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Aliases & Descriptions for EN1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| Hu-En-1 3 | | OTTHUMP00000162091 2 |
| | | Descriptions |
|---|
| engrailed homeobox 1 2 | | engrailed homolog 1 2 |
|
| | Search outside databases for aliases for EN1 genePrevious GC identifers: GC02M116805 GC02M117520 GC02M119506 GC02M119694 |
Summaries for EN1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for EN1: Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq] Gene Wiki entry for EN1 |
Genomic Location for EN1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the EN1 gene 
Entrez Gene cytogenetic band: 2q13-q21 Ensembl cytogenetic band: 2q14.2 HGNC cytogenetic band: 2q14.2EN1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M119315:
(about GC identifiers)
Start:
|
119,316,217 bp from pter |
End:
|
119,322,229 bp from pter |
Size:
|
6,013 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022135.15
| Proteins for EN1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: HME1_HUMAN, Q05925 (See
protein sequence)Recommended Name: Homeobox protein engrailed-1 Size: 392 amino acids; 40115 Da
Subcellular location: Nucleus
Secondary accessions: Q4ZG44REFSEQ proteins: NP_001417.3
ENSEMBL proteins: ENSP00000295206
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for EN1: Assays for EN1: | Protein
Domains/ Families for EN1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q05925
ProtoNet protein and cluster: Q05925 2 Blocks protein families: IPB000047 Lambda and other repressor helix-turn-helix signature IPB000747 'Homeobox' engrailed-type protein
UniProtKB/Swiss-Prot: HME1_HUMAN, Q05925Similarity: Belongs to the engrailed homeobox familySimilarity: Contains 1 homeobox DNA-binding domain | Gene Function for EN1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001426
Applied Biosystems Silencer® siRNAs for EN1
Sigma-Aldrich siRNA for EN1  Sigma-Aldrich shRNA for EN1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001426                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001426                                  untagged cDNA clone in CMV expression vector: NM_001426 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001426
Genatlas biochemistry entry for EN1:Drosophila segment-polarity gene engrailed homolog 1,homeo domain encoding gene,expressed in embryonic ventral limb ectoderm,regulator of the ventral limb patterning,inhibits WNT7A expression in ventral limb bud15/17 MGI mutant phenotypes (inferred from 15 alleles ) (MGI details for En1) (see all 17
):
2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- | About this table | Pathways & Interactions for EN1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for EN1 
5/15 Interacting proteins for EN1 (ENSP000002952063) via UniProtKB, MINT, and/or STRING (see all 15
)About this table
5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12
): About this table
|
Drugs & Compounds for EN1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for EN1
|
Transcripts for EN1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001426
Sigma-Aldrich siRNA for EN1  Sigma-Aldrich shRNA for EN1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001426 REFSEQ mRNAs for EN1 gene: NM_001426.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001426               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001426                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001426                                  untagged cDNA clone in CMV expression vector: NM_001426  2 DOTS entries: DT.441697 DT.92415194 6 AceView cDNA sequences:AI924297 AI287694 AI283135 NM_001426 AA853350 BU617408
highest scoring ESTs for EN1:AA452915 AA853349 AA853350 AI283135 NM_001426 AI287694 AI924297 AA453083 BU617408 BX116136 Unigene Cluster for EN1: Engrailed homeobox 1 Hs.271977 [show with all ESTs]Unigene Representative Sequence: NM_001426
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000295206
|
Expression for EN1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| EN1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for EN1
1 / 2 / 3 3 probe-sets matching EN1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.271977
|
Orthologs for EN1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for EN1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for EN1
ENSEMBL Gene Tree for EN1 | Paralogs for EN1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for EN1 gene
- MEOX12 MEOX22 EN22
|
SNPs/Variants for EN1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for EN1 (up to first 250kb)
|
Disorders & Mutations for EN1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 131290
2 Novoseek disease relationships for EN1 gene
About this table
Genetic Association Database: EN1 Human Genome Epidemiology Navigator: EN1 (3 documents)
|
Medical News for EN1(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications for EN1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/46 PubMed articles for EN1 gene (see all 46
):- Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development. (PubMed id 15240857)1, 3, 6 Weese-Mayer D.E....Marazita M.L. (2004)
- Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions. (PubMed id 1363401)1, 3, 4 Logan C....Joyner A.L. (1992)
- Regional assignment of the human homeobox-containing gene EN1 to chromosome 2q13-q21. (PubMed id 8094370)2, 3 Kohler A....Muenke M. (1993)
- Model-based gene selection shows engrailed 1 is associated with antipsychotic response. (PubMed id 18698228)1, 3 Webb B.T....van den Oord E.J. (2008)
- Polymorphisms of coding trinucleotide repeats of homeogenes in neurodevelopmental psychiatric disorders. (PubMed id 19018235)1, 3 Laroche F....Robel L. (2008)
- Deregulated expression of PAX5 in medulloblastoma. (PubMed id 7777574)1, 3 Kozmik Z....Aguzzi A. (1995)
- Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease. (PubMed id 19345444)3 Haubenberger D....Zimprich A. (2009)
- Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)3 Baranzini S.E....Oksenberg J.R. (2008)
- Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway. (PubMed id 16571670)3 Bachar-Dahan L....Gazit A. (2006)
- Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. (PubMed id 16730693)3 Atit R....Conlon R.A. (2006)
|
Search for EN1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing EN1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing EN1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EN1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for EN1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for EN1:

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|
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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