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ENO1 Gene

protein-coding   GIFtS: 72
GCID: GC01M008921

Enolase 1, (Alpha)


(Previous symbols: ENO1L1, MPB1)
  See ENO1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Enolase 1, (Alpha)1 2     alpha-enolase2
MPB11 2 3 5     enolase-alpha2
ENO1L11 2 3     MYC Promoter-Binding Protein 12
Non-Neural Enolase2 3     tau-crystallin2
Phosphopyruvate Hydratase2 3     MBP-13
Plasminogen-Binding Protein2 3     MBPB13
2-Phospho-D-Glycerate Hydro-Lyase2 3     MPB-13
NNE2 3     C-Myc Promoter-Binding Protein3
EC 4.2.1.113 8     Enolase 13
PPH2 5     EC 4.2.18
Alpha Enolase Like 12     

External Ids:    HGNC: 33501   Entrez Gene: 20232   Ensembl: ENSG000000748007   OMIM: 1724305   UniProtKB: P067333   

Export aliases for ENO1 gene to outside databases

Previous GC identifers: GC01M008541 GC01M008732 GC01M008517 GC01M008630 GC01M008855 GC01M008843 GC01M008070


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ENO1 Gene:
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer
composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in
addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of
this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor
suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1.
Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. (provided by RefSeq, Jan
2011)

GeneCards Summary for ENO1 Gene:
ENO1 (enolase 1, (alpha)) is a protein-coding gene. Diseases associated with ENO1 include non-herpetic acute limbic encephalitis, and enolase deficiency. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ENO3.

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733
Function: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such
as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and
pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the
cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production
Function: MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor

Gene Wiki entry for ENO1 (Alpha-enolase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ENO1 gene promoter:
         RFX1   Sox5   AML1a   CUTL1   GATA-1   c-Ets-1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ENO1 promoter sequence
   Search Chromatin IP Primers for ENO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ENO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.2

ENO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENO1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M008921:  view genomic region     (about GC identifiers)

Start:
8,921,059 bp from pter      End:
8,939,308 bp from pter
Size:
18,250 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733 (See protein sequence)
Recommended Name: Alpha-enolase  
Size: 434 amino acids; 47169 Da
Cofactor: Magnesium. Binds two Mg(2+) per subunit. Required for catalysis and for stabilizing the dimer
Subunit: Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or
heterodimers which are cell-type and development-specific. ENO1 interacts with PLG in the neuronal plasma
membrane and promotes its activation. The C-terminal lysine is required for this binding (By similarity)
Developmental stage: During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta
heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells
Miscellaneous: Used as a diagnostic marker for many tumors and, in the heterodimeric form, alpha/gamma, as a
marker for hypoxic brain injury after cardiac arrest. Also marker for endometriosis. Antibodies against
alpha-enolase are present in sera from patients with cancer-associated retinopathy syndrome (CAR), a progressive
blinding disease which occurs in the presence of systemic tumor growth, primarily small-cell carcinoma of the
lung and other malignancies. Is identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune
disease associated with Hashimoto thyroiditis (HT). HT is a disorder in which destructive processes overcome the
potential capacity of thyroid replacement leading to hypothyroidism
Sequence caution: Sequence=AAA35698.1; Type=Frameshift; Positions=Several; Sequence=AAA35698.1; Type=Miscellaneous
discrepancy; Note=Sequencing errors;
2 PDB 3D structures from and Proteopedia for ENO1:
2PSN (3D)        3B97 (3D)    
Secondary accessions: B2RD59 P22712 Q16704 Q4TUS4 Q53FT9 Q53HR3 Q658M5 Q6GMP2 Q71V37 Q7Z3V6
Q8WU71 Q96GV1 Q9BT62 Q9UCH6 Q9UM55
Alternative initiation: 2 isoforms:  P06733-1   P06733-2   (It is uncertain whether the alternative initiation site is at Met-94 or at Met-97)

