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EMP3 Gene

protein-coding   GIFtS: 56
GCID: GC19P048829

Epithelial Membrane Protein 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Epithelial Membrane Protein 31 2
Hematopoietic Neural Membrane Protein 12 3
EMP-32 3
HNMP-12 3
YMP2 3
Protein YMP3

External Ids:    HGNC: 33351   Entrez Gene: 20142   Ensembl: ENSG000001422277   OMIM: 6023355   UniProtKB: P548523   

Export aliases for EMP3 gene to outside databases

Previous GC identifers: GC19P049473 GC19P049196 GC19P053504 GC19P053520 GC19P045209


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EMP3 Gene:
EMP3 (epithelial membrane protein 3) is a protein-coding gene. An important paralog of this gene is EMP1.

UniProtKB/Swiss-Prot: EMP3_HUMAN, P54852
Function: Probably involved in cell proliferation and cell-cell interactions

Gene Wiki entry for EMP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the EMP3 gene promoter:
         COUP-TF1   STAT1   Bach2   RelA   HNF-4alpha1   E47   AREB6   RORalpha1   HEN1   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEMP3 promoter sequence
   Search Chromatin IP Primers for EMP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EMP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

EMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EMP3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P048829:  view genomic region     (about GC identifiers)

Start:
48,824,766 bp from pter      End:
48,833,810 bp from pter
Size:
9,045 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EMP3_HUMAN, P54852 (See protein sequence)
Recommended Name: Epithelial membrane protein 3  
Size: 163 amino acids; 18429 Da
Secondary accessions: Q6FH01

Explore the universe of human proteins at neXtProt for EMP3: NX_P54852

Explore proteomics data for EMP3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn47, Asn56

  • See EMP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001416.1  
    ENSEMBL proteins: 
     ENSP00000470331   ENSP00000270221   ENSP00000469341   ENSP00000471964   ENSP00000471592  
     ENSP00000469194   ENSP00000469275  

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    Cloud-Clone Corp. Proteins for EMP3

     
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    antibodies-online proteins for EMP3 (6 products) 

     
    antibodies-online peptides for EMP3

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    antibodies-online antibodies for EMP3 (36 products) 

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    Cloud-Clone Corp. ELISAs for EMP3
    Cloud-Clone Corp. CLIAs for EMP3
    Search eBioscience for ELISAs for EMP3 
    antibodies-online kits for EMP3 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004032 PMP22_EMP_MP20
     IPR003934 EMP_3
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry P54852

    ProtoNet protein and cluster: P54852

    2 Blocks protein domains:
    IPB003934 Epithelial membrane protein EMP-3 signature
    IPB004032 PMP-22/EMP/MP20 family


    UniProtKB/Swiss-Prot: EMP3_HUMAN, P54852
    Similarity: Belongs to the PMP-22/EMP/MP20 family


    Find genes that share domains with EMP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EMP3_HUMAN, P54852
    Function: Probably involved in cell proliferation and cell-cell interactions

         Genatlas biochemistry entry for EMP3:
    epithelial membrane protein 3

    Phenotypes:
         1 GenomeRNAi human phenotype for EMP3:
     Decreased POU5F1-GFP protein e 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Emp3):
     no phenotypic analysis 

    Find genes that share phenotypes with EMP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Emp3tm1378Arte for EMP3

       genOway: Develop your customized and physiologically relevant rodent model for EMP3

    miRNA
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    miRTarBase miRNAs that target EMP3:
    hsa-mir-1 (MIRT023708), hsa-mir-26b-5p (MIRT029355)

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EMP3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EMP3_HUMAN, P54852: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with EMP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EMP3
    Interactions:

        GeneGlobe Interaction Network for EMP3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for EMP3 (P548523 ENSP000002702214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    P2RX7ENSP000002618264STRING: ENSP00000261826
    CREMENSP000002653724STRING: ENSP00000265372
    --A8K2Z03I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008285negative regulation of cell proliferation TAS8996089
    GO:0016049cell growth IEA--

    Find genes that share ontologies with EMP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EMP3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EMP3 gene: 
    NM_001425.2  

    Unigene Cluster for EMP3:

    Epithelial membrane protein 3
    Hs.9999  [show with all ESTs]
    Unigene Representative Sequence: BM556279
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000599704 ENST00000270221(uc002piv.2) ENST00000596315 ENST00000594198
    ENST00000597529 ENST00000599255 ENST00000597279 ENST00000593437 ENST00000597057

    miRNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EMP3
      QuantiTect SYBR Green Assays in human, mouse, rat EMP3
      QuantiFast Probe-based Assays in human, mouse, rat EMP3

    Additional mRNA sequence: 

    BC009718.1 BT007124.1 CR456871.1 CR541955.1 U52101.1 U87947.1 X94771.1 

    9 DOTS entries:

    DT.451078  DT.92426508  DT.92426507  DT.100028244  DT.101984584  DT.95277126  DT.97845352  DT.95277122 
    DT.97845351 

    Selected AceView cDNA sequences (see all 234):

    W84406 AA112439 D31214 BM462769 AW236511 BU162781 CR598652 BQ639506 
    N43963 BG340000 N29247 CR612472 AA356683 CR541955 BU627694 AW575377 
    CA434078 CA307611 AI761720 BM726678 BG122684 BU615578 BM705112 BX110227 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EMP3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b
    SP1:                    -                       -     -                     
    SP2:                    -                             -                     
    SP3:                                            -     -                     
    SP4:                    -     -                 -     -                     
    SP5:                                      -     -     -                     


