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Aliases for ENDOV Gene

Aliases for ENDOV Gene

  • Endonuclease V 2 3
  • Inosine-Specific Endoribonuclease 3 4
  • HEndoV 3 4
  • EC 3.1.26.- 4

External Ids for ENDOV Gene

Previous GeneCards Identifiers for ENDOV Gene

  • GC17P078389

Summaries for ENDOV Gene

GeneCards Summary for ENDOV Gene

ENDOV (Endonuclease V) is a Protein Coding gene. GO annotations related to this gene include magnesium ion binding and endodeoxyribonuclease activity, producing 5-phosphomonoesters.

UniProtKB/Swiss-Prot for ENDOV Gene

  • Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3 to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5-IIUI-3 and 5-UIUU-3. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENDOV Gene

Genomics for ENDOV Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ENDOV Gene

Start:
80,415,165 bp from pter
End:
80,438,086 bp from pter
Size:
22,922 bases
Orientation:
Plus strand

Genomic View for ENDOV Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENDOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENDOV Gene

No data available for Regulatory Elements for ENDOV Gene

Proteins for ENDOV Gene

  • Protein details for ENDOV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8Q3-ENDOV_HUMAN
    Recommended name:
    Endonuclease V
    Protein Accession:
    Q8N8Q3
    Secondary Accessions:
    • I3L3S4
    • Q6P2G2
    • Q86X99
    • Q8NAK0

    Protein attributes for ENDOV Gene

    Size:
    282 amino acids
    Molecular mass:
    30792 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Was initially characterized as an endodeoxyribonuclease involved in DNA repair (PubMed:22664237). While it shows some weak endodeoxyribonuclease activity in vitro, such activity probably does not exist in vivo.

    Three dimensional structures from OCA and Proteopedia for ENDOV Gene

    Alternative splice isoforms for ENDOV Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENDOV Gene

Proteomics data for ENDOV Gene at MOPED

Post-translational modifications for ENDOV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ENDOV Gene

Domains for ENDOV Gene

Protein Domains for ENDOV Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ENDOV Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N8Q3

UniProtKB/Swiss-Prot:

ENDOV_HUMAN :
  • Q8N8Q3
Family:
  • Belongs to the endonuclease V family.
genes like me logo Genes that share domains with ENDOV: view

No data available for Gene Families for ENDOV Gene

Function for ENDOV Gene

Molecular function for ENDOV Gene

UniProtKB/Swiss-Prot Function:
Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3 to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5-IIUI-3 and 5-UIUU-3. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.

Enzyme Numbers (IUBMB) for ENDOV Gene

Gene Ontology (GO) - Molecular Function for ENDOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding TAS 23912683
GO:0003727 single-stranded RNA binding IDA 23912683
GO:0004519 endonuclease activity --
GO:0016888 endodeoxyribonuclease activity, producing 5-phosphomonoesters ISS --
GO:0016891 endoribonuclease activity, producing 5-phosphomonoesters IDA 23912683
genes like me logo Genes that share ontologies with ENDOV: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ENDOV Gene

Localization for ENDOV Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENDOV Gene

Cytoplasm. Nucleus, nucleolus.

Gene Ontology (GO) - Cellular Components for ENDOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 23139746
GO:0005737 cytoplasm IDA 23139746
genes like me logo Genes that share ontologies with ENDOV: view

No data available for Subcellular locations from COMPARTMENTS for ENDOV Gene

Pathways for ENDOV Gene

SuperPathways for ENDOV Gene

No Data Available

Gene Ontology (GO) - Biological Process for ENDOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000737 DNA catabolic process, endonucleolytic IEA --
GO:0006281 DNA repair ISS --
GO:0090305 nucleic acid phosphodiester bond hydrolysis --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IDA 23912683
genes like me logo Genes that share ontologies with ENDOV: view

