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Aliases for ENDOD1 Gene

Aliases for ENDOD1 Gene

  • Endonuclease Domain Containing 1 2 3
  • EC 3.1.30.- 4
  • KIAA0830 4

External Ids for ENDOD1 Gene

Previous GeneCards Identifiers for ENDOD1 Gene

  • GC11P094463
  • GC11P094823
  • GC11P090887

Summaries for ENDOD1 Gene

GeneCards Summary for ENDOD1 Gene

ENDOD1 (Endonuclease Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and endonuclease activity.

UniProtKB/Swiss-Prot for ENDOD1 Gene

  • May act as a DNase and a RNase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENDOD1 Gene

Genomics for ENDOD1 Gene

Regulatory Elements for ENDOD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ENDOD1 Gene

Chromosome:
11
Start:
95,089,810 bp from pter
End:
95,132,651 bp from pter
Size:
42,842 bases
Orientation:
Plus strand

Genomic View for ENDOD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENDOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENDOD1 Gene

Proteins for ENDOD1 Gene

  • Protein details for ENDOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94919-ENDD1_HUMAN
    Recommended name:
    Endonuclease domain-containing 1 protein
    Protein Accession:
    O94919
    Secondary Accessions:
    • A8K6K8
    • Q6GQY5
    • Q8TAQ8

    Protein attributes for ENDOD1 Gene

    Size:
    500 amino acids
    Molecular mass:
    55017 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74853.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ENDOD1 Gene

Proteomics data for ENDOD1 Gene at MOPED

Post-translational modifications for ENDOD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENDOD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ENDOD1 Gene

Domains & Families for ENDOD1 Gene

Protein Domains for ENDOD1 Gene

Suggested Antigen Peptide Sequences for ENDOD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94919

UniProtKB/Swiss-Prot:

ENDD1_HUMAN :
  • Belongs to the DNA/RNA non-specific endonuclease family.
Family:
  • Belongs to the DNA/RNA non-specific endonuclease family.
genes like me logo Genes that share domains with ENDOD1: view

No data available for Gene Families for ENDOD1 Gene

Function for ENDOD1 Gene

Molecular function for ENDOD1 Gene

UniProtKB/Swiss-Prot Function:
May act as a DNase and a RNase.

Enzyme Numbers (IUBMB) for ENDOD1 Gene

Gene Ontology (GO) - Molecular Function for ENDOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 endonuclease activity IEA --
GO:0016787 hydrolase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ENDOD1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENDOD1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ENDOD1 Gene

Localization for ENDOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENDOD1 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for ENDOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ENDOD1: view

No data available for Subcellular locations from COMPARTMENTS for ENDOD1 Gene

Pathways & Interactions for ENDOD1 Gene

SuperPathways for ENDOD1 Gene

No Data Available

Interacting Proteins for ENDOD1 Gene

Gene Ontology (GO) - Biological Process for ENDOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ENDOD1: view

No data available for Pathways by source and SIGNOR curated interactions for ENDOD1 Gene

Drugs & Compounds for ENDOD1 Gene

No Compound Related Data Available

Transcripts for ENDOD1 Gene

mRNA/cDNA for ENDOD1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(214) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ENDOD1 Gene

Endonuclease domain containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENDOD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENDOD1 Gene

No ASD Table

Relevant External Links for ENDOD1 Gene

GeneLoc Exon Structure for
ENDOD1
ECgene alternative splicing isoforms for
ENDOD1

Expression for ENDOD1 Gene

mRNA expression in normal human tissues for ENDOD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ENDOD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.4), Urine (9.7), Cervix (9.6), and Platelet (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ENDOD1 Gene



SOURCE GeneReport for Unigene cluster for ENDOD1 Gene Hs.167115

genes like me logo Genes that share expression patterns with ENDOD1: view

Protein tissue co-expression partners for ENDOD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ENDOD1 Gene

Orthologs for ENDOD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ENDOD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ENDOD1 35
  • 81.6 (n)
  • 76.6 (a)
ENDOD1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENDOD1 35
  • 82.89 (n)
  • 76.63 (a)
ENDOD1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Endod1 35
  • 80.4 (n)
  • 76.4 (a)
Endod1 16
Endod1 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ENDOD1 35
  • 98.75 (n)
  • 98.13 (a)
ENDOD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Endod1 35
  • 80.16 (n)
  • 75.75 (a)
oppossum
(Monodelphis domestica)
Mammalia ENDOD1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves ENDOD1 35
  • 57.87 (n)
  • 43.4 (a)
ENDOD1 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENDOD1 36
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia endod1 35
  • 54.04 (n)
  • 45.18 (a)
zebrafish
(Danio rerio)
Actinopterygii CT573337.1 36
  • 22 (a)
OneToMany
ENDOD1 (1 of 15) 36
  • 29 (a)
OneToMany
ENDOD1 (10 of 15) 36
  • 23 (a)
OneToMany
ENDOD1 (11 of 15) 36
  • 25 (a)
OneToMany
ENDOD1 (12 of 15) 36
  • 32 (a)
OneToMany
ENDOD1 (13 of 15) 36
  • 17 (a)
OneToMany
ENDOD1 (15 of 15) 36
  • 29 (a)
OneToMany
ENDOD1 (2 of 15) 36
  • 21 (a)
OneToMany
ENDOD1 (3 of 15) 36
  • 24 (a)
OneToMany
ENDOD1 (4 of 15) 36
  • 27 (a)
OneToMany
ENDOD1 (5 of 15) 36
  • 26 (a)
OneToMany
ENDOD1 (6 of 15) 36
  • 4 (a)
OneToMany
ENDOD1 (7 of 15) 36
  • 24 (a)
OneToMany
ENDOD1 (8 of 15) 36
  • 25 (a)
OneToMany
ENDOD1 (9 of 15) 36
  • 27 (a)
OneToMany
Species with no ortholog for ENDOD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ENDOD1 Gene

ENSEMBL:
Gene Tree for ENDOD1 (if available)
TreeFam:
Gene Tree for ENDOD1 (if available)

Paralogs for ENDOD1 Gene

Pseudogenes.org Pseudogenes for ENDOD1 Gene

genes like me logo Genes that share paralogs with ENDOD1: view

No data available for Paralogs for ENDOD1 Gene

Variants for ENDOD1 Gene

Sequence variations from dbSNP and Humsavar for ENDOD1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7729 -- 95,132,290(-) CAACT(A/C)CCTAG utr-variant-3-prime
rs486616 -- 95,126,728(-) ACTCC(A/G)ACCTG intron-variant
rs496374 -- 95,123,879(-) TGAAT(G/T)GGGAC intron-variant
rs499001 -- 95,123,800(-) ACGCC(A/C)AGCCG intron-variant
rs500849 -- 95,130,335(-) GGGCC(A/C)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ENDOD1 Gene

Variant ID Type Subtype PubMed ID
nsv898188 CNV Loss 21882294
nsv898189 CNV Loss 21882294
esv992223 CNV Insertion 20482838
esv1343006 CNV Insertion 17803354

Variation tolerance for ENDOD1 Gene

Residual Variation Intolerance Score: 54.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.33; 88.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENDOD1 Gene

HapMap Linkage Disequilibrium report
ENDOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENDOD1 Gene

Disorders for ENDOD1 Gene

Relevant External Links for ENDOD1

Genetic Association Database (GAD)
ENDOD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENDOD1
genes like me logo Genes that share disorders with ENDOD1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENDOD1 Gene

Publications for ENDOD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 67
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67
  5. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 67

Products for ENDOD1 Gene

Sources for ENDOD1 Gene

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