Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENDOV Gene

protein-coding   GIFtS: 41
GCID: GC17P078389

Endonuclease V

  Search for ENDOV
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Endonuclease V1 2
EC 3.1.21.-3

External Ids:    HGNC: 266401   Entrez Gene: 2841312   Ensembl: ENSG000001738187   UniProtKB: Q8N8Q33   

Export aliases for ENDOV gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ENDOV Gene: 
ENDOV (endonuclease V) is a protein-coding gene. GO annotations related to this gene include endodeoxyribonuclease activity, producing 5'-phosphomonoesters and magnesium ion binding.

UniProtKB/Swiss-Prot: ENDOV_HUMAN, Q8N8Q3
Function: Selectively cleaves DNA at the second phosphodiester bond 3' to hypoxanthine- and uracil-containing
nucleotides. Shows higher activity towards single-stranded than double-stranded DNA and towards hypoxanthine than
uracil (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ENDOV
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ENDOV

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENDOV


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

ENDOV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENDOV gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P078389:  view genomic region     (about GC identifiers)

Start:
78,388,965 bp from pter      End:
78,411,886 bp from pter
Size:
22,922 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ENDOV_HUMAN, Q8N8Q3 (See protein sequence)
Recommended Name: Endonuclease V  
Size: 282 amino acids; 30792 Da
Cofactor: Magnesium (By similarity)
Secondary accessions: Q6P2G2 Q86X99 Q8NAK0
Alternative splicing: 4 isoforms:  Q8N8Q3-1   Q8N8Q3-2   Q8N8Q3-3   Q8N8Q3-4   

Explore the universe of human proteins at neXtProt for ENDOV: NX_Q8N8Q3

Explore proteomics data for ENDOV at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N8Q3

  • ENDOV Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ENDOV Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001158109.1  NP_001158110.1  NP_775898.2  

    ENSEMBL proteins: 
     ENSP00000430046   ENSP00000429442   ENSP00000429190   ENSP00000431036   ENSP00000427921  
     ENSP00000429183   ENSP00000317810   ENSP00000458185   ENSP00000461194   ENSP00000458391  
     ENSP00000461577   ENSP00000429603   ENSP00000459831   ENSP00000461563   ENSP00000459127  
     ENSP00000458361   ENSP00000461060   ENSP00000460685   ENSP00000428283   ENSP00000430509  
     ENSP00000461376   ENSP00000430639  

    Human Recombinant Protein Products for ENDOV: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ENDOV
    OriGene Protein Over-expression Lysate for ENDOV
    OriGene MassSpec for ENDOV 
    OriGene Custom Protein Services for ENDOV
    GenScript Custom Purified and Recombinant Proteins Services for ENDOV
    Novus Biologicals ENDOV Protein
    Novus Biologicals ENDOV Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ENDOV 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    ENDOV for ontologies           About GeneDecksing



    ENDOV Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ENDOV
    GenScript Custom Superior Antibodies Services for ENDOV
    Novus Biologicals ENDOV Antibodies
    Abcam antibodies for ENDOV
    Cloud-Clone Corp. Antibodies for ENDOV 
    Search ThermoFisher Antibodies for ENDOV
    Search LSBio for Antibodies for ENDOV 

    Assay Products for ENDOV: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ENDOV
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ENDOV
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ENDOV 
    Cloud-Clone Corp. CLIAs for ENDOV


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007581 Endonuclease-V

    Graphical View of Domain Structure for InterPro Entry Q8N8Q3

    ProtoNet protein and cluster: Q8N8Q3

    UniProtKB/Swiss-Prot: ENDOV_HUMAN, Q8N8Q3
    Similarity: Belongs to the endonuclease V family


    ENDOV for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENDOV_HUMAN, Q8N8Q3
    Function: Selectively cleaves DNA at the second phosphodiester bond 3' to hypoxanthine- and uracil-containing
    nucleotides. Shows higher activity towards single-stranded than double-stranded DNA and towards hypoxanthine than
    uracil (By similarity)

         Enzyme Number (IUBMB): EC 3.1.21.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding TAS--
    GO:0003727single-stranded RNA binding IDA--
    GO:0004519endonuclease activity ----
    GO:0016888endodeoxyribonuclease activity, producing 5'-phosphomonoesters ISS--
    GO:0016891endoribonuclease activity, producing 5'-phosphomonoesters IDA--
         
    ENDOV for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ENDOV 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ENDOV

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ENDOV 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ENDOV 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENDOV
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ENDOV
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ENDOV
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENDOV

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ENDOV
    Sirion Biotech Customized adenovirus for overexpression of ENDOV

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ENDOV (see all 18)
    OriGene ORF clones in mouse, rat for ENDOV
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for ENDOV
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENDOV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENDOV
    Sirion Biotech Customized lentivirus for stable overexpression of ENDOV 
                         Customized lentivirus expression plasmids for stable overexpression of ENDOV 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ENDOV
    Search LifeMap BioReagents cell lines for ENDOV
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENDOV


