Aliases for ENC1 Gene
External Ids for ENC1 Gene
Previous HGNC Symbols for ENC1 Gene
Previous GeneCards Identifiers for ENC1 Gene
This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for ENC1 Gene
ENC1 (Ectodermal-Neural Cortex 1) is a Protein Coding gene. Diseases associated with ENC1 include neuroblastoma. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is KBTBD4.
UniProtKB/Swiss-Prot for ENC1 Gene
Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.