No data available for Pathways by source for ENDOV Gene

Transcripts for ENDOV Gene

Unigene Clusters for ENDOV Gene

Endonuclease V:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENDOV

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENDOV Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^
SP1: - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - - - - - - - - -
SP15: - - - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - -
SP18: - - - - - - - - -
SP19: - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - - -
SP21: - - - - - - - - - - - -
SP22: - - - - - - - - - -
SP23: - - - - - -
SP24: -
SP25: - - - - -

ExUns: 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - -
SP7: - - -
SP8: - -
SP9: - -
SP10: -
SP11: - - - - - -
SP12: - - - -
SP13:
SP14: -
SP15: - - - - - - -
SP16:
SP17:
SP18:
SP19: - - - - - -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for ENDOV Gene

GeneLoc Exon Structure for
ENDOV
ECgene alternative splicing isoforms for
ENDOV

Expression for ENDOV Gene

mRNA expression in normal human tissues for ENDOV Gene

Protein differential expression in normal tissues for ENDOV Gene

This gene is overexpressed in Neutrophil (21.4), Monocytes (20.5), Tlymphocyte (15.7), and Peripheral blood mononuclear cells (11.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ENDOV Gene

SOURCE GeneReport for Unigene cluster for ENDOV Gene Hs.728933

genes like me logo Genes that share expressions with ENDOV: view

Expression partners for ENDOV Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ENDOV Gene

Orthologs for ENDOV Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ENDOV Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ENDOV 35
  • 84.12 (n)
  • 77.26 (a)
ENDOV 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Endov 35
  • 82.49 (n)
  • 81.52 (a)
Endov 16
Endov 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ENDOV 35
  • 94.74 (n)
  • 93.91 (a)
ENDOV 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ENDOV 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ENDOV 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ENDOV 35
  • 70.19 (n)
  • 66.67 (a)
ENDOV 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENDOV 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia endov 35
  • 63.16 (n)
  • 62.35 (a)
Str.16545 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G31150 35
  • 52.52 (n)
  • 45.8 (a)
rice
(Oryza sativa)
Liliopsida Os06g0663600 35
  • 54.69 (n)
  • 52.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for ENDOV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ENDOV Gene

ENSEMBL:
Gene Tree for ENDOV (if available)
TreeFam:
Gene Tree for ENDOV (if available)

Paralogs for ENDOV Gene

No data available for Paralogs for ENDOV Gene

Variants for ENDOV Gene

Sequence variations from dbSNP and Humsavar for ENDOV Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4075160 -- 80,425,250(-) TGGAC(C/T)CAGTC intron-variant
rs4075784 -- 80,429,390(+) CACCC(A/C/T)CACTC intron-variant
rs4076133 -- 80,425,204(-) GTTGA(G/T)GTGGG intron-variant
rs4077240 -- 80,424,443(+) GCCAG(C/T)CTGGC intron-variant
rs4306573 -- 80,438,139(+) CCACC(A/G)TGGGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ENDOV Gene

Variant ID Type Subtype PubMed ID
dgv3299n71 CNV Loss 21882294
esv24254 CNV Gain+Loss 19812545
dgv3300n71 CNV Loss 21882294
nsv524479 CNV Loss 19592680

Relevant External Links for ENDOV Gene

HapMap Linkage Disequilibrium report
ENDOV
Human Gene Mutation Database (HGMD)
ENDOV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENDOV Gene

Disorders for ENDOV Gene

No disorders were found for ENDOV Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ENDOV Gene

Publications for ENDOV Gene

  1. Human endonuclease V is a ribonuclease specific for inosine-containing RNA. (PMID: 23912718) Morita Y. … Kuraoka I. (Nat Commun 2013) 3 4
  2. Endonuclease V cleaves at inosines in RNA. (PMID: 23912683) Sebastian Vik E. … Alseth I. (Nat. Commun. 2013) 3 4
  3. The human homolog of Escherichia coli endonuclease V is a nucleolar protein with affinity for branched DNA structures. (PMID: 23139746) Fladeby C. … Alseth I. (PLoS ONE 2012) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V. (PMID: 12853604) Moe A. … Klungland A. (Nucleic Acids Res. 2003) 2 3

Products for ENDOV Gene

Sources for ENDOV Gene

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