Explore the universe of human proteins at neXtProt for ENO1: NX_P06733

Explore proteomics data for ENO1 at MOPED

Post-translational modifications: 

  • ISGylated1
  • Ubiquitination2 at Lys5, Lys28, Lys54, Lys60, Lys64, Lys71, Lys81, Lys89, Lys120, Lys126,
                                 Lys193, Lys197, Lys202, Lys221, Lys228, Lys233, Lys256, Lys262, Lys281, Lys285 (see all 27)
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ENO1 (P06733) (see all 42)
     TGQIKTG  EKGVPLY  ELLKTAI  QEFMILP 


    See ENO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001188412.1  NP_001419.1  

    ENSEMBL proteins: 
     ENSP00000234590   ENSP00000466406   ENSP00000468392  
    Reactome Protein details: P06733

    ENO1 Human Recombinant Protein Products:

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    OriGene Purified Protein for ENO1
    OriGene Protein Over-expression Lysate for ENO1
    OriGene MassSpec for ENO1
    OriGene Custom Protein Services for ENO1
    GenScript Custom Purified and Recombinant Proteins Services for ENO1
    Novus Biologicals ENO1 Proteins
    Novus Biologicals ENO1 Lysates
    Sino Biological Recombinant Protein for ENO1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ENO1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ENO1 

     
    antibodies-online proteins for ENO1 (31 products) 

     
    antibodies-online peptides for ENO1

    ENO1 Antibody Products:

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    Novus Biologicals ENO1 Antibodies
    Abcam antibodies for ENO1 (P06733, P13929)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ENO1
    antibodies-online antibodies for ENO1 (102 products) 

    ENO1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ENO1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ENO1 
    antibodies-online kits for ENO1 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR020810 Enolase_C
     IPR020811 Enolase_N
     IPR000941 Enolase
     IPR020809 Enolase_CS

    Graphical View of Domain Structure for InterPro Entry P06733

    ProtoNet protein and cluster: P06733

    1 Blocks protein domain: IPB000941 Enolase

    UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733
    Similarity: Belongs to the enolase family


    Find genes that share domains with ENO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENOA_HUMAN, P06733
    Function: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such
    as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and
    pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the
    cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production
    Function: MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor
    Catalytic activity: 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O
    Biophysicochemical properties: pH dependence: Enolase activity is lost above pH 9.0. Immunoglobulin production
    stimulating activity is retained at pH 13.0;
    Induction: Induced in diffuse large cell lymphoma (DLCL) after treatment with the natural biological agent, Bryo1.
    Up-regulated in response to enterovirus 71 (EV71) infection (at protein level)

         Genatlas biochemistry entry for ENO1:
    enolase 1,alpha subunit,ubiquitous and embryonic precocious type (2-phospho-D-glycerate
    hydratase),glycolysis,energy pathway

         Enzyme Numbers (IUBMB): EC 4.2.1.111 2 EC 4.2.12

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS2005901
    GO:0003714transcription corepressor activity TAS2005901
    GO:0004634phosphopyruvate hydratase activity IEA--
         
    Find genes that share ontologies with ENO1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ENO1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ENO1:
    hsa-mir-92a-3p (MIRT049082), hsa-mir-378a-3p (MIRT043896), hsa-mir-204-5p (MIRT047021), hsa-mir-744-5p (MIRT037729), hsa-mir-181d-5p (MIRT041167), hsa-mir-222-3p (MIRT046821), hsa-mir-18a-3p (MIRT040892), hsa-mir-1260b (MIRT052701), hsa-mir-484 (MIRT041760), hsa-mir-3177-3p (MIRT052801), hsa-mir-615-3p (MIRT039693), hsa-mir-125a-5p (MIRT045746)

