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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENO1 Gene

protein-coding   GIFtS: 71
GCID: GC01M008921

Enolase 1, (Alpha)


(Previous symbols: ENO1L1, MPB1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Enolase 1, (Alpha)1 2     alpha-enolase2
MPB11 2 3 5     enolase-alpha2
ENO1L11 2 3     MYC Promoter-Binding Protein 12
Non-Neural Enolase2 3     tau-crystallin2
Phosphopyruvate Hydratase2 3     MBP-13
Plasminogen-Binding Protein2 3     MBPB13
2-Phospho-D-Glycerate Hydro-Lyase2 3     MPB-13
NNE2 3     C-Myc Promoter-Binding Protein3
EC 4.2.1.113 8     Enolase 13
PPH2 5     EC 4.2.18
Alpha Enolase Like 12     

External Ids:    HGNC: 33501   Entrez Gene: 20232   Ensembl: ENSG000000748007   OMIM: 1724305   UniProtKB: P067333   

Export aliases for ENO1 gene to outside databases

Previous GC identifers: GC01M008541 GC01M008732 GC01M008517 GC01M008630 GC01M008855 GC01M008843 GC01M008070


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ENO1 Gene:
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer
composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in
addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of
this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor
suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1.
Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. (provided by RefSeq, Jan
2011)

GeneCards Summary for ENO1 Gene: 
ENO1 (enolase 1, (alpha)) is a protein-coding gene. Diseases associated with ENO1 include non-herpetic acute limbic encephalitis, and lymphocytic hypophysitis, and among its related super-pathways are Glycolysis and gluconeogenesis (short map) and Metabolic pathways. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ENO3.

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733
Function: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such
as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and
pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the
cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production
Function: MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor

Gene Wiki entry for ENO1 (Alpha-enolase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_021937.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ENO1 gene promoter:
         RFX1   Sox5   AML1a   CUTL1   GATA-1   c-Ets-1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ENO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ENO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.2

ENO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENO1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M008921:  view genomic region     (about GC identifiers)

Start:
8,921,059 bp from pter      End:
8,939,308 bp from pter
Size:
18,250 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733 (See protein sequence)
Recommended Name: Alpha-enolase  
Size: 434 amino acids; 47169 Da
Cofactor: Magnesium. Required for catalysis and for stabilizing the dimer
Subunit: Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or
heterodimers which are cell-type and development-specific. ENO1 interacts with PLG in the neuronal plasma
membrane and promotes its activation. The C-terminal lysine is required for this binding (By similarity)
Subcellular location: Cytoplasm. Cell membrane. Cytoplasm, myofibril, sarcomere, M line. Note=Can translocate to
the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is
localized to the M line
Subcellular location: Isoform MBP-1: Nucleus
Developmental stage: During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta
heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells
Miscellaneous: Used as a diagnostic marker for many tumors and, in the heterodimeric form, alpha/gamma, as a
marker for hypoxic brain injury after cardiac arrest. Also marker for endometriosis. Antibodies against
alpha-enolase are present in sera from patients with cancer-associated retinopathy syndrome (CAR), a progressive
blinding disease which occurs in the presence of systemic tumor growth, primarily small-cell carcinoma of the
lung and other malignancies. Is identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune
disease associated with Hashimoto thyroiditis (HT). HT is a disorder in which destructive processes overcome the
potential capacity of thyroid replacement leading to hypothyroidism
Sequence caution: Sequence=AAA35698.1; Type=Frameshift; Positions=Several; Sequence=AAA35698.1; Type=Miscellaneous
discrepancy; Note=Sequencing errors;
2 PDB 3D structures from and Proteopedia for ENO1:
2PSN (3D)        3B97 (3D)    
Secondary accessions: B2RD59 P22712 Q16704 Q4TUS4 Q53FT9 Q53HR3 Q658M5 Q6GMP2 Q71V37 Q7Z3V6
Q8WU71 Q9UCH6 Q9UM55
Alternative initiation: 2 isoforms:  P06733-1   P06733-2   (It is uncertain whether the alternative initiation site is at Met-94 or at Met-97)

Explore the universe of human proteins at neXtProt for ENO1: NX_P06733

Explore proteomics data for ENO1 at MOPED 

Post-translational modifications:

