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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENGASE Gene

protein-coding   GIFtS: 54
GCID: GC17P077071

Endo-Beta-N-Acetylglucosaminidase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
endo-beta-N-acetylglucosaminidase1 2     Cytosolic Endo-Beta-N-Acetylglucosaminidase2
Di-N-Acetylchitobiosyl Beta-N-Acetylglucosaminidase1 2     ENGase3
Mannosyl-Glycoprotein Endo-Beta-N-Acetylglucosaminidase1 2     FLJ218655
EC 3.2.1.963 8     NAGLUEB5

External Ids:    HGNC: 246221   Entrez Gene: 647722   Ensembl: ENSG000001672807   OMIM: 6118985   UniProtKB: Q8NFI33   

Export aliases for ENGASE gene to outside databases

Previous GC identifers: GC17P074583 GC17P072493


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ENGASE Gene:
This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose
modifications to produce free oligosaccharides. (provided by RefSeq, Feb 2012)

GeneCards Summary for ENGASE Gene: 
ENGASE (endo-beta-N-acetylglucosaminidase) is a protein-coding gene. Diseases associated with ENGASE include sparganosis, and fucosidosis. GO annotations related to this gene include mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity.

UniProtKB/Swiss-Prot: ENASE_HUMAN, Q8NFI3
Function: Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in
the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ENGASE gene promoter:
         HOXA9   HOXA9B   Sp1   FOXO3   MyoD   FOXO3b   C/EBPalpha   FOXO3a   Meis-1a   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ENGASE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENGASE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

ENGASE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENGASE gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P077071:  view genomic region     (about GC identifiers)

Start:
77,071,019 bp from pter      End:
77,084,681 bp from pter
Size:
13,663 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ENASE_HUMAN, Q8NFI3 (See protein sequence)
Recommended Name: Cytosolic endo-beta-N-acetylglucosaminidase  
Size: 743 amino acids; 83987 Da
Subcellular location: Cytoplasm, cytosol (By similarity)
Sequence caution: Sequence=AAH24213.2; Type=Frameshift; Positions=694;
Secondary accessions: Q659F0 Q8TB86 Q9H6U4
Alternative splicing: 3 isoforms:  Q8NFI3-1   Q8NFI3-2   Q8NFI3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ENGASE: NX_Q8NFI3

Explore proteomics data for ENGASE at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NFI3

  • 2 DME Specific Peptides for ENGASE (Q8NFI3)
     GTFITEW  FDGWLINIEN 

    ENGASE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ENGASE Protein Expression
    REFSEQ proteins: NP_001036038.1  
    ENSEMBL proteins: 
     ENSP00000463537   ENSP00000462333   ENSP00000308158   ENSP00000300682   ENSP00000460579  

    Human Recombinant Protein Products for ENGASE: 
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    OriGene Protein Over-expression Lysate for ENGASE
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ENGASE
    GenScript Custom Purified and Recombinant Proteins Services for ENGASE
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ENGASE 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--

    ENGASE for ontologies           About GeneDecksing



    ENGASE Antibody Products: 
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    Novus Biologicals ENGASE Antibody
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    Cloud-Clone Corp. Antibodies for ENGASE 
    ThermoFisher Antibody for ENGASE
    LSBio Antibodies in human, mouse, rat for ENGASE 

    Assay Products for ENGASE: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ENGASE 
    Cloud-Clone Corp. CLIAs for ENGASE


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR005201 Glyco_hydro_85
     IPR001357 BRCT_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFI3

    ProtoNet protein and cluster: Q8NFI3

    1 Blocks protein domain: IPB001357 BRCT domain

    UniProtKB/Swiss-Prot: ENASE_HUMAN, Q8NFI3
    Similarity: Belongs to the glycosyl hydrolase 85 family
    Similarity: Contains 1 BRCT domain


    ENGASE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENASE_HUMAN, Q8NFI3
    Function: Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in
    the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol
    Catalytic activity: Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and
    glycoproteins containing the -(Man(GlcNAc)(2))Asn-structure. One N-acetyl-D-glucosamine residue remains attached
    to the protein; the rest of the oligosaccharide is released intact

         Enzyme Number (IUBMB): EC 3.2.1.961 2

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0033925mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity IEA--
         
