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Aliases for ENDOU Gene

Aliases for ENDOU Gene

  • Endonuclease, Poly(U) Specific 2 3 5
  • Uridylate-Specific Endoribonuclease 3 4
  • Endonuclease, PolyU-Specific 2 3
  • Placental Protein 11 3 4
  • Protein EndoU 3 4
  • PP11 3 4
  • Poly(U)-Specific Endoribonuclease 3
  • 22 Serine Protease 3
  • 26 Serine Protease 3
  • EC 3.1.-.- 4
  • PRSS26 3
  • P11 3

External Ids for ENDOU Gene

Previous GeneCards Identifiers for ENDOU Gene

  • GC12M048103
  • GC12M045134

Summaries for ENDOU Gene

Entrez Gene Summary for ENDOU Gene

  • This gene encodes a protein with protease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein. [provided by RefSeq, Feb 2010]

GeneCards Summary for ENDOU Gene

ENDOU (Endonuclease, Poly(U) Specific) is a Protein Coding gene. Diseases associated with ENDOU include Non-Gestational Choriocarcinoma. GO annotations related to this gene include RNA binding and serine-type peptidase activity.

UniProtKB/Swiss-Prot for ENDOU Gene

  • Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2-3-cyclic phosphate termini.

Additional gene information for ENDOU Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENDOU Gene

Genomics for ENDOU Gene

Regulatory Elements for ENDOU Gene

Enhancers for ENDOU Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H047751 1.5 Ensembl ENCODE dbSUPER 18 -30.0 -30033 8.9 HDGF PKNOX1 ATF1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B GLIS2 ENDOU RAPGEF3 LOC102725258 ENSG00000268069 ENSG00000257433 SLC48A1 ENSG00000277173
GH12H047779 1.4 Ensembl ENCODE dbSUPER 11.6 -54.1 -54063 1.3 HDAC1 ELF3 TBL1XR1 RB1 ZNF2 RAD21 RFX5 ZNF143 ZNF207 RCOR1 SLC48A1 RPAP3 ENDOU ENSG00000205537 ENSG00000268069 GC12M047752 RAPGEF3
GH12H047772 1.3 ENCODE dbSUPER 11.6 -49.9 -49924 5.5 HDGF PKNOX1 ARNT ZFP64 SIN3A ZNF2 ZNF766 ZNF143 FOS SP5 SLC48A1 RPAP3 ENDOU ENSG00000205537 ENSG00000268069 RAPGEF3 GC12M047752
GH12H047739 1.3 Ensembl ENCODE dbSUPER 10.5 -15.1 -15143 2.3 HDGF CTCF TFAP4 PKNOX1 KLF1 NFIB ETV1 ZNF223 EBF1 ZIC2 ENDOU ENSG00000257433 RAPGEF3 HDAC7 ENSG00000274902 SLC48A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ENDOU on UCSC Golden Path with GeneCards custom track

Genomic Locations for ENDOU Gene

Genomic Locations for ENDOU Gene
15,839 bases
Minus strand

Genomic View for ENDOU Gene

Genes around ENDOU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENDOU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENDOU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENDOU Gene

Proteins for ENDOU Gene

  • Protein details for ENDOU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Poly(U)-specific endoribonuclease
    Protein Accession:
    Secondary Accessions:
    • B2RBJ3
    • B3KQS7
    • B7Z6E1
    • Q2NKJ4

    Protein attributes for ENDOU Gene

    410 amino acids
    Molecular mass:
    46872 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for ENDOU Gene


neXtProt entry for ENDOU Gene

Post-translational modifications for ENDOU Gene

  • It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENDOU Gene

No data available for DME Specific Peptides for ENDOU Gene

Domains & Families for ENDOU Gene

Gene Families for ENDOU Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ENDOU Gene

Suggested Antigen Peptide Sequences for ENDOU Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ENDOU family.
  • Belongs to the ENDOU family.
genes like me logo Genes that share domains with ENDOU: view

Function for ENDOU Gene

Molecular function for ENDOU Gene

UniProtKB/Swiss-Prot Function:
Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2-3-cyclic phosphate termini.

Enzyme Numbers (IUBMB) for ENDOU Gene

Phenotypes From GWAS Catalog for ENDOU Gene

Gene Ontology (GO) - Molecular Function for ENDOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 18936097
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004521 endoribonuclease activity IDA 18936097
GO:0005044 scavenger receptor activity IEA --
genes like me logo Genes that share ontologies with ENDOU: view
genes like me logo Genes that share phenotypes with ENDOU: view

Animal Models for ENDOU Gene

MGI Knock Outs for ENDOU:

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENDOU Gene

Localization for ENDOU Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENDOU Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENDOU gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for ENDOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 1710108
GO:0005615 extracellular space TAS 2350438
GO:0005737 cytoplasm TAS 2350438
GO:0005886 plasma membrane TAS 1710108
genes like me logo Genes that share ontologies with ENDOU: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ENDOU Gene