  • UniProtKB: ISGylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P06733

  • 4/42 DME Specific Peptides for ENO1 (P06733) (see all 42)
     TGQIKTG  EKGVPLY  ELLKTAI  QEFMILP 

    ENO1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ENO1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001188412.1  NP_001419.1  

    ENSEMBL proteins: 
     ENSP00000234590   ENSP00000466406   ENSP00000468392  
    Reactome Protein details: P06733
    Human Recombinant Protein Products for ENO1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for ENO1
    OriGene Protein Over-expression Lysate for ENO1
    OriGene MassSpec for ENO1 
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    GenScript Custom Purified and Recombinant Proteins Services for ENO1
    Novus Biologicals ENO1 Proteins
    Novus Biologicals ENO1 Lysates
    Sino Biological Recombinant Protein for ENO1
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ENO1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000015phosphopyruvate hydratase complex IEA--
    GO:0005634nucleus IC10082554
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--

    ENO1 for ontologies           About GeneDecksing



    ENO1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Assay Products for ENO1: 
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    GenScript Custom Assay Services for ENO1
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR020810 Enolase_C
     IPR020811 Enolase_N
     IPR000941 Enolase
     IPR020809 Enolase_CS

    Graphical View of Domain Structure for InterPro Entry P06733

    ProtoNet protein and cluster: P06733

    1 Blocks protein domain: IPB000941 Enolase

    UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733
    Similarity: Belongs to the enolase family


    ENO1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENOA_HUMAN, P06733
    Function: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such
    as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and
    pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the
    cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production
    Function: MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor
    Catalytic activity: 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O
    Biophysicochemical properties: pH dependence: Enolase activity is lost above pH 9.0. Immunoglobulin production
    stimulating activity is retained at pH 13.0;
    Induction: Induced in diffuse large cell lymphoma (DLCL) after treatment with the natural biological agent, Bryo1.
    Up-regulated in response to enterovirus 71 (EV71) infection (at protein level)

         Genatlas biochemistry entry for ENO1:
    enolase 1,alpha subunit,ubiquitous and embryonic precocious type (2-phospho-D-glycerate
    hydratase),glycolysis,energy pathway

         Enzyme Numbers (IUBMB): EC 4.2.1.111 2 EC 4.2.12

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS2005901
    GO:0003714transcription corepressor activity TAS2005901
    GO:0004634phosphopyruvate hydratase activity IEA--
         
    ENO1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ENO1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ENO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ENO1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ENO1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENO1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ENO1:
    hsa-miR-22 hsa-miR-3168 hsa-miR-558 hsa-miR-4263 hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidENO1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): ENO1 (NM_001428)
    Sino Biological Human cDNA Clone for ENO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENO1
    Sirion Biotech Customized lentivirus for stable overexpression of ENO1 
                         Customized lentivirus expression plasmids for stable overexpression of ENO1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENO1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ENO1 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis (short map)
    Glycolysis and gluconeogenesis (short map)0.60
    Glycolysis / Gluconeogenesis0.46
    Glycolysis and Gluconeogenesis0.60
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Glucose metabolism
    Glucose metabolism0.50
    Glycolysis0.44
    Gluconeogenesis0.50
    4Carbon metabolism
    Carbon metabolism0.37
    Biosynthesis of amino acids0.37
    5Deadenylation-dependent mRNA decay
    RNA degradation0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ENO1
        Glycolysis and gluconeogenesis (short map)


    1 Cell Signaling Technology (CST) Pathway for ENO1
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for ENO1
        Glycolysis and gluconeogenesis (short map)

    4 BioSystems Pathways for ENO1
        Glycolysis and Gluconeogenesis
    HIF-1-alpha transcription factor network
    Notch signaling pathway
    Validated targets of C-MYC transcriptional activation


    5        Reactome Pathways for ENO1
        Gluconeogenesis
    Metabolism of carbohydrates
    Metabolism
    Glucose metabolism
    Glycolysis


    5/6         Kegg Pathways  (Kegg details for ENO1) (see all 6):
        Glycolysis / Gluconeogenesis
    Metabolic pathways
    Carbon metabolism
    Biosynthesis of amino acids
    RNA degradation

    UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733
    Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5


