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EMR1 Gene

protein-coding   GIFtS: 58
GCID: GC19P006838

Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like...

(Previous names: egf-like module containing, mucin-like, hormone receptor-like...)
(Previous symbol: TM7LN3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 11 2
TM7LN31 2 3
Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like Sequence 11 2
EGF-Like Module Receptor 12 3
EMR1 Hormone Receptor2 3
EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 12

External Ids:    HGNC: 33361   Entrez Gene: 20152   Ensembl: ENSG000001748377   OMIM: 6004935   UniProtKB: Q142463   

Export aliases for EMR1 gene to outside databases

Previous GC identifers: GC19P006982 GC19P006827 GC19P006649


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EMR1 Gene:
This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors
(7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from
the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span,
integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for EMR1 Gene:
EMR1 (egf-like module containing, mucin-like, hormone receptor-like 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and calcium ion binding. An important paralog of this gene is GPR97.

UniProtKB/Swiss-Prot: EMR1_HUMAN, Q14246
Function: Could be involved in cell-cell interactions

Gene Wiki entry for EMR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the EMR1 gene promoter:
         AML1a   RelA   NF-kappaB   AREB6   PPAR-alpha   FOXO1a   NF-kappaB1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEMR1 promoter sequence
   Search Chromatin IP Primers for EMR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EMR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

EMR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EMR1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P006838:  view genomic region     (about GC identifiers)

Start:
6,887,577 bp from pter      End:
6,940,470 bp from pter
Size:
52,894 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EMR1_HUMAN, Q14246 (See protein sequence)
Recommended Name: EGF-like module-containing mucin-like hormone receptor-like 1 precursor  
Size: 886 amino acids; 97683 Da
Sequence caution: Sequence=BAC06133.1; Type=Erroneous gene model prediction;
Secondary accessions: A6NHV2 B7Z486 B7Z489 E7EPX9 E9PD45 H9KV79 Q2I7G5 Q6ZMN0 Q8NGA7
Alternative splicing: 5 isoforms:  Q14246-1   Q14246-2   Q14246-3   Q14246-4   Q14246-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EMR1: NX_Q14246

Explore proteomics data for EMR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn94, Asn99, Asn127, Asn167, Asn189, Asn194, Asn232, Asn258, Asn312, Asn366,
                                 Asn375, Asn448
  • Modification sites at PhosphoSitePlus

  • See EMR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001243181.1  NP_001243182.1  NP_001243183.1  NP_001243184.1  NP_001965.3  

    ENSEMBL proteins: 
     ENSP00000250572   ENSP00000370814   ENSP00000311545   ENSP00000405974   ENSP00000370811  
     ENSP00000472553  
    Reactome Protein details: Q14246

    EMR1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for EMR1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRBO: GPCR / Class B : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: EMR1
    Adhesion Class GPCRs

    Selected InterPro protein domains (see all 12):
     IPR017983 GPCR_2_secretin-like_CS
     IPR001881 EGF-like_Ca-bd_dom
     IPR000742 EG-like_dom
     IPR009030 Growth_fac_rcpt_N_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q14246

    ProtoNet protein and cluster: Q14246

    5 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB001740 EMR1 hormone receptor signature
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: EMR1_HUMAN, Q14246
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 6 EGF-like domains
    Similarity: Contains 1 GPS domain


    Find genes that share domains with EMR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EMR1_HUMAN, Q14246
    Function: Could be involved in cell-cell interactions

         Genatlas biochemistry entry for EMR1:
    mucin-like hormone receptor,egf module containing,160kDa,G protein coupled receptor superfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with EMR1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Emr1):
     hematopoietic system  immune system  no phenotypic analysis 

    Find genes that share phenotypes with EMR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Emr1tm1Stst for EMR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EMR1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EMR1

    miRNA
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    miRTarBase miRNAs that target EMR1:
    hsa-mir-335-5p (MIRT018563)