    Block miRNA regulation of human, mouse, rat ENO1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ENO1:
    hsa-miR-22 hsa-miR-3168 hsa-miR-558 hsa-miR-4263 hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidENO1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ENO1
    Predesigned siRNA for gene silencing in human, mouse, rat ENO1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ENO1

    Clone
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    OriGene clones in human, mouse for ENO1 (see all 6)
    OriGene ORF clones in mouse, rat for ENO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ENO1 (NM_001428)
    Sino Biological Human cDNA Clone for ENO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENO1
    Addgene plasmids for ENO1 

    Cell Line
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    eBioscience FlowRNA Probe Sets ( VA1-12402) for ENO1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ENOA_HUMAN, P06733: Cytoplasm. Cell membrane. Cytoplasm, myofibril, sarcomere, M line. Note=Can translocate to
    the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is
    localized to the M line
    ENOA_HUMAN, P06733: Isoform MBP-1: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    plasma membrane5
    cytosol4
    cytoskeleton2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000015phosphopyruvate hydratase complex IEA--
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IC10082554
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ENO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ENO1 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis short map
    Glycolysis and gluconeogenesis short map 0.60
    Glycolysis / Gluconeogenesis0.46
    Glycolysis and Gluconeogenesis0.60
    Glycolysis0.40
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Glucose metabolism
    Glucose metabolism0.44
    Gluconeogenesis0.44
    4Carbon metabolism
    Carbon metabolism0.38
    Biosynthesis of amino acids0.38
    5Deadenylation-dependent mRNA decay
    RNA degradation0.48


    Find genes that share SuperPaths with ENO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ENO1
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for ENO1
        Glycolysis and gluconeogenesis (short map)

    4 BioSystems Pathways for ENO1
        Glycolysis and Gluconeogenesis
    HIF-1-alpha transcription factor network
    Notch signaling pathway
    Validated targets of C-MYC transcriptional activation


    2 Reactome Pathways for ENO1
        Gluconeogenesis
    Glycolysis


    Selected Kegg Pathways  (Kegg details for ENO1) (see all 6):
        Glycolysis / Gluconeogenesis
    Metabolic pathways
    Carbon metabolism
    Biosynthesis of amino acids
    RNA degradation

    UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733
    Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ENO1: 

              Cell Lineage Identification in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ENO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ENO1 (P067331, 2, 3 ENSP000002345904) via UniProtKB, MINT, STRING, and/or I2D (see all 228)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120041, 2, 3, ENSP000003684384EBI-353877,EBI-358311 MINT-7995173 MINT-7995182 MINT-7995334 I2D: score=2 STRING: ENSP00000368438
    AGTPBP1Q9UPW52, 3, ENSP000003385124MINT-2858506 I2D: score=3 STRING: ENSP00000338512
    RIPK2O433532, 3, ENSP000002207514MINT-49071 I2D: score=2 STRING: ENSP00000220751
    YWHAZP631041, 2, 3, ENSP000003095034EBI-353877,EBI-347088 MINT-51023 MINT-3304712 I2D: score=4 STRING: ENSP00000309503
    ACHEP223031, 3, ENSP000003032114EBI-353877,EBI-1637793 I2D: score=1 STRING: ENSP00000303211
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS2005901
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0006096glycolytic process TAS--

    Find genes that share ontologies with ENO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ENO1 (ENOA)