    ENO1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ENO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/132 Interacting proteins for ENO1 (P067331, 2, 3 ENSP000002345904) via UniProtKB, MINT, STRING, and/or I2D (see all 132)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120042, 3MINT-7995173 MINT-7995182 MINT-7995334 I2D: score=2 
    AGTPBP1Q9UPW52, 3, ENSP000003385124MINT-2858506 I2D: score=3 STRING: ENSP00000338512
    RIPK2O433532, 3, ENSP000002207514MINT-49071 I2D: score=2 STRING: ENSP00000220751
    ACHEP223031, 3, ENSP000003032114EBI-353877,EBI-1637793 I2D: score=1 STRING: ENSP00000303211
    YWHAZP631042, 3, ENSP000003095034MINT-51023 MINT-3304712 I2D: score=4 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS2005901
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0006096glycolysis TAS--

    ENO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ENO1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ENO1 (ENOA)

    5 HMDB Compounds for ENO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Phospho-D-glyceric acid2-Phospho-D-glycerate (see all 7)----
    3-Dehydroquinate3-Dehydroquinic acid (see all 4)----
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phosphoenolpyruvic acid2-hydroxy-Acrylic acid dihydrogen phosphate (see all 6)138-08-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/32 Novoseek inferred chemical compound relationships for ENO1 gene (see all 32)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-phosphoglycerate 76 4 12435062 (1), 18456007 (1)
    glyceraldehyde 3-phosphate 75.1 42 17123137 (2), 16530755 (2), 15975915 (1), 16342241 (1) (see all 33)
    lysine 50 3 10428809 (1), 1656542 (1), 11127872 (1)
    4-hydroxynonenal 44.7 4 16530755 (2), 15749392 (1), 19508232 (1)
    phosphoenolpyruvate 39.1 6 18456007 (2), 12435062 (1), 14506152 (1)
    isocitrate 37.2 4 18647502 (1), 15596215 (1), 10870966 (1), 16009011 (1)
    manganese superoxide 32.8 2 16876904 (1), 19374891 (1)
    aldose 32.3 3 15975915 (1), 19407367 (1), 16342238 (1)
    3-phosphoglycerate 32.1 2 11681208 (1), 16707281 (1)
    pyruvate 29.6 10 18926919 (1), 19407367 (1), 19657000 (1), 11681208 (1) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about ENO1 / ENOA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ENO1 gene (2 alternative transcripts): 
    NM_001201483.1  NM_001428.3  

    Unigene Cluster for ENO1:

    Enolase 1, (alpha)
    Hs.517145  [show with all ESTs]
    Unigene Representative Sequence: AK298600
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234590(uc001apj.2 uc009vml.2) ENST00000464920(uc001api.2)
    ENST00000497492 ENST00000486051 ENST00000492343 ENST00000489867
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ENO1:
    hsa-miR-22 hsa-miR-3168 hsa-miR-558 hsa-miR-4263 hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidENO1 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): ENO1 (NM_001428)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENO1
    Sirion Biotech Customized lentivirus for stable overexpression of ENO1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ENO1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENO1

    Additional mRNA sequence: 

    AF035286.1 AK098420.1 AK222517.1 AK223192.1 AK298600.1 AK309177.1 AK309291.1 AK315417.1 
    AL833741.1 BC001810.2 BC004325.1 BC004458.1 BC005884.1 BC009218.2 BC009912.2 BC011130.1 
    BC015641.2 BC021166.2 BC022545.1 BC027725.2 BC050642.2 BC113034.1 BT007163.1 BX537400.1 
    D28437.1 EF036495.1 GU170215.1 M14328.1 X84907.1 

    24/180 DOTS entries (see all 180):

    DT.95167954  DT.100734628  DT.92049624  DT.92386651  DT.92472607  DT.100734610  DT.100734682  DT.95167955 
    DT.100734719  DT.97863410  DT.100734673  DT.92472698  DT.97848082  DT.95167907  DT.92472680  DT.92472726 
    DT.92393969  DT.100734614  DT.100870305  DT.100734688  DT.100734633  DT.100734671  DT.100876328  DT.100060472 

    24/148 AceView cDNA sequences (see all 148):

