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ENO1 Gene

protein-coding GIFtS: 69

GC01M008855

enolase 1, (alpha)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ENO1L1, MPB1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 4.2.1.11 ^³
ENO1L1 ^², ³
MBP-1 ^¹, ², ³
MBPB1 ^³
MPB-1 ^³
MPB1 ^², ³, ⁵
NNE ^², ³
OTTHUMP00000001706 ^²
PPH ^¹, ², ⁵
tau-crystallin ^²

Descriptions
2-phospho-D-glycerate hydro-lyase ^², ³
C-myc promoter-binding protein ^³
Enolase 1 ^², ³
MYC promoter-binding protein 1 ^²
Non-neural enolase ^², ³
Phosphopyruvate hydratase ^², ³
Plasminogen-binding protein ^³
alpha enolase like 1 ^²
enolase 1, (alpha) ^²

External Ids
HGNC: 3350¹
Entrez Gene: 2023²
UniProtKB: P06733³
Ensembl: ENSG00000074800⁷

Search outside databases for aliases for ENO1 gene

Previous GC identifers: GC01M008541 GC01M008732 GC01M008517 GC01M008630

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ENO1:

This gene encodes one of three enolase isoenzymes found in mammals; it encodes alpha-enolase, a

homodimeric soluble enzyme, and also encodes a shorter monomeric structural lens protein,

tau-crystallin. The two proteins are made from the same message. The full length protein, the

isoenzyme, is found in the cytoplasm. The shorter protein is produced from an alternative

translation start, is localized to the nucleus, and has been found to bind to an element in the

c-myc promoter. A pseudogene has been identified that is located on the other arm of the same

chromosome. [provided by RefSeq]

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733

Function: MBP1 binds to the c-myc promoter and acts as a transcriptional repressor. May be a tumor

suppressor

Gene Wiki entry for ENO1 (Alpha-enolase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ENO1 gene

Entrez Gene cytogenetic band: 1p36.3-p36.2 Ensembl cytogenetic band: 1p36.23 HGNC cytogenetic band: 1p36.2

ENO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M008855: (about GC identifiers)

Start:	8,843,650 bp from pter
End:	8,861,367 bp from pter
Size:	17,718 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_021937.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733 (See protein sequence)

Recommended Name: Alpha-enolase

Size: 434 amino acids; 47169 Da

Cofactor: Magnesium. Required for catalysis and for stabilizing the dimer

Subunit: Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form

homodimers or heterodimers which are cell-type and development-specific. ENO1 interacts with PLG

in the neuronal plasma membrane and promotes its activation. The C-terminal lysine is required for

this binding (By similarity)

Subcellular location: Cytoplasm. Cell membrane. Cytoplasm, myofibril, sarcomere, M-band. Note=Can

translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric

(alpha/gamma) form. ENO1 is localized to the M-band

Subcellular location: Isoform MBP-1: Nucleus

Developmental stage: During ontogenesis, there is a transition from the alpha/alpha homodimer to

the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve

cells

Miscellaneous: Used as a diagnostic marker for many tumors and, in the heterodimeric form,

alpha/gamma, as a marker for hypoxic brain injury after cardiac arrest. Also marker for

endometriosis

Sequence caution: Sequence=AAA35698.1; Type=Frameshift; Positions=Several; Sequence=AAA35698.1;

Type=Miscellaneous discrepancy; Note=Sequencing errors;

PDB structure from and Proteopedia :

2PSN (3D)

3B97 (3D)

Secondary accessions: B2RD59 P22712 Q16704 Q4TUS4 Q53FT9 Q53HR3 Q658M5 Q6GMP2 Q71V37 Q7Z3V6 Q8WU71

Q9UCH6 Q9UM55

Alternative initiation: 2 isoforms: P06733-1 P06733-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001419.1

ENSEMBL proteins:

ENSP00000234590

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Non Neuronal Enolase, ENO1)
	Human Recombinant Proteins from Abnova (ENO1)

OriGene Purified Recombinant Human Protein: ENO1

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000015	phosphopyruvate hydratase complex	IEA	--
GO:0005634	nucleus	IC	10082554
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for ENO1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ENO1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Non Neuronal Enolase, ENO1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ENO1)
	Novus Biologicals Antibodies for ENO1

Assays for ENO1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P06733

ProtoNet protein and cluster: P06733

1 Blocks protein family: IPB000941 Enolase

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733

Similarity: Belongs to the enolase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ENO1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ENO1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001428

