Aliases for ENC1 Gene
External Ids for ENC1 Gene
Previous HGNC Symbols for ENC1 Gene
Previous GeneCards Identifiers for ENC1 Gene
This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for ENC1 Gene
ENC1 (Ectodermal-Neural Cortex 1 (With BTB Domain)) is a Protein Coding gene. Diseases associated with ENC1 include neuroblastoma. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include actin binding. An important paralog of this gene is KBTBD6.
UniProtKB/Swiss-Prot for ENC1 Gene
Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.