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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ENO1 Gene

protein-coding GIFtS: 70
GCID: GC01M008921

enolase 1, (alpha)

(Previous symbols: ENO1L1, MPB1)

Explore 100 diseases affiliated with
ENO1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Enolase 1, (Alpha)¹ ²		Alpha Enolase Like 1²
MPB1¹ ² ³ ⁵		Alpha-Enolase¹
ENO1L1¹ ² ³		Enolase-Alpha¹
PPH¹ ² ⁵		MYC Promoter-Binding Protein 1²
MBP-1¹ ³		Tau-Crystallin¹
Non-Neural Enolase² ³		MBPB1³
Phosphopyruvate Hydratase² ³		MPB-1³
Plasminogen-Binding Protein² ³		C-Myc Promoter-Binding Protein³
2-Phospho-D-Glycerate Hydro-Lyase² ³		Enolase 1³
NNE² ³		EC 4.2.1⁸
EC 4.2.1.11³ ⁸

External Ids:	HGNC: 3350¹	Entrez Gene: 2023²	Ensembl: ENSG00000074800⁷	OMIM: 172430⁵	UniProtKB: P06733³

Export aliases for ENO1 gene to outside databases

Previous GC identifers: GC01M008541 GC01M008732 GC01M008517 GC01M008630 GC01M008855 GC01M008843 GC01M008070

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ENO1:

This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer

composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition,

functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene

results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor.

Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been

identified as an autoantigen in Hashimoto encephalopathy. (provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733

Function: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as

growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular

fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of

several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production

Function: MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor

Gene Wiki entry for ENO1 (Alpha-enolase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_021937.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ENO1 gene promoter:
RFX1 Sox5 AML1a CUTL1 GATA-1 c-Ets-1 PPAR-gamma1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ENO1 promoter sequence

Search SABiosciences Chromatin IP Primers for ENO1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENO1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2 Ensembl cytogenetic band: 1p36.23 HGNC cytogenetic band: 1p36.2

ENO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENO1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M008921: view genomic region (about GC identifiers)

Start:	8,921,061 bp from pter	End:	8,939,308 bp from pter
Size:	18,248 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733 (See protein sequence)

Recommended Name: Alpha-enolase

Size: 434 amino acids; 47169 Da

Cofactor: Magnesium. Required for catalysis and for stabilizing the dimer

Subunit: Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or

heterodimers which are cell-type and development-specific. ENO1 interacts with PLG in the neuronal plasma membrane and

promotes its activation. The C-terminal lysine is required for this binding (By similarity)

Subcellular location: Cytoplasm. Cell membrane. Cytoplasm, myofibril, sarcomere, M line. Note=Can translocate to the

plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the

M line

Subcellular location: Isoform MBP-1: Nucleus

Developmental stage: During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta

heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells

Miscellaneous: Used as a diagnostic marker for many tumors and, in the heterodimeric form, alpha/gamma, as a marker for

hypoxic brain injury after cardiac arrest. Also marker for endometriosis. Antibodies against alpha-enolase are present

in sera from patients with cancer-associated retinopathy syndrome (CAR), a progressive blinding disease which occurs

in the presence of systemic tumor growth, primarily small-cell carcinoma of the lung and other malignancies. Is

identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune disease associated with Hashimoto

thyroiditis (HT). HT is a disorder in which destructive processes overcome the potential capacity of thyroid

replacement leading to hypothyroidism

Sequence caution: Sequence=AAA35698.1; Type=Frameshift; Positions=Several; Sequence=AAA35698.1; Type=Miscellaneous

discrepancy; Note=Sequencing errors;

2 PDB 3D structures from and Proteopedia for ENO1:

2PSN (3D)

3B97 (3D)

Secondary accessions: B2RD59 P22712 Q16704 Q4TUS4 Q53FT9 Q53HR3 Q658M5 Q6GMP2 Q71V37 Q7Z3V6 Q8WU71