    ECgene alternative splicing isoforms for EMP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EMP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGACGAGGAG
    EMP3 Expression
    About this image


    EMP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Endochondral Facial Bones
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
     
     Heart (Cardiovascular System)
             Heart Tube
    EMP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EMP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.9999
        Custom PCR Arrays for EMP3
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EMP3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Emp31 , 5 epithelial membrane protein 31, 5 86.81(n)1
    91.67(a)1
      7 (29.60 cM)5
    137321  NM_001146346.11  NP_001139818.11 
     459180235 
    lizard
    (Anolis carolinensis)
    Reptilia EMP36
    epithelial membrane protein 3
    63(a)
    1 ↔ 1
    GL343329.1(180525-194393)
    African clawed frog
    (Xenopus laevis)
    Amphibia emp3-prov2 epithelial membrane protein 3 75.78(n)    BC046703.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1141271 zgc:114127 61.11(n)
    54.17(a)
      560722  NM_001025508.1  NP_001020679.1 


    ENSEMBL Gene Tree for EMP3 (if available)
    TreeFam Gene Tree for EMP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EMP3 gene
    EMP12  EMP22  PMP222  
    3 SIMAP similar genes for EMP3 using alignment to 7 protein entries:     EMP3_HUMAN (see all proteins):
    PMP22    EMP1    EMP2

    Find genes that share paralogs with EMP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EMP3 (see all 192)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81051591,2
    C,F,A,H--45207396(+) tacgcC/Ttgtaa 1 -- us2k113Minor allele frequency- T:0.43NA WA CSA EA 376
    rs359131101,2
    C--45207493(+) CTCTA-/CTAAAAAT
    ACAAAAATTGG
    CTGGG
    1 -- us2k10--------
    rs1881159561,2
    --45207520(+) GGCGTA/GGTGGC 1 -- us2k10--------
    rs129837001,2
    C,F--48826675(+) gaaccG/Aggagg 1 -- us2k13Minor allele frequency- A:0.33NA 6
    rs1809679491,2
    --48826685(+) GTGGAA/GGTTGC 1 -- us2k10--------
    rs2019159571,2
    C--48826749(+) ATCTC-/AAAAAA 1 -- us2k10--------
    rs1393669571,2
    --48826809(+) CACTGC/TACTTA 1 -- us2k10--------
    rs1861690401,2
    --48826834(+) CCCCTC/TCCCTA 1 -- us2k10--------
    rs1496856381,2
    --48826854(+) GGCACA/CCTTTG 1 -- us2k10--------
    rs1995742291,2
    C--48826988(+) CCGAC-/CCCCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EMP3 (48824766 - 48833810 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for EMP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833854CNV Loss17160897
    esv34181CNV Loss18971310
    nsv9739CNV Gain+Loss18304495
    nsv469623CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EMP3
    DNA2.0 Custom Variant and Variant Library Synthesis for EMP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602335    OMIM disorders: --


    Find genes that share disorders with EMP3           About GenesLikeMe

    3 Novoseek inferred disease relationships for EMP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 56.2 2 17187361 (1), 18823699 (1)
    tumors 23.1 4 17187361 (1), 18823699 (1), 15805250 (1), 19466912 (1)
    cancer 6.93 2 19270820 (1)

    Genetic Association Database (GAD): EMP3
    Human Genome Epidemiology (HuGE) Navigator: EMP3 (1 document)

    Export disorders for EMP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EMP3 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with EMP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. (PubMed id 8996089)1, 2, 3 Ben-Porath I. and Benvenisty N. (Gene 1996)
    2. Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family. (PubMed id 8917086)1, 2, 9 Taylor V. and Suter U. (Gene 1996)
    3. Analysis of candidate genes for prostate cancer. (PubMed id 15583422)1, 4, 9 Burmester J.K....Catalona W.J. (Hum. Hered. 2004)
    4. HNMP-1: a novel hematopoietic and neural membrane protein differentially regulated in neural development and injury. (PubMed id 9204931)1, 2, 9 Bolin L.M.... McClanahan T.K. (J. Neurosci. 1997)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Regional localization of the human epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, EMP3) to 12p12.3, 16p13.2, and 19q13.3. (PubMed id 10331954)1, 3 Liehr T....Rautenstrauss B. (Genomics 1999)
    7. EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma. (PubMed id 18823699)1, 9 Fumoto S....Nishiyama M. (Cancer Lett. 2009)
    8. EMP3 overexpression in primary breast carcinomas is not associated with epigenetic aberrations. (PubMed id 19270820)1, 9 Zhou W....Yu J. (J. Korean Med. Sci. 2009)
    9. EMP3 overexpression is associated with oligodendroglial tumors retaining chromosome arms 1p and 19q. (PubMed id 17187361)1, 9 Li K.K....Ng H.K. (Int. J. Cancer 2007)
    10. Epithelial membrane protein 3 is frequently shown as promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. (PubMed id 23920144)1 Xue Q....Mao G. (Exp. Mol. Pathol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2014 HGNC: 3335 AceView: EMP3 Ensembl:ENSG00000142227 euGenes: HUgn2014
    ECgene: EMP3 H-InvDB: EMP3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EMP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EMP3 gene:
    Search GeneIP for patents involving EMP3

    GeneCards and IP:
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