Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENOPH1 Gene

protein-coding   GIFtS: 56
GCID: GC04P083351

Enolase-Phosphatase 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Enolase-Phosphatase 11 2     MASA Homolog2 3
Acireductone Synthase1 2     EC 3.1.3.773 8
Enolase-Phosphatase E11 2     E12
2,3-Diketo-5-Methylthio-1-Phosphopentane Phosphatase2 3     MST1452
MASA2 3     mtnC2

External Ids:    HGNC: 245991   Entrez Gene: 584782   Ensembl: ENSG000001452937   UniProtKB: Q9UHY73   

Export aliases for ENOPH1 gene to outside databases

Previous GC identifers: GC04P083570 GC04P079093


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ENOPH1 Gene: 
ENOPH1 (enolase-phosphatase 1) is a protein-coding gene. Diseases associated with ENOPH1 include primary biliary cirrhosis, and papilloma, and among its related super-pathways are S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I and Cysteine and methionine metabolism. GO annotations related to this gene include magnesium ion binding and acireductone synthase activity.

UniProtKB/Swiss-Prot: ENOPH_HUMAN, Q9UHY7
Function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate
(DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is
then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ENOPH1 gene promoter:
         E2F-4   E2F-3a   HFH-3   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidENOPH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ENOPH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENOPH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.22   Ensembl cytogenetic band:  4q21.22   HGNC cytogenetic band: 4q21.3

ENOPH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENOPH1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P083351:  view genomic region     (about GC identifiers)

Start:
83,351,715 bp from pter      End:
83,382,244 bp from pter
Size:
30,530 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ENOPH_HUMAN, Q9UHY7 (See protein sequence)
Recommended Name: Enolase-phosphatase E1  
Size: 261 amino acids; 28933 Da
Cofactor: Binds 1 magnesium ion per subunit
Subunit: Monomer
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Sequence caution: Sequence=AAQ13671.1; Type=Frameshift; Positions=235;
2 PDB 3D structures from and Proteopedia for ENOPH1:
1YNS (3D)        1ZS9 (3D)    
Secondary accessions: Q7Z4C5 Q9BVC2
Alternative splicing: 2 isoforms:  Q9UHY7-1   Q9UHY7-2   

Explore the universe of human proteins at neXtProt for ENOPH1: NX_Q9UHY7

Explore proteomics data for ENOPH1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHY7

  • 4/10 DME Specific Peptides for ENOPH1 (Q9UHY7) (see all 10)
     LLDIEGT  IGHKVES  NILFLTDV  SSGSVEAQ 

    ENOPH1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ENOPH1 Protein Expression
    REFSEQ proteins: NP_067027.1  
    ENSEMBL proteins: 
     ENSP00000273920   ENSP00000422005   ENSP00000427209  
    Reactome Protein details: Q9UHY7
    Human Recombinant Protein Products for ENOPH1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ENOPH1
    OriGene Protein Over-expression Lysate for ENOPH1
    OriGene MassSpec for ENOPH1 
    OriGene Custom Protein Services for ENOPH1
    GenScript Custom Purified and Recombinant Proteins Services for ENOPH1
    Novus Biologicals ENOPH1 Proteins
    Novus Biologicals ENOPH1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ENOPH1
    Cloud-Clone Corp. Proteins for ENOPH1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    ENOPH1 for ontologies           About GeneDecksing



    ENOPH1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ENOPH1
    GenScript Custom Superior Antibodies Services for ENOPH1
    Novus Biologicals ENOPH1 Antibodies
    Abcam antibodies for ENOPH1
    Cloud-Clone Corp. Antibodies for ENOPH1 
    ThermoFisher Antibodies for ENOPH1
    LSBio Antibodies in human, mouse, rat for ENOPH1 

    Assay Products for ENOPH1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ENOPH1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ENOPH1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ENOPH1 
    Cloud-Clone Corp. CLIAs for ENOPH1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR006439 HAD-SF_hydro_IA_v1
     IPR023214 HAD-like_dom
     IPR027511 ENOPH1_eukaryotes
     IPR023943 Enolase-ppase_E1

