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Aliases for ENDOG Gene

Aliases for ENDOG Gene

  • Endonuclease G 2 3 5
  • EC 3.1.30.- 4
  • Endo G 4

External Ids for ENDOG Gene

Previous GeneCards Identifiers for ENDOG Gene

  • GC09P122695
  • GC09P123227
  • GC09P125034
  • GC09P126956
  • GC09P128660
  • GC09P130620
  • GC09P131580
  • GC09P101189

Summaries for ENDOG Gene

Entrez Gene Summary for ENDOG Gene

  • The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for ENDOG Gene

ENDOG (Endonuclease G) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and Granzyme Pathway. GO annotations related to this gene include nucleic acid binding and endonuclease activity. An important paralog of this gene is EXOG.

UniProtKB/Swiss-Prot for ENDOG Gene

  • Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).

Gene Wiki entry for ENDOG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENDOG Gene

Genomics for ENDOG Gene

Regulatory Elements for ENDOG Gene

Enhancers for ENDOG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G129380 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6 +564.4 564355 4.6 PKNOX1 PTBP1 RAD21 ZBTB7B GLIS2 RCOR1 FOS CEBPB ZHX2 GATAD2B NTMT1 C9orf50 ENDOG GLE1 USP20 C9orf106 C9orf78 MIGA2 TOR1B ASB6
GH09G128844 1.5 Ensembl ENCODE dbSUPER 6.6 +27.5 27470 2.2 HDGF PKNOX1 FOXA2 ARNT SIN3A TCF12 GATA2 FOS DEK NCOA1 SPOUT1 LRRC8A KYAT1 DOLK NUP188 TBC1D13 PHYHD1 ZDHHC12 LOC100506100 PKN3
GH09G128909 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +93.8 93825 5.5 PKNOX1 FOXA2 ARID4B ZBTB7B YY1 TCF12 GLIS2 GATA2 FOS SP5 LRRC8A KYAT1 PHYHD1 NUP188 DOLK SPOUT1 LOC100506100 ZDHHC12 PKN3 GLE1
GH09G129172 1.8 FANTOM5 ENCODE dbSUPER 5.2 +357.3 357349 7.5 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 PPARGC1A CRAT LOC101929314 SPOUT1 ENSG00000272696 USP20 PTPA ENDOG NTMT1 IER5L PHYHD1
GH09G128877 1.4 ENCODE dbSUPER 6.2 +64.9 64873 12.3 HDGF PKNOX1 FOXA2 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 SPOUT1 LOC101929314 ENSG00000272696 USP20 PHYHD1 NUP188 DOLK PKN3 LOC100506100 ZDHHC12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ENDOG on UCSC Golden Path with GeneCards custom track

Promoters for ENDOG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241909 289 1401 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1 YY1

Genomic Location for ENDOG Gene

Chromosome:
9
Start:
128,818,411 bp from pter
End:
128,822,678 bp from pter
Size:
4,268 bases
Orientation:
Plus strand

Genomic View for ENDOG Gene

Genes around ENDOG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENDOG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENDOG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENDOG Gene

Proteins for ENDOG Gene

  • Protein details for ENDOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14249-NUCG_HUMAN
    Recommended name:
    Endonuclease G, mitochondrial
    Protein Accession:
    Q14249
    Secondary Accessions:
    • Q5T281
    • Q9BSP2

    Protein attributes for ENDOG Gene

    Size:
    297 amino acids
    Molecular mass:
    32620 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.

neXtProt entry for ENDOG Gene

Post-translational modifications for ENDOG Gene

  • Ubiquitination at isoforms=66, isoforms=76, isoforms=153, Lys210, and isoforms=214
  • Modification sites at PhosphoSitePlus

Other Protein References for ENDOG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ENDOG (ENDOG)
  • Cloud-Clone Corp. Antibodies for ENDOG

No data available for DME Specific Peptides for ENDOG Gene

Domains & Families for ENDOG Gene

Suggested Antigen Peptide Sequences for ENDOG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14249

UniProtKB/Swiss-Prot:

NUCG_HUMAN :
  • Belongs to the DNA/RNA non-specific endonuclease family.
Family:
  • Belongs to the DNA/RNA non-specific endonuclease family.
genes like me logo Genes that share domains with ENDOG: view

No data available for Gene Families for ENDOG Gene

Function for ENDOG Gene

Molecular function for ENDOG Gene

GENATLAS Biochemistry:
endonuclease G,involved in mitochondrial biogenesis
UniProtKB/Swiss-Prot Function:
Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).

Enzyme Numbers (IUBMB) for ENDOG Gene

Gene Ontology (GO) - Molecular Function for ENDOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004536 deoxyribonuclease activity IEA --
GO:0005515 protein binding IPI 25036637
genes like me logo Genes that share ontologies with ENDOG: view
genes like me logo Genes that share phenotypes with ENDOG: view

Animal Models for ENDOG Gene

MGI Knock Outs for ENDOG:

Animal Model Products

CRISPR Products

miRNA for ENDOG Gene

miRTarBase miRNAs that target ENDOG

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENDOG Gene

Localization for ENDOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENDOG Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENDOG gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 4
endoplasmic reticulum 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ENDOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IEA --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with ENDOG: view

