Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ENKUR Gene

Aliases for ENKUR Gene

  • Enkurin, TRPC Channel Interacting Protein 2 3
  • C10orf63 3 4
  • Chromosome 10 Open Reading Frame 63 2
  • CFAP106 3

External Ids for ENKUR Gene

Previous HGNC Symbols for ENKUR Gene

  • C10orf63

Previous GeneCards Identifiers for ENKUR Gene

  • GC10M025311

Summaries for ENKUR Gene

Entrez Gene Summary for ENKUR Gene

  • This gene encodes a protein that interacts with calmodulin and several transient receptor potential canonical cation channel proteins. The encoded protein may function as an adaptor to localize signal transduction machinery to calcium channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for ENKUR Gene

ENKUR (Enkurin, TRPC Channel Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include calmodulin binding and SH3 domain binding.

UniProtKB/Swiss-Prot for ENKUR Gene

  • Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.

Gene Wiki entry for ENKUR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENKUR Gene

Genomics for ENKUR Gene

Regulatory Elements for ENKUR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ENKUR Gene

Chromosome:
10
Start:
24,981,979 bp from pter
End:
25,062,279 bp from pter
Size:
80,301 bases
Orientation:
Minus strand

Genomic View for ENKUR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENKUR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENKUR Gene

Proteins for ENKUR Gene

  • Protein details for ENKUR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC29-ENKUR_HUMAN
    Recommended name:
    Enkurin
    Protein Accession:
    Q8TC29
    Secondary Accessions:
    • A8K8Y0
    • D3DRV2

    Protein attributes for ENKUR Gene

    Size:
    256 amino acids
    Molecular mass:
    29454 Da
    Quaternary structure:
    • Binds calmodulin via its IQ domain. Interacts with TRPC1, TRPC2, TRPC5, but not TRPC3 (By similarity).

neXtProt entry for ENKUR Gene

Proteomics data for ENKUR Gene at MOPED

Post-translational modifications for ENKUR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENKUR Gene

No data available for DME Specific Peptides for ENKUR Gene

Domains & Families for ENKUR Gene

Protein Domains for ENKUR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ENKUR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TC29

UniProtKB/Swiss-Prot:

ENKUR_HUMAN :
  • Residues 160-255 contains the TRPC2 binding site.
Domain:
  • Residues 160-255 contains the TRPC2 binding site.
  • The IQ motif is involved in calmodulin binding.
  • Contains 1 enkurin domain.
  • Contains 1 IQ domain.
genes like me logo Genes that share domains with ENKUR: view

No data available for Gene Families for ENKUR Gene

Function for ENKUR Gene

Molecular function for ENKUR Gene

UniProtKB/Swiss-Prot Function:
Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.

Gene Ontology (GO) - Molecular Function for ENKUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IEA --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with ENKUR: view

Phenotypes for ENKUR Gene

GenomeRNAi human phenotypes for ENKUR:
genes like me logo Genes that share phenotypes with ENKUR: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENKUR Gene

Localization for ENKUR Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENKUR Gene

Cell projection, cilium, flagellum. Note=Sperm acrosomal crescent and flagellar principal piece.

Gene Ontology (GO) - Cellular Components for ENKUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with ENKUR: view

No data available for Subcellular locations from COMPARTMENTS for ENKUR Gene

Pathways & Interactions for ENKUR Gene

SuperPathways for ENKUR Gene

No Data Available

Gene Ontology (GO) - Biological Process for ENKUR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ENKUR Gene

Drugs & Compounds for ENKUR Gene

(1) Drugs for ENKUR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with ENKUR: view

Transcripts for ENKUR Gene

Unigene Clusters for ENKUR Gene

Enkurin, TRPC channel interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ENKUR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - -
SP2:
SP3: - - -

Relevant External Links for ENKUR Gene

GeneLoc Exon Structure for
ENKUR
ECgene alternative splicing isoforms for
ENKUR

Expression for ENKUR Gene

mRNA expression in normal human tissues for ENKUR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENKUR Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.0), Brain - Hypothalamus (x5.0), Brain - Nucleus accumbens (basal ganglia) (x4.5), and Brain - Putamen (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for ENKUR Gene

This gene is overexpressed in Esophagus (32.0), Stomach (18.5), and Neutrophil (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ENKUR Gene



SOURCE GeneReport for Unigene cluster for ENKUR Gene Hs.534486

genes like me logo Genes that share expression patterns with ENKUR: view

Protein tissue co-expression partners for ENKUR Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ENKUR Gene

Orthologs for ENKUR Gene

This gene was present in the common ancestor of animals.

Orthologs for ENKUR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ENKUR 35
  • 90.81 (n)
  • 89.37 (a)
ENKUR 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENKUR 35
  • 90.03 (n)
  • 88.19 (a)
ENKUR 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Enkur 35
  • 83.86 (n)
  • 87.8 (a)
Enkur 16
Enkur 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ENKUR 35
  • 99.48 (n)
  • 98.83 (a)
ENKUR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Enkur 35
  • 82.68 (n)
  • 85.43 (a)
oppossum
(Monodelphis domestica)
Mammalia ENKUR 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENKUR 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ENKUR 35
  • 69.73 (n)
  • 65.2 (a)
ENKUR 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia enkur 35
  • 64.38 (n)
  • 60.48 (a)
Str.16241 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.32096 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14980 35
enkur 35
  • 61.68 (n)
  • 57.09 (a)
enkur 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2710 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007240 35
  • 45.83 (n)
  • 37.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16984 35
  • 42.53 (n)
  • 36.45 (a)
CG16984 36
  • 25 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6938 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4557 36
  • 57 (a)
OneToOne
Species with no ortholog for ENKUR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ENKUR Gene

ENSEMBL:
Gene Tree for ENKUR (if available)
TreeFam:
Gene Tree for ENKUR (if available)

Paralogs for ENKUR Gene

No data available for Paralogs for ENKUR Gene

Variants for ENKUR Gene

Sequence variations from dbSNP and Humsavar for ENKUR Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs902903 -- 24,981,512(+) GTCCT(C/G)TCCTG downstream-variant-500B
rs902904 -- 25,029,397(-) TCTAT(G/T)TTGAT intron-variant
rs902905 -- 25,027,905(-) GTCTC(A/G)TTAAC intron-variant
rs902906 -- 25,062,267(+) GTGTT(C/T)CTCTC utr-variant-5-prime
rs950609 -- 25,008,669(+) ACTGT(A/C)AACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENKUR Gene

Variant ID Type Subtype PubMed ID
esv1965232 CNV Deletion 18987734
esv2734151 CNV Deletion 23290073
esv2734162 CNV Deletion 23290073

Variation tolerance for ENKUR Gene

Residual Variation Intolerance Score: 81.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENKUR Gene

HapMap Linkage Disequilibrium report
ENKUR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENKUR Gene

Disorders for ENKUR Gene

Relevant External Links for ENKUR

Genetic Association Database (GAD)
ENKUR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENKUR
genes like me logo Genes that share disorders with ENKUR: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENKUR Gene

Publications for ENKUR Gene

  1. Canonical transient receptor potential 5. (PMID: 17217053) Beech D.J. (Handb Exp Pharmacol 2007) 2 23 67
  2. Enkurin is a novel calmodulin and TRPC channel binding protein in sperm. (PMID: 15385169) Sutton K.A. … Florman H.M. (Dev. Biol. 2004) 2 67
  3. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PMID: 19875614) Paterson A.D. … Bull S.B. (Diabetes 2010) 67
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for ENKUR Gene

Sources for ENKUR Gene

Back to Top

Content