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENDOV

    4 Interacting proteins for ENDOV (Q8N8Q32, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NELFCDQ8IXH72, 3MINT-64859 I2D: score=4 
    PRPSAP2O602563I2D: score=3 
    --Q6ZTP63, 2MINT-64937 I2D: score=1 
    --Q6ZTP63, 2MINT-64937 I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair ISS--

    ENDOV for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ENDOV

    Search CenterWatch for drugs/clinical trials and news about ENDOV

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ENDOV gene (3 alternative transcripts): 
    NM_001164637.1  NM_001164638.1  NM_173627.3  

    Unigene Cluster for ENDOV:

    Endonuclease V
    Hs.728933  [show with all ESTs]
    Unigene Representative Sequence: AK096344
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000520537 ENST00000520484 ENST00000522577 ENST00000518137(uc021ueo.1)
    ENST00000520367(uc002jyl.2) ENST00000523999(uc002jyj.1) ENST00000519117
    ENST00000323854(uc002jyk.3) ENST00000521330 ENST00000522751 ENST00000520136
    ENST00000520284(uc021uep.1) ENST00000517795(uc021uer.1) ENST00000523228
    ENST00000523828 ENST00000522200 ENST00000520118 ENST00000521565
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENDOV
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ENDOV
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ENDOV
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENDOV
    Clone
    Products:
         
    OriGene clones in human, mouse for ENDOV (see all 18)
    OriGene ORF clones in mouse, rat for ENDOV
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for ENDOV
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENDOV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENDOV
    Sirion Biotech Customized lentivirus for stable overexpression of ENDOV 
                         Customized lentivirus expression plasmids for stable overexpression of ENDOV 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ENDOV
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ENDOV
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ENDOV
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENDOV

    Additional mRNA sequence: 

    AK092539.1 AK096344.1 AK096802.1 AK123689.1 BC037889.2 BC045824.1 BC059781.1 BC064545.1 
    BX647411.1 

    21 DOTS entries:

    DT.208913  DT.75143572  DT.102828293  DT.101979459  DT.101957626  DT.95276311  DT.102828295  DT.120997536 
    DT.437610  DT.101979460  DT.97789476  DT.97839311  DT.100747151  DT.120997479  DT.120997569  DT.120997491 
    DT.75192764  DT.97839313  DT.426809  DT.91950961  DT.95185459 

    24/126 AceView cDNA sequences (see all 126):

    AI610991 BM554738 BQ957094 BC059781 AA679287 BX106170 BQ923151 BM714470 
    AI635870 BM007984 AA451847 CR617882 AX747589 BE219425 BQ772531 BF686490 
    BQ346495 Z41683 AI140171 AA699359 AA720808 BM043073 BC064545 AA351280 

    GeneLoc Exon Structure

    5/25 Alternative Splicing Database (ASD) splice patterns (SP) for ENDOV (see all 25)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^
    SP1:              -     -     -     -     -     -                 -     -     -     -     -     -     -     -           -                             -     -   
    SP2:              -     -     -     -     -     -                 -     -     -     -     -     -     -     -     -     -                             -     -   
    SP3:              -     -     -     -     -     -                 -     -     -     -     -     -     -     -     -     -                             -     -   
    SP4:                                                  -     -     -     -     -     -     -     -     -     -     -     -                             -     -   
    SP5:                                                              -     -     -     -     -     -     -     -           -                             -     -   

    ExUns: 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
    SP1:        -                       -                       -                     
    SP2:        -                       -                       -                     
    SP3:        -                       -                                             
    SP4:        -                       -                       -                     
    SP5:                                -                                             


    ECgene alternative splicing isoforms for ENDOV

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ENDOV expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACGCTTTC
    ENDOV Expression
    About this image


    See ENDOV Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ENDOV

    SOURCE GeneReport for Unigene cluster: Hs.728933
        SABiosciences Custom PCR Arrays for ENDOV
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ENDOV
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ENDOV
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ENDOV
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENDOV
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENDOV

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ENDOV gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Endov1 , 5 RIKEN cDNA A730011L01 gene5
    endonuclease V1
    82.49(n)1
    81.52(a)1
      11 (83.80 cM)5
    3383711  NM_001164636.11  NP_001158108.11 
     1194913475 
    chicken
    (Gallus gallus)
    Aves ENDOV1 endonuclease V 69.55(n)
    65.35(a)
      422079  XM_420082.3  XP_420082.1 
    lizard
    (Anolis carolinensis)
    Reptilia ENDOV6
    Uncharacterized protein
    63(a)
    1 ↔ 1
    2(100346863-100358663)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.165452 Transcribed sequence with weak similarity to protein more 72.98(n)    CF346869.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G311501 deoxyribonuclease V 52.52(n)
    45.8(a)
      829243  NM_119265.3  NP_567868.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06636001 hypothetical protein 54.23(n)
    51.41(a)
      4341765  NM_001064828.1  NP_001058293.1 