    5 HMDB Compounds for ENO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Phospho-D-glyceric acid2-Phospho-D-glycerate (see all 7)----
    3-Dehydroquinate3-Dehydroquinic acid (see all 4)----
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phosphoenolpyruvic acid2-hydroxy-Acrylic acid dihydrogen phosphate (see all 6)138-08-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for ENO1 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-phosphoglycerate 76 4 12435062 (1), 18456007 (1)
    glyceraldehyde 3-phosphate 75.1 42 17123137 (2), 16530755 (2), 15975915 (1), 16342241 (1) (see all 33)
    lysine 50 3 10428809 (1), 1656542 (1), 11127872 (1)
    4-hydroxynonenal 44.7 4 16530755 (2), 15749392 (1), 19508232 (1)
    phosphoenolpyruvate 39.1 6 18456007 (2), 12435062 (1), 14506152 (1)
    isocitrate 37.2 4 18647502 (1), 15596215 (1), 10870966 (1), 16009011 (1)
    manganese superoxide 32.8 2 16876904 (1), 19374891 (1)
    aldose 32.3 3 15975915 (1), 19407367 (1), 16342238 (1)
    3-phosphoglycerate 32.1 2 11681208 (1), 16707281 (1)
    pyruvate 29.6 10 18926919 (1), 19407367 (1), 19657000 (1), 11681208 (1) (see all 9)



    Find genes that share compounds with ENO1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ENO1 gene (2 alternative transcripts): 
    NM_001201483.1  NM_001428.3  

    Unigene Cluster for ENO1:

    Enolase 1, (alpha)
    Hs.517145  [show with all ESTs]
    Unigene Representative Sequence: AK298600
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234590(uc001apj.2 uc009vml.2) ENST00000464920(uc001api.2)
    ENST00000497492 ENST00000486051 ENST00000492343 ENST00000489867
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate ENO1:
    hsa-miR-22 hsa-miR-3168 hsa-miR-558 hsa-miR-4263 hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidENO1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ENO1
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    GenScript: all cDNA clones in your preferred vector (see all 2): ENO1 (NM_001428)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENO1
    Addgene plasmids for ENO1 
    Primer
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    OriGene qPCR primer pairs and template standards for ENO1
    OriGene qSTAR qPCR primer pairs in human, mouse for ENO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ENO1
      QuantiTect SYBR Green Assays in human, mouse, rat ENO1
      QuantiFast Probe-based Assays in human, mouse, rat ENO1
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12402) for ENO1 

    Additional mRNA sequence: 

    AF035286.1 AK098420.1 AK222517.1 AK223192.1 AK298600.1 AK309177.1 AK309291.1 AK315417.1 
    AL833741.1 BC001810.2 BC004325.1 BC004458.1 BC005884.1 BC009218.2 BC009912.2 BC011130.1 
    BC015641.2 BC021166.2 BC022545.1 BC027725.2 BC050642.2 BC113034.1 BT007163.1 BX537400.1 
    D28437.1 EF036495.1 GU170215.1 M14328.1 X84907.1 

    Selected DOTS entries (see all 180):

    DT.95167954  DT.100734628  DT.92049624  DT.92386651  DT.92472607  DT.100734610  DT.100734682  DT.95167955 
    DT.100734719  DT.97863410  DT.100734673  DT.92472698  DT.97848082  DT.95167907  DT.92472680  DT.92472726 
    DT.92393969  DT.100734614  DT.100870305  DT.100734688  DT.100734633  DT.100734671  DT.100876328  DT.100060472 

    Selected AceView cDNA sequences (see all 148):

    CR612932 CR604703 CR598066 CR617914 CR622336 CR612019 CR613962 BC009218 
    CR615779 CR617876 CR594303 CR611520 CR593962 BC004325 CR614232 CR616632 
    CR593938 CR626731 CR598051 CR595389 BC027725 CR596253 CR613408 CR601750 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ENO1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                      -                 -     -                                                         
    SP2:                    -     -     -     -                 -     -                                                         
    SP3:                                      -                                                                                 
    SP4:                                      -                                                                                 
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for ENO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ENO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCACATCG
    ENO1 Expression
    About this image


    ENO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 6 entries
             Conjunctival Superbasal Epithelial Cells Conjunctival Epithelium
             Lens
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Epithelial Cells
             Conjunctival Superbasal Epithelial Cells Conjunctival Epithelium
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
    ENO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ENO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517145

    UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733
    Tissue specificity: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta
    heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the
    gamma/gamma homodimer in neurons

