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Aliases for ENHO Gene

Aliases for ENHO Gene

  • Energy Homeostasis Associated 2 3 5
  • Energy Homeostasis-Associated Protein 3 4
  • C9orf165 3 4
  • Adropin 2 3
  • Chromosome 9 Open Reading Frame 165 2
  • GAAI470 3
  • UNQ470 3

External Ids for ENHO Gene

Previous HGNC Symbols for ENHO Gene

  • C9orf165

Summaries for ENHO Gene

GeneCards Summary for ENHO Gene

ENHO (Energy Homeostasis Associated) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ENHO Gene

  • Involved in the regulation of glucose homeostasis and lipid metabolism.

Additional gene information for ENHO Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENHO Gene

Genomics for ENHO Gene

GeneHancer (GH) Regulatory Elements for ENHO Gene

Promoters and enhancers for ENHO Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I034522 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 0.0 -14 0.7 PKNOX1 RB1 INSM2 DEAF1 ZNF335 GLIS2 ZNF366 FOS THAP11 SP3 ENHO ENSG00000230729 ENSG00000228352 PIGO PIR49822
GH09I034523 Enhancer 0.7 ENCODE 550.8 -0.4 -409 0.1 DRAP1 PKNOX1 SAP130 MAX DEAF1 GLIS2 POLR2A NFYB PRDM10 ZBTB20 ENHO ENSG00000230729 PIR49822
GH09I034575 Enhancer 0.8 FANTOM5 ENCODE 15.5 -55.2 -55187 5.1 ZFHX2 POLR2A ZNF366 ZNF341 REST EZH2 EGR2 GC09P034579 GC09P034580 GALT RPP25L ENSG00000230074 ENHO FAM219A ENSG00000232983 ARID3C CNTFR
GH09I034500 Enhancer 0.7 ENCODE 11.5 +22.2 22193 0.2 CTCF ZNF654 ARID4B JUNB TRIM22 REST BATF ZNF2 IRF4 RAD21 FAM219A ENSG00000230729 ENHO DNAI1 ARID3C SIGMAR1 GALT PIR54959 RN7SKP24
GH09I034450 Enhancer 0.7 Ensembl ENCODE 11 +71.7 71652 0.9 OSR2 ZNF449 NFE2 BATF IRF4 RUNX3 RPP25L ENHO ENSG00000230729 CNTFR DCTN3 FAM219A DNAI1 C9orf24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ENHO on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ENHO gene promoter:

Genomic Locations for ENHO Gene

Genomic Locations for ENHO Gene
chr9:34,521,040-34,523,041
(GRCh38/hg38)
Size:
2,002 bases
Orientation:
Minus strand
chr9:34,521,038-34,523,039
(GRCh37/hg19)

Genomic View for ENHO Gene

Genes around ENHO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENHO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENHO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENHO Gene

Proteins for ENHO Gene

  • Protein details for ENHO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWT2-ENHO_HUMAN
    Recommended name:
    Adropin
    Protein Accession:
    Q6UWT2
    Secondary Accessions:
    • Q8N666

    Protein attributes for ENHO Gene

    Size:
    76 amino acids
    Molecular mass:
    7927 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89021.1; Type=Frameshift; Positions=38; Evidence={ECO:0000305};

    Alternative splice isoforms for ENHO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENHO Gene

Post-translational modifications for ENHO Gene

No Post-translational modifications

Other Protein References for ENHO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ENHO Gene

Domains & Families for ENHO Gene

Gene Families for ENHO Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ENHO Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ENHO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ENHO: view

No data available for UniProtKB/Swiss-Prot for ENHO Gene

Function for ENHO Gene

Molecular function for ENHO Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of glucose homeostasis and lipid metabolism.
genes like me logo Genes that share phenotypes with ENHO: view

Animal Models for ENHO Gene

MGI Knock Outs for ENHO:

Animal Model Products

CRISPR Products

miRNA for ENHO Gene

miRTarBase miRNAs that target ENHO

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENHO Gene

Localization for ENHO Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENHO Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENHO gene
Compartment Confidence
extracellular 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ENHO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ENHO: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ENHO Gene

Pathways & Interactions for ENHO Gene

No Data Available

Interacting Proteins for ENHO Gene

Gene Ontology (GO) - Biological Process for ENHO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045747 positive regulation of Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with ENHO: view

No data available for Pathways by source and SIGNOR curated interactions for ENHO Gene

Drugs & Compounds for ENHO Gene

No Compound Related Data Available

Transcripts for ENHO Gene

mRNA/cDNA for ENHO Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(49) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ENHO Gene

Energy homeostasis associated:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENHO Gene

No ASD Table

Relevant External Links for ENHO Gene

GeneLoc Exon Structure for
ENHO
ECgene alternative splicing isoforms for
ENHO

Expression for ENHO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENHO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENHO Gene

This gene is overexpressed in Brain - Amygdala (x5.7), Brain - Putamen (basal ganglia) (x5.7), Brain - Caudate (basal ganglia) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.1), Brain - Hippocampus (x4.4), and Brain - Substantia nigra (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of ENHO Gene:

ENHO

SOURCE GeneReport for Unigene cluster for ENHO Gene:

Hs.522085

mRNA Expression by UniProt/SwissProt for ENHO Gene:

Q6UWT2-ENHO_HUMAN
Tissue specificity: Expressed in liver and brain.

Evidence on tissue expression from TISSUES for ENHO Gene

  • Skin(4.1)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with ENHO: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENHO Gene

Orthologs for ENHO Gene

This gene was present in the common ancestor of mammals.

Orthologs for ENHO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENHO 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia ENHO 34
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Enho 33 16 34
  • 94.3 (n)
dog
(Canis familiaris)
Mammalia ENHO 33
  • 92.54 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912292 33
  • 92.54 (n)
Species where no ortholog for ENHO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ENHO Gene

ENSEMBL:
Gene Tree for ENHO (if available)
TreeFam:
Gene Tree for ENHO (if available)

Paralogs for ENHO Gene

No data available for Paralogs for ENHO Gene

Variants for ENHO Gene

Sequence variations from dbSNP and Humsavar for ENHO Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs138460682 uncertain-significance, Primary ciliary dyskinesia 34,520,701(-) T/C downstream_transcript_variant
rs576215372 likely-benign, Primary ciliary dyskinesia 34,520,675(-) G/A downstream_transcript_variant
rs886038585 likely-benign, not specified 34,520,650(-) C/T downstream_transcript_variant
rs1000202179 -- 34,522,299(-) T/C intron_variant
rs1000599024 -- 34,521,114(-) T/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ENHO Gene

Variant ID Type Subtype PubMed ID
esv3620335 CNV gain 21293372
nsv1125318 OTHER inversion 24896259
nsv519946 CNV loss 19592680
nsv831543 CNV loss 17160897

Variation tolerance for ENHO Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENHO Gene

Human Gene Mutation Database (HGMD)
ENHO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENHO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENHO Gene

Disorders for ENHO Gene

Additional Disease Information for ENHO

No disorders were found for ENHO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENHO Gene

Publications for ENHO Gene

  1. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. (PMID: 19041763) Kumar KG … Butler AA (Cell metabolism 2008) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  3. Association between aerobic exercise training effects of serum adropin level, arterial stiffness, and adiposity in obese elderly adults. (PMID: 27897440) Fujie S … Iemitsu M (Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2017) 3 58
  4. A possible connection between tumor necrosis factor alpha and adropin levels in polycystic ovary syndrome. (PMID: 26969461) Kume T … Calan OG (Journal of endocrinological investigation 2016) 3 58
  5. Serum adropin level and ENHO gene expression in systemic sclerosis. (PMID: 27079850) Yolbas S … Koca SS (Clinical rheumatology 2016) 3 58

Products for ENHO Gene

Sources for ENHO Gene

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