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CTTN Gene

protein-coding GIFtS: 63

GC11P069922

cortactin
(Previous name: ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EMS1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
1110020L01Rik ^²
Amplaxin ^³
EMS1 ^², ³, ⁵
FLJ34459 ^²
cortactin ^²

Descriptions
Oncogene EMS1 ^², ³
ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate) ^¹, ²

External Ids
HGNC: 3338¹
Entrez Gene: 2017²
UniProtKB: Q14247³
Ensembl: ENSG00000085733⁷

Search outside databases for aliases for CTTN gene

Previous GC identifer: GC11P069971

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CTTN:

This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The

encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This

gene has two roles: (1) regulating the interactions between components of adherens-type junctions

and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells.

During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant

regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants

that encode different isoforms have been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247

Function: May contribute to the organization of cell structure. The SH3 motif may function as a

binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to

cellular growth regulation and transformation

Gene Wiki entry for CTTN (Cortactin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CTTN gene

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.3 HGNC cytogenetic band: 11q13

CTTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P069922: (about GC identifiers)

Start:	69,922,292 bp from pter
End:	69,960,338 bp from pter
Size:	38,047 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033927.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247 (See protein sequence)

Recommended Name: Src substrate cortactin

Size: 550 amino acids; 61586 Da

Subunit: Interacts with SHANK2 and SHANK3 via its SH2 domain. Also interacts with FGD1 (By

similarity). Interacts with PLXDC2

Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cell projection, lamellipodium (By

similarity). Cell projection, ruffle (By similarity). Note=Associated with membrane ruffles and

lamellipodia (By similarity)

PDB structure from and Proteopedia :

1X69 (3D)

2D1X (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_005222.2 NP_612632.1

ENSEMBL proteins:

ENSP00000365745 ENSP00000301843 ENSP00000317189 ENSP00000377348

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Cortactin)
	Human Recombinant Proteins from Abnova (CTTN)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	ISS	--
GO:0005625	soluble fraction	TAS	9054437
GO:0005737	cytoplasm	ISS	--
GO:0005856	cytoskeleton	TAS	9054437
GO:0005938	cell cortex	ISS	--

About this table

Antibodies for CTTN:

	Invitrogen Antibodies for CTTN
	Millipore Mono- and Polyclonal Antibodies for the study of CTTN
	Sigma-Aldrich Antibody Arrays and Antibodies for CTTN
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CTTN (Cortactin)
	Antibodies from Abcam (Cortactin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CTTN)
	Novus Biologicals Antibodies for CTTN

Assays for CTTN:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q14247

ProtoNet protein and cluster: Q14247

2 Blocks protein families:

IPB001452 SH3 domain signature

IPB003134 Hs1/Cortactin

UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247

Similarity: Contains 7 cortactin repeats

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CTTN)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005231

Applied Biosystems Silencer® siRNAs for CTTN

Sigma-Aldrich siRNA for CTTN

Sigma-Aldrich shRNA Panels and shRNA for CTTN

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CTTN
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005231
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005231
untagged cDNA clones in CMV expression vector (see all 2): NM_005231

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005231

UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247

Function: May contribute to the organization of cell structure. The SH3 motif may function as a

binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to

cellular growth regulation and transformation

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for CTTN (Your Favorite Gene powered by Ingenuity)

Leukocyte Extravasation Signaling
Clathrin-mediated Endocytosis
Agrin Interactions at Neuromuscular Junction

GeneDecks CTTN for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CTTN

5/70 Interacting proteins for CTTN (ENSP00000365745³ Q14247^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 70 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
WIPF1	O43516¹	STRING (score=.975) EBI-351886, EBI-346356
PTPN1	P18031²	STRING (score=.769) MINT-6795189 MINT-6795199
PAK1	Q13153²	STRING (score=.71) MINT-6541935
WASL	O00401²	STRING (score=.993) MINT-6541916
PAK2	Q13177²	MINT-6541954

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CTTN
10/17 Novoseek chemical compound relationships for CTTN gene (see all 17 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	72.46	202	9748248 (5), 10952984 (5), 17420251 (5), 12851885 (5) (see all 84)
threonine	34.60	6	16109479 (2), 9683637 (1), 15169891 (1), 18768925 (1) (see all 5)
phosphotyrosine	23.63	4	16442522 (2), 18240308 (1)
pip2	22.42	1	17217950 (1)
thromboxane a2	17.81	2	10438543 (2)
proline	12.96	7	16636290 (5), 16474900 (1), 18678675 (1)
matrigel	11.60	1	15242766 (1)
phorbol	10.49	1	14676275 (1)
fibrinogen	8.73	9	10865942 (5), 9459347 (2)
oxygen	2.89	8	17562703 (6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CTTN)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005231

Sigma-Aldrich siRNA for CTTN

Sigma-Aldrich shRNA Panels and shRNA for CTTN

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005231 NM_138565

REFSEQ mRNAs for CTTN gene (2 alternative transcripts):