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ENO1: 
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              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ENO1 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm55061 , 5 predicted gene 55061, 5 88.25(n)1
    94.7(a)1
      18 (25.33 cM)5
    4331821  NM_001025388.11  NP_001020559.11 
     480453355 
    chicken
    (Gallus gallus)
    Aves ENO11 enolase 1, (alpha) 83.45(n)
    93.5(a)
      396017  NM_205120.1  NP_990451.1 
    lizard
    (Anolis carolinensis)
    Reptilia ENO16
    enolase 1, (alpha)
    73(a)
    1 ↔ 1
    GL343334.1(1787-10608)
    African clawed frog
    (Xenopus laevis)
    Amphibia eno1-prov2 enolase 1, alpha 80.26(n)    BC054169.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi32b032 Danio rerio cDNA clone MGC73152 IMAGE4144055, complete more 82.39(n)    BC059511.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eno1 , 3 glycolysis phosphopyruvate hydratase3
    Enolase1
    72(a)3
    69.53(n)1
    73.09(a)1
      22B13
    333511  NM_164432.31  NP_722722.11 
    worm
    (Caenorhabditis elegans)
    Secernentea enol-11 enol-1 69.84(n)
    75.64(a)
      174423  NM_001027178.2  NP_001022349.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ENO2(YHR174W)4
    ERR21
    Enolase II, a phosphopyruvate hydratase that catalyzes more4
    ERR21
    58.14(n)1
    59.53(a)1
      8(451327-452640)4
    8558481  NP_015042.11  8565794 
     NP_012044.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ENO11 ENO1 62.88(n)
    69.19(a)
      843741  NM_106062.3  NP_177543.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.124622 Transcribed sequence with moderate similarity to protein more 76.2(n)    BG300628.1 


    ENSEMBL Gene Tree for ENO1 (if available)
    TreeFam Gene Tree for ENO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ENO1 gene
    ENO32  ENO22  ENO42  
    4 SIMAP similar genes for ENO1 using alignment to 4 protein entries:     ENOA_HUMAN (see all proteins):
    EDARADD    ENO3    ENO2    TMEM237

    Find genes that share paralogs with ENO1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for ENO1
    PGOHUM00000247276 PGOHUM00000244018 PGOHUM00000237744


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ENO1 (see all 538)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339747251,2
    C--8921940(+) AAAAAA/-AAAAA 2 -- int11Minor allele frequency- -:0.00NA 2
    rs289990881,2
    C,F--8925909(-) CCACTG/-GGCTT 2 -- int15Minor allele frequency- -:0.02NS 184
    rs1124040681,2
    C--8930973(+) AGAGAGA/-CTCAG 2 -- int1 ut511Minor allele frequency- -:0.50CSA 2
    rs1116715231,2
    C--8932446(+) GGTACTT/-CTTTT 2 -- int1 us2k11Minor allele frequency- -:0.00CSA 2
    rs1402697361,2
    C--8934636(+) TCTCA-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs802018101,2
    C--8935367(+) AAAAA-/AAGAGAG 1 -- int10--------
    rs289991041,2
    C,F,H--8939088(-) AGAAGG/AGCATC 2 -- ds50018Minor allele frequency- A:0.00NS NA 416
    rs1890457341,2
    --8939158(+) CCCTGA/GGAAGA 2 -- ds50010--------
    rs20714141,2
    C,F,O,A,H--8939211(-) TTCAGA/CCCAGA 2 -- ds500131Minor allele frequency- C:0.39NA NS EA WA 3030
    rs289991031,2
    C,F--8939219(-) CAGCCA/GTATTC 2 -- ds50017Minor allele frequency- G:0.04NS WA 306

    HapMap Linkage Disequilibrium report for ENO1 (8921059 - 8939308 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ENO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871026CNV Loss21882294
    nsv871694CNV Gain21882294