    ENGASE for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ENGASE:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ENGASE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ENGASE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ENGASE 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ENGASE 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENGASE
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ENGASE (see all 12):
    hsa-miR-1178 hsa-miR-3163 hsa-miR-3184 hsa-miR-1226 hsa-miR-539 hsa-miR-634 hsa-miR-513a-3p hsa-miR-423-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ENGASE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENGASE

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ENGASE

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ENGASE (see all 7)
    OriGene ORF clones in mouse, rat for ENGASE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ENGASE (NM_001042573)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENGASE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENGASE
    Sirion Biotech Customized lentivirus for stable overexpression of ENGASE 
                         Customized lentivirus expression plasmids for stable overexpression of ENGASE 

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    Search LifeMap BioReagents cell lines for ENGASE
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENGASE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ENGASE About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Other glycan degradation
    Other glycan degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for ENGASE):
        Other glycan degradation


    ENGASE for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENGASE

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for ENGASE (Q8NFI33 ENSP000003006824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZP3P217543, ENSP000003783264I2D: score=1 STRING: ENSP00000378326
    ACTR6Q9GZN13I2D: score=3 
    GYS1P138073I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ENGASE (ENASE)

    Search CenterWatch for drugs/clinical trials and news about ENGASE / ENASE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ENGASE gene (2 alternative transcripts): 
    NM_022759.1  NM_001042573.2  

    Unigene Cluster for ENGASE:

    Endo-beta-N-acetylglucosaminidase
    Hs.29288  [show with all ESTs]
    Unigene Representative Sequence: AL110283
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000578419 ENST00000579016 ENST00000311595 ENST00000300682(uc002jwv.3 uc002jww.3)
    ENST00000583646 ENST00000584568 ENST00000577783 ENST00000583041 ENST00000579809
    ENST00000585160 ENST00000539857(uc002jwu.1 uc010wtz.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENGASE
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ENGASE (see all 12):
    hsa-miR-1178 hsa-miR-3163 hsa-miR-3184 hsa-miR-1226 hsa-miR-539 hsa-miR-634 hsa-miR-513a-3p hsa-miR-423-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ENGASE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENGASE
    Clone
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    OriGene clones in human, mouse for ENGASE (see all 7)
    OriGene ORF clones in mouse, rat for ENGASE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ENGASE (NM_001042573)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENGASE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENGASE
    Sirion Biotech Customized lentivirus for stable overexpression of ENGASE 
                         Customized lentivirus expression plasmids for stable overexpression of ENGASE 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ENGASE
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ENGASE
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ENGASE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENGASE

    Additional mRNA sequence: 

    AF512564.1 AK025518.1 AK301115.1 AL110283.1 BC024213.2 BC042158.1 

    8 DOTS entries:

    DT.109748  DT.100784413  DT.100784412  DT.95285502  DT.75186775  DT.95239993  DT.100784414  DT.95142027 

    24/122 AceView cDNA sequences (see all 122):

    BM903787 AI066626 AI625027 CD251206 AW235218 BQ003731 AI902587 BQ777080 
    CA431605 BQ695205 AF512564 BM725961 T05698 BE298781 BX507037 BQ448058 
    BX451473 AA770245 CB149771 AA633169 BM915393 BF059471 BC024213 AA256273 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ENGASE (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                  -     -                 -                 -     -                                                   
    SP2:                                                                          -                 -     -                                                   
    SP3:                                                                          -                 -     -                                                   
    SP4:                                                                          -                                                                           
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for ENGASE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ENGASE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGGCTCGC
    ENGASE Expression
    About this image


    See ENGASE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ENGASE

    SOURCE GeneReport for Unigene cluster: Hs.29288

    UniProtKB/Swiss-Prot: ENASE_HUMAN, Q8NFI3
    Tissue specificity: Widely expressed. Expressed at higher level in thymus and spleen

