Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ENDOU Gene

Aliases for ENDOU Gene

  • Endonuclease, Poly(U) Specific 2 3 5
  • Uridylate-Specific Endoribonuclease 3 4
  • Endonuclease, PolyU-Specific 2 3
  • Placental Protein 11 3 4
  • Protein EndoU 3 4
  • PP11 3 4
  • 22 Serine Protease 3
  • 26 Serine Protease 3
  • EC 3.1.-.- 4
  • PRSS26 3
  • P11 3

External Ids for ENDOU Gene

Previous GeneCards Identifiers for ENDOU Gene

  • GC12M048103
  • GC12M045134

Summaries for ENDOU Gene

Entrez Gene Summary for ENDOU Gene

  • This gene encodes a protein with protease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein. [provided by RefSeq, Feb 2010]

GeneCards Summary for ENDOU Gene

ENDOU (Endonuclease, Poly(U) Specific) is a Protein Coding gene. Diseases associated with ENDOU include non-gestational choriocarcinoma. GO annotations related to this gene include RNA binding and serine-type peptidase activity.

UniProtKB/Swiss-Prot for ENDOU Gene

  • Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2-3-cyclic phosphate termini.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENDOU Gene

Genomics for ENDOU Gene

Genomic Location for ENDOU Gene

Chromosome:
12
Start:
47,709,734 bp from pter
End:
47,725,572 bp from pter
Size:
15,839 bases
Orientation:
Minus strand

Genomic View for ENDOU Gene

Genes around ENDOU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENDOU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENDOU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENDOU Gene

No data available for Regulatory Elements for ENDOU Gene

Proteins for ENDOU Gene

  • Protein details for ENDOU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21128-ENDOU_HUMAN
    Recommended name:
    Poly(U)-specific endoribonuclease
    Protein Accession:
    P21128
    Secondary Accessions:
    • B2RBJ3
    • B3KQS7
    • B7Z6E1
    • Q2NKJ4

    Protein attributes for ENDOU Gene

    Size:
    410 amino acids
    Molecular mass:
    46872 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for ENDOU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENDOU Gene

Proteomics data for ENDOU Gene at MOPED

Post-translational modifications for ENDOU Gene

  • It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENDOU Gene

No data available for DME Specific Peptides for ENDOU Gene

Domains & Families for ENDOU Gene

Gene Families for ENDOU Gene

Protein Domains for ENDOU Gene

Suggested Antigen Peptide Sequences for ENDOU Gene

Graphical View of Domain Structure for InterPro Entry

P21128

UniProtKB/Swiss-Prot:

ENDOU_HUMAN :
  • Contains 2 SMB (somatomedin-B) domains.
  • Belongs to the ENDOU family.
Domain:
  • Contains 2 SMB (somatomedin-B) domains.
Family:
  • Belongs to the ENDOU family.
genes like me logo Genes that share domains with ENDOU: view

Function for ENDOU Gene

Molecular function for ENDOU Gene

UniProtKB/Swiss-Prot Function:
Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2-3-cyclic phosphate termini.

Enzyme Numbers (IUBMB) for ENDOU Gene

Gene Ontology (GO) - Molecular Function for ENDOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 18936097
GO:0008236 NOT serine-type peptidase activity IDA 18936097
genes like me logo Genes that share ontologies with ENDOU: view
genes like me logo Genes that share phenotypes with ENDOU: view

Animal Models for ENDOU Gene

MGI Knock Outs for ENDOU:

Animal Model Products

  • Taconic Biosciences Mouse Models for ENDOU

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENDOU Gene

Localization for ENDOU Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENDOU Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENDOU Gene COMPARTMENTS Subcellular localization image for ENDOU gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ENDOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 1710108
genes like me logo Genes that share ontologies with ENDOU: view

Pathways & Interactions for ENDOU Gene

SuperPathways for ENDOU Gene

No Data Available

Interacting Proteins for ENDOU Gene

Gene Ontology (GO) - Biological Process for ENDOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 2350438
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IDA 18936097
genes like me logo Genes that share ontologies with ENDOU: view

No data available for Pathways by source and SIGNOR curated interactions for ENDOU Gene

Drugs & Compounds for ENDOU Gene

(1) Drugs for ENDOU Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ENDOU: view

Transcripts for ENDOU Gene

Unigene Clusters for ENDOU Gene

Endonuclease, polyU-specific:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ENDOU Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10
SP1:
SP2:
SP3: -
SP4: - -
SP5:

Relevant External Links for ENDOU Gene

GeneLoc Exon Structure for
ENDOU
ECgene alternative splicing isoforms for
ENDOU

Expression for ENDOU Gene

mRNA expression in normal human tissues for ENDOU Gene

mRNA differential expression in normal tissues according to GTEx for ENDOU Gene

This gene is overexpressed in Esophagus - Mucosa (x18.4), Vagina (x6.1), Minor Salivary Gland (x4.6), Skin - Not Sun Exposed (Suprapubic) (x4.5), Cervix - Ectocervix (x4.4), and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for ENDOU Gene

This gene is overexpressed in Placenta (45.9) and Cervix (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ENDOU Gene



SOURCE GeneReport for Unigene cluster for ENDOU Gene Hs.997

mRNA Expression by UniProt/SwissProt for ENDOU Gene

P21128-ENDOU_HUMAN
Tissue specificity: Placental-specific, but also associated with various malignant neoplasms.
genes like me logo Genes that share expression patterns with ENDOU: view

Protein tissue co-expression partners for ENDOU Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ENDOU Gene

Orthologs for ENDOU Gene

This gene was present in the common ancestor of animals.

Orthologs for ENDOU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENDOU 36
  • 100 (a)
OneToOne
ENDOU 35
  • 99.84 (n)
  • 99.76 (a)
cow
(Bos Taurus)
Mammalia ENDOU 35
  • 86.59 (n)
  • 85.85 (a)
ENDOU 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENDOU 36
  • 79 (a)
OneToOne
ENDOU 35
  • 85.37 (n)
  • 81.71 (a)
mouse
(Mus musculus)
Mammalia Endou 16
Endou 36
  • 67 (a)
OneToOne
Endou 35
  • 82.72 (n)
  • 82.4 (a)
oppossum
(Monodelphis domestica)
Mammalia ENDOU 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENDOU 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Endou 35
  • 83.05 (n)
  • 81.66 (a)
chicken
(Gallus gallus)
Aves ENDOU 35
  • 68.38 (n)
  • 63.64 (a)
ENDOU 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490819 35
  • 60.66 (n)
  • 58.6 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1715 35
zebrafish
(Danio rerio)
Actinopterygii endou 36
  • 51 (a)
OneToOne
endou 35
  • 60.9 (n)
  • 55.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3303 36
  • 23 (a)
OneToMany
CG2145 35
  • 48.06 (n)
  • 36.7 (a)
worm
(Caenorhabditis elegans)
Secernentea K02A11.3 35
  • 46.92 (n)
  • 37.31 (a)
K02A11.3 36
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
CSA.5199 36
  • 33 (a)
OneToMany
Species with no ortholog for ENDOU:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENDOU Gene

ENSEMBL:
Gene Tree for ENDOU (if available)
TreeFam:
Gene Tree for ENDOU (if available)

Paralogs for ENDOU Gene

No data available for Paralogs for ENDOU Gene

Variants for ENDOU Gene

Sequence variations from dbSNP and Humsavar for ENDOU Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_014793 -
VAR_014794 -

Structural Variations from Database of Genomic Variants (DGV) for ENDOU Gene

Variant ID Type Subtype PubMed ID
esv2751101 CNV Gain 17911159
nsv470289 CNV Gain 18288195
nsv696 CNV Insertion 18451855

Variation tolerance for ENDOU Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENDOU Gene

HapMap Linkage Disequilibrium report
ENDOU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENDOU Gene

Disorders for ENDOU Gene

MalaCards: The human disease database

(1) MalaCards diseases for ENDOU Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-gestational choriocarcinoma
  • choriocarcinoma, non-gestational
- elite association - COSMIC cancer census association via MalaCards
Search ENDOU in MalaCards View complete list of genes associated with diseases

Relevant External Links for ENDOU

Human Genome Epidemiology (HuGE) Navigator
ENDOU
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENDOU
genes like me logo Genes that share disorders with ENDOU: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ENDOU Gene

Publications for ENDOU Gene

  1. Cloning and expression of a cDNA encoding human placental protein 11, a putative serine protease with diagnostic significance as a tumor marker. (PMID: 2350438) Grundmann U. … Amann E. (DNA Cell Biol. 1990) 2 3 4 23 67
  2. The tumor marker human placental protein 11 is an endoribonuclease. (PMID: 18936097) Laneve P. … Caffarelli E. (J. Biol. Chem. 2008) 2 3 23
  3. Functional characterization of XendoU, the endoribonuclease involved in small nucleolar RNA biosynthesis. (PMID: 15755742) Gioia U. … Caffarelli E. (J. Biol. Chem. 2005) 2 3
  4. Homology of placental protein 11 and pea seed albumin 2 with vitronectin. (PMID: 1710108) Jenne D.E. (Biochem. Biophys. Res. Commun. 1991) 2 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for ENDOU Gene

Sources for ENDOU Gene

Back to Top

Content