Aliases for EN1 Gene
External Ids for EN1 Gene
Previous GeneCards Identifiers for EN1 Gene
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
GeneCards Summary for EN1 Gene
EN1 (Engrailed Homeobox 1) is a Protein Coding gene. Diseases associated with EN1 include salivary gland adenoid cystic carcinoma and tyrosinemia, type iii. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and SIDS Susceptibility Pathways. GO annotations related to this gene include sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is EN2.