Applied Biosystems Silencer® siRNAs for ENO1

Sigma-Aldrich siRNA for ENO1

Sigma-Aldrich shRNA for ENO1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ENO1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001428
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001428
untagged cDNA clone in CMV expression vector: NM_001428

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001428

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733

Function: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various

processes such as growth control, hypoxia tolerance and allergic responses. May also function in

the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor

and activator of plasminogen on the cell surface of several cell-types such as leukocytes and

neurons. Stimulates immunoglobulin production

Function: MBP1 binds to the c-myc promoter and acts as a transcriptional repressor. May be a tumor

suppressor

Catalytic activity: 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O

Biophysicochemical properties: pH dependence: Enolase activity is lost above pH 9.0. Immunoglobulin

production stimulating activity is retained at pH 13.0;

Induction: Induced in diffuse large cell lymphoma (DLCL) after treatment with the natural

biological agent, Bryo1

Enzyme Number (IUBMB): EC 4.2.1.11

Genatlas biochemistry entry for ENO1:

enolase 1,alpha subunit,ubiquitous and embryonic precocious type (2-phospho-D-glycerate

hydratase),glycolysis,energy pathway

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Eno1):

embryogenesis

growth/size

lethality-prenatal/perinatal

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0003700	transcription factor activity	TAS	2005901
GO:0003714	transcription corepressor activity	TAS	2005901
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0004634	phosphopyruvate hydratase activity	TAS	3529090

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for ENO1 (Your Favorite Gene powered by Ingenuity)

TR/RXR Activation
Phenylalanine, Tyrosine and Tryptophan Biosynthesis
Glycolysis/Gluconeogenesis

GeneDecks ENO1 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733

Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5

Gene Network Central^TM Interacting Genes and Proteins Network for ENO1

4 Interacting proteins for ENO1 (P06733²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAZ	P63104²	MINT-51023 MINT-3304712
AGTPBP1	Q9UPW5²	MINT-2858506
MAP3K7	O43318²	MINT-49243
RIPK2	O43353²	MINT-49071

About this table
4 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 2005901
GO:0006096 glycolysis IEA --
GO:0006350 transcription IEA --
GO:0030308 negative regulation of cell growth IDA 10082554
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ENO1
10/20 Novoseek chemical compound relationships for ENO1 gene (see all 20 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
2-phosphoglycerate	74.53	4	12435062 (1), 18456007 (1)
glyceraldehyde 3-phosphate	73.84	37	17123137 (2), 16530755 (2), 15975915 (1), 16342241 (1) (see all 28)
lysine	50.96	3	10428809 (1), 1656542 (1), 11127872 (1)
isocitrate	39.84	4	18647502 (1), 15596215 (1), 10870966 (1), 16009011 (1)
phosphoenolpyruvate	36.20	6	18456007 (2), 12435062 (1), 14506152 (1)
aldose	34.62	3	15975915 (1), 19407367 (1), 16342238 (1)
3-phosphoglycerate	34.15	2	11681208 (1), 16707281 (1)
pyruvate	28.45	9	18926919 (1), 19407367 (1), 11681208 (1), 16466929 (1) (see all 8)
manganese superoxide	27.04	1	16876904 (1)
inosine monophosphate	22.02	2	11681208 (1), 16707281 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ENO1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ENO1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001428

Sigma-Aldrich siRNA for ENO1

Sigma-Aldrich shRNA for ENO1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001428

REFSEQ mRNAs for ENO1 gene:

NM_001428.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001428

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001428
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001428
                                 untagged cDNA clone in CMV expression vector: NM_001428

Additional cDNA sequence:

AF035286.1 AK098420.1 AK222517.1 AK223192.1 AK298600.1 AK309177.1 AK309291.1 AK315417.1

AL833741.1 BC001810.2 BC004325.1 BC004458.1 BC009218.2 BC009912.2 BC011130.1 BC015641.2

BC021166.2 BC022545.1 BC027725.2 BC050642.2 BC113034.1 BT007163.1 BX537400.1 CR590515.1

CR590766.1 CR590981.1 CR591098.1 CR591671.1 CR591792.1 CR592364.1 CR593070.1 CR593266.1

CR593938.1 CR593962.1 CR594090.1 CR594212.1 CR594303.1 CR594572.1 CR594620.1 CR595389.1

CR595532.1 CR595542.1 CR596040.1 CR596253.1 CR596356.1 CR596722.1 CR596860.1 CR597003.1

CR597121.1 CR597248.1 CR597447.1 CR597864.1 CR598051.1 CR598066.1 CR598611.1 CR599182.1

CR599278.1 CR599549.1 CR600265.1 CR600408.1 CR600587.1 CR600843.1 CR601208.1 CR601750.1

CR601993.1 CR602502.1 CR603187.1 CR603412.1 CR603775.1 CR604703.1 CR604754.1 CR604831.1

CR605152.1 CR605229.1 CR605325.1 CR605814.1 CR606095.1 CR606187.1 CR606447.1 CR606604.1

CR606616.1 CR608388.1 CR608511.1 CR608989.1 CR609018.1 CR609108.1 CR609504.1 CR609597.1

CR609808.1 CR610099.1 CR610631.1 CR610731.1 CR611164.1 CR611233.1 CR611520.1 CR611563.1

CR611826.1 CR612019.1 CR612658.1 CR612932.1 CR612967.1 CR613408.1 CR613637.1 CR613769.1

CR613921.1 CR613962.1 CR614232.1 CR614260.1 CR614386.1 CR614745.1 CR614888.1 CR614954.1

CR615234.1 CR615779.1 CR616632.1 CR616771.1 CR617373.1 CR617876.1 CR617914.1 CR618230.1

CR618800.1 CR619241.1 CR619284.1 CR619767.1 CR619978.1 CR620572.1 CR620667.1 CR621195.1

CR621350.1 CR621749.1 CR622287.1 CR622336.1 CR622388.1 CR622552.1 CR623000.1 CR623540.1

CR623647.1 CR623991.1 CR624186.1 CR624210.1 CR624798.1 CR625669.1 CR626413.1 CR626731.1

D28437.1 EF036495.1 M14328.1 X84907.1

24/179 DOTS entries (see all 179 ):

DT.95167954 DT.100734628 DT.92386651 DT.92049624 DT.100734682 DT.92472607 DT.100734610 DT.100734719

DT.97863410 DT.95167955 DT.100734673 DT.92472698 DT.97848082 DT.95167907 DT.92472680 DT.92472726

DT.92393969 DT.100734614 DT.100734688 DT.100734633 DT.100734671 DT.100870305 DT.100876328 DT.100060472

24/148 AceView cDNA sequences (see all 148 ):

CR600408 CR617373 CR590981 CR590766 CR622552 CR600265 CR596253 CR612967

CR598611 CR604754 CR623647 CR599278 CR598051 BC004458 CR615234 CR593938

CR620572 CR590515 CR602502 CR624798 CR594620 CR614954 CR609108 CR595389

highest scoring ESTs for ENO1:

AA362672 AA610475 AK098420 BC001810 BC004458 BC009912 BC011130 BC015641 BC022545 BC027725

Unigene Cluster for ENO1:

Enolase 1, (alpha)

Hs.517145 [show with all ESTs]

Unigene Representative Sequence: AK298600

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ENO1 (see all 6 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14
SP1:													-						-		-
SP2:							-		-		-		-						-		-
SP3:													-
SP4:													-
SP5:

About this scheme

ECgene alternative splicing isoforms for ENO1

1 Ensembl transcript including schematic representation:

ENST00000234590

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ENO1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ENO1

¹ / ² / ³

5 probe-sets matching ENO1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2035_s_at²^{, 3}	U95-A	4	1.00	0.91	1.00	1.00	M55914	0.60	1.00	0.82	1
201231_s_at²^{, 3}	U133-A	4	1.00	0.80	--	--	NM_001428	0.60	1.00	0.82	1
217294_s_at²^{, 3}	U133-A	4	1.00	0.55	--	--	U88968	0.40	1.00	0.76	1
201231_s_at²	U133Plus2	4	1.00	0.80	--	--	--	--	--	--	--
217294_s_at²	U133Plus2	4	1.00	0.55	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGAGCCTCGT

SOURCE GeneReport for Unigene cluster: Hs.517145
Expression variation in blood from EXPOLDB for ENO1
UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733
Tissue specificity: The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The
alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the
alpha/gamma heterodimer and the gamma/gamma homodimer in neurons