Q9UCH6 Q9UM55

Alternative initiation: 2 isoforms: P06733-1 P06733-2 (It is uncertain whether the alternative initiation site is at Met-94 or at Met-97)

Explore the universe of human proteins at neXtProt for ENO1: NX_P06733

Post-translational modifications:

ISGylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P06733

4/42 DME Specific Peptides for ENO1 (P06733) (see all 42)

TGQIKTG

EKGVPLY

ELLKTAI

QEFMILP

ENO1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001188412.1 NP_001419.1

ENSEMBL proteins:

ENSP00000234590 ENSP00000466752 ENSP00000466406 ENSP00000467802 ENSP00000468392

Reactome Protein details: P06733
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ENO1 OriGene Protein Over-expression Lysate: ENO1 OriGene Custom Protein Services for ENO1
	GenScript Custom Purified and Recombinant Proteins Services for ENO1
	Novus Biologicals ENO1 Proteins Novus Biologicals ENO1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for ENO1
	Uscn Proteins for ENO1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000015	phosphopyruvate hydratase complex	IEA	--
GO:0005634	nucleus	IC	10082554
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	IEA	--

ENO1 for ontologies About GeneDecksing

ENO1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for ENO1
	OriGene Antibodies: ENO1 OriGene Custom Antibody Services for ENO1
	GenScript Custom Superior Antibodies Services for ENO1
	Novus Biologicals ENO1 Antibodies
	Abcam antibodies for ENO1
	Uscn Antibodies for ENO1
	ThermoFisher Antibody for ENO1

Assay Products for ENO1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ENO1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ENO1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ENO1 for domains About GeneDecksing

4 InterPro domains/families:

IPR020810 Enolase_C

IPR020811 Enolase_N

IPR000941 Enolase

IPR020809 Enolase_CS

Graphical View of Domain Structure for InterPro Entry P06733

ProtoNet protein and cluster: P06733

1 Blocks protein family: IPB000941 Enolase

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733

Similarity: Belongs to the enolase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733

Function: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as

growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular

fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of

several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production

Function: MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor

Catalytic activity: 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O

Biophysicochemical properties: pH dependence: Enolase activity is lost above pH 9.0. Immunoglobulin production

stimulating activity is retained at pH 13.0;

Induction: Induced in diffuse large cell lymphoma (DLCL) after treatment with the natural biological agent, Bryo1.

Up-regulated in response to enterovirus 71 (EV71) infection (at protein level)

Genatlas biochemistry entry for ENO1:

enolase 1,alpha subunit,ubiquitous and embryonic precocious type (2-phospho-D-glycerate hydratase),glycolysis,energy

pathway

Enzyme Numbers (IUBMB): EC 4.2.1.11¹ ² EC 4.2.1²

miRNA Products:		OriGene 3'-UTR Clone: ENO1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENO1
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate ENO1:
		hsa-miR-22 hsa-miR-3168 hsa-miR-558 hsa-miR-4263 hsa-miR-497*
		SwitchGear 3'UTR luciferase reporter plasmid: ENO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ENO1 OriGene shRNA RFP: ENO1 OriGene siRNA: ENO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENO1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ENO1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ENO1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ENO1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ENO1 (NM_001428)
		Sino Biological Human cDNA Clone for ENO1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENO1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENO1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ENO1
		Search LifeMap BioReagents cell lines for ENO1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENO1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	2005901
GO:0003714	transcription corepressor activity	TAS	2005901
GO:0004634	phosphopyruvate hydratase activity	IEA	--

ENO1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glycolysis and gluconeogenesis (short map)

	Glycolysis and gluconeogenesis (short map)	1.00			Glycolysis and Gluconeogenesis	0.60
	Glycolysis and gluconeogenesis (short map)	0.97			Glycolysis / Gluconeogenesis	0.41