    CR604831 CR608989 CR615234 CR622336 CR613962 CR617914 CR595542 CR624798 
    CR619767 CR623000 CR599549 CR606095 CR619284 CR598611 CR620667 CR593070 
    BC021166 CR609108 CR603187 CR614954 CR593266 CR594303 CR611520 CR593962 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ENO1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                      -                 -     -                                                         
    SP2:                    -     -     -     -                 -     -                                                         
    SP3:                                      -                                                                                 
    SP4:                                      -                                                                                 
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for ENO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ENO1 expression in normal human tissues (normalized intensities)      ENO1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCACATCG
    ENO1 Expression
    About this image


    ENO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Septum   
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             heart/atrium   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             sensory organ/eye/cornea   

    See ENO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ENO1

    SOURCE GeneReport for Unigene cluster: Hs.517145

    UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733
    Tissue specificity: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta
    heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the
    gamma/gamma homodimer in neurons

        SABiosciences Expression via Pathway-Focused PCR Arrays including ENO1: 
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              Hypoxia Signaling Pathway in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ENO1 gene from 10/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm55061 , 5 predicted gene 55061, 5 88.25(n)1
    94.7(a)1
      18 (25.33 cM)5
    4331821  NM_001025388.11  NP_001020559.11 
     480453355 
    chicken
    (Gallus gallus)
    Aves ENO11 enolase 1, (alpha) 83.45(n)
    93.5(a)
      396017  NM_205120.1  NP_990451.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    ENO16
    enolase 1, (alpha)
    91(a)
    73(a)
    possible ortholog
    1 ↔ 1
    AAWZ02039863(3182-6736)
    GL343334.1(1787-10608)
    African clawed frog
    (Xenopus laevis)
    Amphibia eno1-prov2 enolase 1, alpha 80.26(n)    BC054169.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi32b032 Danio rerio cDNA clone MGC73152 IMAGE4144055, complete more 82.39(n)    BC059511.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eno1 , 3 glycolysis phosphopyruvate hydratase3
    Enolase1
    72(a)3
    69.53(n)1
    73.09(a)1
      22B13
    333511  NM_164431.21  NP_722721.11 
    worm
    (Caenorhabditis elegans)
    Secernentea enol-11 Protein ENOL-1 69.84(n)
    75.64(a)
      174423  NM_001027178.1  NP_001022349.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ENO2(YHR174W)4
    ENO11
    Enolase II, a phosphopyruvate hydratase that catalyzes more4
    Eno1p1
    61.86(n)1
    63.95(a)1
      8(451327-452640)4
    8531691  NP_011770.31  8565794 
     NP_012044.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ENO11 enolase 1 62.88(n)
    69.19(a)
      843741  NM_106062.3  NP_177543.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.124622 Transcribed sequence with moderate similarity to protein more 76.2(n)    BG300628.1 


    ENSEMBL Gene Tree for ENO1 (if available)
    TreeFam Gene Tree for ENO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ENO1 gene
    ENO32  ENO22  ENO42  
    4 SIMAP similar genes for ENO1 using alignment to 6 protein entries:     ENOA_HUMAN (see all proteins):
    ENO3    EDARADD    ENO2    TMEM237

    ENO1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ENO1
    PGOHUM00000247276 PGOHUM00000244018 PGOHUM00000237744


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/538 SNPs in ENO1 are shown (see all 538)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339747251,2
    C--8921940(+) AAAAAA/-AAAAA 2 -- int11Minor allele frequency- -:0.00NA 2
    rs289990881,2
    C,F--8925909(-) CCACTG/-GGCTT 2 -- int15Minor allele frequency- -:0.02NS 184
    rs1124040681,2
    C--8930973(+) AGAGAGA/-CTCAG 2 -- int1 ut511Minor allele frequency- -:0.50CSA 2
    rs1116715231,2
    C--8932446(+) GGTACTT/-CTTTT 2 -- int1 us2k11Minor allele frequency- -:0.00CSA 2
    rs1402697361,2
    C--8934636(+) TCTCA-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs802018101,2
    C--8935367(+) AAAAA-/AAGAGAG 1 -- int10--------
    rs289991041,2
    C,F,H--8939088(-) AGAAGG/AGCATC 2 -- ds50018Minor allele frequency- A:0.00NS NA 416
    rs1890457341,2
    --8939158(+) CCCTGA/GGAAGA 2 -- ds50010--------
    rs20714141,2
    C,F,O,A,H--8939211(-) TTCAGA/CCCAGA 2 -- ds500131Minor allele frequency- C:0.39NA NS EA WA 3030
    rs289991031,2
    C,F--8939219(-) CAGCCA/GTATTC 2 -- ds50017Minor allele frequency- G:0.04NS WA 306

