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Aliases for ENGASE Gene

Aliases for ENGASE Gene

  • Endo-Beta-N-Acetylglucosaminidase 2 3
  • EC 4 63
  • Mannosyl-Glycoprotein Endo-Beta-N-Acetylglucosaminidase 2
  • Di-N-Acetylchitobiosyl Beta-N-Acetylglucosaminidase 2
  • FLJ21865 6
  • ENGase 4

External Ids for ENGASE Gene

Previous GeneCards Identifiers for ENGASE Gene

  • GC17P074583
  • GC17P077071
  • GC17P072493

Summaries for ENGASE Gene

Entrez Gene Summary for ENGASE Gene

  • This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012]

GeneCards Summary for ENGASE Gene

ENGASE (Endo-Beta-N-Acetylglucosaminidase) is a Protein Coding gene. Diseases associated with ENGASE include sparganosis and fucosidosis. Among its related pathways are Other glycan degradation. GO annotations related to this gene include mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity.

UniProtKB/Swiss-Prot for ENGASE Gene

  • Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENGASE Gene

Genomics for ENGASE Gene

Regulatory Elements for ENGASE Gene

Genomic Location for ENGASE Gene

79,071,494 bp from pter
79,088,603 bp from pter
17,110 bases
Plus strand

Genomic View for ENGASE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENGASE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENGASE Gene

Proteins for ENGASE Gene

  • Protein details for ENGASE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytosolic endo-beta-N-acetylglucosaminidase
    Protein Accession:
    Secondary Accessions:
    • Q659F0
    • Q8TB86
    • Q9H6U4

    Protein attributes for ENGASE Gene

    743 amino acids
    Molecular mass:
    83987 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH24213.2; Type=Frameshift; Positions=694; Evidence={ECO:0000305};

    Alternative splice isoforms for ENGASE Gene


neXtProt entry for ENGASE Gene

Proteomics data for ENGASE Gene at MOPED

Selected DME Specific Peptides for ENGASE Gene

Post-translational modifications for ENGASE Gene

  • Ubiquitination at Lys381
  • Modification sites at PhosphoSitePlus

Other Protein References for ENGASE Gene

Antibody Products

Domains for ENGASE Gene

Protein Domains for ENGASE Gene


Suggested Antigen Peptide Sequences for ENGASE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8NFI3
  • Contains 1 BRCT domain.
  • Belongs to the glycosyl hydrolase 85 family.
genes like me logo Genes that share domains with ENGASE: view

No data available for Gene Families for ENGASE Gene

Function for ENGASE Gene

Molecular function for ENGASE Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endohydrolysis of the N,N-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)(2))Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact
UniProtKB/Swiss-Prot Function:
Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol.

Enzyme Numbers (IUBMB) for ENGASE Gene

Gene Ontology (GO) - Molecular Function for ENGASE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity IEA --
genes like me logo Genes that share ontologies with ENGASE: view

Phenotypes for ENGASE Gene

genes like me logo Genes that share phenotypes with ENGASE: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ENGASE Gene

Localization for ENGASE Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENGASE Gene

Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for ENGASE Gene COMPARTMENTS Subcellular localization image for ENGASE gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3
nucleus 3
cytosol 2
extracellular 2
mitochondrion 2
plasma membrane 2
cytoskeleton 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ENGASE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with ENGASE: view

Pathways for ENGASE Gene

SuperPathways for ENGASE Gene

Superpath Contained pathways
1 Other glycan degradation
genes like me logo Genes that share pathways with ENGASE: view

Pathways by source for ENGASE Gene

1 KEGG pathway for ENGASE Gene

Interacting Proteins for ENGASE Gene

Gene Ontology (GO) - Biological Process for ENGASE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ENGASE: view

Transcripts for ENGASE Gene

Unigene Clusters for ENGASE Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENGASE

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENGASE Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: -

Relevant External Links for ENGASE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ENGASE Gene

mRNA expression in normal human tissues for ENGASE Gene

Protein differential expression in normal tissues for ENGASE Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.8), Ovary (9.3), Retina (7.7), and Lymph node (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ENGASE Gene

SOURCE GeneReport for Unigene cluster for ENGASE Gene Hs.29288

mRNA Expression by UniProt/SwissProt for ENGASE Gene

Tissue specificity: Widely expressed. Expressed at higher level in thymus and spleen.
genes like me logo Genes that share expressions with ENGASE: view

