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Aliases for ENO4 Gene

Aliases for ENO4 Gene

  • Enolase Family Member 4 2 3
  • C10orf134 3 4
  • Chromosome 10 Open Reading Frame 134 2

External Ids for ENO4 Gene

Previous HGNC Symbols for ENO4 Gene

  • C10orf134

Previous GeneCards Identifiers for ENO4 Gene

  • GC10P118599
  • GC10P112237

Summaries for ENO4 Gene

GeneCards Summary for ENO4 Gene

ENO4 (Enolase Family Member 4) is a Protein Coding gene. GO annotations related to this gene include protein heterodimerization activity and phosphopyruvate hydratase activity. An important paralog of this gene is ENO2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENO4 Gene

Genomics for ENO4 Gene

Genomic Location for ENO4 Gene

Chromosome:
10
Start:
116,849,212 bp from pter
End:
116,943,974 bp from pter
Size:
94,763 bases
Orientation:
Plus strand

Genomic View for ENO4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENO4 Gene

No data available for Regulatory Elements for ENO4 Gene

Proteins for ENO4 Gene

  • Protein details for ENO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNW6-ENO4_HUMAN
    Recommended name:
    Enolase-like protein ENO4
    Protein Accession:
    A6NNW6
    Secondary Accessions:
    • B8ZZN9

    Protein attributes for ENO4 Gene

    Size:
    628 amino acids
    Molecular mass:
    68821 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ENO4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENO4 Gene

Proteomics data for ENO4 Gene at MOPED

Post-translational modifications for ENO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENO4 Gene

No data available for DME Specific Peptides for ENO4 Gene

Domains & Families for ENO4 Gene

Protein Domains for ENO4 Gene

Suggested Antigen Peptide Sequences for ENO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NNW6

UniProtKB/Swiss-Prot:

ENO4_HUMAN :
  • Belongs to the enolase family.
Family:
  • Belongs to the enolase family.
genes like me logo Genes that share domains with ENO4: view

No data available for Gene Families for ENO4 Gene

Function for ENO4 Gene

Gene Ontology (GO) - Molecular Function for ENO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003674 molecular_function ND --
GO:0004634 phosphopyruvate hydratase activity IEA --
GO:0005515 protein binding --
GO:0046982 protein heterodimerization activity --
genes like me logo Genes that share ontologies with ENO4: view

Phenotypes for ENO4 Gene

genes like me logo Genes that share phenotypes with ENO4: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ENO4 Gene

Localization for ENO4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENO4 Gene COMPARTMENTS Subcellular localization image for ENO4 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for ENO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000015 phosphopyruvate hydratase complex IEA --
GO:0005575 cellular_component ND --
GO:0097228 sperm principal piece --
genes like me logo Genes that share ontologies with ENO4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ENO4 Gene

Pathways & Interactions for ENO4 Gene

SuperPathways for ENO4 Gene

No Data Available

Interacting Proteins for ENO4 Gene

Gene Ontology (GO) - Biological Process for ENO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006096 glycolytic process IEA --
GO:0008150 biological_process ND --
GO:0030317 sperm motility --
GO:0044782 cilium organization --
genes like me logo Genes that share ontologies with ENO4: view

No data available for Pathways by source and SIGNOR curated interactions for ENO4 Gene

Drugs & Compounds for ENO4 Gene

No Compound Related Data Available

Transcripts for ENO4 Gene

mRNA/cDNA for ENO4 Gene

(8) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ENO4 Gene

Enolase family member 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENO4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENO4 Gene

No ASD Table

Relevant External Links for ENO4 Gene

GeneLoc Exon Structure for
ENO4
ECgene alternative splicing isoforms for
ENO4

Expression for ENO4 Gene

mRNA expression in normal human tissues for ENO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ENO4 Gene

This gene is overexpressed in CD4 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ENO4 Gene



SOURCE GeneReport for Unigene cluster for ENO4 Gene Hs.693248

genes like me logo Genes that share expression patterns with ENO4: view

Protein tissue co-expression partners for ENO4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ENO4 Gene

Orthologs for ENO4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENO4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ENO4 35
  • 86.44 (n)
  • 84.31 (a)
ENO4 36
  • 42 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENO4 35
  • 85.04 (n)
  • 80.88 (a)
ENO4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eno4 35
  • 78.08 (n)
  • 73.05 (a)
Eno4 16
Eno4 36
  • 36 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ENO4 35
  • 99.2 (n)
  • 99.04 (a)
ENO4 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eno4 35
  • 78.52 (n)
  • 73.75 (a)
oppossum
(Monodelphis domestica)
Mammalia ENO4 36
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENO4 36
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves ENO4 35
  • 62.57 (n)
  • 53.02 (a)
ENO4 36
  • 24 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENO4 36
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eno4 35
  • 58.5 (n)
  • 52.99 (a)
zebrafish
(Danio rerio)
Actinopterygii eno4 35
  • 52.07 (n)
  • 43.05 (a)
eno4 36
  • 18 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENO1 36
  • 11 (a)
ManyToMany
ENO2 36
  • 10 (a)
ManyToMany
ERR1 36
  • 12 (a)
ManyToMany
ERR2 36
  • 12 (a)
ManyToMany
ERR3 36
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToOne
Species with no ortholog for ENO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ENO4 Gene

ENSEMBL:
Gene Tree for ENO4 (if available)
TreeFam:
Gene Tree for ENO4 (if available)

Paralogs for ENO4 Gene

Paralogs for ENO4 Gene

genes like me logo Genes that share paralogs with ENO4: view

Variants for ENO4 Gene

Sequence variations from dbSNP and Humsavar for ENO4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1616412 -- 116,855,387(+) CCCCA(C/T)ATACC intron-variant
rs1617023 -- 116,873,634(-) TCTAA(A/C)GCTTG intron-variant
rs1623567 -- 116,861,236(-) TATAT(A/T)TTTTT intron-variant
rs1637570 -- 116,860,018(+) TGTTC(A/G)TTTGA intron-variant
rs1637571 -- 116,868,525(+) TGTGC(A/G)TGTAT intron-variant

Variation tolerance for ENO4 Gene

Gene Damage Index Score: 2.58; 44.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENO4 Gene

HapMap Linkage Disequilibrium report
ENO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ENO4 Gene

Disorders for ENO4 Gene

Relevant External Links for ENO4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENO4
genes like me logo Genes that share disorders with ENO4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENO4 Gene

Publications for ENO4 Gene

  1. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 67

Products for ENO4 Gene

Sources for ENO4 Gene

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