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Aliases for EMP3 Gene

Aliases for EMP3 Gene

  • Epithelial Membrane Protein 3 2 3 5
  • Hematopoietic Neural Membrane Protein 1 3 4
  • HNMP-1 3 4
  • EMP-3 3 4
  • YMP 3 4
  • Protein YMP 4

External Ids for EMP3 Gene

Previous GeneCards Identifiers for EMP3 Gene

  • GC19P049473
  • GC19P049196
  • GC19P053504
  • GC19P053520
  • GC19P048829
  • GC19P045209

Summaries for EMP3 Gene

Entrez Gene Summary for EMP3 Gene

  • The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for EMP3 Gene

EMP3 (Epithelial Membrane Protein 3) is a Protein Coding gene. Diseases associated with EMP3 include Phaeochromocytoma and Charcot-Marie-Tooth Disease. An important paralog of this gene is EMP1.

UniProtKB/Swiss-Prot for EMP3 Gene

  • Probably involved in cell proliferation and cell-cell interactions.

Gene Wiki entry for EMP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMP3 Gene

Genomics for EMP3 Gene

Regulatory Elements for EMP3 Gene

Enhancers for EMP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EMP3 on UCSC Golden Path with GeneCards custom track

Promoters for EMP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EMP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for EMP3 Gene

48,321,509 bp from pter
48,330,555 bp from pter
9,047 bases
Plus strand

Genomic View for EMP3 Gene

Genes around EMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMP3 Gene

Proteins for EMP3 Gene

  • Protein details for EMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Epithelial membrane protein 3
    Protein Accession:
    Secondary Accessions:
    • Q6FH01

    Protein attributes for EMP3 Gene

    163 amino acids
    Molecular mass:
    18429 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EMP3 Gene

Proteomics data for EMP3 Gene at MOPED

Post-translational modifications for EMP3 Gene

  • Glycosylation at Asn 47 and Asn 56
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for EMP3 Gene

Domains & Families for EMP3 Gene

Suggested Antigen Peptide Sequences for EMP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PMP-22/EMP/MP20 family.
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with EMP3: view

No data available for Gene Families for EMP3 Gene

Function for EMP3 Gene

Molecular function for EMP3 Gene

GENATLAS Biochemistry:
epithelial membrane protein 3
UniProtKB/Swiss-Prot Function:
Probably involved in cell proliferation and cell-cell interactions.
genes like me logo Genes that share phenotypes with EMP3: view

Animal Models for EMP3 Gene

MGI Knock Outs for EMP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for EMP3

miRNA for EMP3 Gene

miRTarBase miRNAs that target EMP3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EMP3 Gene

Localization for EMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMP3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for EMP3 Gene COMPARTMENTS Subcellular localization image for EMP3 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for EMP3 Gene

Pathways & Interactions for EMP3 Gene

SuperPathways for EMP3 Gene

No Data Available

Interacting Proteins for EMP3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000270221 P54852-EMP3_HUMAN for EMP3 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for EMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS 8996089
genes like me logo Genes that share ontologies with EMP3: view

No data available for Pathways by source and SIGNOR curated interactions for EMP3 Gene

Drugs & Compounds for EMP3 Gene

No Compound Related Data Available

Transcripts for EMP3 Gene

Unigene Clusters for EMP3 Gene

Epithelial membrane protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EMP3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - -
SP6: -
SP7: - - - - - -

Relevant External Links for EMP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EMP3 Gene

mRNA expression in normal human tissues for EMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EMP3 Gene

This gene is overexpressed in Whole Blood (x9.7).

Protein differential expression in normal tissues from HIPED for EMP3 Gene

This gene is overexpressed in Colon (11.1) and Esophagus (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EMP3 Gene

SOURCE GeneReport for Unigene cluster for EMP3 Gene Hs.9999

genes like me logo Genes that share expression patterns with EMP3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for EMP3 Gene

Orthologs for EMP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EMP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EMP3 35
  • 89.81 (n)
  • 94.44 (a)
EMP3 36
  • 95 (a)
(Canis familiaris)
Mammalia EMP3 35
  • 92.59 (n)
  • 95.14 (a)
EMP3 36
  • 96 (a)
(Mus musculus)
Mammalia Emp3 35
  • 86.81 (n)
  • 91.67 (a)
Emp3 16
Emp3 36
  • 92 (a)
(Pan troglodytes)
Mammalia EMP3 35
  • 99.59 (n)
  • 99.39 (a)
EMP3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Emp3 35
  • 86.81 (n)
  • 92.36 (a)
(Anolis carolinensis)
Reptilia EMP3 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia emp3 35
  • 64.58 (n)
  • 60.42 (a)
Str.8279 35
African clawed frog
(Xenopus laevis)
Amphibia emp3-prov 35
(Danio rerio)
Actinopterygii zgc:114127 35
  • 61.11 (n)
  • 54.17 (a)
EMP3 (1 of 2) 36
  • 51 (a)
EMP3 (2 of 2) 36
  • 52 (a)
Species with no ortholog for EMP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EMP3 Gene

Gene Tree for EMP3 (if available)
Gene Tree for EMP3 (if available)

Paralogs for EMP3 Gene

Paralogs for EMP3 Gene

(3) SIMAP similar genes for EMP3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with EMP3: view

Variants for EMP3 Gene

Sequence variations from dbSNP and Humsavar for EMP3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs4893 - 48,330,351(+) AGGAG(A/G)TCCTG reference, missense
rs8102349 -- 48,329,297(+) AGGTG(A/G)AGCTG intron-variant
rs62131980 -- 48,325,874(+) GTCCC(C/T)GAGAT intron-variant
rs62131981 -- 48,326,491(+) ATGCC(A/T)AATTT intron-variant
rs62131983 -- 48,330,173(+) GGGAA(A/G)GAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EMP3 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
esv34181 CNV Loss 18971310
nsv469623 CNV Complex 16826518
nsv833854 CNV Loss 17160897

Variation tolerance for EMP3 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for EMP3 Gene

Disorders for EMP3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EMP3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • pheochromocytoma
charcot-marie-tooth disease
  • dejerine-sottas disease
- elite association - COSMIC cancer census association via MalaCards
Search EMP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EMP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with EMP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EMP3 Gene

Publications for EMP3 Gene

  1. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. (PMID: 8996089) Ben-Porath I. … Benvenisty N. (Gene 1996) 2 3 4 67
  2. EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma. (PMID: 18823699) Fumoto S. … Nishiyama M. (Cancer Lett. 2009) 3 23
  3. EMP3 overexpression in primary breast carcinomas is not associated with epigenetic aberrations. (PMID: 19270820) Zhou W. … Yu J. (J. Korean Med. Sci. 2009) 3 23
  4. EMP3 overexpression is associated with oligodendroglial tumors retaining chromosome arms 1p and 19q. (PMID: 17187361) Li K.K. … Ng H.K. (Int. J. Cancer 2007) 3 23
  5. Analysis of candidate genes for prostate cancer. (PMID: 15583422) Burmester J.K. … Catalona W.J. (Hum. Hered. 2004) 3 23

Products for EMP3 Gene

Sources for EMP3 Gene