    Block miRNA regulation of human, mouse, rat EMR1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate EMR1
    SwitchGear 3'UTR luciferase reporter plasmidEMR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EMR1

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EMR1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EMR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EMR1_HUMAN, Q14246: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS7601460
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0071944cell periphery ----

    Find genes that share ontologies with EMR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EMR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    2Peptide ligand-binding receptors
    GPCR ligand binding0.71
    3ADP signalling through P2Y purinoceptor 12
    Class B/2 (Secretin family receptors)0.36
    4GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like


    Find genes that share SuperPaths with EMR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for EMR1
        GPCRs, Class B Secretin-like

    1 Reactome Pathway for EMR1
        Class B/2 (Secretin family receptors)


        Pathway & Disease-focused RT2 Profiler PCR Arrays including EMR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Insulin Resistance in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for EMR1

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS7601460
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS7601460
    GO:0007218neuropeptide signaling pathway IEA--

    Find genes that share ontologies with EMR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EMR1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EMR1 gene (5 alternative transcripts): 
    NM_001256252.1  NM_001256253.1  NM_001256254.1  NM_001256255.1  NM_001974.4  

    Unigene Cluster for EMR1:

    Egf-like module containing, mucin-like, hormone receptor-like 1
    Hs.2375  [show with all ESTs]
    Unigene Representative Sequence: NM_001974
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250572 ENST00000381407 ENST00000312053(uc002mfw.3 uc010dvc.3 uc010xji.2 uc010xjj.2)
    ENST00000450315 ENST00000381404(uc010dvb.3) ENST00000601198 ENST00000596944
    ENST00000595026
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat EMR1

    Additional mRNA sequence: 

    AK057344.1 AK131562.1 AK290401.1 AK291518.1 AK297003.1 AK297011.1 AK313495.1 BC059395.1 
    X81479.1 

    5 DOTS entries:

    DT.409671  DT.100742168  DT.100691222  DT.95282074  DT.100663233 

    24 AceView cDNA sequences:

    NM_001974 BC059395 CD697015 CB992593 BQ707316 BX102513 AK131562 X81479 
    CB961679 CB996889 BX436337 BV183829 BF215611 BV198810 T66981 AW083977 
    BG745562 T66980 AI765726 BI018353 T70730 BG745827 T69746 R08294 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for EMR1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                    -                       -                                                                             -                           
    SP2:                    -                       -                                                           -                 -                           
    SP3:                    -           -           -                                                                                                         
    SP4:                                                                                                                                                      


    ECgene alternative splicing isoforms for EMR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EMR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGTCTGGGG
    EMR1 Expression
    About this image


    EMR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 8 entries
             Primitive Macrophages Liver Bud
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Primitive Macrophages Liver Bud
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)    fully expand to see all 2 entries
             Primitive Macrophages Extraembryonic Blood Islands
     
     Placenta (Extraembryonic Tissues)
             Hofbauer Cells Chorionic Villus
     
     Chorion (Extraembryonic Tissues)
             Hofbauer Cells Chorionic Villus
    EMR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EMR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2375

    UniProtKB/Swiss-Prot: EMR1_HUMAN, Q14246
    Tissue specificity: Wide expression; increased levels in peripheral blood mononuclear cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EMR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Insulin Resistance in human mouse rat

    Primer
    Products:
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EMR1
    QuantiTect SYBR Green Assays in human, mouse, rat EMR1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EMR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EMR1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Emr11 , 5 EGF-like module containing, mucin-like, hormone receptor-like more1, 5 71.89(n)1
    65.32(a)1
      17 (29.80 cM)5
    137331  NM_010130.41  NP_034260.11 
     573586865 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.183112 Xenopus laevis transcribed sequence with weak similarity more 77.72(n)    BX854068.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-268p17.16
    si:ch73-268p17.1
    28(a)
    many ↔ many
    1(56202294-56208193) ENSDARG00000079050