Glucose metabolism

	Glucose metabolism	1.00			Glycolysis	0.44
	Gluconeogenesis	0.50

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

gluconeogenesis I

gluconeogenesis I

1.00

glycolysis I

0.58

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ENO1

Glycolysis and gluconeogenesis (short map)

1 Cell Signaling Technology (CST) Pathway for ENO1

Glucose / Energy Metabolism

1 GeneGo (Thomson Reuters) Pathway for ENO1

Glycolysis and gluconeogenesis (short map)

5/6 BioSystems Pathways for ENO1 (see all 6)

	Glycolysis and Gluconeogenesis
	Notch signaling pathway
	glycolysis I
	Validated targets of C-MYC transcriptional activation
	HIF-1-alpha transcription factor network

5 Reactome Pathways for ENO1

	Gluconeogenesis
	Metabolism of carbohydrates
	Metabolism
	Glucose metabolism
	Glycolysis

3 Kegg Pathways (Kegg details for ENO1):

	Glycolysis / Gluconeogenesis
	Metabolic pathways
	RNA degradation

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733

Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5

ENO1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ENO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/132 Interacting proteins for ENO1 (P06733^{1, 2, 3} ENSP00000234590⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 132)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PCNA	P12004²^,³	MINT-7995173 MINT-7995182 MINT-7995334 I2D: score=2
AGTPBP1	Q9UPW5²^,³, ENSP00000338512⁴	MINT-2858506 I2D: score=3 STRING: ENSP00000338512
RIPK2	O43353²^,³, ENSP00000220751⁴	MINT-49071 I2D: score=2 STRING: ENSP00000220751
ACHE	P22303¹^,³, ENSP00000303211⁴	EBI-353877,EBI-1637793 I2D: score=1 STRING: ENSP00000303211
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-51023 MINT-3304712 I2D: score=4 STRING: ENSP00000309503

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS	2005901
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006006	glucose metabolic process	TAS	--
GO:0006094	gluconeogenesis	TAS	--
GO:0006096	glycolysis	TAS	--

ENO1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ENO1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ENO1

5 HMDB Compounds for ENO1 About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Phospho-D-glyceric acid	2-Phospho-D-glycerate (see all 7)	--	--
3-Dehydroquinate	3-Dehydroquinic acid (see all 4)	--	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
Phosphoenolpyruvic acid	2-hydroxy-Acrylic acid dihydrogen phosphate (see all 6)	138-08-9	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

10/32 Novoseek chemical compound relationships for ENO1 gene (see all 32) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
2-phosphoglycerate	76	4	12435062 (1), 18456007 (1)
glyceraldehyde 3-phosphate	75.1	42	17123137 (2), 16530755 (2), 15975915 (1), 16342241 (1) (see all 33)
lysine	50	3	10428809 (1), 1656542 (1), 11127872 (1)
4-hydroxynonenal	44.7	4	16530755 (2), 15749392 (1), 19508232 (1)
phosphoenolpyruvate	39.1	6	18456007 (2), 12435062 (1), 14506152 (1)
isocitrate	37.2	4	18647502 (1), 15596215 (1), 10870966 (1), 16009011 (1)
manganese superoxide	32.8	2	16876904 (1), 19374891 (1)
aldose	32.3	3	15975915 (1), 19407367 (1), 16342238 (1)
3-phosphoglycerate	32.1	2	11681208 (1), 16707281 (1)
pyruvate	29.6	10	18926919 (1), 19407367 (1), 19657000 (1), 11681208 (1) (see all 9)

Search CenterWatch for drugs/clinical trials and news about ENO1 / ENOA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ENO1 gene (2 alternative transcripts):

NM_001201483.1 NM_001428.3

Unigene Clusters for ENO1:

Enolase 1, (alpha)

Hs.517145 [show with all ESTs], Hs.701472 [show with all ESTs]

Unigene Representative Sequences: AK298600, BG253883

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000234590(uc001apj.2 uc009vml.2) ENST00000464920(uc001api.2)