    Graphical View of Domain Structure for InterPro Entry Q9UHY7

    ProtoNet protein and cluster: Q9UHY7

    UniProtKB/Swiss-Prot: ENOPH_HUMAN, Q9UHY7
    Similarity: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family


    ENOPH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENOPH_HUMAN, Q9UHY7
    Function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate
    (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is
    then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)
    Catalytic activity: 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one
    + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.771 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0008967phosphoglycolate phosphatase activity ----
    GO:0016787hydrolase activity ----
    GO:0043874acireductone synthase activity TAS--
         
    ENOPH1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ENOPH1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ENOPH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ENOPH1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ENOPH1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENOPH1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ENOPH1:
    hsa-miR-3163 hsa-miR-1323 hsa-miR-548o hsa-miR-340 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidENOPH1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ENOPH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENOPH1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ENOPH1
    Sirion Biotech Customized adenovirus for overexpression of ENOPH1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ENOPH1 (see all 8)
    OriGene ORF clones in mouse, rat for ENOPH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ENOPH1 (NM_021204)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENOPH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENOPH1
    Sirion Biotech Customized lentivirus for stable overexpression of ENOPH1 
                         Customized lentivirus expression plasmids for stable overexpression of ENOPH1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ENOPH1
    Search LifeMap BioReagents cell lines for ENOPH1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENOPH1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ENOPH1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Methionine salvage pathway
    Methionine salvage pathway0.67
    Metabolism of polyamines0.40
    S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I0.67
    2Cysteine and methionine metabolism
    Cysteine and methionine metabolism0.37
    Sulfur amino acid metabolism0.37
    3Metabolism
    Metabolism0.40
    4Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ENOPH1
        S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I

    5        Reactome Pathways for ENOPH1
        Metabolism of polyamines
    Metabolism
    Methionine salvage pathway
    Sulfur amino acid metabolism
    Metabolism of amino acids and derivatives


    1         Kegg Pathway  (Kegg details for ENOPH1):
        Cysteine and methionine metabolism

    UniProtKB/Swiss-Prot: ENOPH_HUMAN, Q9UHY7
    Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from
    S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6
    Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from
    S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6


    ENOPH1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENOPH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/22 Interacting proteins for ENOPH1 (Q9UHY72, 3 ENSP000002739204) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS27P426772, 3, ENSP000003575554MINT-8269318 I2D: score=4 STRING: ENSP00000357555
    RAB10P610262, 3, ENSP000002647104MINT-8267731 I2D: score=2 STRING: ENSP00000264710
    ADI1Q9BV573, ENSP000003336664I2D: score=1 STRING: ENSP00000333666
    APIPQ96GX93, ENSP000002783594I2D: score=1 STRING: ENSP00000278359
    VBP1P617583, ENSP000002864284I2D: score=1 STRING: ENSP00000286428
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0006595polyamine metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0019509L-methionine salvage from methylthioadenosine TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--

    ENOPH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ENOPH1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ENOPH1 (ENOPH)

    3 HMDB Compounds for ENOPH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for ENOPH1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-OXOHEPTYLPHOSPHONIC ACID-- --target--10592235

    3 Novoseek inferred chemical compound relationships for ENOPH1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 48.4 4 8321287 (1), 11890701 (1), 1515036 (1), 20164921 (1)
    pyruvate 25 3 8344439 (1), 9007715 (1)
    atp 15.8 3 1649632 (1), 20448897 (1)

    Search CenterWatch for drugs/clinical trials and news about ENOPH1 / ENOPH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ENOPH1 gene: 
    NM_021204.3  

    Unigene Cluster for ENOPH1:

    Enolase-phosphatase 1
    Hs.18442  [show with all ESTs]
    Unigene Representative Sequence: NM_021204
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273920(uc003hmv.3 uc003hmx.3) ENST00000509635 ENST00000505846

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENOPH1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ENOPH1:
    hsa-miR-3163 hsa-miR-1323 hsa-miR-548o hsa-miR-340 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidENOPH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ENOPH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENOPH1
    Clone
    Products:
         
