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Aliases for ENDOU Gene

Aliases for ENDOU Gene

  • Endonuclease, Poly(U) Specific 2 3 5
  • Uridylate-Specific Endoribonuclease 3 4
  • Endonuclease, PolyU-Specific 2 3
  • Placental Protein 11 3 4
  • Protein EndoU 3 4
  • PP11 3 4
  • Poly(U)-Specific Endoribonuclease 3
  • 22 Serine Protease 3
  • 26 Serine Protease 3
  • EC 3.1.-.- 4
  • PRSS26 3
  • P11 3

External Ids for ENDOU Gene

Previous GeneCards Identifiers for ENDOU Gene

  • GC12M048103
  • GC12M045134

Summaries for ENDOU Gene

Entrez Gene Summary for ENDOU Gene

  • This gene encodes a protein with protease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein. [provided by RefSeq, Feb 2010]

GeneCards Summary for ENDOU Gene

ENDOU (Endonuclease, Poly(U) Specific) is a Protein Coding gene. Diseases associated with ENDOU include Non-Gestational Choriocarcinoma. GO annotations related to this gene include RNA binding and serine-type peptidase activity.

UniProtKB/Swiss-Prot for ENDOU Gene

  • Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2-3-cyclic phosphate termini.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENDOU Gene

Genomics for ENDOU Gene

Regulatory Elements for ENDOU Gene

Enhancers for ENDOU Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F047751 1.1 ENCODE 18 -30.0 -30033 8.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 CBX5 ZNF143 FOS ENDOU RAPGEF3 LOC102725258 ENSG00000268069 ENSG00000257433 SLC48A1 ENSG00000277173
GH12F047804 1.5 FANTOM5 ENCODE 10.4 -92.2 -92177 25.6 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LOC390314 KANSL2 CCNT1 RAPGEF3 ASB8 VDR SENP1 SLC48A1 LOC102725258 RPL37P19
GH12F047841 1.2 Ensembl ENCODE 10.8 -116.5 -116474 0.9 HDAC1 ATF1 PTRF ZNF766 KLF13 ZBTB11 NCOA1 HDAC8 CREB3 TFDP1 RAPGEF3 SLC48A1 ENSG00000205537 ENDOU VDR TMEM106C LOC390314 CCNT1 ASB8 CCDC184
GH12F047772 1.1 ENCODE 11.6 -49.9 -49924 5.5 PKNOX1 ARNT ZFP64 SIN3A ZNF2 FOS ZNF263 SP5 SMARCB1 SREBF1 SLC48A1 RPAP3 ENDOU ENSG00000205537 ENSG00000268069 RAPGEF3 GC12M047752
GH12F047739 1.2 Ensembl ENCODE 10.5 -15.5 -15507 3.0 PKNOX1 ARNT WRNIP1 ZNF48 ZNF2 ZNF143 DEK ZNF263 SP5 REST ENDOU ENSG00000257433 RAPGEF3 HDAC7 ENSG00000274902 SLC48A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ENDOU on UCSC Golden Path with GeneCards custom track

Genomic Location for ENDOU Gene

Chromosome:
12
Start:
47,709,734 bp from pter
End:
47,725,572 bp from pter
Size:
15,839 bases
Orientation:
Minus strand

Genomic View for ENDOU Gene

Genes around ENDOU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENDOU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENDOU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENDOU Gene

Proteins for ENDOU Gene

  • Protein details for ENDOU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21128-ENDOU_HUMAN
    Recommended name:
    Poly(U)-specific endoribonuclease
    Protein Accession:
    P21128
    Secondary Accessions:
    • B2RBJ3
    • B3KQS7
    • B7Z6E1
    • Q2NKJ4

    Protein attributes for ENDOU Gene

    Size:
    410 amino acids
    Molecular mass:
    46872 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for ENDOU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENDOU Gene

Post-translational modifications for ENDOU Gene

  • It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENDOU Gene

No data available for DME Specific Peptides for ENDOU Gene

Domains & Families for ENDOU Gene

Gene Families for ENDOU Gene

Protein Domains for ENDOU Gene

Suggested Antigen Peptide Sequences for ENDOU Gene

Graphical View of Domain Structure for InterPro Entry

P21128

UniProtKB/Swiss-Prot:

ENDOU_HUMAN :
  • Contains 2 SMB (somatomedin-B) domains.
  • Belongs to the ENDOU family.
Domain:
  • Contains 2 SMB (somatomedin-B) domains.
Family:
  • Belongs to the ENDOU family.
genes like me logo Genes that share domains with ENDOU: view

Function for ENDOU Gene

Molecular function for ENDOU Gene

UniProtKB/Swiss-Prot Function:
Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2-3-cyclic phosphate termini.