Expression partners for ENGASE Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ENGASE Gene

Orthologs for ENGASE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ENGASE Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ENGASE 35
  • 82.61 (n)
  • 80.11 (a)
  • 78 (a)
(Canis familiaris)
Mammalia ENGASE 35
  • 82.85 (n)
  • 81.5 (a)
  • 78 (a)
(Mus musculus)
Mammalia Engase 35
  • 80.66 (n)
  • 81.48 (a)
Engase 16
Engase 36
  • 79 (a)
(Pan troglodytes)
Mammalia ENGASE 35
  • 99.19 (n)
  • 99.6 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Engase 35
  • 79.53 (n)
  • 78.8 (a)
(Monodelphis domestica)
Mammalia ENGASE 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia ENGASE 36
  • 51 (a)
(Gallus gallus)
Aves ENGASE 35
  • 65.92 (n)
  • 59.88 (a)
  • 54 (a)
(Anolis carolinensis)
Reptilia ENGASE 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia engase 35
  • 58.17 (n)
  • 53.24 (a)
(Danio rerio)
Actinopterygii engase 35
  • 58.26 (n)
  • 52.24 (a)
engase 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5613 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea eng-1 36
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G05460 35
  • 45.36 (n)
  • 37.2 (a)
(Oryza sativa)
Liliopsida Os.7077 35
Os05g0346500 35
  • 48.94 (n)
  • 41.65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for ENGASE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENGASE Gene

Gene Tree for ENGASE (if available)
Gene Tree for ENGASE (if available)

Paralogs for ENGASE Gene

No data available for Paralogs for ENGASE Gene

Variants for ENGASE Gene

Sequence variations from dbSNP and Humsavar for ENGASE Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1374 -- 79,088,464(-) ATTCT(A/G)CCACA utr-variant-3-prime, nc-transcript-variant
rs10073 -- 79,088,192(+) ATTCC(C/T)GGGAG utr-variant-3-prime, nc-transcript-variant
rs11557 -- 79,088,572(+) ACTGC(G/T)CTGAA utr-variant-3-prime, nc-transcript-variant
rs1317421 -- 79,082,027(-) TTCCC(C/T)CGAGC reference, synonymous-codon, upstream-variant-2KB, nc-transcript-variant
rs1806455 -- 79,084,611(-) GACGT(C/T)CGTGG missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ENGASE Gene

Variant ID Type Subtype PubMed ID
dgv3284n71 CNV Loss 21882294
nsv523650 CNV Loss 19592680
nsv470610 CNV Loss 18288195
nsv908905 CNV Gain 21882294
dgv3285n71 CNV Loss 21882294
nsv470611 CNV Gain 18288195
nsv833556 CNV Loss 17160897
dgv3286n71 CNV Loss 21882294
nsv2157 CNV Insertion 18451855
nsv828114 CNV Gain 20364138
nsv908911 CNV Loss 21882294
dgv3287n71 CNV Loss 21882294
esv23539 CNV Loss 19812545
nsv524700 CNV Loss 19592680
nsv527899 CNV Loss 19592680

Relevant External Links for ENGASE Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENGASE Gene

Disorders for ENGASE Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ENGASE Gene in MalaCards »

(2) Diseases for ENGASE Gene including...

(2) University of Copenhagen DISEASES for ENGASE Gene

genes like me logo Genes that share disorders with ENGASE: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for ENGASE Gene

Publications for ENGASE Gene

  1. Endo-beta-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol. (PMID: 12114544) Suzuki T. … Emori Y. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4
  2. Characterization of beta-N-acetylglucosaminidase cleavage by caspase-3 during apoptosis. (PMID: 18586680) Butkinaree C. … Hart G.W. (J. Biol. Chem. 2008) 2 3
  3. Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds. (PMID: 20026047) Dorfmueller H.C. … van Aalten D.M. (FEBS Lett. 2010) 3
  4. Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals with pre-diabetes and diabetes. (PMID: 20413512) Park K. … Hart G.W. (Diabetes 2010) 3
  5. Identification of roles for peptide: N-glycanase and endo-beta-N-acetylglucosaminidase (Engase1p) during protein N-glycosylation in human HepG2 cells. (PMID: 20668520) Chantret I. … Moore S.E. (PLoS ONE 2010) 3

Products for ENGASE Gene

Sources for ENGASE Gene

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