ENST00000464594 ENST00000497492 ENST00000486051 ENST00000463324(uc009vmm.2)

ENST00000492343 ENST00000489867

miRNA Products:		OriGene 3'-UTR Clone: ENO1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENO1
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate ENO1:
		hsa-miR-22 hsa-miR-3168 hsa-miR-558 hsa-miR-4263 hsa-miR-497*
		SwitchGear 3'UTR luciferase reporter plasmid: ENO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ENO1 OriGene shRNA RFP: ENO1 OriGene siRNA: ENO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENO1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ENO1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ENO1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ENO1 (NM_001428)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENO1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENO1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ENO1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ENO1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ENO1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENO1

Additional cDNA sequence: D28437.1

24/181 DOTS entries (see all 181):

DT.95167954 DT.100734628 DT.92049624 DT.92386651 DT.92472607 DT.100734682 DT.100734610 DT.100734719

DT.97863410 DT.95167955 DT.92472698 DT.100734673 DT.97848082 DT.95167907 DT.92472680 DT.92472726

DT.92393969 DT.100734614 DT.100734688 DT.100734671 DT.100734633 DT.100870305 DT.100876328 DT.100060472

24/148 AceView cDNA sequences (see all 148):

D28437 CR611233 CR617914 CR623000 CR624210 CR603775 CR625669 CR615234

CR594572 BC009218 CR617876 CR619978 CR596356 CR613962 CR610631 CR598611

CR606095 CR608989 CR591792 CR619767 CR604831 CR595532 CR601208 CR622336

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ENO1 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14
SP1:													-						-		-
SP2:							-		-		-		-						-		-
SP3:													-
SP4:													-
SP5:

ECgene alternative splicing isoforms for ENO1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ENO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCACATCG

About this image

ENO1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Blood Islands

Primitive Erythrocytes

Blood

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mature follicles (In-vitro growth and ...)

See ENO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ENO1

SOURCE GeneReport for Unigene clusters: Hs.517145 Hs.701472

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733

Tissue specificity: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta

heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the

gamma/gamma homodimer in neurons

SABiosciences Expression via Pathway-Focused PCR Arrays including ENO1:

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Glucose Metabolism in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for ENO1 gene from 10/45 species (see all 45) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ENO1¹	enolase 1, (alpha)	83.45(n) 93.5(a)		396017 NM_205120.1 NP_990451.1
lizard (Anolis carolinensis)	Reptilia	-- ENO1⁶	--	91(a) 86(a)	possible ortholog 1 ↔ 1	AAWZ02039863(3182-6736) GL343334.1(1892-9679)
African clawed frog (Xenopus laevis)	Amphibia	eno1-prov²	enolase 1, alpha	80.26(n)		BC054169.1
zebrafish (Danio rerio)	Actinopterygii	wufi32b03²	Danio rerio cDNA clone MGC73152 IMAGE4144055, complete more	82.39(n)		BC059511.1
fruit fly (Drosophila melanogaster)	Insecta	Eno^{1 , 3}	glycolysis phosphopyruvate hydratase³ Enolase¹	72(a)³ 69.53(n)¹ 73.09(a)¹		22B1³ 33351¹ NM_164431.2¹ NP_722721.1¹
worm (Caenorhabditis elegans)	Secernentea	enol-1¹	Protein ENOL-1	69.84(n) 75.64(a)		174423 NM_001027178.1 NP_001022349.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ENO2(YHR174W)⁴ ENO1¹	Enolase II, a phosphopyruvate hydratase that catalyzes more⁴ Eno1p¹	61.86(n)¹ 63.95(a)¹		8(451327-452640)⁴ 853169¹ NP_011770.3¹ 856579⁴ NP_012044.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	ENO1¹	enolase 1	62.88(n) 69.19(a)		843741 NM_106062.3 NP_177543.1
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	enolase, putative, expressed (see all 5)	69(a) 69(a) (see all 5)	many ↔ many many ↔ many (see all 5)	6(1930297-1935381) 3(7846930-7851761)
E. coli (Escherichia coli)	Gamma proteobacteria	eno⁶	enolase	52(a)	1 → many	Chromosome(2904665-2905963)