    ENSEMBL Gene Tree for EMR1 (if available)
    TreeFam Gene Tree for EMR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EMR1 gene
    GPR972  CD972  ELTD12  LPHN22  LPHN12  GPR1142  LPHN32  EMR22  
    GPR1332  GPR1122  GPR1442  EMR32  GPR562  GPR1262  GPR642  
    10 SIMAP similar genes for EMR1 using alignment to 2 protein entries:     EMR1_HUMAN (see all proteins):
    FLJ00046    FLJ00015    EMR4P    EMR3    ELTD1    LTBP3
    CD97    EMR2    FBLN2    PROS1

    Find genes that share paralogs with EMR1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for EMR1
    PGOHUM00000234473


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EMR1 (see all 1649)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461838971,2
    C--6885623(+) ACCTAA/TAGCTC 5 -- us2k10--------
    rs575530641,2
    C,F--6885691(+) TCTCTT/CTGCAG 5 -- us2k13Minor allele frequency- C:0.33WA CSA 121
    rs1996929571,2
    --6885737(+) TTTCT-/TTTC  
            
    TTTCT
    5 -- us2k10--------
    rs2007936021,2
    --6885746(+) TTTCT-/TTCTTTTT 5 -- us2k10--------
    rs104189031,2
    C--6885748(+) tctttC/Tttttt 5 -- us2k1 trp32Minor allele frequency- T:0.33NA CSA 3
    rs1484190491,2
    C--6885791(+) CACCCA/GGGCTG 5 -- us2k10--------
    rs580929631,2
    C,F--6885811(+) GGCACG/AATCTC 5 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs1131801771,2
    C,F--6885896(+) GCATGC/AGCCAC 5 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs1133340051,2
    C,F--6886000(+) GTCTCG/AGCCTC 5 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs1859949631,2
    --6886013(+) AAAGTG/TCTGGG 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for EMR1 (6887577 - 6940470 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EMR1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678266CNV Deletion23128226
    dgv14e196CNV Duplication17116639
    esv1597449CNV Insertion17803354
    nsv510752CNV Loss20534489
    nsv833729CNV Loss17160897
    dgv3706n71CNV Gain21882294
    dgv393n27CNV Gain19166990
    nsv910943CNV Gain21882294
    esv2751809CNV Gain17911159
    dgv136e55CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for EMR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600493    OMIM disorders: --


    Find genes that share disorders with EMR1           About GenesLikeMe

    Genetic Association Database (GAD): EMR1
    Human Genome Epidemiology (HuGE) Navigator: EMR1 (1 document)

    Export disorders for EMR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EMR1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with EMR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments. (PubMed id 7601460)1, 2, 3, 9 Baud V.... Lipinski M. (Genomics 1995)
    2. The EGF-TM7 family: unusual structures at the leukocyte surface. (PubMed id 9500513)1, 3, 9 McKnight A.J. and Gordon S. (J. Leukoc. Biol. 1998)
    3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. EMR1, the human homolog of F4/80, is an eosinophil-specific receptor. (PubMed id 17823986)1, 9 Hamann J....Kwakkenbos M.J. (Eur. J. Immunol. 2007)
    6. Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. (PubMed id 10903844)1, 9 Lin H.-H.... McKnight A.J. (Genomics 2000)
    7. Exploring the genetic basis of chronic periodontitis: a genome-wide association study. (PubMed id 23459936)1 Divaris K....Offenbacher S. (Hum. Mol. Genet. 2013)
    8. Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. (PubMed id 20625511)1 Plager D.A....Kita H. (PLoS ONE 2010)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2015 HGNC: 3336 AceView: EMR1 Ensembl:ENSG00000174837 euGenes: HUgn2015
    ECgene: EMR1 H-InvDB: EMR1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EMR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EMR1 gene:
    Search GeneIP for patents involving EMR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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