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Aliases for EMP3 Gene

Aliases for EMP3 Gene

  • Epithelial Membrane Protein 3 2 3
  • Hematopoietic Neural Membrane Protein 1 3 4
  • HNMP-1 3 4
  • EMP-3 3 4
  • YMP 3 4
  • Protein YMP 4

External Ids for EMP3 Gene

Previous GeneCards Identifiers for EMP3 Gene

  • GC19P049473
  • GC19P049196
  • GC19P053504
  • GC19P053520
  • GC19P048829
  • GC19P045209

Summaries for EMP3 Gene

GeneCards Summary for EMP3 Gene

EMP3 (Epithelial Membrane Protein 3) is a Protein Coding gene. An important paralog of this gene is PMP22.

UniProtKB/Swiss-Prot for EMP3 Gene

  • Probably involved in cell proliferation and cell-cell interactions

Gene Wiki entry for EMP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMP3 Gene

Genomics for EMP3 Gene

Regulatory Elements for EMP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EMP3 Gene

Start:
48,321,509 bp from pter
End:
48,330,553 bp from pter
Size:
9,045 bases
Orientation:
Plus strand

Genomic View for EMP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMP3 Gene

Proteins for EMP3 Gene

  • Protein details for EMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54852-EMP3_HUMAN
    Recommended name:
    Epithelial membrane protein 3
    Protein Accession:
    P54852
    Secondary Accessions:
    • Q6FH01

    Protein attributes for EMP3 Gene

    Size:
    163 amino acids
    Molecular mass:
    18429 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EMP3 Gene

Proteomics data for EMP3 Gene at MOPED

Post-translational modifications for EMP3 Gene

  • Glycosylation at Asn47 and Asn56
  • Modification sites at PhosphoSitePlus

Other Protein References for EMP3 Gene

No data available for DME Specific Peptides for EMP3 Gene

Domains for EMP3 Gene

Suggested Antigen Peptide Sequences for EMP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54852

UniProtKB/Swiss-Prot:

EMP3_HUMAN :
  • P54852
Family:
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with EMP3: view

No data available for Gene Families for EMP3 Gene

Function for EMP3 Gene

Molecular function for EMP3 Gene

GENATLAS Biochemistry: epithelial membrane protein 3
UniProtKB/Swiss-Prot Function: Probably involved in cell proliferation and cell-cell interactions

Gene Ontology (GO) - Molecular Function for EMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12107182
genes like me logo Genes that share ontologies with EMP3: view

Phenotypes for EMP3 Gene

MGI mutant phenotypes for EMP3:
inferred from 1 alleles
GenomeRNAi human phenotypes for EMP3:
genes like me logo Genes that share phenotypes with EMP3: view

Animal Models for EMP3 Gene

MGI Knock Outs for EMP3:

Animal Model Products

CRISPR Products

miRNA for EMP3 Gene

miRTarBase miRNAs that target EMP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EMP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EMP3 Gene

Localization for EMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMP3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EMP3 Gene COMPARTMENTS Subcellular localization image for EMP3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for EMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 12107182
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EMP3: view

Pathways for EMP3 Gene

SuperPathways for EMP3 Gene

No Data Available

Interacting Proteins for EMP3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000270221%0d%0a9606.ENSP00000363680%0d%0a9606.ENSP00000442349%0d%0a9606.ENSP00000265372%0d%0a
Selected Interacting proteins: ENSP00000270221 P54852-EMP3_HUMAN for EMP3 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for EMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008219 cell death IDA 12107182
GO:0008285 negative regulation of cell proliferation TAS 8996089
GO:0016049 cell growth IEA --
GO:0032060 bleb assembly IDA 12107182
genes like me logo Genes that share ontologies with EMP3: view

No data available for Pathways by source for EMP3 Gene

Transcripts for EMP3 Gene

Unigene Clusters for EMP3 Gene

Epithelial membrane protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EMP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EMP3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - -
SP6: -
SP7: - - - - - -

