Aliases for ENO1 Gene
External Ids for ENO1 Gene
Previous HGNC Symbols for ENO1 Gene
Previous GeneCards Identifiers for ENO1 Gene
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]
GeneCards Summary for ENO1 Gene
ENO1 (Enolase 1) is a Protein Coding gene. Diseases associated with ENO1 include Cancer-Associated Retinopathy and Non-Herpetic Acute Limbic Encephalitis. Among its related pathways are HIF-1 signaling pathway and Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include poly(A) RNA binding and transcription corepressor activity. An important paralog of this gene is ENO3.
UniProtKB/Swiss-Prot for ENO1 Gene
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.
MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.