Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ENKUR Gene

Aliases for ENKUR Gene

  • Enkurin, TRPC Channel Interacting Protein 2 3 5
  • C10orf63 3 4
  • Chromosome 10 Open Reading Frame 63 2
  • CFAP106 3
  • Enkurin 3

External Ids for ENKUR Gene

Previous HGNC Symbols for ENKUR Gene

  • C10orf63

Previous GeneCards Identifiers for ENKUR Gene

  • GC10M025311

Summaries for ENKUR Gene

Entrez Gene Summary for ENKUR Gene

  • This gene encodes a protein that interacts with calmodulin and several transient receptor potential canonical cation channel proteins. The encoded protein may function as an adaptor to localize signal transduction machinery to calcium channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for ENKUR Gene

ENKUR (Enkurin, TRPC Channel Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include calmodulin binding and SH3 domain binding.

UniProtKB/Swiss-Prot for ENKUR Gene

  • Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.

Gene Wiki entry for ENKUR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENKUR Gene

Genomics for ENKUR Gene

Regulatory Elements for ENKUR Gene

Enhancers for ENKUR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G024968 0.8 ENCODE dbSUPER 17.1 +92.5 92487 1.8 SOX13 CTCF RFX1 EP300 ENKUR THNSL1 PRTFDC1
GH10G024992 0.7 ENCODE 18.4 +68.8 68765 1.4 MAFG ZNF592 CREB3 ZNF316 ZNF512 NFE2 KDM1A HNF4A EMSY MAFK ENKUR THNSL1 ARHGAP21 PRTFDC1
GH10G024974 1.1 Ensembl ENCODE dbSUPER 10.3 +87.1 87094 1.2 CTCF CEBPB HNF4A ZBTB33 RAD21 CHAMP1 THNSL1 PRTFDC1 ENKUR
GH10G024962 1.1 ENCODE dbSUPER 10.1 +98.9 98934 2.1 FOXA2 RAD21 RARA YY1 IKZF2 USF2 CEBPB ZEB2 PPARG SMARCA4 THNSL1 ENKUR PRTFDC1
GH10G025067 1.4 FANTOM5 ENCODE dbSUPER 6.8 -6.0 -5956 2.3 PKNOX1 ATF1 INSM2 FEZF1 ZBTB7B ZNF366 ZSCAN5C SCRT2 FOS CREM THNSL1 ENKUR LINC01516
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ENKUR on UCSC Golden Path with GeneCards custom track

Genomic Location for ENKUR Gene

Chromosome:
10
Start:
24,981,979 bp from pter
End:
25,062,279 bp from pter
Size:
80,301 bases
Orientation:
Minus strand

Genomic View for ENKUR Gene

Genes around ENKUR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENKUR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENKUR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENKUR Gene

Proteins for ENKUR Gene

  • Protein details for ENKUR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC29-ENKUR_HUMAN
    Recommended name:
    Enkurin
    Protein Accession:
    Q8TC29
    Secondary Accessions:
    • A8K8Y0
    • D3DRV2

    Protein attributes for ENKUR Gene

    Size:
    256 amino acids
    Molecular mass:
    29454 Da
    Quaternary structure:
    • Binds calmodulin via its IQ domain. Interacts with TRPC1, TRPC2, TRPC5, but not TRPC3 (By similarity).

neXtProt entry for ENKUR Gene

Post-translational modifications for ENKUR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ENKUR Gene

Domains & Families for ENKUR Gene

Protein Domains for ENKUR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ENKUR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TC29

UniProtKB/Swiss-Prot:

ENKUR_HUMAN :
  • Residues 160-255 contains the TRPC2 binding site.
Domain:
  • Residues 160-255 contains the TRPC2 binding site.
  • The IQ motif is involved in calmodulin binding.
genes like me logo Genes that share domains with ENKUR: view

No data available for Gene Families for ENKUR Gene

Function for ENKUR Gene

Molecular function for ENKUR Gene

UniProtKB/Swiss-Prot Function:
Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.

