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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EMP2 Gene

protein-coding   GIFtS: 51
GCID: GC16M010622

Epithelial Membrane Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Epithelial Membrane Protein 21 2
EMP-22 3
XMP2 3
Protein XMP3

External Ids:    HGNC: 33341   Entrez Gene: 20132   Ensembl: ENSG000002138537   OMIM: 6023345   UniProtKB: P548513   

Export aliases for EMP2 gene to outside databases

Previous GC identifers: GC16M010419 GC16M010771 GC16M010588 GC16M010593 GC16M010529 GC16M010541


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for EMP2 Gene: 
EMP2 (epithelial membrane protein 2) is a protein-coding gene. Diseases associated with EMP2 include charcot-marie-tooth disease type 1c, and endometrioid ovary carcinoma. An important paralog of this gene is EMP1.

Gene Wiki entry for EMP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EMP2 gene promoter:
         c-Fos   AP-1   MAZR   JunB   Fra-1   FosB   S8   JunD   FOXJ2 (long isoform)   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEMP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for EMP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EMP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.2   Ensembl cytogenetic band:  16p13.13   HGNC cytogenetic band: 16p13.2

EMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EMP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M010622:  view genomic region     (about GC identifiers)

Start:
10,622,279 bp from pter      End:
10,674,555 bp from pter
Size:
52,277 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EMP2_HUMAN, P54851 (See protein sequence)
Recommended Name: Epithelial membrane protein 2  
Size: 167 amino acids; 19199 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B2R7V6 D3DUF8

Explore the universe of human proteins at neXtProt for EMP2: NX_P54851

Explore proteomics data for EMP2 at MOPED 

EMP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

EMP2 Protein Expression

REFSEQ proteins: NP_001415.1  
ENSEMBL proteins: 
 ENSP00000352540   ENSP00000445712  

Human Recombinant Protein Products for EMP2: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for EMP2
OriGene Protein Over-expression Lysate for EMP2
OriGene MassSpec for EMP2 
OriGene Custom Protein Services for EMP2
GenScript Custom Purified and Recombinant Proteins Services for EMP2
Novus Biologicals EMP2 Protein
Novus Biologicals EMP2 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for EMP2 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--
GO:0016324apical plasma membrane IEA--

EMP2 for ontologies           About GeneDecksing



EMP2 Antibody Products: 
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Novus Biologicals EMP2 Antibodies
Abcam antibodies for EMP2
Cloud-Clone Corp. Antibodies for EMP2 
Search ThermoFisher Antibodies for EMP2
LSBio Antibodies in human, mouse, rat for EMP2 

Assay Products for EMP2: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for EMP2
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for EMP2
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for EMP2 
Cloud-Clone Corp. CLIAs for EMP2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR003933 EMP_2
 IPR004032 PMP22_EMP_MP20
 IPR004031 PMP22/EMP/MP20/Claudin

Graphical View of Domain Structure for InterPro Entry P54851

ProtoNet protein and cluster: P54851

2 Blocks protein domains:
IPB003933 Epithelial membrane protein EMP-2 signature
IPB004032 PMP-22/EMP/MP20 family


UniProtKB/Swiss-Prot: EMP2_HUMAN, P54851
Similarity: Belongs to the PMP-22/EMP/MP20 family


EMP2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for EMP2:
epithelial membrane protein 2

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005178integrin binding IPI16216233
     
EMP2 for ontologies           About GeneDecksing


Phenotypes:
     3 GenomeRNAi human phenotypes for EMP2:
 Increased G1 DNA content  Increased circadian period len  Upregulation of Wnt/beta-caten 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for EMP2 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EMP2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EMP2 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EMP2 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EMP2
8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate EMP2 (see all 47):
hsa-miR-562 hsa-miR-330-5p hsa-miR-300 hsa-miR-29a hsa-let-7a-2* hsa-miR-3653 hsa-miR-10b* hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidEMP2 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for EMP2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EMP2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for EMP2
Sirion Biotech Customized adenovirus for overexpression of EMP2

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for EMP2 (see all 7)
OriGene ORF clones in mouse, rat for EMP2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: EMP2 (NM_001424)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for EMP2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EMP2
Sirion Biotech Customized lentivirus for stable overexpression of EMP2 
                     Customized lentivirus expression plasmids for stable overexpression of EMP2 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for EMP2
Search LifeMap BioReagents cell lines for EMP2
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EMP2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EMP2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for EMP2 (P548513 ENSP000003525404) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
EPM2AIP1Q7L7753, ENSP000004060274I2D: score=1 STRING: ENSP00000406027
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001954positive regulation of cell-matrix adhesion IDA16216233
GO:0008283cell proliferation TAS8996089
GO:2001046positive regulation of integrin-mediated signaling pathway IDA16216233

