DT.95148785  DT.97796737  DT.91746894 

    Selected AceView cDNA sequences (see all 255):

    AA468653 AI768023 AI204417 AF177286 BF195902 BM849398 AA496200 CA424329 
    CR615673 BM702528 AI695232 BU153607 BQ053059 BU629399 AI699162 AA631541 
    AA831182 AI985488 BG499942 AI382666 AI263018 BU615698 AI702502 AA279850 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ENOPH1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e
    SP1:              -     -     -     -     -     -     -                                         -                                                   
    SP2:                                      -     -     -                                         -                                                   
    SP3:                                -     -     -     -                 -                       -                                                   
    SP4:                                -     -     -     -                                         -                                                   
    SP5:                                                  -                                                                                             


    ECgene alternative splicing isoforms for ENOPH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ENOPH1 expression in normal human tissues (normalized intensities)      ENOPH1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTGATTAA
    ENOPH1 Expression
    About this image


    ENOPH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    ENOPH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ENOPH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.18442
        Pathway & Disease-focused RT2 Profiler PCR Array including ENOPH1: 
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ENOPH1
    OriGene qSTAR qPCR primer pairs in human, mouse for ENOPH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ENOPH1
    QuantiTect SYBR Green Assays in human, mouse, rat ENOPH1
    QuantiFast Probe-based Assays in human, mouse, rat ENOPH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENOPH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ENOPH1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Enoph11 , 5 enolase-phosphatase 11, 5 85.34(n)1
    94.55(a)1
      5 (48.46 cM)5
    678701  NM_026421.31  NP_080697.21 
     1000399945 
    chicken
    (Gallus gallus)
    Aves ENOPH11 enolase-phosphatase 1 72.8(n)
    78.54(a)
      422600  XM_420559.4  XP_420559.4 
    lizard
    (Anolis carolinensis)
    Reptilia ENOPH16
    enolase-phosphatase 1
    72(a)
    1 ↔ 1
    5(42909871-42935984)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.135902 Xenopus laevis transcribed sequence with weak similarity more 73.83(n)    BX847718.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI890272.12   -- 71.76(n)    BI890272.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG121731 CG12173 52.79(n)
    43.35(a)
      40630  NM_141266.3  NP_649523.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F58H1.31 F58H1.3 51.18(n)
    44.81(a)
      179634  NM_001047673.2  NP_001041138.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UTR4(YEL038W)4 Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate more   --   5(80462-81145) 856673  NP_010876.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g01012001 Os01g0101200 51.9(n)
    49.37(a)
      4326460  NM_001048276.1  NP_001041741.1 


    ENSEMBL Gene Tree for ENOPH1 (if available)
    TreeFam Gene Tree for ENOPH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ENOPH1 gene

    ENOPH1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ENOPH1
    PGOHUM00000237900


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ENOPH1 (see all 563)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1412663301,2
    --83353475(+) AAGAAA/CTCGAG 1 -- int10--------
    rs1875370121,2
    --83353530(+) TCTCGC/TTCTGT 1 -- int10--------
    rs1927896031,2
    --83353616(+) TCGCAC/GCCTCT 1 -- int10--------
    rs1854337401,2
    --83353727(+) AAGTGA/GTTCAC 1 -- int10--------
    rs579442081,2
    C--83353801(+) TGTTT-/TGTTT/T
    GTTTTGTTT
    GAGAC
    1 -- int10--------
    rs1890580831,2
    C--83353863(+) GAATAC/TAGTGG 1 -- int10--------
    rs76731561,2
    C--83353944(+) cgcacA/Caccac 1 -- int10--------
    rs1483274501,2
    --83353958(+) CGGCTA/GATTTT 1 -- int10--------
    rs1919087651,2
    --83354045(+) GGCGCA/GAGCCA 1 -- int10--------
    rs1842958611,2
    --83354054(+) CACCGC/TGCCTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ENOPH1 (83351715 - 83382244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ENOPH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829988CNV Loss17160897
    nsv829989CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ENOPH1
    DNA2.0 Custom Variant and Variant Library Synthesis for ENOPH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    8 diseases for ENOPH1:    About MalaCards
    primary biliary cirrhosis    papilloma    multiple myeloma    myeloma
    retinoblastoma    parkinson's disease    malaria    leukemia


    ENOPH1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for ENOPH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ENOPH1 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with ENOPH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of human E1 enzyme and its complex with a substrate analog reveals the mechanism of its phosphatase/enolase activity. (PubMed id 15843022)1, 2, 3, 9 Wang H.... Rao Z. (J. Mol. Biol. 2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    7. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58478 HGNC: 24599 AceView: MASA Ensembl:ENSG00000145293 euGenes: HUgn58478
    ECgene: ENOPH1 Kegg: 58478 H-InvDB: ENOPH1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ENOPH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ENOPH1 gene:
    Search GeneIP for patents involving ENOPH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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