Pathways & Interactions for ENDOG Gene

genes like me logo Genes that share pathways with ENDOG: view

Pathways by source for ENDOG Gene

1 GeneTex pathway for ENDOG Gene
1 Cell Signaling Technology pathway for ENDOG Gene
1 KEGG pathway for ENDOG Gene
1 R&D Systems pathway for ENDOG Gene

SIGNOR curated interactions for ENDOG Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ENDOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006309 apoptotic DNA fragmentation IBA --
GO:0006310 DNA recombination TAS 18309324
GO:0007568 aging IEA --
GO:0009612 response to mechanical stimulus IEA --
genes like me logo Genes that share ontologies with ENDOG: view

Drugs & Compounds for ENDOG Gene

(9) Drugs for ENDOG Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 34
Magnesium Nutra 0

(4) Additional Compounds for ENDOG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ENDOG: view

Transcripts for ENDOG Gene

mRNA/cDNA for ENDOG Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(102) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ENDOG Gene

Endonuclease G:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENDOG Gene

No ASD Table

Relevant External Links for ENDOG Gene

GeneLoc Exon Structure for
ENDOG
ECgene alternative splicing isoforms for
ENDOG

Expression for ENDOG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENDOG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENDOG Gene

This gene is overexpressed in Muscle - Skeletal (x5.1).

Protein differential expression in normal tissues from HIPED for ENDOG Gene

This gene is overexpressed in Bone marrow stromal cell (11.9), Liver (11.7), Adrenal (6.2), and Fetal heart (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ENDOG Gene



NURSA nuclear receptor signaling pathways regulating expression of ENDOG Gene:

ENDOG

SOURCE GeneReport for Unigene cluster for ENDOG Gene:

Hs.745161

Evidence on tissue expression from TISSUES for ENDOG Gene

  • Nervous system(4.5)
  • Muscle(3)
  • Liver(2)
genes like me logo Genes that share expression patterns with ENDOG: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENDOG Gene

Orthologs for ENDOG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENDOG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENDOG 34 35
  • 95.24 (n)
dog
(Canis familiaris)
Mammalia ENDOG 34 35
  • 90.37 (n)
cow
(Bos Taurus)
Mammalia ENDOG 34 35
  • 87.88 (n)
mouse
(Mus musculus)
Mammalia Endog 34 16 35
  • 83.9 (n)
rat
(Rattus norvegicus)
Mammalia Endog 34
  • 82.54 (n)
oppossum
(Monodelphis domestica)
Mammalia ENDOG 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859613 34
  • 76.16 (n)
-- 35
  • 75 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia endog 34
  • 65.97 (n)
zebrafish
(Danio rerio)
Actinopterygii endog 34 35
  • 63.48 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007845 34
  • 57.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta EndoG 34 35
  • 57.06 (n)
CG8862 36
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea cps-6 36 34 35
  • 52.96 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR144C 34
  • 53.46 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D00440g 34
  • 48.39 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUC1 34 35 37
  • 48.34 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00030 34
  • 58.37 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pnu1 34
  • 47.42 (n)
Species where no ortholog for ENDOG was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENDOG Gene

ENSEMBL:
Gene Tree for ENDOG (if available)
TreeFam:
Gene Tree for ENDOG (if available)

Paralogs for ENDOG Gene

Paralogs for ENDOG Gene

(1) SIMAP similar genes for ENDOG Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ENDOG: view

Variants for ENDOG Gene

Sequence variations from dbSNP and Humsavar for ENDOG Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs864309587 Benign 128,822,605(+) GCAGT(-/AAGT)GAGGG reference, utr-variant-3-prime, frameshift-variant
rs1000377291 -- 128,819,721(+) ACAGT(A/C)ATGTA intron-variant, utr-variant-3-prime
rs1000742076 -- 128,819,925(+) GGCTG(C/T)TGTGG intron-variant, utr-variant-3-prime
rs1002121987 -- 128,817,105(+) TGCTA(A/G)GAGTG upstream-variant-2KB
rs1002880121 -- 128,819,336(+) GAGCA(C/T)TGGGC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ENDOG Gene

Variant ID Type Subtype PubMed ID
nsv521120 CNV loss 19592680
nsv615411 CNV loss 21841781
nsv615412 CNV loss 21841781

Variation tolerance for ENDOG Gene

Gene Damage Index Score: 1.97; 36.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENDOG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENDOG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENDOG Gene

Disorders for ENDOG Gene

Relevant External Links for ENDOG

Genetic Association Database (GAD)
ENDOG
Human Genome Epidemiology (HuGE) Navigator
ENDOG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENDOG

No disorders were found for ENDOG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENDOG Gene

Publications for ENDOG Gene

  1. Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis. (PMID: 7789991) Tiranti V. … Zeviani M. (Genomics 1995) 2 3 4 22 64
  2. EGCG induces apoptosis in human laryngeal epidermoid carcinoma Hep2 cells via mitochondria with the release of apoptosis-inducing factor and endonuclease G. (PMID: 19781850) Lee J.H. … Jung J.Y. (Cancer Lett. 2010) 3 22 64
  3. Role of endonuclease G in senescence-associated cell death of human endothelial cells. (PMID: 20211237) Diener T. … Jansen-DA1rr P. (Exp. Gerontol. 2010) 3 22 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G. (PMID: 19199036) Noda T. … Yura Y. (Apoptosis 2009) 3 22 64

Products for ENDOG Gene

Sources for ENDOG Gene

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