    OriGene clones in human, mouse for ENOPH1 (see all 8)
    OriGene ORF clones in mouse, rat for ENOPH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ENOPH1 (NM_021204)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENOPH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENOPH1
    Sirion Biotech Customized lentivirus for stable overexpression of ENOPH1 
                         Customized lentivirus expression plasmids for stable overexpression of ENOPH1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ENOPH1
    OriGene qSTAR qPCR primer pairs in human, mouse for ENOPH1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ENOPH1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ENOPH1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENOPH1

    Additional mRNA sequence: 

    AF087881.1 AF113125.1 AF177286.1 AK022656.1 AL110167.1 BC001317.1 BC065815.1 CR457141.1 

    23 DOTS entries:

    DT.95215271  DT.99955049  DT.121220779  DT.75136185  DT.91759671  DT.100645207  DT.100815443  DT.121220876 
    DT.91759674  DT.100815445  DT.95215269  DT.95215272  DT.100815444  DT.121220687  DT.121220706  DT.121220710 
    DT.121220861  DT.121220899  DT.121220932  DT.91976208  DT.95148785  DT.97796737  DT.91746894 

    24/255 AceView cDNA sequences (see all 255):

    AA360888 BU615698 R18965 AI248672 BU153607 BQ053059 AA831636 CR593619 
    AA496200 AA631541 AA338858 BC065815 AA831182 AI382666 AI263018 AI699162 
    AI270773 CR623426 BC001317 BG499942 AA468653 AA384769 AI768023 BU629399 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ENOPH1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e
    SP1:              -     -     -     -     -     -     -                                         -                                                   
    SP2:                                      -     -     -                                         -                                                   
    SP3:                                -     -     -     -                 -                       -                                                   
    SP4:                                -     -     -     -                                         -                                                   
    SP5:                                                  -                                                                                             


    ECgene alternative splicing isoforms for ENOPH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ENOPH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTGATTAA
    ENOPH1 Expression
    About this image


    See ENOPH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ENOPH1

    SOURCE GeneReport for Unigene cluster: Hs.18442
        SABiosciences Expression via Pathway-Focused PCR Array including ENOPH1: 
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ENOPH1
    OriGene qSTAR qPCR primer pairs in human, mouse for ENOPH1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ENOPH1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ENOPH1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENOPH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENOPH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ENOPH1 gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Enoph11 , 5 enolase-phosphatase 11, 5 85.34(n)1
    94.55(a)1
      5 (48.46 cM)5
    678701  NM_001163035.11  NP_001156507.11 
     1000399945 
    chicken
    (Gallus gallus)
    Aves ENOPH11 enolase-phosphatase 1 72.8(n)
    78.54(a)
      422600  XM_420559.3  XP_420559.3 
    lizard
    (Anolis carolinensis)
    Reptilia ENOPH16
    enolase-phosphatase 1
    73(a)
    1 ↔ 1
    5(42909871-42935984)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.135902 Xenopus laevis transcribed sequence with weak similarity more 73.83(n)    BX847718.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI890272.12   -- 71.76(n)    BI890272.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG121731 CG12173 52.36(n)
    42.92(a)
      40630  NM_141266.2  NP_649523.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F58H1.31 Protein F58H1.3 51.4(n)
    44.96(a)
      179634  NM_001047673.1  NP_001041138.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UTR4(YEL038W)4
    UTR41
    Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate more4
    Utr4p1
    48.57(n)1
    38.57(a)1
      5(80462-81145)4
    8566731, 4  NP_010876.21, 4 
    rice
    (Oryza sativa)
    Liliopsida Os01g01012001 hypothetical protein 52.06(n)
    49.79(a)
      4326460  NM_001048276.1  NP_001041741.1 


    ENSEMBL Gene Tree for ENOPH1 (if available)
    TreeFam Gene Tree for ENOPH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ENOPH1 gene

    ENOPH1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ENOPH1
    PGOHUM00000237900