    ENSEMBL Gene Tree for ENDOV (if available)
    TreeFam Gene Tree for ENDOV (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/554 SNPs in ENDOV are shown (see all 554)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0462884
    ----see VAR_0462882 H Y mis40--------
    VAR_0462854
    ----see VAR_0462852 V I mis40--------
    rs412986841,2
    C,F--78393816(+) GAAAAG/AGATAC 3 -- int16Minor allele frequency- A:0.05NS WA 288
    rs1161191841,2
    F--78393819(+) AAGGAT/CACGTT 3 -- int11Minor allele frequency- C:0.01WA 118
    rs129453681,2
    C,F,A--78393884(+) CTCTCG/ACGCAC 3 -- int117Minor allele frequency- A:0.39NA EA NS WA CSA 812
    rs1510407351,2
    C--78393907(+) TGTGCG/TTGTGT 3 -- int10--------
    rs412986881,2
    C,F--78393968(+) CCTGAG/AAATGA 3 -- int18Minor allele frequency- A:0.05NS CSA WA 294
    rs116566801,2
    H--78393991(+) CAGCCA/TCAGTG 3 -- int10--------
    rs1409558701,2
    C--78394092(+) CCCCTC/TCTGTG 3 -- int10--------
    rs1502137591,2
    C--78394133(+) TCACTC/GTGCAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for ENDOV (78388965 - 78411886 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ENDOV:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3300n71CNV Loss21882294
    dgv3299n71CNV Loss21882294
    nsv524479CNV Loss19592680
    esv24254CNV Gain+Loss19812545


    Human Gene Mutation Database (HGMD): ENDOV
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ENDOV
    DNA2.0 Custom Variant and Variant Library Synthesis for ENDOV

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ENDOV for disorders           About MalaCards

    ENDOV for disorders           About GeneDecksing


    Export disorders for ENDOV gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENDOV gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ENDOV)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Incision at hypoxanthine residues in DNA by a mammali an homologue of the Escherichia coli antimutator enzyme endonuclease V. (PubMed id 12853604)1, 3 Moe A....Klungland A. (2003)
    3. Human endonuclease V is a ribonuclease specific for in osine-containing RNA. (PubMed id 23912718)1 Morita Y....Kuraoka I. (2013)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. The human homolog of Escherichia coli endonuclease V i s a nucleolar protein with affinity for branched DNA structures. (PubMed id 23139746)1 Fladeby C....Alseth I. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    8. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1 Zhang X....Wu X. (2010)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284131 HGNC: 26640 AceView: FLJ35220 Ensembl:ENSG00000173818 euGenes: HUgn284131
    ECgene: ENDOV H-InvDB: ENDOV

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ENDOV Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/flj35220/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ENDOV gene:
    Search GeneIP for patents involving ENDOV

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ENDOV  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ENDOV  
     OriGene MassSpec something-or-other for ENDOV   OriGene clones in human, mouse for ENDOV  
     OriGene qSTAR qPCR primer pairs in human, mouse for ENDOV   OriGene Purified Protein for ENDOV  
     OriGene ORF clones in mouse, rat for ENDOV   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ENDOV   OriGene Custom Protein Services for ENDOV  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ENDOV
     QIAGEN SeqTarget long-range PCR primers for resequencing ENDOV
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENDOV
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENDOV
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENDOV
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ENDOV
     GenScript Custom Purified and Recombinant Proteins Services for ENDOV GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ENDOV
     GenScript Custom Assay Services for ENDOV GenScript Custom Superior Antibodies Services for ENDOV
     GenScript Custom overexpressing Cell Line Services for ENDOV CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for ENDOV
     Search Chromatin IP Primers for ENDOV
     RT2 qPCR Primer Assay in human, mouse, rat ENDOV
     Search GNC Networks for ENDOV
     SABiosciences Custom PCR Arrays for ENDOV
     Search Tocris compounds for ENDOV
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ENDOV antibodies
     ENDOV proteins
     ENDOV lysates
     Antibodies for ENDOV
     See all of Abcam's Antibodies, Kits and Proteins for ENDOV
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ENDOV
     Antibodies for ENDOV
     ELISAs for ENDOV
     CLIAs for ENDOV
     Search LifeMap BioReagents cell lines for ENDOV
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENDOV
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ENDOV
     Browse SwitchGear Promoter luciferase reporter plasmids for ENDOV
     Search ThermoFisher Antibodies for ENDOV
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENDOV
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ENDOV
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ENDOV
    Customized:
     lentivirus for stable overexpression of ENDOV
     lentivirus expression plasmids for stable overexpression of ENDOV
     adenovirus for overexpression of ENDOV
     Search LSBio for Antibodies for ENDOV
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ENDOV gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4