EMP2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMP2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for EMP2

1 Novoseek inferred chemical compound relationship for EMP2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
lipid 11.9 6 12763482 (2), 16736513 (1), 14978215 (1), 12710941 (1)

Search CenterWatch for drugs/clinical trials and news about EMP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for EMP2 gene: 
NM_001424.4  

Unigene Cluster for EMP2:

Epithelial membrane protein 2
Hs.531561  [show with all ESTs]
Unigene Representative Sequence: NM_001424
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000359543(uc002czx.3) ENST00000566033 ENST00000536829 ENST00000342147

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EMP2
8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate EMP2 (see all 47):
hsa-miR-562 hsa-miR-330-5p hsa-miR-300 hsa-miR-29a hsa-let-7a-2* hsa-miR-3653 hsa-miR-10b* hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidEMP2 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for EMP2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EMP2
Clone
Products:
     
OriGene clones in human, mouse for EMP2 (see all 7)
OriGene ORF clones in mouse, rat for EMP2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: EMP2 (NM_001424)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for EMP2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EMP2
Sirion Biotech Customized lentivirus for stable overexpression of EMP2 
                     Customized lentivirus expression plasmids for stable overexpression of EMP2 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for EMP2
OriGene qSTAR qPCR primer pairs in human, mouse for EMP2
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EMP2
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EMP2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EMP2

Additional mRNA sequence: 

AF190163.1 AK096403.1 AK313134.1 BC009687.1 BC016019.1 U52100.1 X94770.1 

14 DOTS entries:

DT.100736805  DT.92452864  DT.218014  DT.100043016  DT.100788232  DT.120676339  DT.97864161  DT.100044678 
DT.91799381  DT.92452849  DT.40293515  DT.92452851  DT.95245542  DT.95300383 

24/266 AceView cDNA sequences (see all 266):

BG026433 BQ774225 BU154463 CD675991 AA025422 AA664064 AI193944 BQ425935 
BE328556 AA664205 BM995649 AK096403 CD677165 N22176 BX105962 BM930489 
AI695630 CA421190 AA587290 BM817626 AA447410 BI819846 BU630237 T94632 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EMP2 expression in normal human tissues (normalized intensities)      EMP2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAAAATAAAG
EMP2 Expression
About this image


EMP2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/15 selected tissues (see all 15) fully expand
 
 Tooth (Integumentary System)    fully expand to see all 4 entries
         visceral organ/oral region/upper jaw   
 
 Lung (Respiratory System)    fully expand to see all 3 entries
         Trachea
         visceral organ/lung/right lung   
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Adult Endothelial Cells Blood Brain Barrier
         Medulla Oblongata
         brain/forebrain/telencephalon   
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Metencephalon
         spinal cord/lateral wall/ventricular layer   
 
 Endothelium (Cardiovascular System)    fully expand to see all 2 entries
         Adult Endothelial Cells Blood Brain Barrier
         aorta   

See EMP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EMP2

SOURCE GeneReport for Unigene cluster: Hs.531561
    SABiosciences Custom PCR Arrays for EMP2
Primer
Products:
OriGene qPCR primer pairs and template standards for EMP2
OriGene qSTAR qPCR primer pairs in human, mouse for EMP2
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EMP2
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EMP2
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EMP2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EMP2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for EMP2 gene from 5/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Emp21 , 5 epithelial membrane protein 21, 5 80.24(n)1
77.84(a)1
  16 (5.54 cM)5
137311  NM_007929.21  NP_031955.21 
 102817495 
chicken
(Gallus gallus)
Aves EMP21 epithelial membrane protein 2 68.67(n)
71.08(a)
  416636  XM_414935.3  XP_414935.1 
lizard
(Anolis carolinensis)
Reptilia EMP26
Uncharacterized protein
73(a)
1 ↔ 1
GL343592.1(265018-269164)
African clawed frog
(Xenopus laevis)
Amphibia MGC529162 similar to epithelial membrane protein 2 74.78(n)    BC044968.1 
zebrafish
(Danio rerio)
Actinopterygii emp21 epithelial membrane protein 2 62.31(n)
56.86(a)
  445506  NM_001004119.1  NP_001004119.1 