ENSEMBL Gene Tree for ENO1 (if available)
TreeFam Gene Tree for ENO1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ENO1 gene

ENO3² ENO2² ENO4²

2 SIMAP similar genes for ENO1 using alignment to 8 protein entries: ENOA_HUMAN (see all proteins):

ENO3 ENO2

ENO1 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for ENO1
PGOHUM00000247276 PGOHUM00000244018 PGOHUM00000237744

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28999104^1,2	C,F,H	--	8920589(-)	`AGAAGG/AGCATC`	2	--	ds500¹		8		NS NA	416
rs189045734^1,2		--	8920659(+)	`CCCTGA/GGAAGA`	2	--	ds500¹		0	--	--	--	--
rs2071414^1,2	C,F,O,A,H,	--	8920712(-)	`TTCAGA/CCCAGA`	2	--	ds500¹		31		NA NS EA WA	3030
rs28999103^1,2	C,F,	--	8920720(-)	`CAGCCA/GTATTC`	2	--	ds500¹		7		NS WA	306
rs2781071^1,2	H	--	8920736(-)	`TAGCTA/TCTAGG`	2	--	ds500¹		4		NS EA	420
rs2781070^1,2	C,H	--	8920737(-)	`GTAGCT/AACTAG`	2	--	ds500¹		4		NS EA	418
rs17032778^1,2	C,F,	--	8920814(+)	`AGTCTC/TGCTCT`	2	--	ds500¹		11		NA NS CSA WA	448
rs1065737^1,2	A	--	8921168(-)	`TTTCCA/CCCAAG`	2	--	ut3¹		3		MN NA	188
rs28999102^1,2	C,	--	8921194(-)	`CCAAGT/ACATTG`	2	--	ut3¹ ese³		5		NS	190
rs138375821^1,2	F	--	8921419(+)	`ACAGCT/CTACTT`	4	/*	syn¹		1		NA	4552

HapMap Linkage Disequilibrium report for ENO1 (8921061 - 8939308 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ENO1: --
Human Gene Mutation Database (HGMD): ENO1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ENO1 for disorders           About GeneDecksing

OMIM gene information: 172430    OMIM disorders: --

20/100 diseases for ENO1 (see all 100):    About MalaCards

open-angle glaucoma primary open angle glaucoma connective tissue disease sclerosing cholangitis

heart block primary sclerosing cholangitis enolase deficiency congenital heart block

limbic encephalitis lymphocytic hypophysitis giardiasis inflammatory bowel disease

bladder transitional cell carcinoma cholangitis transitional cell carcinoma primary biliary cirrhosis

membranous glomerulonephritis premature ovarian failure amyotrophic lateral sclerosis cryoglobulinemia

1 disease from the University of Copenhagen DISEASES database for ENO1:

Cancer

10/48 Novoseek disease relationships for ENO1 gene (see all 48) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	51.2	31	12922171 (1), 15378762 (1), 16048908 (1), 20448348 (1) (see all 29)
autoimmune diseases	41.2	10	15966408 (1), 17289554 (1), 11836316 (1), 11169399 (1) (see all 8)
encephalopathy	37.1	9	17335908 (3), 15833368 (3), 17154034 (1), 16405264 (1) (see all 5)
autoimmunity	36.8	3	19898480 (2), 11836316 (1)
rheumatoid arthritis	35.9	7	16277695 (1), 18668562 (1), 18926919 (1), 20476908 (1) (see all 7)
behcet disease	33	1	12847697 (1)
retinopathy	30.5	6	15324934 (2), 15860281 (1), 9878089 (1), 17235687 (1) (see all 5)
retinal degeneration	29.6	3	15860281 (1), 9878089 (1), 17235687 (1)
cholangitis primary sclerosing	29.1	1	9649223 (1)
lupus erythematosus systemic	28.3	2	8455367 (1), 10594566 (1)