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/563 SNPs in ENOPH1 are shown (see all 563)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1412663301,2
    --83353475(+) AAGAAA/CTCGAG 1 -- int10--------
    rs1875370121,2
    --83353530(+) TCTCGC/TTCTGT 1 -- int10--------
    rs1927896031,2
    --83353616(+) TCGCAC/GCCTCT 1 -- int10--------
    rs1854337401,2
    --83353727(+) AAGTGA/GTTCAC 1 -- int10--------
    rs579442081,2
    C--83353801(+) TGTTT-/TGTTT/T
    GTTTTGTTT
    GAGAC
    1 -- int10--------
    rs1890580831,2
    C--83353863(+) GAATAC/TAGTGG 1 -- int10--------
    rs76731561,2
    C--83353944(+) cgcacA/Caccac 1 -- int10--------
    rs1483274501,2
    --83353958(+) CGGCTA/GATTTT 1 -- int10--------
    rs1919087651,2
    --83354045(+) GGCGCA/GAGCCA 1 -- int10--------
    rs1842958611,2
    --83354054(+) CACCGC/TGCCTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ENOPH1 (83351715 - 83382244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ENOPH1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829988CNV Loss17160897
    nsv829989CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ENOPH1
    DNA2.0 Custom Variant and Variant Library Synthesis for ENOPH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    7 diseases for ENOPH1:    About MalaCards
    primary biliary cirrhosis    papilloma    multiple myeloma    retinoblastoma
    myeloma    parkinson's disease    leukemia


    ENOPH1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for ENOPH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENOPH1 gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with ENOPH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of human E1 enzyme and its complex with a substrate analog reveals the mechanism of its phosphatase/enolase activity. (PubMed id 15843022)1, 2, 3, 9 Wang H.... Rao Z. (2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58478 HGNC: 24599 AceView: MASA Ensembl:ENSG00000145293 euGenes: HUgn58478
    ECgene: ENOPH1 Kegg: 58478 H-InvDB: ENOPH1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ENOPH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ENOPH1 gene:
    Search GeneIP for patents involving ENOPH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ENOPH1  
     OriGene qPCR primer pairs and template standards for ENOPH1   OriGene Protein Over-expression Lysate for ENOPH1  
     OriGene MassSpec something-or-other for ENOPH1   OriGene clones in human, mouse for ENOPH1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ENOPH1   OriGene Purified Protein for ENOPH1  
     OriGene ORF clones in mouse, rat for ENOPH1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ENOPH1   OriGene Custom Protein Services for ENOPH1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ENOPH1
     QIAGEN SeqTarget long-range PCR primers for resequencing ENOPH1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENOPH1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENOPH1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENOPH1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ENOPH1
     GenScript Custom Purified and Recombinant Proteins Services for ENOPH1 GenScript cDNA clones with any tag delivered in your preferred vector for ENOPH1
     GenScript Custom Assay Services for ENOPH1 GenScript Custom Superior Antibodies Services for ENOPH1
     GenScript Custom overexpressing Cell Line Services for ENOPH1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ENOPH1 promoter
     Search Chromatin IP Primers for ENOPH1
     RT2 qPCR Primer Assay in human, mouse, rat ENOPH1
     Search GNC Networks for ENOPH1
     SABiosciences PCR Arrays including human, mouse, rat ENOPH1
     Search Tocris compounds for ENOPH1 (ENOPH)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ENOPH1 antibodies
     ENOPH1 proteins
     ENOPH1 lysates
     Antibodies for ENOPH1
     See all of Abcam's Antibodies, Kits and Proteins for ENOPH1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ENOPH1




     Proteins for ENOPH1
     Antibodies for ENOPH1
     ELISAs for ENOPH1
     CLIAs for ENOPH1
     Search LifeMap BioReagents cell lines for ENOPH1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENOPH1
     SwitchGear 3'UTR luciferase reporter plasmids for ENOPH1
     SwitchGear Promoter luciferase reporter plasmids for ENOPH1
     ThermoFisher Antibodies for ENOPH1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENOPH1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ENOPH1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ENOPH1
    Customized:
     lentivirus for stable overexpression of ENOPH1
     lentivirus expression plasmids for stable overexpression of ENOPH1
     adenovirus for overexpression of ENOPH1
     LSBio Antibodies in human, mouse, rat for ENOPH1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ENOPH1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4