        SABiosciences Custom PCR Arrays for ENGASE
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENGASE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ENGASE gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Engase1 , 5 endo-beta-N-acetylglucosaminidase1, 5 80.05(n)1
    79.51(a)1
      11 (83.21 cM)5
    2173641  NM_172573.21  NP_766161.11 
     1184768295 
    chicken
    (Gallus gallus)
    Aves ENGASE1 endo-beta-N-acetylglucosaminidase 64.96(n)
    58.46(a)
      430102  XM_427660.3  XP_427660.3 
    lizard
    (Anolis carolinensis)
    Reptilia ENGASE6
    endo-beta-N-acetylglucosaminidase
    51(a)
    1 ↔ 1
    2(101627626-101642607)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1586491 zgc:158649 57.58(n)
    51.32(a)
      561239  NM_001080578.1  NP_001074047.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56136
    --
    30(a)
    1 ↔ 1
    X(17317624-17322767)
    worm
    (Caenorhabditis elegans)
    Secernentea eng-16
    Protein ENG-1, isoform b
    35(a)
    1 ↔ 1
    III(5866497-5868501)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G054601 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase 45.25(n)
    37.36(a)
      830429  NM_120628.4  NP_196165.3 
    rice
    (Oryza sativa)
    Liliopsida Os.70772 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72.51(n)    AK112067.1 


    ENSEMBL Gene Tree for ENGASE (if available)
    TreeFam Gene Tree for ENGASE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/573 SNPs in ENGASE are shown (see all 573)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs790838261,2
    C--77069080(+) GATAAA/CTATGC 1 -- us2k10--------
    rs1151776521,2
    C,F--77069315(+) ACAGGG/AGCTAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs80697481,2
    C,F--77069361(+) AGGGGC/TGTGCA 1 -- us2k13Minor allele frequency- T:0.07WA CSA 122
    rs1931858001,2
    --77069464(+) AGACTG/TAGCAT 1 -- us2k10--------
    rs1497384271,2
    --77069551(+) GCTAAA/GCTGCA 1 -- us2k10--------
    rs1141955951,2
    C,F--77069557(+) CTGCAG/AGTGAG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1467270961,2
    C--77069616(+) TCCGGC/TGCACC 1 -- us2k10--------
    rs620637721,2
    C--77069621(+) TGCACC/TCCTGA 1 -- us2k14Minor allele frequency- T:0.14NA EA 244
    rs1846485451,2
    --77069624(+) ACCCCC/TGAACA 1 -- us2k10--------
    rs1888711651,2
    --77069662(+) GCCCTC/TGCTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ENGASE (77071019 - 77084681 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for ENGASE (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2157CNV Insertion18451855
    nsv527899CNV Loss19592680
    nsv908911CNV Loss21882294
    dgv3287n71CNV Loss21882294
    nsv524700CNV Loss19592680
    nsv833556CNV Loss17160897
    dgv3284n71CNV Loss21882294
    dgv3286n71CNV Loss21882294
    dgv3285n71CNV Loss21882294
    nsv523650CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611898    OMIM disorders: --

    8 diseases for ENGASE:    About MalaCards
    sparganosis    fucosidosis    protein c deficiency    mucolipidosis
    pneumonia    influenza    rheumatoid arthritis    arthritis

    2 diseases from the University of Copenhagen DISEASES database for ENGASE:
    Fucosidosis     Sparganosis

    ENGASE for disorders           About GeneDecksing


    Export disorders for ENGASE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENGASE gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ENGASE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Endo-beta-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol. (PubMed id 12114544)1, 2, 3 Suzuki T.... Emori Y. (2002)
    2. Characterization of beta-N-acetylglucosaminidase cleavage by caspase-3 during apoptosis. (PubMed id 18586680)1, 3 Butkinaree C....Hart G.W. (2008)
    3. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    4. Telomere dysfunction-related serological markers are a ssociated with type 2 diabetes. (PubMed id 21873561)1 Xiao F....Ju Z. (2011)
    5. Identification of roles for peptide: N-glycanase and endo-beta-N-acetylglucosaminidase (Engase1p) during protein N-glycosylation in human HepG2 cells. (PubMed id 20668520)1 Chantret I....Moore S.E. (2010)
    6. Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals with pre-diabetes and diabetes. (PubMed id 20413512)1 Park K....Hart G.W. (2010)
    7. Screening-based discovery of drug-like O-GlcNAcase in hibitor scaffolds. (PubMed id 20026047)1 Dorfmueller H.C. and van Aalten D.M. (2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64772 HGNC: 24622 AceView: FLJ21865 Ensembl:ENSG00000167280 euGenes: HUgn64772
    ECgene: ENGASE Kegg: 64772 H-InvDB: ENGASE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ENGASE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ENGASE gene:
    Search GeneIP for patents involving ENGASE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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