Human Genome Epidemiology (HuGE) Navigator: ENO1 (2 documents)

Export disorders for ENO1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ENO1 gene, integrated from 9 sources (see all 347):
(articles sorted by number of sources associating them with ENO1)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and expression analysis of five novel genes in chromosome 1p36. (PubMed id 9653645)^{1, 2, 3, 9} Onyango P.... Weith A. (1998)
ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1). (PubMed id 10802057)^{1, 2, 9} Feo S.... Giallongo A. (2000)
Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. (PubMed id 10681589)^{1, 2, 9} Subramanian A. and Miller D.M. (2000)
Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation. (PubMed id 10082554)^{1, 2, 9} Ghosh A.K.... Ray R.B. (1999)
A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1. (PubMed id 11134351)^{1, 2, 9} Ghosh A.K.... Ray R.B. (2001)
Identification of an epitope of alpha-enolase (a candidate plasminogen receptor) by phage display. (PubMed id 9308760)^{1, 2, 9} Arza B.... Munoz-Canoves P. (1997)
Induced expression of alpha-enolase in differentiated diffuse large cell lymphoma. (PubMed id 7787969)^{1, 2, 9} Mohamad R.M.... Al-Katib A. (1995)
Autoreactive epitopes within the human alpha-enolase and their recognition by sera from patients with endometriosis. (PubMed id 8824716)^{1, 2, 9} Walter M.... Northemann W. (1995)
Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-enolase. (PubMed id 12666133)^{1, 2, 9} Lopez-Alemany R.... Felez J. (2003)
Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy. (PubMed id 12297304)^{1, 2, 9} Ochi H.... Kira J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2023	HGNC: 3350	AceView: ENO1	Ensembl:ENSG00000074800	euGenes: HUgn2023
ECgene: ENO1	Kegg: 2023	H-InvDB: ENO1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ENO1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ENO1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/eno1/

Intellectual Property for ENO1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ENO1 gene:
Search GeneIP for patents involving ENO1

GeneCards and IP:
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ENO1 Gene

enolase 1, (alpha)

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ENO1 (Gene Symbol)
Enolase 1, (Alpha)
MPB1
ENO1L1
PPH
MBP-1
Non-Neural Enolase
Phosphopyruvate Hydratase
Plasminogen-Binding Protein
2-Phospho-D-Glycerate Hydro-Lyase
NNE
EC 4.2.1.11
Alpha Enolase Like 1
Alpha-Enolase
Enolase-Alpha
MYC Promoter-Binding Protein 1
Tau-Crystallin
MBPB1
MPB-1
C-Myc Promoter-Binding Protein
Enolase 1
EC 4.2.1

Neurodegenerative Diseases
Visual loss
Autoimmune Diseases
BREAST CARCINOMA
LUNG TUMOR
Melanoma
Neurological Disorders
Vasculitis
Mixed cryoglobulinemia
Herpes Simplex
Pituitary Tumors
Colitis Ulcerative
Carcinoma
retinopathy
ADENOCARCINOMA LUNG
LUNG CARCINOMA
Leukemia
Breast Cancer
Ovarian Failure Premature
NSCLC
Keratoconus
HEPATOCELLULAR CARCINOMA
Adenocarcinoma
CERVICAL CARCINOMA
BILIARY CIRRHOSIS PRIMARY
ENCEPHALOPATHY
Cancer
Pancreatic Cancer
Cancer Lung
Connective Tissue Diseases
Inflammatory Bowel Diseases
CHOLANGITIS PRIMARY SCLEROSING
Shock
RENAL DISEASE
BEHCET DISEASE
Giardiasis
Tuberculosis
Carcinoma Squamous Cell
immunodeficiency
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Rheumatoid Arthritis
prostate cancer
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ENO1 Gene

enolase 1, (alpha)

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