    Human Gene Mutation Database (HGMD): ENO1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ENO1
    DNA2.0 Custom Variant and Variant Library Synthesis for ENO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 172430    OMIM disorders: --

    7 diseases for ENO1:    
    About MalaCards
    non-herpetic acute limbic encephalitis    enolase deficiency    giardiasis    autoimmune retinopathy
    cancer-associated retinopathy    limbic encephalitis    lymphocytic hypophysitis

    1 disease from the University of Copenhagen DISEASES database for ENO1:
    Cancer

    Find genes that share disorders with ENO1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ENO1 gene (see all 48)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 51.2 31 12922171 (1), 15378762 (1), 16048908 (1), 20448348 (1) (see all 29)
    autoimmune diseases 41.2 10 15966408 (1), 17289554 (1), 11836316 (1), 11169399 (1) (see all 8)
    encephalopathy 37.1 9 17335908 (3), 15833368 (3), 17154034 (1), 16405264 (1) (see all 5)
    autoimmunity 36.8 3 19898480 (2), 11836316 (1)
    rheumatoid arthritis 35.9 7 16277695 (1), 18668562 (1), 18926919 (1), 20476908 (1) (see all 7)
    behcet disease 33 1 12847697 (1)
    retinopathy 30.5 6 15324934 (2), 15860281 (1), 9878089 (1), 17235687 (1) (see all 5)
    retinal degeneration 29.6 3 15860281 (1), 9878089 (1), 17235687 (1)
    cholangitis primary sclerosing 29.1 1 9649223 (1)
    lupus erythematosus systemic 28.3 2 8455367 (1), 10594566 (1)

    Genetic Association Database (GAD): ENO1
    Human Genome Epidemiology (HuGE) Navigator: ENO1 (2 documents)

    Export disorders for ENO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ENO1 gene, integrated from 10 sources (see all 368):
    (articles sorted by number of sources associating them with ENO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression analysis of five novel genes in chromosome 1p36. (PubMed id 9653645)1, 2, 3, 9 Onyango P.... Weith A. (Genomics 1998)
    2. ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1). (PubMed id 10802057)1, 2, 9 Feo S.... Giallongo A. (FEBS Lett. 2000)
    3. Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. (PubMed id 10681589)1, 2, 9 Subramanian A. and Miller D.M. (J. Biol. Chem. 2000)
    4. Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation. (PubMed id 10082554)1, 2, 9 Ghosh A.K.... Ray R.B. (Mol. Cell. Biol. 1999)
    5. A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1. (PubMed id 11134351)1, 2, 9 Ghosh A.K.... Ray R.B. (Mol. Cell. Biol. 2001)
    6. Identification of an epitope of alpha-enolase (a candidate plasminogen receptor) by phage display. (PubMed id 9308760)1, 2, 9 Arza B.... Munoz-Canoves P. (Thromb. Haemost. 1997)
    7. Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme. (PubMed id 18560153)1, 2, 9 Kang H.J....Chung S.J. (Acta Crystallogr. D Biol. Crystallogr. 2008)
    8. Autoreactive epitopes within the human alpha-enolase and their recognition by sera from patients with endometriosis. (PubMed id 8824716)1, 2, 9 Walter M.... Northemann W. (J. Autoimmun. 1995)
    9. Induced expression of alpha-enolase in differentiated diffuse large cell lymphoma. (PubMed id 7787969)1, 2, 9 Mohamad R.M.... Al-Katib A. (Enzyme Protein 1994)
    10. Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-enolase. (PubMed id 12666133)1, 2, 9 Lopez-Alemany R.... Felez J. (Am. J. Hematol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2023 HGNC: 3350 AceView: ENO1 Ensembl:ENSG00000074800 euGenes: HUgn2023
    ECgene: ENO1 Kegg: 2023 H-InvDB: ENO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ENO1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ENO1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/eno1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ENO1 gene:
    Search GeneIP for patents involving ENO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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