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EMR2 Gene

protein-coding   GIFtS: 59
GCID: GC19M014844

Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like...

(Previous names: egf-like module containing, mucin-like, hormone receptor-like...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 21 2
Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like Sequence 21
CD3122
EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 22
CD312 Antigen3
EGF-Like Module Receptor 23

External Ids:    HGNC: 33371   Entrez Gene: 308172   Ensembl: ENSG000001275077   OMIM: 6061005   UniProtKB: Q9UHX33   

Export aliases for EMR2 gene to outside databases

Previous GC identifers: GC19M015215 GC19M014688 GC19M014704 GC19M014409


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EMR2 Gene:
This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors.
These proteins are characterized by an extended extracellular region with a variable number of N-terminal
epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein
is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin
sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced
transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Aug 2012)

GeneCards Summary for EMR2 Gene:
EMR2 (egf-like module containing, mucin-like, hormone receptor-like 2) is a protein-coding gene. Diseases associated with EMR2 include gaucher's disease, and multiple sclerosis. GO annotations related to this gene include chondroitin sulfate binding and calcium ion binding. An important paralog of this gene is GPR97.

UniProtKB/Swiss-Prot: EMR2_HUMAN, Q9UHX3
Function: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and
promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes
the release of inflammatory cytokines, including IL8 and TNF

Gene Wiki entry for EMR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EMR2 gene promoter:
         NRSF form 1   POU3F1   Nkx2-5   NRSF form 2   FOXO3b   FOXO1a   c-Myb   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EMR2 promoter sequence
   Search Chromatin IP Primers for EMR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EMR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

EMR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EMR2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M014844:  view genomic region     (about GC identifiers)

Start:
14,843,205 bp from pter      End:
14,889,353 bp from pter
Size:
46,149 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EMR2_HUMAN, Q9UHX3 (See protein sequence)
Recommended Name: EGF-like module-containing mucin-like hormone receptor-like 2 precursor  
Size: 823 amino acids; 90472 Da
Subunit: Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a
seven-transmembrane moiety. Interacts with chondroitin sulfate; the interaction with chondroitin sulfate is
calcium-dependent. Interacts with CD55
Sequence caution: Sequence=BAC06146.1; Type=Erroneous gene model prediction;
3 PDB 3D structures from and Proteopedia for EMR2:
2BO2 (3D)        2BOU (3D)        2BOX (3D)    
Secondary accessions: B4DQ96 E7ESD7 E9PBR1 E9PEL6 E9PFQ5 E9PG91 Q8NG96 Q9Y4B1
Alternative splicing: 6 isoforms:  Q9UHX3-1   Q9UHX3-2   Q9UHX3-3   Q9UHX3-4   Q9UHX3-5   Q9UHX3-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EMR2: NX_Q9UHX3

Explore proteomics data for EMR2 at MOPED

Post-translational modifications: 

  • Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit1
  • Glycosylation2 at Asn41, Asn111, Asn206, Asn298, Asn347, Asn354, Asn456, Asn460
  • Modification sites at PhosphoSitePlus

  • See EMR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257981.1  NP_038475.2  

    ENSEMBL proteins: 
     ENSP00000319883   ENSP00000472280   ENSP00000376692   ENSP00000470725   ENSP00000472735  
     ENSP00000469277   ENSP00000471297   ENSP00000469605   ENSP00000376689   ENSP00000376694  
     ENSP00000263380   ENSP00000319454   ENSP00000319838   ENSP00000376691  
    Reactome Protein details: Q9UHX3

    EMR2 Human Recombinant Protein Products:

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    EMR2 Assay Products:

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    Cloud-Clone Corp. CLIAs for EMR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRBO: GPCR / Class B : Orphans
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: EMR2
    Adhesion Class GPCRs

    Selected InterPro protein domains (see all 10):
     IPR017983 GPCR_2_secretin-like_CS
     IPR001881 EGF-like_Ca-bd_dom
     IPR000742 EG-like_dom
     IPR009030 Growth_fac_rcpt_N_dom
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry Q9UHX3

    ProtoNet protein and cluster: Q9UHX3

    4 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: EMR2_HUMAN, Q9UHX3
    Domain: The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire
    extracellular stalk
    Domain: Binding to chondroitin sulfate is mediated by the fourth EGF domain
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 5 EGF-like domains
    Similarity: Contains 1 GPS domain


    EMR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EMR2_HUMAN, Q9UHX3
    Function: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and
    promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes
    the release of inflammatory cytokines, including IL8 and TNF