ENSEMBL Gene Tree for EMP2 (if available)
TreeFam Gene Tree for EMP2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for EMP2 gene
EMP12  PMP222  EMP32  
3 SIMAP similar genes for EMP2 using alignment to 1 protein entry:     EMP2_HUMAN:
PMP22    EMP1    EMP3

EMP2 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for EMP2
PGOHUM00000239998


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1527 SNPs in EMP2 are shown (see all 1527)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs71925781,2
C--10621810(+) tggctC/Gccacc 1 -- ds50010--------
rs99361391,2
C,H--10621815(+) cccacC/Ttgcaa 1 -- ds50016Minor allele frequency- T:0.02NS EA WA 532
rs1395661381,2
--10621862(+) ATGAGC/TCCAGG 1 -- ds50010--------
rs18759281,2
C,F,H--10621885(+) GCATAG/AGCAAC 1 -- ds500119Minor allele frequency- A:0.19NS EA NA WA CSA 938
rs353792311,2
C,F--10621890(+) AGCAAC/GAGACC 1 -- ds50014Minor allele frequency- G:0.11NA 126
rs1914696201,2
--10621900(+) CCCCCA/GCCCCA 1 -- ds50010--------
rs71914111,2
C,F,A,H--10621940(+) GAACGG/AATACA 1 -- ds500121Minor allele frequency- A:0.07NS EA NA CSA WA 2340
rs1495985821,2
--10621960(+) GGAGCA/GTTCTT 1 -- ds50010--------
rs1806938401,2
--10622021(+) CGGACA/GCAGTG 1 -- ds50010--------
rs71936621,2
C,F,H--10622052(+) ccagcA/Tgtttg 1 -- ds50014Minor allele frequency- T:0.00NS EA 412

HapMap Linkage Disequilibrium report for EMP2 (10622279 - 10674555 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for EMP2:    About this table     
Variant IDTypeSubtypePubMed ID
esv2663799CNV Deletion23128226
nsv516716CNV Loss19592680
nsv905339CNV Loss21882294
nsv528167CNV Loss19592680
nsv905340CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing EMP2
DNA2.0 Custom Variant and Variant Library Synthesis for EMP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 602334    OMIM disorders: --

16 diseases for EMP2:    About MalaCards
charcot-marie-tooth disease type 1c    endometrioid ovary carcinoma    charcot-marie-tooth disease type 1    myoclonus epilepsy
progressive myoclonus epilepsy    myoclonus    proliferative vitreoretinopathy    charcot-marie-tooth disease
tooth disease    endometrial adenocarcinoma    malaria    neuropathy
adenocarcinoma    ovarian cancer    hepatocellular carcinoma    gastric cancer

1 disease from the University of Copenhagen DISEASES database for EMP2:
Proliferative vitreoretinopathy

EMP2 for disorders           About GeneDecksing

3 Novoseek inferred disease relationships for EMP2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
shock 5.77 2 15280250 (2)
tumors 0 8 19010852 (2), 12710941 (1), 18400107 (1), 12189152 (1)
cancer 0 6 16736513 (1)

Genetic Association Database (GAD): EMP2

Export disorders for EMP2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for EMP2 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with EMP2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. (PubMed id 8996089)1, 2, 3 Ben-Porath I. and Benvenisty N. (1996)
  2. Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium. (PubMed id 16216233)1, 3, 9 Wadehra M....Braun J. (2005)
  3. Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family. (PubMed id 8917086)1, 2, 9 Taylor V. and Suter U. (1996)
  4. Regional localization of the human epithelial membran e protein genes 1, 2, and 3 (EMP1, EMP2, EMP3) to 12p12.3, 16p13.2, and 19q13.3 . (PubMed id 10331954)1, 3, 9 Liehr T....Rautenstrauss B. (1999)
  5. Family-based genome-wide association scan of attentio n-deficit/hyperactivity disorder. (PubMed id 20732626)1, 4 Mick E....Faraone S.V. (2010)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. Steroid hormone regulation of EMP2 expression and localization in the endometrium. (PubMed id 18400107)1, 9 Wadehra M....Braun J. (2008)
  9. Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye. (PubMed id 12710941)1, 9 Wadehra M....Goodglick L. (2003)
  10. Diabodies targeting epithelial membrane protein 2 reduce tumorigenicity of human endometrial cancer cell lines. (PubMed id 19010852)1, 9 Shimazaki K....Wadehra M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2013 HGNC: 3334 AceView: EMP2 Ensembl:ENSG00000213853 euGenes: HUgn2013
ECgene: EMP2 H-InvDB: EMP2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for EMP2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for EMP2 gene:
Search GeneIP for patents involving EMP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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