Enzyme Numbers (IUBMB) for ENDOU Gene

Gene Ontology (GO) - Molecular Function for ENDOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 18936097
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004521 endoribonuclease activity IDA 18936097
GO:0005044 scavenger receptor activity IEA --
genes like me logo Genes that share ontologies with ENDOU: view
genes like me logo Genes that share phenotypes with ENDOU: view

Animal Models for ENDOU Gene

MGI Knock Outs for ENDOU:

Animal Model Products

  • Taconic Biosciences Mouse Models for ENDOU

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENDOU Gene

Localization for ENDOU Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENDOU Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENDOU gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for ENDOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 1710108
GO:0005615 extracellular space TAS 2350438
GO:0005737 cytoplasm TAS 2350438
GO:0005886 plasma membrane TAS 1710108
genes like me logo Genes that share ontologies with ENDOU: view

Pathways & Interactions for ENDOU Gene

SuperPathways for ENDOU Gene

No Data Available

Interacting Proteins for ENDOU Gene

Selected Interacting proteins: P21128-ENDOU_HUMAN for ENDOU Gene via IID

Gene Ontology (GO) - Biological Process for ENDOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 2350438
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006955 immune response IEA --
GO:0007565 female pregnancy IEP 2350438
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ENDOU: view

No data available for Pathways by source and SIGNOR curated interactions for ENDOU Gene

Drugs & Compounds for ENDOU Gene

(1) Drugs for ENDOU Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ENDOU: view

Transcripts for ENDOU Gene

Unigene Clusters for ENDOU Gene

Endonuclease, polyU-specific:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENDOU Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10
SP1:
SP2:
SP3: -
SP4: - -
SP5:

Relevant External Links for ENDOU Gene

GeneLoc Exon Structure for
ENDOU
ECgene alternative splicing isoforms for
ENDOU

Expression for ENDOU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ENDOU Gene

mRNA differential expression in normal tissues according to GTEx for ENDOU Gene

This gene is overexpressed in Esophagus - Mucosa (x18.4), Vagina (x6.1), Minor Salivary Gland (x4.6), Skin - Not Sun Exposed (Suprapubic) (x4.5), Cervix - Ectocervix (x4.4), and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for ENDOU Gene

This gene is overexpressed in Placenta (45.9) and Cervix (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ENDOU Gene



Protein tissue co-expression partners for ENDOU Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ENDOU Gene:

ENDOU

SOURCE GeneReport for Unigene cluster for ENDOU Gene:

Hs.997

mRNA Expression by UniProt/SwissProt for ENDOU Gene:

P21128-ENDOU_HUMAN
Tissue specificity: Placental-specific, but also associated with various malignant neoplasms.
genes like me logo Genes that share expression patterns with ENDOU: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ENDOU Gene

Orthologs for ENDOU Gene

This gene was present in the common ancestor of animals.

Orthologs for ENDOU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENDOU 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia ENDOU 34 35
  • 86.59 (n)
dog
(Canis familiaris)
Mammalia ENDOU 34 35
  • 85.37 (n)
rat
(Rattus norvegicus)
Mammalia Endou 34
  • 83.05 (n)
mouse
(Mus musculus)
Mammalia Endou 34 16 35
  • 82.72 (n)
oppossum
(Monodelphis domestica)
Mammalia ENDOU 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENDOU 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves ENDOU 34 35
  • 68.38 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490819 34
  • 60.66 (n)
zebrafish
(Danio rerio)
Actinopterygii endou 34 35
  • 60.9 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1715 34
fruit fly
(Drosophila melanogaster)
Insecta CG2145 34
  • 48.06 (n)
CG3303 35
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K02A11.3 34 35
  • 46.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
CSA.5199 35
  • 33 (a)
OneToMany
Species where no ortholog for ENDOU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENDOU Gene

ENSEMBL:
Gene Tree for ENDOU (if available)
TreeFam:
Gene Tree for ENDOU (if available)

Paralogs for ENDOU Gene

No data available for Paralogs for ENDOU Gene

Variants for ENDOU Gene

Sequence variations from dbSNP and Humsavar for ENDOU Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs111400576 -- 47,712,080(+) ATGGA(A/G)GAGAA intron-variant
rs111421098 -- 47,720,254(+) GGTAG(A/G)CTGGA intron-variant, nc-transcript-variant, downstream-variant-500B
rs11168204 -- 47,714,625(+) TACTA(A/G)GCTTT intron-variant
rs11168206 -- 47,722,633(+) CCCGT(C/T)GACAC intron-variant, downstream-variant-500B
rs11168207 -- 47,722,650(+) TCTAG(C/T)TGACA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ENDOU Gene

Variant ID Type Subtype PubMed ID
nsv696 CNV insertion 18451855
nsv470289 CNV gain 18288195
esv2751101 CNV gain 17911159

Variation tolerance for ENDOU Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENDOU Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENDOU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENDOU Gene

Disorders for ENDOU Gene

MalaCards: The human disease database

(1) MalaCards diseases for ENDOU Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-gestational choriocarcinoma
  • choriocarcinoma, non-gestational
- elite association - COSMIC cancer census association via MalaCards
Search ENDOU in MalaCards View complete list of genes associated with diseases

Relevant External Links for ENDOU

Human Genome Epidemiology (HuGE) Navigator
ENDOU
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENDOU
genes like me logo Genes that share disorders with ENDOU: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ENDOU Gene

Publications for ENDOU Gene

  1. The tumor marker human placental protein 11 is an endoribonuclease. (PMID: 18936097) Laneve P. … Caffarelli E. (J. Biol. Chem. 2008) 2 3 4 22 64
  2. Cloning and expression of a cDNA encoding human placental protein 11, a putative serine protease with diagnostic significance as a tumor marker. (PMID: 2350438) Grundmann U. … Amann E. (DNA Cell Biol. 1990) 2 3 4 22 64
  3. Homology of placental protein 11 and pea seed albumin 2 with vitronectin. (PMID: 1710108) Jenne D.E. (Biochem. Biophys. Res. Commun. 1991) 2 3 4 64
  4. Functional characterization of XendoU, the endoribonuclease involved in small nucleolar RNA biosynthesis. (PMID: 15755742) Gioia U. … Caffarelli E. (J. Biol. Chem. 2005) 2 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ENDOU Gene

Sources for ENDOU Gene

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