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ENO1 gene from 5/26 species (see all 26 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ENO1¹	--	enolase 1, (alpha)	83.06(n) 84.94(a)	479597 XM_854346.1 XP_859439.1
chimpanzee (Pan troglodytes)	ENO1¹	--	enolase 1, (alpha)	99.39(n) 100(a)	457913 XM_514354.2 XP_514354.2
cow (Bos taurus)	ENO1¹	--	enolase 1, (alpha)	90.32(n) 95.62(a)	281141 NM_174049.2 NP_776474.2
rat (Rattus norvegicus)	LOC688509¹	--	enolase 1, alpha pseudogene	88.25(n) 94.47(a)	688509 XM_001067222.1 XP_001067222.1
mouse (Mus musculus)	Eno1⁵ EG433182¹	4 (79.00 cM)⁵	enolase 1, alpha non-neuron⁵ predicted gene, EG433182¹	88.25(n)¹ 94.7(a)¹	433182¹ NM_001025388.1¹ NP_001020559.1¹ AI841389⁵ AK002322⁵ (see all 88)

About this table Species with no ortholog for ENO1

ENSEMBL Gene Tree for ENO1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ENO1 gene

ENSG00000215809² C10orf134²

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/157 NCBI SNPs in ENO1 are shown (see all 157 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 107)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2071414^1,2	A,C,F,H,O	8843299(-)	`TTCAGA/CCCAGA`	1	--	ng5¹		16	NA NS EU EA WA	1108
	rs1325920^1,2	A,C,F,H,O	8862429(+)	`GCTGAA/GATGAT`	1	--	ng3¹		12	EA NA MN EU WA	1024
--	rs11544514^1,2	C,F,H	8846630(-)	`CAACCC/AAAAGA`	1	Q/P	mis¹		8	EU EA WA	808
--	rs17032778^1,2	C,F	8843401(+)	`AGTCTC/TGCTCT`	1	--	ng5¹		8	NA NS	326
--	rs11544513^1,2	C	8849061(-)	`GCAAAA/C/TTTCAG`	2	N/K N/N	mis¹ syn¹ ese³		5	NS	190
--	rs2781071^1,2	H	8843323(-)	`TAGCTA/TCTAGG`	1	--	ng5¹		4	EU EA WA	420
	rs11544503^1,2	H	8854593(-)	`AACTGG/CTATCT`	1	A/G	mis¹ ese³		4	EU EA WA	406
	rs1065737^1,2	A	8843755(-)	`TTTCCA/CCCAAG`	1	--	ut3¹		1	MN	184
	rs29000583^1,2	F	8862869(-)	`CAGTAG/AGAGAT`	1	--	ng3¹		5	NS	186
--	rs11544519^1,2	H	8849837(-)	`GTGCCG/CTTGAG`	1	L/V	mis¹ ese³		4	EU EA WA	402

About this table

HapMap Linkage Disequilibrium images for ENO1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 172430

UniProtKB/Swiss-Prot: ENOA_HUMAN, P06733

ENO1 is identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune

disease associated with Hashimoto thyroiditis (HT). HT is a disorder in which destructive

processes overcome the potential capacity of thyroid replacement leading to hypothyroidism

Antibodies against alpha-enolase are present in sera from patients with cancer-associated

retinopathy syndrome (CAR), a progressive blinding disease which occurs in the presence of

systemic tumor growth, primarily small-cell carcinoma of the lung and other malignancies

10/48 Novoseek disease relationships for ENO1 gene (see all 48 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	47.48	23	12922171 (1), 15378762 (1), 16048908 (1), 15673657 (1) (see all 21)
autoimmune diseases	43.94	10	15966408 (1), 17289554 (1), 11836316 (1), 11169399 (1) (see all 8)
encephalopathy	39.73	9	17335908 (3), 15833368 (3), 17154034 (1), 16405264 (1) (see all 5)
behcet disease	34.83	1	12847697 (1)
retinopathy	33.19	6	15324934 (2), 15860281 (1), 9878089 (1), 17235687 (1) (see all 5)
retinal degeneration	32.49	3	15860281 (1), 9878089 (1), 17235687 (1)
cholangitis primary sclerosing	31.70	1	9649223 (1)
autoimmunity	31.18	1	11836316 (1)
mixed cryoglobulinemia	30.38	1	9444422 (1)
keratoconus	29.38	3	17200661 (2), 16083875 (1)