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0035374chondroitin sulfate binding IMP12829604
         
    EMR2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for EMR2:
     Decreased substrate adherent c  Increased cell number in G1, s  Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EMR2
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    hsa-mir-98-5p (MIRT027542), hsa-mir-20a-5p (MIRT050536)

    Block miRNA regulation of human, mouse, rat EMR2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate EMR2:
    hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidEMR2 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for EMR2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EMR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EMR2_HUMAN, Q9UHX3: Cell membrane; Multi-pass membrane protein. Cell projection, ruffle membrane; Multi-pass
    membrane protein. Note=Localized at the leading edge of migrating cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0031256leading edge membrane IDA17928360
    GO:0032587ruffle membrane IEA--

    EMR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EMR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    2Peptide ligand-binding receptors
    GPCR ligand binding0.71
    3ADP signalling through P2Y purinoceptor 12
    Class B/2 (Secretin family receptors)0.36
    4GPCRs, Other
    GPCRs, Other
    5GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for EMR2
        GPCRs, Other
    GPCRs, Class B Secretin-like


    1 Reactome Pathway for EMR2
        Class B/2 (Secretin family receptors)



    EMR2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EMR2
    Interactions:

        GeneGlobe Interaction Network for EMR2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for EMR2 (ENSP000003198834) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD97ENSP000002427864STRING: ENSP00000242786
    HDAC7ENSP000000800594STRING: ENSP00000080059
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0007155cell adhesion IMP12829604
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS15203201
    GO:0007218neuropeptide signaling pathway IEA--

    EMR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EMR2

    1 Novoseek inferred chemical compound relationship for EMR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin sulfate 63.5 8 15498814 (3), 15693006 (1), 12829604 (1)



    EMR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EMR2 gene (8 alternative transcripts): 
    NM_001271052.1  NM_013447.3  NM_152916.1  NM_152917.1  NM_152918.1  NM_152919.1  NM_152920.1  NM_152921.1  

    Unigene Cluster for EMR2:

    Egf-like module containing, mucin-like, hormone receptor-like 2
    Hs.531619  [show with all ESTs]
    Unigene Representative Sequence: NM_013447
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315576(uc010xnw.1 uc002mzp.1) ENST00000360222 ENST00000596991
    ENST00000392965 ENST00000594294 ENST00000594076 ENST00000595839 ENST00000601345
    ENST00000595208 ENST00000392962 ENST00000601619 ENST00000599423 ENST00000598500
    ENST00000392967(uc002mzo.1) ENST00000346057(uc002mzq.1 uc002mzr.1 uc010xnx.1 uc010xny.1)
    ENST00000353876(uc002mzt.1 uc002mzu.1) ENST00000353005(uc010dzs.1 uc002mzs.1)
    ENST00000392964
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate EMR2:
    hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidEMR2 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat EMR2

    Additional mRNA sequence: 

    AF114491.1 AK024426.1 AK024454.1 AK222891.1 AK291776.1 AK298690.1 AK298700.1 AK301458.1 
    BC082991.1 BC127004.1 BC127005.1 CR936819.1 

    13 DOTS entries:

    DT.100825494  DT.302471  DT.121504070  DT.121504100  DT.95237050  DT.95370179  DT.121504098  DT.121504099 
    DT.100029178  DT.92066377  DT.95237038  DT.92325991  DT.95237034 

    Selected AceView cDNA sequences (see all 55):

    CA447031 AI394057 NM_013447 NM_152916 AI624538 NM_152917 NM_152919 NM_152918 
    NM_152921 CB305807 BQ018172 AF114491 AA157797 CN480316 AK024454 AK024426 
    AA031353 BX434166 AA031354 BQ706794 BU507349 BU684391 BX280094 AI273280 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for EMR2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                                      -                                                     -                                                               
    SP2:                                      -                                                                                                           -         
    SP3:                                      -           -                                         -                                                     -         
    SP4:                                                                                            -     -     -                                         -         
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for EMR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EMR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGTAATC
    EMR2 Expression
    About this image


    EMR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    EMR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EMR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531619

    UniProtKB/Swiss-Prot: EMR2_HUMAN, Q9UHX3
    Tissue specificity: Expression is restricted to myeloid cells. Highest expression was found in peripheral blood
    leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal
    liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is
    also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EMR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EMR2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia EMR21 egf-like module containing, mucin-like, hormone receptor-like more 81.44(n)
    71.98(a)
      610750  NM_001038667.1  NP_001033756.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    35(a)
    1 → many
    4(106658909-106701296)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-9c18.66
    si:dkey-9c18.6
    28(a)
    many ↔ many
    1(56103335-56114069) ENSDARG00000096588


