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Aliases for EMP1 Gene

Aliases for EMP1 Gene

  • Epithelial Membrane Protein 1 2 3 5
  • Tumor-Associated Membrane Protein 3 4
  • CL-20 3 4
  • EMP-1 3 4
  • TMP 3 4
  • Protein B4B 4
  • B4B 4

External Ids for EMP1 Gene

Previous GeneCards Identifiers for EMP1 Gene

  • GC12P013091
  • GC12P013494
  • GC12P013249
  • GC12P013240
  • GC12P013210
  • GC12P013119
  • GC12P013349

Summaries for EMP1 Gene

GeneCards Summary for EMP1 Gene

EMP1 (Epithelial Membrane Protein 1) is a Protein Coding gene. Diseases associated with EMP1 include Endobronchial Lipoma and Bronchial Neoplasm. An important paralog of this gene is EMP3.

Gene Wiki entry for EMP1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMP1 Gene

Genomics for EMP1 Gene

Regulatory Elements for EMP1 Gene

Enhancers for EMP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EMP1 on UCSC Golden Path with GeneCards custom track

Promoters for EMP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EMP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EMP1 Gene

Chromosome:
12
Start:
13,196,668 bp from pter
End:
13,219,939 bp from pter
Size:
23,272 bases
Orientation:
Plus strand

Genomic View for EMP1 Gene

Genes around EMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMP1 Gene

Proteins for EMP1 Gene

  • Protein details for EMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54849-EMP1_HUMAN
    Recommended name:
    Epithelial membrane protein 1
    Protein Accession:
    P54849
    Secondary Accessions:
    • B2R5N1
    • B4DRR1
    • O00681
    • Q13481
    • Q13834

    Protein attributes for EMP1 Gene

    Size:
    157 amino acids
    Molecular mass:
    17563 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EMP1 Gene

Proteomics data for EMP1 Gene at MOPED

Post-translational modifications for EMP1 Gene

  • Glycosylation at Asn 43 and Asn 46

Other Protein References for EMP1 Gene

No data available for DME Specific Peptides for EMP1 Gene

Domains & Families for EMP1 Gene

Graphical View of Domain Structure for InterPro Entry

P54849

UniProtKB/Swiss-Prot:

EMP1_HUMAN :
  • Belongs to the PMP-22/EMP/MP20 family.
Family:
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with EMP1: view

No data available for Gene Families for EMP1 Gene

Function for EMP1 Gene

Molecular function for EMP1 Gene

GENATLAS Biochemistry:
epithelial membrane protein 1,rabbit CL-20 homolog,tumor associated membrane protein,expressed in mammary tumor and T cell lymphoma,c-Myc target

Phenotypes for EMP1 Gene

MGI mutant phenotypes for EMP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for EMP1:
genes like me logo Genes that share phenotypes with EMP1: view

Animal Models for EMP1 Gene

MGI Knock Outs for EMP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for EMP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EMP1 Gene

Localization for EMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMP1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EMP1 Gene COMPARTMENTS Subcellular localization image for EMP1 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for EMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 8996089
genes like me logo Genes that share ontologies with EMP1: view

Pathways & Interactions for EMP1 Gene

SuperPathways for EMP1 Gene

No Data Available

Interacting Proteins for EMP1 Gene

Gene Ontology (GO) - Biological Process for EMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development TAS 8996089
GO:0008544 epidermis development TAS 7499420
GO:0032060 bleb assembly IDA 12107182
genes like me logo Genes that share ontologies with EMP1: view

No data available for Pathways by source and SIGNOR curated interactions for EMP1 Gene

Drugs & Compounds for EMP1 Gene

(2) Drugs for EMP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with EMP1: view

Transcripts for EMP1 Gene

Unigene Clusters for EMP1 Gene

Epithelial membrane protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EMP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - -
SP7:
SP8:

Relevant External Links for EMP1 Gene

GeneLoc Exon Structure for
EMP1
ECgene alternative splicing isoforms for
EMP1

Expression for EMP1 Gene

mRNA expression in normal human tissues for EMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EMP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x16.6), Vagina (x5.1), Cervix - Ectocervix (x4.2), and Minor Salivary Gland (x4.1).

SOURCE GeneReport for Unigene cluster for EMP1 Gene Hs.719042

genes like me logo Genes that share expression patterns with EMP1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for EMP1 Gene

Orthologs for EMP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EMP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EMP1 35
  • 82.17 (n)
  • 80.89 (a)
EMP1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EMP1 35
  • 85.35 (n)
  • 86.62 (a)
EMP1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Emp1 35
  • 79.83 (n)
  • 77.07 (a)
Emp1 16
Emp1 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EMP1 35
  • 99.15 (n)
  • 97.45 (a)
EMP1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Emp1 35
  • 77.28 (n)
  • 75.8 (a)
oppossum
(Monodelphis domestica)
Mammalia EMP1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EMP1 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves EMP1 35
  • 67.73 (n)
  • 68.79 (a)
EMP1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EMP1 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia emp1 35
  • 62.82 (n)
  • 60.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5505 35
zebrafish
(Danio rerio)
Actinopterygii emp1 36
  • 31 (a)
OneToOne
Species with no ortholog for EMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EMP1 Gene

ENSEMBL:
Gene Tree for EMP1 (if available)
TreeFam:
Gene Tree for EMP1 (if available)

Paralogs for EMP1 Gene

Paralogs for EMP1 Gene

(3) SIMAP similar genes for EMP1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with EMP1: view

Variants for EMP1 Gene

Sequence variations from dbSNP and Humsavar for EMP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs34412222 - 13,213,570(+) TGCCA(A/G)TGAAG reference, missense
rs2069086 -- 13,215,388(+) CCTCA(A/G/T)GGAGA utr-variant-3-prime
rs8885 -- 13,216,262(+) CTCAT(C/T)CATTT utr-variant-3-prime
rs10845711 -- 13,197,706(+) GGAGA(C/T)GGTGG intron-variant
rs10845712 -- 13,198,764(+) ATACT(A/G)TAGGT intron-variant

Variation tolerance for EMP1 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for EMP1 Gene

Disorders for EMP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EMP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
endobronchial lipoma
bronchial neoplasm
  • bronchus neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search EMP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EMP1

Genetic Association Database (GAD)
EMP1
Human Genome Epidemiology (HuGE) Navigator
EMP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EMP1
genes like me logo Genes that share disorders with EMP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EMP1 Gene

Publications for EMP1 Gene

  1. cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family. (PMID: 9126480) Chen Y. … Jetten A.M. (Genomics 1997) 2 3 4 23 67
  2. Up-regulation of epithelial membrane protein-1 in the temporal neocortex of patients with intractable epilepsy. (PMID: 19288191) Li Y.Q. … Yao L. (Neurochem. Res. 2009) 3 23
  3. Epithelial membrane protein-1 is a biomarker of gefitinib resistance. (PMID: 16087880) Jain A. … Agus D.B. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23
  4. Analysis of gene expression profile induced by EMP-1 in esophageal cancer cells using cDNA Microarray. (PMID: 12632483) Wang H.T. … Liu Z.H. (World J. Gastroenterol. 2003) 3 23
  5. Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. (PMID: 12107182) Wilson H.L. … North R.A. (J. Biol. Chem. 2002) 3 23

Products for EMP1 Gene

Sources for EMP1 Gene

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