About this table

Human Gene Mutation Database: ENO1
Human Genome Epidemiology Navigator: ENO1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/259 PubMed articles for ENO1 gene (see all 259 ):

Molecular cloning and expression analysis of five novel genes in chromosome 1p36. (PubMed id 9653645)^{1, 2, 3, 4} Onyango P.... Weith A. (1998)
ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1). (PubMed id 10802057)^{1, 3, 4} Feo S.... Giallongo A. (2000)
Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. (PubMed id 10681589)^{1, 3, 4} Subramanian A. and Miller D.M. (2000)
Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation. (PubMed id 10082554)^{1, 3, 4} Ghosh A.K.... Ray R.B. (1999)
A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1. (PubMed id 11134351)^{1, 3, 4} Ghosh A.K.... Ray R.B. (2001)
Identification of an epitope of alpha-enolase (a candidate plasminogen receptor) by phage display. (PubMed id 9308760)^{1, 3, 4} Arza B.... Munoz-Canoves P. (1997)
Induced expression of alpha-enolase in differentiated diffuse large cell lymphoma. (PubMed id 7787969)^{1, 3, 4} Mohamad R.M.... Al-Katib A. (1995)
Autoreactive epitopes within the human alpha-enolase and their recognition by sera from patients with endometriosis. (PubMed id 8824716)^{1, 3, 4} Walter M.... Northemann W. (1995)
Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-enolase. (PubMed id 12666133)^{1, 3, 4} Lopez-Alemany R.... Felez J. (2003)
Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy. (PubMed id 12297304)^{1, 3, 4} Ochi H.... Kira J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2023	HGNC: 3350	AceView: ENO1	Ensembl:ENSG00000074800	euGenes: HUgn2023
ECgene: ENO1	H-InvDB: ENO1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ENO1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/eno1/

Licensable Technologies for ENO1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ENO1:

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Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ENO1-related products

	Millipore Custom Antibody & Bulk Services
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ENO1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for ENO1

Summaries
for ENO1

Genomic Location
for ENO1

Proteins
for ENO1

Protein Domains/
Families
for ENO1

Gene Function
for ENO1

Pathways & Interactions
for ENO1

Drugs & Compounds
for ENO1

Transcripts
for ENO1

Expression
for ENO1

Orthologs
for ENO1

Paralogs
for ENO1

SNPs/Variants
for ENO1

Disorders & Mutations
for ENO1

Medical News
for ENO1

Publications
for ENO1

Search for ENO1

Genome Databases showing ENO1

Other Databases showing ENO1

Specialized Databases showing ENO1

Licensable Technologies
for ENO1

Services
for ENO1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ENO1 (Gene Symbol)
EC 4.2.1.11
ENO1L1
MBP-1
MBPB1
MPB-1
MPB1
NNE
OTTHUMP00000001706
PPH
tau-crystallin
2-phospho-D-glycerate hydro-lyase
C-myc promoter-binding protein
Enolase 1
MYC promoter-binding protein 1
Non-neural enolase
Phosphopyruvate hydratase
Plasminogen-binding protein
alpha enolase like 1
enolase 1, (alpha)

ENO1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor ENO1

Summariesfor ENO1

Genomic Locationfor ENO1

Proteinsfor ENO1

Protein Domains/Familiesfor ENO1

Gene Functionfor ENO1

Pathways & Interactionsfor ENO1

Drugs & Compoundsfor ENO1

Transcriptsfor ENO1

Expression for ENO1

Orthologsfor ENO1

Paralogsfor ENO1

SNPs/Variantsfor ENO1

Disorders & Mutationsfor ENO1

Medical Newsfor ENO1

Publicationsfor ENO1

Search for ENO1

Genome Databases showing ENO1

Other Databases showing ENO1

Specialized Databases showing ENO1

Licensable Technologiesfor ENO1

Servicesfor ENO1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ENO1

Summaries
for ENO1

Genomic Location
for ENO1

Proteins
for ENO1

Protein Domains/
Families
for ENO1

Gene Function
for ENO1

Pathways & Interactions
for ENO1

Drugs & Compounds
for ENO1

Transcripts
for ENO1

Expression
for ENO1

Orthologs
for ENO1

Paralogs
for ENO1

SNPs/Variants
for ENO1

Disorders & Mutations
for ENO1

Medical News
for ENO1

Publications
for ENO1

Licensable Technologies
for ENO1

Services
for ENO1