NM_005231.3 NM_138565.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005231 NM_138565

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005231
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005231
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005231

Additional cDNA sequence:

AK091778.1 AK222613.1 AK291097.1 AK304582.1 BC008799.2 BC033889.1 CR600359.1 M98343.1

24/32 DOTS entries (see all 32 ):

DT.91882382 DT.447076 DT.100818545 DT.100818541 DT.91771079 DT.95183963 DT.91899683 DT.91976081

DT.92070660 DT.100030904 DT.100754041 DT.92415497 DT.99960412 DT.120746422 DT.91771082 DT.101971696

DT.120746195 DT.120746431 DT.75105205 DT.91743354 DT.91993609 DT.87018110 DT.91866291 DT.92025209

24/220 AceView cDNA sequences (see all 220 ):

AA576139 BU541128 AA789012 AI127977 CB109016 NM_138565 AI096916 AI302758

AA322557 AI146717 CR600359 BI062728 AW001339 BF061580 BQ961429 BM459048

CA389487 BQ070136 AA430469 BQ896402 CD107269 BQ647254 BQ941445 AA845427

highest scoring ESTs for CTTN:

M98343 AA028199 AA115513 AA325227 AA366981 AA386174 AA565044 AA576139 AA578525 AA613424

Unigene Cluster for CTTN:

Cortactin

Hs.596164 [show with all ESTs]

Unigene Representative Sequence: NM_005231

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CTTN (see all 8 )

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	^	15	^	16a	·	16b	^	17a	·	17b	^	18a	·	18b	·
SP1:									-												-				-		-																-		-						-
SP2:									-												-						-																-		-
SP3:									-												-				-		-																-		-
SP4:																																											-		-
SP5:																																											-

ExUns:	18c	·	18d	^	19	^	20
SP1:	-		-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CTTN

4 Ensembl transcripts including schematic representations:

ENST00000376561 ENST00000301843 ENST00000346329 ENST00000393747

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CTTN expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CTTN

¹ / ² / ³

7 probe-sets matching CTTN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39861_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M98343	1.00	1.00	1.00	1
201059_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005231	0.60	1.00	0.82	1
214782_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU155105	0.20	1.00	0.72	1
214074_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BG475299	0.20	1.00	0.72	1
201059_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214782_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214074_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTCAATTTCA

SOURCE GeneReport for Unigene cluster: Hs.596164
Expression variation in blood from EXPOLDB for CTTN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CTTN gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CTTN¹	--	cortactin	87.03(n) 92.81(a)	610283 XM_846224.1 XP_851317.1
chimpanzee (Pan troglodytes)	CTTN¹	--	cortactin	80.53(n) 78.81(a)	451391 XM_508613.2 XP_508613.2
cow (Bos taurus)	CTTN¹	--	cortactin	84.9(n) 90.42(a)	506939 NM_001075287.1 NP_001068755.1
rat (Rattus norvegicus)	Cttn¹	--	cortactin	85.85(n) 91.94(a)	60465 NM_021868.2 NP_068640.2
mouse (Mus musculus)	Cttn^{1, 5}	7⁵	cortactin^{1, 5}	84.74(n)¹ 91.94(a)¹	13043¹ NM_007803.3¹ NP_031829.2¹ AI256617⁵ AI464324⁵ (see all 44)

About this table Species with no ortholog for CTTN

ENSEMBL Gene Tree for CTTN

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CTTN gene

DBN1² HCLS1² DBNL²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/205 NCBI SNPs in CTTN are shown (see all 205 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 84)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6894^1,2	A,C,F,H,O	69960277(-)	`ACCTAG/TGAGGT`	2	--	ut3¹ ese³		12		MN EA NA EU WA	2662
	rs3740719^1,2	C,F,H	69960760(-)	`GAGCCG/AGAACC`	2	--	ng3¹		6		EA EU WA	2082
	rs12576561^1,2	C,F,H	69921951(+)	`ACGGCT/CGAGGG`	2	--	ng5¹		5		EU EA WA	590
--	rs11825736^1,2	A,C	69922304(+)	`CCTGGC/TGCCTG`	2	--	ut5¹ ese³		0	--	--	--	--
	rs2275986^1,2	H	69929106(+)	`CAAGCG/TGAAAG`	2	--	ut5¹ ese³ trp³		4		EU EA WA	418
	rs12280329^1,2	H	69959387(+)	`GAGGAG/AAGGAC`	2	--	ut3¹ ese³ trp³		4		EU EA WA	414
--	rs12283131^1,2	A	69921289(+)	`GGGCGA/Ggggtc`	2	--	ng5¹		0	--	--	--	--
	rs643301^1,2	C,F,H,O	69957414(-)	`TCATCG/ATAGGT`	2	Y/Y	syn¹		10		MN EU EA WA NA	2284
	rs2298397^1,2	C,F,H	69931123(+)	`GAGACC/TGACCC`	2	T/T	syn¹		11		EA MN NA EU WA	2498
--	rs676889^1,2	A,C,F,H,O	69955899(-)	`GCAGCG/ACAGCC`	2	--	int¹		3		EA WA	294