Gene Ontology (GO) - Molecular Function for ENKUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IEA --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with ENKUR: view
genes like me logo Genes that share phenotypes with ENKUR: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENKUR Gene

Localization for ENKUR Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENKUR Gene

Cell projection, cilium, flagellum. Note=Sperm acrosomal crescent and flagellar principal piece.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENKUR gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ENKUR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005929 cilium IEA --
GO:0031514 motile cilium IEA --
GO:0042995 cell projection IEA --
GO:0097228 sperm principal piece IEA --
genes like me logo Genes that share ontologies with ENKUR: view

Pathways & Interactions for ENKUR Gene

SuperPathways for ENKUR Gene

No Data Available

Gene Ontology (GO) - Biological Process for ENKUR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ENKUR Gene

Drugs & Compounds for ENKUR Gene

(1) Drugs for ENKUR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ENKUR: view

Transcripts for ENKUR Gene

Unigene Clusters for ENKUR Gene

Enkurin, TRPC channel interacting protein:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENKUR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - -
SP2:
SP3: - - -

Relevant External Links for ENKUR Gene

GeneLoc Exon Structure for
ENKUR
ECgene alternative splicing isoforms for
ENKUR

Expression for ENKUR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENKUR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENKUR Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.0), Brain - Hypothalamus (x5.0), Brain - Nucleus accumbens (basal ganglia) (x4.5), and Brain - Putamen (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for ENKUR Gene

This gene is overexpressed in Esophagus (32.0), Stomach (18.5), and Neutrophil (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ENKUR Gene



Protein tissue co-expression partners for ENKUR Gene

NURSA nuclear receptor signaling pathways regulating expression of ENKUR Gene:

ENKUR

SOURCE GeneReport for Unigene cluster for ENKUR Gene:

Hs.534486

Evidence on tissue expression from TISSUES for ENKUR Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ENKUR: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENKUR Gene

Orthologs for ENKUR Gene

This gene was present in the common ancestor of animals.

Orthologs for ENKUR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENKUR 34 35
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia ENKUR 34 35
  • 90.81 (n)
dog
(Canis familiaris)
Mammalia ENKUR 34 35
  • 90.03 (n)
mouse
(Mus musculus)
Mammalia Enkur 34 16 35
  • 83.86 (n)
rat
(Rattus norvegicus)
Mammalia Enkur 34
  • 82.68 (n)
oppossum
(Monodelphis domestica)
Mammalia ENKUR 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENKUR 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ENKUR 34 35
  • 69.73 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia enkur 34
  • 64.38 (n)
Str.16241 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.32096 34
zebrafish
(Danio rerio)
Actinopterygii enkur 34 35
  • 61.68 (n)
Dr.14980 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2710 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007240 34
  • 45.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG16984 34 35
  • 42.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4557 35
  • 57 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6938 34
Species where no ortholog for ENKUR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ENKUR Gene

ENSEMBL:
Gene Tree for ENKUR (if available)
TreeFam:
Gene Tree for ENKUR (if available)

Paralogs for ENKUR Gene

No data available for Paralogs for ENKUR Gene

Variants for ENKUR Gene

Sequence variations from dbSNP and Humsavar for ENKUR Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000037406 -- 25,015,862(+) TACCT(A/G)GGAGG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs1000039019 -- 25,015,986(+) CTCCC(C/T)GTCCC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000046400 -- 25,007,141(+) CAGTG(A/T)TTATA intron-variant
rs1000144010 -- 25,050,436(+) ACGTC(A/T)TGCAT intron-variant
rs1000177235 -- 25,055,887(+) CTGCC(A/G)GGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENKUR Gene

Variant ID Type Subtype PubMed ID
esv1965232 CNV deletion 18987734
esv2734151 CNV deletion 23290073
esv2734162 CNV deletion 23290073
esv3443158 OTHER inversion 20981092
nsv1036683 CNV gain 25217958
nsv550224 CNV gain 21841781

Variation tolerance for ENKUR Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENKUR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENKUR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENKUR Gene

Disorders for ENKUR Gene

Relevant External Links for ENKUR

Genetic Association Database (GAD)
ENKUR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENKUR

No disorders were found for ENKUR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENKUR Gene

Publications for ENKUR Gene

  1. Canonical transient receptor potential 5. (PMID: 17217053) Beech D.J. (Handb Exp Pharmacol 2007) 2 3 22 64
  2. Enkurin is a novel calmodulin and TRPC channel binding protein in sperm. (PMID: 15385169) Sutton K.A. … Florman H.M. (Dev. Biol. 2004) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ENKUR Gene

Sources for ENKUR Gene

Content
Loading form....