Pathways & Interactions for ENDOU Gene

SuperPathways for ENDOU Gene

No Data Available

Interacting Proteins for ENDOU Gene

Selected Interacting proteins: P21128-ENDOU_HUMAN for ENDOU Gene via IID

Gene Ontology (GO) - Biological Process for ENDOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 2350438
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006955 immune response IEA --
GO:0007565 female pregnancy IEP 2350438
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ENDOU: view

No data available for Pathways by source and SIGNOR curated interactions for ENDOU Gene

Drugs & Compounds for ENDOU Gene

(1) Drugs for ENDOU Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ENDOU: view

Transcripts for ENDOU Gene

Unigene Clusters for ENDOU Gene

Endonuclease, polyU-specific:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENDOU Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10
SP3: -
SP4: - -

Relevant External Links for ENDOU Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ENDOU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENDOU Gene

mRNA differential expression in normal tissues according to GTEx for ENDOU Gene

This gene is overexpressed in Esophagus - Mucosa (x18.4), Vagina (x6.1), Minor Salivary Gland (x4.6), Skin - Not Sun Exposed (Suprapubic) (x4.5), Cervix - Ectocervix (x4.4), and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for ENDOU Gene

This gene is overexpressed in Placenta (45.9) and Cervix (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ENDOU Gene

Protein tissue co-expression partners for ENDOU Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ENDOU Gene:


SOURCE GeneReport for Unigene cluster for ENDOU Gene:


mRNA Expression by UniProt/SwissProt for ENDOU Gene:

Tissue specificity: Placental-specific, but also associated with various malignant neoplasms.

Evidence on tissue expression from TISSUES for ENDOU Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ENDOU: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENDOU Gene

Orthologs for ENDOU Gene

This gene was present in the common ancestor of animals.

Orthologs for ENDOU Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ENDOU 33 34
  • 99.84 (n)
(Bos Taurus)
Mammalia ENDOU 33 34
  • 86.59 (n)
(Canis familiaris)
Mammalia ENDOU 33 34
  • 85.37 (n)
(Rattus norvegicus)
Mammalia Endou 33
  • 83.05 (n)
(Mus musculus)
Mammalia Endou 33 16 34
  • 82.72 (n)
(Monodelphis domestica)
Mammalia ENDOU 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia ENDOU 34
  • 61 (a)
(Gallus gallus)
Aves ENDOU 33 34
  • 68.38 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 73 (a)
-- 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490819 33
  • 60.66 (n)
(Danio rerio)
Actinopterygii endou 33 34
  • 60.9 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1715 33
fruit fly
(Drosophila melanogaster)
Insecta CG2145 33
  • 48.06 (n)
CG3303 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea K02A11.3 33 34
  • 46.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
CSA.5199 34
  • 33 (a)
Species where no ortholog for ENDOU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENDOU Gene

Gene Tree for ENDOU (if available)
Gene Tree for ENDOU (if available)

Paralogs for ENDOU Gene

No data available for Paralogs for ENDOU Gene

Variants for ENDOU Gene

Sequence variations from dbSNP and Humsavar for ENDOU Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000170129 -- 47,717,595(+) ATTGG(A/T)GGTGC intron-variant, nc-transcript-variant, reference, missense
rs1000280617 -- 47,711,880(+) ATTAG(-/TAAT)GGGCC intron-variant
rs1000344496 -- 47,724,337(+) CCATG(A/G)TTGGG intron-variant
rs1000362763 -- 47,723,987(+) CCCTG(A/C)CACCT intron-variant
rs1000404430 -- 47,724,280(+) CTCTC(C/T)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENDOU Gene

Variant ID Type Subtype PubMed ID
nsv696 CNV insertion 18451855
nsv470289 CNV gain 18288195
esv2751101 CNV gain 17911159

Variation tolerance for ENDOU Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENDOU Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENDOU Gene

Disorders for ENDOU Gene

MalaCards: The human disease database

(1) MalaCards diseases for ENDOU Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-gestational choriocarcinoma
  • choriocarcinoma, non-gestational
- elite association - COSMIC cancer census association via MalaCards
Search ENDOU in MalaCards View complete list of genes associated with diseases

Relevant External Links for ENDOU

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ENDOU: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ENDOU Gene

Publications for ENDOU Gene

  1. The tumor marker human placental protein 11 is an endoribonuclease. (PMID: 18936097) Laneve P … Caffarelli E (The Journal of biological chemistry 2008) 2 3 4 22 60
  2. Cloning and expression of a cDNA encoding human placental protein 11, a putative serine protease with diagnostic significance as a tumor marker. (PMID: 2350438) Grundmann U … Amann E (DNA and cell biology 1990) 2 3 4 22 60
  3. Homology of placental protein 11 and pea seed albumin 2 with vitronectin. (PMID: 1710108) Jenne D (Biochemical and biophysical research communications 1991) 2 3 4 60
  4. Functional characterization of XendoU, the endoribonuclease involved in small nucleolar RNA biosynthesis. (PMID: 15755742) Gioia U … Caffarelli E (The Journal of biological chemistry 2005) 2 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for ENDOU Gene

Sources for ENDOU Gene

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