About this table

HapMap Linkage Disequilibrium images for CTTN (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164765

10/23 Novoseek disease relationships for CTTN gene (see all 23 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hnscc	67.58	40	16912177 (6), 17909038 (3), 18931703 (3), 17483334 (3) (see all 9)
carcinoma squamous cell	58.61	33	10955801 (3), 19125793 (2), 18607838 (2), 17909038 (2) (see all 19)
wiskott-aldrich syndrome	53.66	3	12517700 (1), 15585574 (1), 15579908 (1)
laryngeal carcinoma	41.38	3	18268491 (3)
carcinoma	39.61	39	16280034 (3), 16912177 (3), 9054437 (3), 18776588 (2) (see all 18)
metastasis	37.71	48	15464244 (5), 17178864 (4), 16636290 (3), 16912177 (3) (see all 20)
tumors	35.79	106	19125793 (4), 16912177 (4), 18607838 (4), 18931703 (3) (see all 39)
breast cancer	33.55	41	9747885 (6), 16636290 (3), 9380415 (3), 8945620 (3) (see all 17)
mammary tumor	31.40	5	16536875 (1), 9309140 (1), 18334127 (1), 9533029 (1)
cancer	30.79	29	16261345 (3), 18403644 (3), 18406052 (2), 11064458 (2) (see all 15)

About this table

Human Genome Epidemiology Navigator: CTTN (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/322 PubMed articles for CTTN gene (see all 322 ):

Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. (PubMed id 15574754)^{1, 3, 4} Nanda A.... St Croix B. (2004)
The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell- substratum contact sites. (PubMed id 8474448)^{1, 3, 4} Schuuring E.M.D.... Michalides R.J.A. (1993)
Amplified region of chromosome band 11q13 in breast and squamous cell carcinomas encompasses three CpG islands telomeric of FGF3, including the expressed gene EMS1. (PubMed id 7685625)^{1, 2, 3} Brookes S....Peters G. (1993)
Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. (PubMed id 1532244)^{1, 3, 4} Schuuring E.M.D.... Michalides R.J.A. (1992)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC). (PubMed id 16212419)^{3, 4} Amanchy R.... Pandey A. (2005)
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)^{3, 4} Zhang Y.... White F.M. (2005)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2017	HGNC: 3338	AceView: CTTN	Ensembl:ENSG00000085733	euGenes: HUgn2017
ECgene: CTTN	H-InvDB: CTTN

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CTTN	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Cortactin

Licensable Technologies for CTTN
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CTTN:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CTTN-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CTTN		Antibodies for CTTN
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CTTN		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (CTTN)
	Antibodies (CTTN)
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Antibodies & Assays for CTTN (Cortactin)

	Recombinant Proteins (Cortactin)
	Antibodies (Cortactin)

Search OriGene for CTTN

Search Tocris compounds for CTTN

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Antibodies for CTTN

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CTTN Gene at Home site.
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CTTN Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for CTTN

Summaries
for CTTN

Genomic Location
for CTTN

Proteins
for CTTN

Protein Domains/
Families
for CTTN

Gene Function
for CTTN

Pathways & Interactions
for CTTN

Drugs & Compounds
for CTTN

Transcripts
for CTTN

Expression
for CTTN

Orthologs
for CTTN

Paralogs
for CTTN

SNPs/Variants
for CTTN

Disorders & Mutations
for CTTN

Medical News
for CTTN

Publications
for CTTN

Search for CTTN

Genome Databases showing CTTN

Other Databases showing CTTN

Specialized Databases showing CTTN

Licensable Technologies
for CTTN

Services
for CTTN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CTTN Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor CTTN

Summariesfor CTTN

Genomic Locationfor CTTN

Proteinsfor CTTN

Protein Domains/Familiesfor CTTN

Gene Functionfor CTTN

Pathways & Interactionsfor CTTN

Drugs & Compoundsfor CTTN

Transcriptsfor CTTN

Expression for CTTN

Orthologsfor CTTN

Paralogsfor CTTN

SNPs/Variantsfor CTTN

Disorders & Mutationsfor CTTN

Medical Newsfor CTTN

Publicationsfor CTTN

Search for CTTN

Genome Databases showing CTTN

Other Databases showing CTTN

Specialized Databases showing CTTN

Licensable Technologiesfor CTTN

Servicesfor CTTN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CTTN

Summaries
for CTTN

Genomic Location
for CTTN

Proteins
for CTTN

Protein Domains/
Families
for CTTN

Gene Function
for CTTN

Pathways & Interactions
for CTTN

Drugs & Compounds
for CTTN

Transcripts
for CTTN

Expression
for CTTN

Orthologs
for CTTN

Paralogs
for CTTN

SNPs/Variants
for CTTN

Disorders & Mutations
for CTTN

Medical News
for CTTN

Publications
for CTTN

Licensable Technologies
for CTTN

Services
for CTTN