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Aliases for ENDOD1 Gene

Aliases for ENDOD1 Gene

  • Endonuclease Domain Containing 1 2 3 5
  • EC 3.1.30.- 4
  • KIAA0830 4

External Ids for ENDOD1 Gene

Previous GeneCards Identifiers for ENDOD1 Gene

  • GC11P094463
  • GC11P094823
  • GC11P090887

Summaries for ENDOD1 Gene

GeneCards Summary for ENDOD1 Gene

ENDOD1 (Endonuclease Domain Containing 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include nucleic acid binding and endonuclease activity.

UniProtKB/Swiss-Prot for ENDOD1 Gene

  • May act as a DNase and a RNase.

Additional gene information for ENDOD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENDOD1 Gene

Genomics for ENDOD1 Gene

Regulatory Elements for ENDOD1 Gene

Enhancers for ENDOD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H095133 1.2 Ensembl ENCODE dbSUPER 23.8 +44.7 44723 2 MAFG OSR2 ZFHX2 JUND ZNF316 POLR2A PRDM10 ZNF600 EMSY MAFK ENDOD1 BUD13P1 ENSG00000270578 CWC15 KDM4D KDM4E SRSF8 LOC105369435 GC11P095138 GC11M095076
GH11H095066 1.4 ENCODE dbSUPER 17.1 -21.9 -21913 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENDOD1 KDM4F ENSG00000257012 LOC100420801 ENSG00000233536 CEP57 SRSF8 FGFR3P2 LOC101929295 FAM76B
GH11H095076 1 ENCODE dbSUPER 19.8 -13.3 -13260 0 SRF PKNOX1 MAX CEBPB CEBPG EP300 NR2F2 PRDM6 ELK1 CEBPA ENDOD1 LOC101929295 GC11P095083 GC11P095067
GH11H095140 0.8 ENCODE 19.3 +51.1 51107 1 ATF1 FEZF1 CEBPG ZIC2 HIC1 ZFHX2 EGR1 ZSCAN5C ATF7 ZBTB20 ENDOD1 KDM4E GC11P095138 BUD13P1
GH11H095095 1.3 Ensembl ENCODE dbSUPER 11 +6.4 6435 1 PKNOX1 TBL1XR1 BATF EED ATF7 ETV6 RUNX3 IKZF2 CREM MAZ LOC101929295 ENDOD1 KDM4D CWC15 KDM4E GC11P095093 GC11M095076
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ENDOD1 on UCSC Golden Path with GeneCards custom track

Promoters for ENDOD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000043550 90 1401 HDGF ATF1 ARID4B SIN3A YY1 ZNF143 ZNF207 ATF7 RUNX3 SP3

Genomic Location for ENDOD1 Gene

Chromosome:
11
Start:
95,089,810 bp from pter
End:
95,132,651 bp from pter
Size:
42,842 bases
Orientation:
Plus strand

Genomic View for ENDOD1 Gene

Genes around ENDOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENDOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENDOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENDOD1 Gene

Proteins for ENDOD1 Gene

  • Protein details for ENDOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94919-ENDD1_HUMAN
    Recommended name:
    Endonuclease domain-containing 1 protein
    Protein Accession:
    O94919
    Secondary Accessions:
    • A8K6K8
    • Q6GQY5
    • Q8TAQ8

    Protein attributes for ENDOD1 Gene

    Size:
    500 amino acids
    Molecular mass:
    55017 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74853.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ENDOD1 Gene

Post-translational modifications for ENDOD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENDOD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ENDOD1 Gene

Domains & Families for ENDOD1 Gene

Gene Families for ENDOD1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for ENDOD1 Gene

Suggested Antigen Peptide Sequences for ENDOD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94919

UniProtKB/Swiss-Prot:

ENDD1_HUMAN :
  • Belongs to the DNA/RNA non-specific endonuclease family.
Family:
  • Belongs to the DNA/RNA non-specific endonuclease family.
genes like me logo Genes that share domains with ENDOD1: view

Function for ENDOD1 Gene

Molecular function for ENDOD1 Gene

UniProtKB/Swiss-Prot Function:
May act as a DNase and a RNase.

Enzyme Numbers (IUBMB) for ENDOD1 Gene

Phenotypes From GWAS Catalog for ENDOD1 Gene

Gene Ontology (GO) - Molecular Function for ENDOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ENDOD1: view

Phenotypes for ENDOD1 Gene

GenomeRNAi human phenotypes for ENDOD1:
genes like me logo Genes that share phenotypes with ENDOD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ENDOD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENDOD1 Gene

Localization for ENDOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENDOD1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENDOD1 gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ENDOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ENDOD1: view

Pathways & Interactions for ENDOD1 Gene

genes like me logo Genes that share pathways with ENDOD1: view

Interacting Proteins for ENDOD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000278505%0d%0a9606.ENSP00000381148%0d%0a9606.ENSP00000286713%0d%0a
Selected Interacting proteins: O94919-ENDD1_HUMAN ENSP00000278505 for ENDOD1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ENDOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ENDOD1: view