    HapMap Linkage Disequilibrium report for ENO1 (8921059 - 8939308 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ENO1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv871026CNV Loss21882294
    nsv871694CNV Gain21882294


    Human Gene Mutation Database (HGMD): ENO1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 172430    OMIM disorders: --

    20/94 diseases for ENO1 (see all 94):    About MalaCards
    non-herpetic acute limbic encephalitis    lymphocytic hypophysitis    cancer-associated retinopathy    giardiasis
    mixed cryoglobulinemia    limbic encephalitis    cryoglobulinemia    cholangitis
    congenital heart block    membranous glomerulonephritis    keratoconus    behcet's disease
    follicular thyroid carcinoma    bladder transitional cell carcinoma    tauopathy    transitional cell carcinoma
    vasculitis    primary sclerosing cholangitis    sclerosing cholangitis    chordoma

    1 disease from the University of Copenhagen DISEASES database for ENO1:
    Cancer

    ENO1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/48 Novoseek inferred disease relationships for ENO1 gene (see all 48)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 51.2 31 12922171 (1), 15378762 (1), 16048908 (1), 20448348 (1) (see all 29)
    autoimmune diseases 41.2 10 15966408 (1), 17289554 (1), 11836316 (1), 11169399 (1) (see all 8)
    encephalopathy 37.1 9 17335908 (3), 15833368 (3), 17154034 (1), 16405264 (1) (see all 5)
    autoimmunity 36.8 3 19898480 (2), 11836316 (1)
    rheumatoid arthritis 35.9 7 16277695 (1), 18668562 (1), 18926919 (1), 20476908 (1) (see all 7)
    behcet disease 33 1 12847697 (1)
    retinopathy 30.5 6 15324934 (2), 15860281 (1), 9878089 (1), 17235687 (1) (see all 5)
    retinal degeneration 29.6 3 15860281 (1), 9878089 (1), 17235687 (1)
    cholangitis primary sclerosing 29.1 1 9649223 (1)
    lupus erythematosus systemic 28.3 2 8455367 (1), 10594566 (1)

    Genetic Association Database (GAD): ENO1
    Human Genome Epidemiology (HuGE) Navigator: ENO1 (2 documents)

    Export disorders for ENO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENO1 gene, integrated from 9 sources (see all 364):
    (articles sorted by number of sources associating them with ENO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression analysis of five novel genes in chromosome 1p36. (PubMed id 9653645)1, 2, 3, 9 Onyango P.... Weith A. (1998)
    2. ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1). (PubMed id 10802057)1, 2, 9 Feo S.... Giallongo A. (2000)
    3. Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. (PubMed id 10681589)1, 2, 9 Subramanian A. and Miller D.M. (2000)
    4. Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation. (PubMed id 10082554)1, 2, 9 Ghosh A.K.... Ray R.B. (1999)
    5. A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1. (PubMed id 11134351)1, 2, 9 Ghosh A.K.... Ray R.B. (2001)
    6. Identification of an epitope of alpha-enolase (a candidate plasminogen receptor) by phage display. (PubMed id 9308760)1, 2, 9 Arza B.... Munoz-Canoves P. (1997)
    7. Induced expression of alpha-enolase in differentiated diffuse large cell lymphoma. (PubMed id 7787969)1, 2, 9 Mohamad R.M.... Al-Katib A. (1995)
    8. Autoreactive epitopes within the human alpha-enolase and their recognition by sera from patients with endometriosis. (PubMed id 8824716)1, 2, 9 Walter M.... Northemann W. (1995)
    9. Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-enolase. (PubMed id 12666133)1, 2, 9 Lopez-Alemany R.... Felez J. (2003)
    10. Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy. (PubMed id 12297304)1, 2, 9 Ochi H.... Kira J. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2023 HGNC: 3350 AceView: ENO1 Ensembl:ENSG00000074800 euGenes: HUgn2023
    ECgene: ENO1 Kegg: 2023 H-InvDB: ENO1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ENO1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ENO1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/eno1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ENO1 gene:
    Search GeneIP for patents involving ENO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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