Relevant External Links for EMP3 Gene

GeneLoc Exon Structure for
EMP3
ECgene alternative splicing isoforms for
EMP3

Expression for EMP3 Gene

mRNA expression in normal human tissues for EMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EMP3 Gene

This gene is overexpressed in Whole Blood (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EMP3 Gene

SOURCE GeneReport for Unigene cluster for EMP3 Gene Hs.9999

genes like me logo Genes that share expressions with EMP3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for EMP3 Gene

Orthologs for EMP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EMP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EMP3 35
  • 99.59 (n)
  • 99.39 (a)
EMP3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EMP3 35
  • 89.81 (n)
  • 94.44 (a)
EMP3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EMP3 35
  • 92.59 (n)
  • 95.14 (a)
EMP3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Emp3 35
  • 86.81 (n)
  • 91.67 (a)
Emp3 16
Emp3 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Emp3 35
  • 86.81 (n)
  • 92.36 (a)
lizard
(Anolis carolinensis)
Reptilia EMP3 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia emp3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia emp3 35
  • 64.58 (n)
  • 60.42 (a)
Str.8279 35
zebrafish
(Danio rerio)
Actinopterygii EMP3 (1 of 2) 36
  • 51 (a)
OneToMany
EMP3 (2 of 2) 36
  • 52 (a)
OneToMany
zgc:114127 35
  • 61.11 (n)
  • 54.17 (a)
Species with no ortholog for EMP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EMP3 Gene

ENSEMBL:
Gene Tree for EMP3 (if available)
TreeFam:
Gene Tree for EMP3 (if available)

Paralogs for EMP3 Gene

Paralogs for EMP3 Gene

Selected SIMAP similar genes for EMP3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with EMP3: view

Variants for EMP3 Gene

Sequence variations from dbSNP and Humsavar for EMP3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4893 - 48,330,351(+) AGGAG(A/G)TCCTG reference, missense
rs8355 -- 48,330,543(+) AAAAC(C/T)TTAAC utr-variant-3-prime
rs11665 -- 48,330,549(+) TTAAC(C/G)GCGGG utr-variant-3-prime
rs1044391 -- 48,329,458(+) GGTCT(C/T)TTCTA reference, synonymous-codon
rs1044395 -- 48,329,461(+) CTCTT(C/T)TATGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for EMP3 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
esv34181 CNV Loss 18971310
nsv469623 CNV Complex 16826518
nsv833854 CNV Loss 17160897

Relevant External Links for EMP3 Gene

HapMap Linkage Disequilibrium report
EMP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EMP3 Gene

Disorders for EMP3 Gene

(3) Novoseek inferred disease relationships for EMP3 Gene

Disease -log(P) Hits PubMed IDs
glioma 56.2 2
tumors 23.1 4
cancer 6.93 1

Relevant External Links for EMP3

Genetic Association Database (GAD)
EMP3
Human Genome Epidemiology (HuGE) Navigator
EMP3
genes like me logo Genes that share disorders with EMP3: view

No data available for UniProtKB/Swiss-Prot for EMP3 Gene

Publications for EMP3 Gene

  1. Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family. (PMID: 8917086) Taylor V. … Suter U. (Gene 1996) 3 4 23
  2. HNMP-1: a novel hematopoietic and neural membrane protein differentially regulated in neural development and injury. (PMID: 9204931) Bolin L.M. … McClanahan T.K. (J. Neurosci. 1997) 3 4 23
  3. Analysis of candidate genes for prostate cancer. (PMID: 15583422) Burmester J.K. … Catalona W.J. (Hum. Hered. 2004) 3 23 48
  4. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. (PMID: 8996089) Ben-Porath I. … Benvenisty N. (Gene 1996) 2 3 4
  5. Regional localization of the human epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, EMP3) to 12p12.3, 16p13.2, and 19q13.3. (PMID: 10331954) Liehr T. … Rautenstrauss B. (Genomics 1999) 2 3

Products for EMP3 Gene

Sources for EMP3 Gene

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