Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EMP3 Gene

Aliases for EMP3 Gene

  • Epithelial Membrane Protein 3 2 3 5
  • Hematopoietic Neural Membrane Protein 1 3 4
  • HNMP-1 3 4
  • EMP-3 3 4
  • YMP 3 4
  • Protein YMP 4

External Ids for EMP3 Gene

Previous GeneCards Identifiers for EMP3 Gene

  • GC19P049473
  • GC19P049196
  • GC19P053504
  • GC19P053520
  • GC19P048829
  • GC19P045209

Summaries for EMP3 Gene

Entrez Gene Summary for EMP3 Gene

  • The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for EMP3 Gene

EMP3 (Epithelial Membrane Protein 3) is a Protein Coding gene. An important paralog of this gene is PMP22.

UniProtKB/Swiss-Prot for EMP3 Gene

  • Probably involved in cell proliferation and cell-cell interactions.

Gene Wiki entry for EMP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMP3 Gene

Genomics for EMP3 Gene

Regulatory Elements for EMP3 Gene

Enhancers for EMP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G048253 1.8 FANTOM5 ENCODE dbSUPER 14.3 -64.1 -64058 7.1 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 TBX21 MEF2D ZNF610 CARD8-AS1 ENSG00000268746 PLA2G4C EMP3 SNORD23 CARD8 RPL18 TMEM143 SYNGR4 KDELR1
GH19G048247 1.6 Ensembl ENCODE dbSUPER 12.3 -71.5 -71519 4.1 HDGF PKNOX1 ARNT SIN3A ZNF2 ZBTB7B YY1 ZNF766 ZNF143 ZNF207 CARD8-AS1 BICRA GRWD1 EMP3 EHD2 RASIP1 ENSG00000268746 PLA2G4C GC19M048250 PIR59935
GH19G048328 1.7 FANTOM5 ENCODE dbSUPER 11.3 +10.2 10157 5.8 CREB3L1 AGO1 FEZF1 YBX1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TMEM143 BICRA GRWD1 CA11 C19orf68 SYNGR4 NOP53-AS1 EMP3 RASIP1 SLC8A2
GH19G048880 1.5 Ensembl ENCODE dbSUPER 12.1 +560.0 560017 1.8 ATF1 CREB3L1 ETS1 ZNF121 ZNF766 ELK1 ZNF143 KLF13 CAVIN1 ZNF592 RRAS TULP2 PRR12 EMP3 NUCB1 FLT3LG TEAD2 ENSG00000268157 IRF3 GC19M048876
GH19G048319 1.4 ENCODE dbSUPER 10.3 +2.4 2433 8.2 CREB3L1 AGO1 YBX1 FEZF1 YY1 ZNF143 ZNF263 SP3 MEF2D ZNF610 SNORD23 TMEM143 CCDC114 RPL18 KDELR1 EMP3 ENSG00000268746 CARD8-AS1 GRIN2D
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EMP3 on UCSC Golden Path with GeneCards custom track

Promoters for EMP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110688 191 1001 HDGF PKNOX1 CREB3L1 ARNT AGO1 SIN3A FEZF1 YY1 ZNF766 ZNF143

Genomic Location for EMP3 Gene

48,321,509 bp from pter
48,330,555 bp from pter
9,047 bases
Plus strand

Genomic View for EMP3 Gene

Genes around EMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMP3 Gene

Proteins for EMP3 Gene

  • Protein details for EMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Epithelial membrane protein 3
    Protein Accession:
    Secondary Accessions:
    • Q6FH01

    Protein attributes for EMP3 Gene

    163 amino acids
    Molecular mass:
    18429 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EMP3 Gene

Post-translational modifications for EMP3 Gene

  • Glycosylation at Asn47 and Asn56
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EMP3 Gene

Domains & Families for EMP3 Gene

Suggested Antigen Peptide Sequences for EMP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PMP-22/EMP/MP20 family.
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with EMP3: view

No data available for Gene Families for EMP3 Gene

Function for EMP3 Gene

Molecular function for EMP3 Gene

GENATLAS Biochemistry:
epithelial membrane protein 3
UniProtKB/Swiss-Prot Function:
Probably involved in cell proliferation and cell-cell interactions.