No data available for SIGNOR curated interactions for ENDOD1 Gene

Drugs & Compounds for ENDOD1 Gene

No Compound Related Data Available

Transcripts for ENDOD1 Gene

mRNA/cDNA for ENDOD1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(214) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ENDOD1 Gene

Endonuclease domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ENDOD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ENDOD1 Gene

No ASD Table

Relevant External Links for ENDOD1 Gene

GeneLoc Exon Structure for
ENDOD1
ECgene alternative splicing isoforms for
ENDOD1

Expression for ENDOD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENDOD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ENDOD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.4), Urine (9.7), Cervix (9.6), and Platelet (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ENDOD1 Gene



Protein tissue co-expression partners for ENDOD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ENDOD1 Gene:

ENDOD1

SOURCE GeneReport for Unigene cluster for ENDOD1 Gene:

Hs.167115

Evidence on tissue expression from TISSUES for ENDOD1 Gene

  • Nervous system(4.8)
  • Blood(4.2)
  • Liver(2.3)
genes like me logo Genes that share expression patterns with ENDOD1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENDOD1 Gene

Orthologs for ENDOD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ENDOD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENDOD1 33 34
  • 98.75 (n)
dog
(Canis familiaris)
Mammalia ENDOD1 33 34
  • 82.89 (n)
cow
(Bos Taurus)
Mammalia ENDOD1 33 34
  • 81.6 (n)
mouse
(Mus musculus)
Mammalia Endod1 33 16 34
  • 80.4 (n)
rat
(Rattus norvegicus)
Mammalia Endod1 33
  • 80.16 (n)
oppossum
(Monodelphis domestica)
Mammalia ENDOD1 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
OneToMany
-- 34
  • 59 (a)
OneToMany
-- 34
  • 27 (a)
OneToMany
chicken
(Gallus gallus)
Aves ENDOD1 33 34
  • 57.87 (n)
lizard
(Anolis carolinensis)
Reptilia ENDOD1 34
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia endod1 33
  • 54.04 (n)
zebrafish
(Danio rerio)
Actinopterygii ENDOD1 (12 of 15) 34
  • 32 (a)
OneToMany
ENDOD1 (1 of 15) 34
  • 29 (a)
OneToMany
ENDOD1 (15 of 15) 34
  • 29 (a)
OneToMany
ENDOD1 (4 of 15) 34
  • 27 (a)
OneToMany
ENDOD1 (9 of 15) 34
  • 27 (a)
OneToMany
ENDOD1 (5 of 15) 34
  • 26 (a)
OneToMany
ENDOD1 (11 of 15) 34
  • 25 (a)
OneToMany
ENDOD1 (8 of 15) 34
  • 25 (a)
OneToMany
ENDOD1 (3 of 15) 34
  • 24 (a)
OneToMany
ENDOD1 (7 of 15) 34
  • 24 (a)
OneToMany
ENDOD1 (10 of 15) 34
  • 23 (a)
OneToMany
CT573337.1 34
  • 22 (a)
OneToMany
ENDOD1 (2 of 15) 34
  • 21 (a)
OneToMany
ENDOD1 (13 of 15) 34
  • 17 (a)
OneToMany
ENDOD1 (6 of 15) 34
  • 4 (a)
OneToMany
Species where no ortholog for ENDOD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ENDOD1 Gene

ENSEMBL:
Gene Tree for ENDOD1 (if available)
TreeFam:
Gene Tree for ENDOD1 (if available)

Paralogs for ENDOD1 Gene

Pseudogenes.org Pseudogenes for ENDOD1 Gene

genes like me logo Genes that share paralogs with ENDOD1: view

No data available for Paralogs for ENDOD1 Gene

Variants for ENDOD1 Gene

Sequence variations from dbSNP and Humsavar for ENDOD1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000026675 -- 95,096,586(+) AAATA(C/T)TATTT intron-variant
rs1000075796 -- 95,096,252(+) TTTTT(C/T)CAAAT intron-variant
rs1000198742 -- 95,102,912(+) TTCCC(A/G)GTTTT intron-variant
rs1000243705 -- 95,109,273(+) CATGA(A/G)TCAGA intron-variant
rs1000369317 -- 95,090,245(+) GTTCC(A/C)GAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENDOD1 Gene

Variant ID Type Subtype PubMed ID
esv1343006 CNV insertion 17803354
esv3413248 CNV duplication 20981092
esv992223 CNV insertion 20482838
nsv1138065 CNV deletion 24896259

Variation tolerance for ENDOD1 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.33; 88.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENDOD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENDOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENDOD1 Gene

Disorders for ENDOD1 Gene

Relevant External Links for ENDOD1

Genetic Association Database (GAD)
ENDOD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENDOD1

No disorders were found for ENDOD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENDOD1 Gene

Publications for ENDOD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Towards complete analysis of the platelet proteome. (PMID: 11921445) O'Neill EE … Hebestreit HF (Proteomics 2002) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for ENDOD1 Gene

Sources for ENDOD1 Gene

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