    ENSEMBL Gene Tree for EMR2 (if available)
    TreeFam Gene Tree for EMR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EMR2 gene
    GPR972  CD972  ELTD12  LPHN22  LPHN12  GPR1142  EMR12  LPHN32  
    GPR1332  GPR1122  GPR1442  EMR32  GPR562  GPR1262  GPR642  
    16 SIMAP similar genes for EMR2 using alignment to 7 protein entries:     EMR2_HUMAN (see all proteins):
    FLJ00046    FLJ00015    EMR4P    CD97    NELL2    EMR3
    ELTD1    BAI3    FBN1    LDLR    EMR1    FBN2
    CUBN    NOTCH2    SCUBE2    SNED1

    EMR2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for EMR2
    PGOHUM00000234527


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EMR2 (see all 1478)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs680296791,2
    C--14784014(+) CTTTT-/C/CT  
            
    TTTTT
    2 -- int12NA 4
    rs1442794171,2
    --14843016(+) GCAGCC/GCTGTG 2 -- ds50010--------
    rs7572961,2
    C,F,A,H--14843036(+) TCTGTT/AGGTGC 2 -- ds500111Minor allele frequency- A:0.18NA WA CSA EA 376
    rs600026241,2
    C,F--14843092(+) TTTTTC/TAGGAA 2 -- ds50011Minor allele frequency- T:0.50WA 2
    rs7572971,2
    C,F,A,H--14843162(+) ATTACG/AGTATA 2 -- ds500128Minor allele frequency- A:0.17NS EA NA WA CSA 2776
    rs7572981,2
    C,F,O,H--14843292(+) TGTATG/CTGCTC 2 -- ds5001 ese316Minor allele frequency- C:0.20MN NA NS EA WA CSA 1110
    rs788980281,2
    C,F--14843386(+) GGGCAG/ATGAGT 2 -- ds50011Minor allele frequency- A:0.06EA 120
    rs7572991,2
    C,F,H--14843490(+) GTGTCA/CCATGA 2 -- ds5001 ese334Minor allele frequency- C:0.19MN NA NS EA WA CSA 3518
    rs1870437161,2
    --14843502(+) TGATAC/TATGAA 2 -- ds50010--------
    rs1180574431,2
    C,F--14843583(+) TGTTTT/ACATAT 2 -- ut311Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for EMR2 (14843205 - 14889353 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for EMR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656782CNV Deletion23128226
    esv1001961CNV Insertion20482838
    nsv509722CNV Insertion20534489
    nsv458357CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EMR2
    DNA2.0 Custom Variant and Variant Library Synthesis for EMR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606100    OMIM disorders: --

    8 diseases for EMR2:    
    About MalaCards
    gaucher's disease    multiple sclerosis    atherosclerosis    hepatitis b
    esophagitis    hepatitis    adenocarcinoma    pancreatitis


    EMR2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for EMR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 12761622 (4)

    Genetic Association Database (GAD): EMR2
    Human Genome Epidemiology (HuGE) Navigator: EMR2 (1 document)

    Export disorders for EMR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EMR2 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with EMR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. (PubMed id 10903844)1, 2, 9 Lin H.-H.... McKnight A.J. (Genomics 2000)
    2. The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells. (PubMed id 11994511)1, 2, 9 Kwakkenbos M.J.... Hamann J. (J. Leukoc. Biol. 2002)
    3. Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. (PubMed id 17928360)1, 2, 9 Yona S.... Stacey M. (FASEB J. 2008)
    4. The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans. (PubMed id 12829604)1, 2, 9 Stacey M.... Lin H.-H. (Blood 2003)
    5. Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains. (PubMed id 22310662)1, 2 Huang Y.S.... Lin H.H. (Mol. Cell. Biol. 2012)
    6. Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55. (PubMed id 17449467)1, 2 Abbott R.J.... Lea S.M. (J. Biol. Chem. 2007)
    7. Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif. (PubMed id 15150276)1, 2 Lin H.H.... Gordon S. (J. Biol. Chem. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    10. Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif. (PubMed id 12860403)1, 2 Chang G.-W....Lin H.-H. (FEBS Lett. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 30817 HGNC: 3337 AceView: EMR2 Ensembl:ENSG00000127507 euGenes: HUgn30817
    ECgene: EMR2 H-InvDB: EMR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EMR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EMR2 gene:
    Search GeneIP for patents involving EMR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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