Gene Ontology (GO) - Molecular Function for EMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12107182
genes like me logo Genes that share ontologies with EMP3: view
genes like me logo Genes that share phenotypes with EMP3: view

Animal Models for EMP3 Gene

MGI Knock Outs for EMP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for EMP3

miRNA for EMP3 Gene

miRTarBase miRNAs that target EMP3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EMP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EMP3 Gene

Localization for EMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMP3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EMP3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for EMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 12107182
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EMP3: view

Pathways & Interactions for EMP3 Gene

No Data Available

Interacting Proteins for EMP3 Gene

Gene Ontology (GO) - Biological Process for EMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008219 cell death IDA 12107182
GO:0008285 negative regulation of cell proliferation TAS 8996089
GO:0016049 cell growth IEA --
GO:0032060 bleb assembly IDA 12107182
genes like me logo Genes that share ontologies with EMP3: view

No data available for Pathways by source and SIGNOR curated interactions for EMP3 Gene

Drugs & Compounds for EMP3 Gene

No Compound Related Data Available

Transcripts for EMP3 Gene

Unigene Clusters for EMP3 Gene

Epithelial membrane protein 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EMP3

Alternative Splicing Database (ASD) splice patterns (SP) for EMP3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - -
SP6: -
SP7: - - - - - -

Relevant External Links for EMP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EMP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EMP3 Gene

This gene is overexpressed in Whole Blood (x9.7).

Protein differential expression in normal tissues from HIPED for EMP3 Gene

This gene is overexpressed in Colon (11.1) and Esophagus (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EMP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of EMP3 Gene:


SOURCE GeneReport for Unigene cluster for EMP3 Gene:


Evidence on tissue expression from TISSUES for EMP3 Gene

  • Lung(4.4)
  • Spleen(4.3)
  • Nervous system(2.5)
  • Skin(2.4)
  • Bone marrow(2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with EMP3: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EMP3 Gene

Orthologs for EMP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EMP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EMP3 34 35
  • 99.59 (n)
(Canis familiaris)
Mammalia EMP3 34 35
  • 92.59 (n)
(Bos Taurus)
Mammalia EMP3 34 35
  • 89.81 (n)
(Mus musculus)
Mammalia Emp3 34 16 35
  • 86.81 (n)
(Rattus norvegicus)
Mammalia Emp3 34
  • 86.81 (n)
(Anolis carolinensis)
Reptilia EMP3 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia emp3 34
  • 64.58 (n)
Str.8279 34
African clawed frog
(Xenopus laevis)
Amphibia emp3-prov 34
(Danio rerio)
Actinopterygii zgc:114127 34
  • 61.11 (n)
EMP3 (2 of 2) 35
  • 52 (a)
EMP3 (1 of 2) 35
  • 51 (a)
Species where no ortholog for EMP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EMP3 Gene

Gene Tree for EMP3 (if available)
Gene Tree for EMP3 (if available)

Paralogs for EMP3 Gene

Paralogs for EMP3 Gene

(3) SIMAP similar genes for EMP3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with EMP3: view

Variants for EMP3 Gene

Sequence variations from dbSNP and Humsavar for EMP3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000049741 -- 48,325,625(+) CAGTC(C/T)GTTAT intron-variant, upstream-variant-2KB
rs1000103620 -- 48,330,695(+) CTCCC(A/G/T)AGGAC downstream-variant-500B
rs1000622336 -- 48,330,970(+) GGACT(C/G)TTTTT downstream-variant-500B
rs1000910810 -- 48,325,120(+) AAACT(A/C)AAGGG upstream-variant-2KB
rs1001354085 -- 48,330,181(+) ACCAC(A/G)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EMP3 Gene

Variant ID Type Subtype PubMed ID
esv34181 CNV loss 18971310
nsv469623 CNV loss 16826518
nsv833854 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for EMP3 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EMP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EMP3 Gene

Disorders for EMP3 Gene

Relevant External Links for EMP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EMP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EMP3 Gene

Publications for EMP3 Gene

  1. Analysis of candidate genes for prostate cancer. (PMID: 15583422) Burmester J.K. … Catalona W.J. (Hum. Hered. 2004) 3 22 46 64
  2. HNMP-1: a novel hematopoietic and neural membrane protein differentially regulated in neural development and injury. (PMID: 9204931) Bolin L.M. … McClanahan T.K. (J. Neurosci. 1997) 3 4 22 64
  3. Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family. (PMID: 8917086) Taylor V. … Suter U. (Gene 1996) 3 4 22 64
  4. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. (PMID: 8996089) Ben-Porath I. … Benvenisty N. (Gene 1996) 2 3 4 64
  5. EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma. (PMID: 18823699) Fumoto S. … Nishiyama M. (Cancer Lett. 2009) 3 22 64

Products for EMP3 Gene

Sources for EMP3 Gene

Loading form....