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Aliases for ENC1 Gene

Aliases for ENC1 Gene

  • Ectodermal-Neural Cortex 1 (With BTB Domain) 2 3
  • PIG10 3 4 6
  • Ectodermal-Neural Cortex 1 (With BTB-Like Domain) 2 3
  • Nuclear Matrix Protein NRP/B 3 4
  • Kelch-Like Family Member 37 2 3
  • P53-Induced Gene 10 Protein 3 4
  • Kelch-Like Protein 37 3 4
  • KLHL37 3 4
  • ENC-1 3 4
  • NRPB 3 4
  • Nuclear Restricted Protein, BTB Domain-Like (Brain) 3
  • Tumor Protein P53 Inducible Protein 10 3
  • Ectoderm-Neural Cortex Protein 1 3
  • Kelch-Like 35 3
  • TP53I10 3
  • KLHL35 3
  • CCL28 3

External Ids for ENC1 Gene

Previous Symbols for ENC1 Gene

  • NRPB

Summaries for ENC1 Gene

Entrez Gene Summary for ENC1 Gene

  • This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for ENC1 Gene

ENC1 (Ectodermal-Neural Cortex 1 (With BTB Domain)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include actin binding. An important paralog of this gene is KBTBD6.

UniProtKB/Swiss-Prot for ENC1 Gene

  • Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.

Gene Wiki entry for ENC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENC1 Gene

Genomics for ENC1 Gene

Genomic Location for ENC1 Gene

74,627,406 bp from pter
74,641,424 bp from pter
14,019 bases
Minus strand

Genomic View for ENC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENC1 Gene

Regulatory Elements for ENC1 Gene

Proteins for ENC1 Gene

  • Protein details for ENC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ectoderm-neural cortex protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DHJ1
    • E9PFU0
    • O75464
    • Q9UPG9

    Protein attributes for ENC1 Gene

    589 amino acids
    Molecular mass:
    66130 Da
    Quaternary structure:
    • Binds to RB1. Hypophosphorylated RB1 associates with ENC1 during neuronal differentiation, while hyperphosphorylated RB1 associates with ENC1 in undifferentiating cells. Part of a complex that contains CUL3, RBX1 and ENC1. Interacts indirectly with KEAP1.

    Alternative splice isoforms for ENC1 Gene


neXtProt entry for ENC1 Gene

Proteomics data for ENC1 Gene at MOPED

Post-translational modifications for ENC1 Gene

  • Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ENC1 Gene

Domains for ENC1 Gene

Gene Families for ENC1 Gene

  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like


  • Contains 1 BTB (POZ) domain.:
    • O14682
  • Contains 6 Kelch repeats.:
    • O14682
genes like me logo Genes that share domains with ENC1: view

Function for ENC1 Gene

Molecular function for ENC1 Gene

GENATLAS Biochemistry: ectodermal-neural cortex 1,nuclear matrix protein,expressed in the brain and spinal cord,associating with RB1,involved in differentiation of neural crest cells,may be down-regulated in neuroblastoma
UniProtKB/Swiss-Prot Function: Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.
UniProtKB/Swiss-Prot Induction: By p53/TP53.

Gene Ontology (GO) - Molecular Function for ENC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 19424503
genes like me logo Genes that share ontologies with ENC1: view
genes like me logo Genes that share phenotypes with ENC1: view

miRNA for ENC1 Gene

miRTarBase miRNAs that target ENC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ENC1 Gene

Localization for ENC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENC1 Gene

Nucleus matrix. Cytoplasm. Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for ENC1 Gene COMPARTMENTS Subcellular localization image for ENC1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
mitochondrion 2
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ENC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus TAS 9566959
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA 19424503
genes like me logo Genes that share ontologies with ENC1: view

Pathways for ENC1 Gene

genes like me logo Genes that share pathways with ENC1: view

Gene Ontology (GO) - Biological Process for ENC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development TAS 9566959
GO:0007399 nervous system development TAS 9566959
GO:0010499 proteasomal ubiquitin-independent protein catabolic process IDA 19424503
GO:0010976 positive regulation of neuron projection development IEA --
GO:0016567 protein ubiquitination IDA 15983046
genes like me logo Genes that share ontologies with ENC1: view

Transcripts for ENC1 Gene

Unigene Clusters for ENC1 Gene

Ectodermal-neural cortex 1 (with BTB domain):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ENC1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5
SP1: - - -
SP2: -
SP4: - - - -

