Aliases for ENO2 Gene
External Ids for ENO2 Gene
Previous GeneCards Identifiers for ENO2 Gene
This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]
GeneCards Summary for ENO2 Gene
ENO2 (Enolase 2) is a Protein Coding gene. Diseases associated with ENO2 include Creutzfeldt-Jakob Disease and Pediatric Ovarian Dysgerminoma. Among its related pathways are HIF-1 signaling pathway and Glucose metabolism. GO annotations related to this gene include magnesium ion binding and phosphopyruvate hydratase activity. An important paralog of this gene is ENO1.
UniProtKB/Swiss-Prot for ENO2 Gene
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).