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EMR3 Gene

protein-coding   GIFtS: 56
GCID: GC19M014730

Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 31 2
EGF-Like Module Receptor 32 3
EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 32
Egf-Like Module-Containing Mucin-Like Receptor 32

External Ids:    HGNC: 236471   Entrez Gene: 846582   Ensembl: ENSG000001313557   OMIM: 6061015   UniProtKB: Q9BY153   

Export aliases for EMR3 gene to outside databases

Previous GC identifers: GC19M015099 GC19M014575 GC19M014591 GC19M014570 GC19M014298


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EMR3 Gene:
This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly
by cells of the immune system. Family members are characterized by an extended extracellular region with a
variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like
spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone
receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and
inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms.
(provided by RefSeq, Jan 2014)

GeneCards Summary for EMR3 Gene:
EMR3 (egf-like module containing, mucin-like, hormone receptor-like 3) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and calcium ion binding. An important paralog of this gene is GPR97.

UniProtKB/Swiss-Prot: EMR3_HUMAN, Q9BY15
Function: Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand
for the soluble form of this receptor is present at the surface of momocytes-derived macrophages and activated
neutrophils

Gene Wiki entry for EMR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for EMR3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEMR3 promoter sequence
   Search Chromatin IP Primers for EMR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EMR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

EMR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EMR3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M014730:  view genomic region     (about GC identifiers)

Start:
14,729,929 bp from pter      End:
14,800,839 bp from pter
Size:
70,911 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EMR3_HUMAN, Q9BY15 (See protein sequence)
Recommended Name: EGF-like module-containing mucin-like hormone receptor-like 3 precursor  
Size: 652 amino acids; 72621 Da
Subunit: Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to
a seven-transmembrane moiety (beta subunit) (By similarity)
Alternative splicing: 3 isoforms:  Q9BY15-1   Q9BY15-2   Q9BY15-3   (Soluble form)

Explore the universe of human proteins at neXtProt for EMR3: NX_Q9BY15

Explore proteomics data for EMR3 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit (By
    similarity)1
  • Glycosylation2 at Asn34, Asn39, Asn145, Asn189, Asn202, Asn250, Asn279, Asn327, Asn334

  • See EMR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001276087.1  NP_001276088.1  NP_115960.2  

    ENSEMBL proteins: 
     ENSP00000396208   ENSP00000471853   ENSP00000253673   ENSP00000469965   ENSP00000340758  
    Reactome Protein details: Q9BY15

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRBO: GPCR / Class B : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: EMR3
    Adhesion Class GPCRs

    Selected InterPro protein domains (see all 11):
     IPR017983 GPCR_2_secretin-like_CS
     IPR001881 EGF-like_Ca-bd_dom
     IPR000742 EG-like_dom
     IPR009030 Growth_fac_rcpt_N_dom
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry Q9BY15

    ProtoNet protein and cluster: Q9BY15

    3 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)


    UniProtKB/Swiss-Prot: EMR3_HUMAN, Q9BY15
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 GPS domain


    Find genes that share domains with EMR3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EMR3_HUMAN, Q9BY15
    Function: Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand
    for the soluble form of this receptor is present at the surface of momocytes-derived macrophages and activated
    neutrophils

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with EMR3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for EMR3:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    hsa-mir-335-5p (MIRT018551)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EMR3_HUMAN, Q9BY15: EGF-like module-containing mucin-like hormone receptor-like 3: Cell membrane; Multi-pass
    membrane protein
    EMR3_HUMAN, Q9BY15: EGF-like module-containing mucin-like hormone receptor-like 3 subunit beta: Cell membrane;
    Multi-pass membrane protein
    EMR3_HUMAN, Q9BY15: EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha: Secreted,
    extracellular space. Note=A soluble form is also detected (alpha subunit)
    EMR3_HUMAN, Q9BY15: Isoform 3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005639integral component of nuclear inner membrane ----
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with EMR3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EMR3 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    2Peptide ligand-binding receptors
    GPCR ligand binding0.71
    3ADP signalling through P2Y purinoceptor 12
    Class B/2 (Secretin family receptors)0.36
    4GPCRs, Other
    GPCRs, Other


    Find genes that share SuperPaths with EMR3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for EMR3
        GPCRs, Other


    1 Reactome Pathway for EMR3
        Class B/2 (Secretin family receptors)


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    Interactions:

        Search GeneGlobe Interaction Network for EMR3

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS15203201
    GO:0007218neuropeptide signaling pathway IEA--

    Find genes that share ontologies with EMR3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for EMR3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EMR3 gene (4 alternative transcripts): 
    NM_001289158.1  NM_001289159.1  NM_032571.4  NM_152939.1  

    Unigene Cluster for EMR3:

    Egf-like module containing, mucin-like, hormone receptor-like 3
    Hs.658712  [show with all ESTs]
    Unigene Representative Sequence: AL832663
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000443157 ENST00000599900 ENST00000253673(uc002mzi.4) ENST00000595472
    ENST00000344373(uc010dzp.3 uc010xnv.2)
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    Additional mRNA sequence: 

    AF239764.1 AK290909.1 AK298653.1 AL832663.1 AY358817.1 BC121130.2 BC121131.2 BC128053.1 
    BC142639.1 BC148282.2 

    3 DOTS entries:

    DT.91680000  DT.100000987  DT.100012190 

    12 AceView cDNA sequences:

    AF239764 NM_032571 NM_152939 AY358817 AW450761 BU663241 AL832663 CD368657 
    BX281782 BF900467 H70762 H70763 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EMR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCTCTTTG
    EMR3 Expression
    About this image


    EMR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    EMR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EMR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658712

    UniProtKB/Swiss-Prot: EMR3_HUMAN, Q9BY15
    Tissue specificity: Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils,
    monocytes and macrophages

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EMR3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    37(a)
    1 → many
    4(106658909-106701296)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-29n3.16
    si:ch73-341p18.56
    (see all 9)
    si:ch73-341p18.5
    (see all 9)
    38(a)
    38(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    3(52783533-52804868) ENSDARG00000056062
    1(56242923-56247139) ENSDARG00000095494
            Species with no ortholog for EMR3

    ENSEMBL Gene Tree for EMR3 (if available)
    TreeFam Gene Tree for EMR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EMR3 gene
    GPR972  CD972  ELTD12  LPHN22  LPHN12  GPR1142  EMR12  LPHN32  
    EMR22  GPR1332  GPR1122  GPR1442  GPR562  GPR1262  GPR642  
    9 SIMAP similar genes for EMR3 using alignment to 8 protein entries:     EMR3_HUMAN (see all proteins):
    FLJ00015    FLJ00046    EMR4P    EMR2    ELTD1    EMR1
    LPHN3    BAI3    LPHN2

    Find genes that share paralogs with EMR3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for EMR3
    PGOHUM00000259297


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EMR3 (see all 1404)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1511709381,2
    --14729583(+) GAATCA/GCTTGA 1 -- ds50010--------
    rs1927711851,2
    --14729592(+) GAACCC/TGGGAG 1 -- ds50010--------
    rs558236011,2
    C,F--14729614(+) ACTCAC/TGCCGT 1 -- ds50015Minor allele frequency- T:0.07NA WA CSA 243
    rs24821,2
    C,F,A,H--14730109(+) AACAGC/TTTGGG 1 -- ut31 ese323Minor allele frequency- T:0.09NA NS EA WA CSA 2128
    rs116665841,2
    H--14730187(+) TTCTTC/GATAAT 1 -- ut314Minor allele frequency- G:0.00NS EA 416
    rs2020178951,2
    C--14730312(+) GGTGGA/TTGTAA 1 -- int10--------
    rs1401541471,2
    C--14730544(+) TTTCAG/TCCCCC 1 -- int10--------
    rs1838417441,2
    --14730547(+) CAGCCC/TCCTGG 1 -- int10--------
    rs1503013691,2
    C--14730563(+) TTTTTA/GTCTAT 1 -- int10--------
    rs1378690861,2
    C--14730574(+) GAAGAA/TAGGTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for EMR3 (14729929 - 14800839 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EMR3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718218CNV Deletion23290073
    esv2534308CNV Deletion19546169
    nsv820830CNV Deletion20802225
    esv1027269CNV Deletion17803354
    esv995429CNV Deletion20482838
    esv1975584CNV Deletion18987734
    esv2718219CNV Deletion23290073
    nsv512565CNV Loss21212237
    esv995771CNV Loss20482838
    esv5910CNV Loss19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606101    OMIM disorders: --


    Find genes that share disorders with EMR3           About GenesLikeMe

    Genetic Association Database (GAD): EMR3
    Human Genome Epidemiology (HuGE) Navigator: EMR3 (1 document)

    Export disorders for EMR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EMR3 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with EMR3)
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    1. Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. (PubMed id 11279179)1, 2, 3, 9 Stacey M.... McKnight A.J. (J. Biol. Chem. 2001)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    4. Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. (PubMed id 20625511)1 Plager D.A....Kita H. (PLoS ONE 2010)
    5. EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target. (PubMed id 20827226)1 Kane A.J....Parsa A.T. (Neuroreport 2010)
    6. The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. (PubMed id 17108056)1 Matmati M....Hamann J. (J. Leukoc. Biol. 2007)
    7. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    9. The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PubMed id 15203201)1 Bjarnadottir T.K.... Schioeth H.B. (Genomics 2004)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84658 HGNC: 23647 AceView: EMR3 Ensembl:ENSG00000131355 euGenes: HUgn84658
    ECgene: EMR3 H-InvDB: EMR3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EMR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EMR3 gene:
    Search GeneIP for patents involving EMR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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