Relevant External Links for ENC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ENC1 Gene

mRNA expression in normal human tissues for ENC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENC1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (10.0), Brain - Anterior cingulate cortex (BA24) (8.6), Brain - Cortex (7.5), Brain - Hippocampus (5.5), and Brain - Amygdala (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ENC1 Gene

SOURCE GeneReport for Unigene cluster for ENC1 Gene Hs.104925

mRNA Expression by UniProt/SwissProt for ENC1 Gene

Tissue specificity: Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas. May be down-regulated in neuroblastoma tumors
genes like me logo Genes that share expressions with ENC1: view

Orthologs for ENC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ENC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ENC1 36
  • 99.26 (n)
  • 99.83 (a)
ENC1 37
  • 100 (a)
(Bos Taurus)
Mammalia ENC1 36
  • 91.74 (n)
  • 99.83 (a)
ENC1 37
  • 100 (a)
(Canis familiaris)
Mammalia ENC1 36
  • 89.19 (n)
  • 99.83 (a)
ENC1 37
  • 100 (a)
(Mus musculus)
Mammalia Enc1 36
  • 90.32 (n)
  • 99.32 (a)
Enc1 16
Enc1 37
  • 99 (a)
(Monodelphis domestica)
Mammalia ENC1 37
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia ENC1 37
  • 98 (a)
(Rattus norvegicus)
Mammalia Enc1 36
  • 89.93 (n)
  • 99.49 (a)
(Gallus gallus)
Aves ENC1 36
  • 82.91 (n)
  • 97.11 (a)
ENC1 37
  • 97 (a)
(Anolis carolinensis)
Reptilia ENC1 37
  • 96 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2226 36
tropical clawed frog
(Silurana tropicalis)
Amphibia enc1 36
  • 79.23 (n)
  • 93.38 (a)
Str.6584 36
(Danio rerio)
Actinopterygii enc1 36
enc1 37
  • 88 (a)
LOC559101 36
  • 76.63 (n)
  • 88.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
Species with no ortholog for ENC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ENC1 Gene

Gene Tree for ENC1 (if available)
Gene Tree for ENC1 (if available)

Paralogs for ENC1 Gene

genes like me logo Genes that share paralogs with ENC1: view

Variants for ENC1 Gene

Sequence variations from dbSNP and Humsavar for ENC1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs9176 -- 74,636,490(-) TGGAA(A/G)CAAAA utr-variant-5-prime, intron-variant
rs300239 -- 74,634,926(+) CCCAC(C/G/T)TTGGT synonymous-codon, missense, reference, intron-variant
rs300240 -- 74,634,617(+) CTCAC(C/T)CCATG intron-variant
rs300241 -- 74,631,455(+) AGACC(C/T)ACCTA intron-variant
rs300259 -- 74,628,234(+) ATGGA(C/T)GGACA utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ENC1 Gene

Variant ID Type Subtype PubMed ID
nsv830351 CNV Loss 17160897

Relevant External Links for ENC1 Gene

HapMap Linkage Disequilibrium report

Disorders for ENC1 Gene

(1) Novoseek inferred disease relationships for ENC1 Gene

Disease -log(P) Hits PubMed IDs
colon cancer 36.9 3
genes like me logo Genes that share disorders with ENC1: view

No data available for UniProtKB/Swiss-Prot for ENC1 Gene

Publications for ENC1 Gene

  1. A model for p53-induced apoptosis. (PMID: 9305847) Polyak K. … Vogelstein B. (Nature 1997) 2 3 4
  2. NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation. (PMID: 9566959) Kim T.-A. … Avraham S. (J. Cell Biol. 1998) 2 3 4
  3. Cloning of human ENC-1 and evaluation of its expression and regulation in nervous system tumors. (PMID: 9683534) Hernandez M.-C. … Israel M.A. (Exp. Cell Res. 1998) 3 4
  4. Assignment of the ectodermal-neural cortex 1 gene (ENC1) to human chromosome band 5q13 by in situ hybridization. (PMID: 10640818) Hernandez M.C. … Israel M.A. (Cytogenet. Cell Genet. 1999) 3 23
  5. Genomic organization, chromosomal localization and regulation of expression of the neuronal nuclear matrix protein NRP/B in human brain tumors. (PMID: 10974570) Kim T.A. … Avraham S. (Gene 2000) 3 23

Products for ENC1 Gene

  • Addgene plasmids for ENC1

Sources for ENC1 Gene

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