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Aliases & Descriptions for EMP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Protein B4B 3 | | Tumor-associated membrane protein 3 | | epithelial membrane protein 1 2 |
|
| | Search outside databases for aliases for EMP1 genePrevious GC identifers: GC12P013091 GC12P013494 GC12P013249 GC12P013240 |
Summaries for EMP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for EMP1 |
Genomic Location for EMP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the EMP1 gene 
Entrez Gene cytogenetic band: 12p12.3 Ensembl cytogenetic band: 12p13.1 HGNC cytogenetic band: 12p12.3EMP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P013210:
(about GC identifiers)
Start:
|
13,187,140 bp from pter |
End:
|
13,260,975 bp from pter |
Size:
|
73,836 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009714.16
| Proteins for EMP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: EMP1_HUMAN, P54849 (See
protein sequence)Recommended Name: Epithelial membrane protein 1 Size: 157 amino acids; 17563 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O00681 Q13481 Q13834REFSEQ proteins: NP_001414.1
ENSEMBL proteins: ENSP00000379595 ENSP00000256951
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for EMP1: Assays for EMP1: | Protein
Domains/ Families for EMP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P54849
ProtoNet protein and cluster: P54849 2 Blocks protein families: IPB003932 Epithelial membrane protein EMP-1 signature IPB004032 PMP-22/EMP/MP20 family
UniProtKB/Swiss-Prot: EMP1_HUMAN, P54849Similarity: Belongs to the PMP-22/EMP/MP20 family | Gene Function for EMP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001423
Applied Biosystems Silencer® siRNAs for EMP1
Sigma-Aldrich siRNA and siRNA Panels for EMP1  Sigma-Aldrich shRNA for EMP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001423                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001423                                  untagged cDNA clone in CMV expression vector: NM_001423 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001423
Genatlas biochemistry entry for EMP1:epithelial membrane protein 1,rabbit CL-20 homolog,tumor associated membrane protein,expressed in mammary tumor and T cell lymphoma,c-Myc target | Pathways & Interactions for EMP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/6 Interacting proteins for EMP1 (ENSP000002569513) via UniProtKB, MINT, and/or STRING (see all 6
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for EMP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for EMP1
|
Transcripts for EMP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001423
Sigma-Aldrich siRNA and siRNA Panels for EMP1  Sigma-Aldrich shRNA for EMP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001423 REFSEQ mRNAs for EMP1 gene: NM_001423.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001423               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001423                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001423                                  untagged cDNA clone in CMV expression vector: NM_001423  Additional cDNA sequence: AK299388.1 AK308505.1 AK310798.1 AK312246.1 BC017854.1 BC047300.1 CR608144.1 U43916.1 U77085.1 Y07909.1 Z50751.1 23 DOTS entries: DT.118516 DT.100882920 DT.209718 DT.121183529 DT.453065 DT.121183498 DT.100705808 DT.100882919 DT.100882907 DT.95356869 DT.121183540 DT.97769860 DT.40268524 DT.121183424 DT.121183435 DT.121183439 DT.121183491 DT.121183515 DT.95292525 DT.95356894 DT.121183520 DT.70102025 DT.91764028 24/519 AceView cDNA sequences (see all 519
):CA429050 CA421863 U43916 AA384452 F13094 CN481103 BM974726 AA370297 BQ897579 CB054682 AI379651 BU681388 CR608144 AA314702 CD364356 CA446854 BU150998 CA441779 CA406080 BE742343 AL602524 AI435003 AI129735 BQ575560
highest scoring ESTs for EMP1:U43916 Y07909 AA046025 AA157008 AA303202 AA314702 AA343071 AA375282 AA386096 AA442410 Unigene Cluster for EMP1: Epithelial membrane protein 1 Hs.707901 [show with all ESTs]Unigene Representative Sequence: NM_001423
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for EMP1 (see all 8
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c | · | 6d | |
| SP1: | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for EMP1
2 Ensembl transcripts including schematic representations: ENST00000396301
ENST00000256951
|
Expression for EMP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| EMP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for EMP1
1 / 2 / 3 7 probe-sets matching EMP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TAATTTGCAT
SOURCE GeneReport for Unigene cluster: Hs.707901
Expression variation in blood from EXPOLDB for EMP1 |
Orthologs for EMP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for EMP1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for EMP1
ENSEMBL Gene Tree for EMP1 | Paralogs for EMP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for EMP1 gene
- EMP22 PMP222 EMP32
|
SNPs/Variants for EMP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for EMP1 (up to first 250kb)
|
Disorders & Mutations for EMP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602333
4 Novoseek disease relationships for EMP1 gene
About this table
|
Medical News for EMP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for EMP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/42 PubMed articles for EMP1 gene (see all 42
):- cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family. (PubMed id 9126480)1, 2, 3, 4 Chen Y....Jetten A.M. (1997)
- Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. (PubMed id 8996089)2, 3, 4 Ben-Porath I. and Benvenisty N. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Differential gene expression in human mammary carcinoma cells: identification of a new member of a receptor family. (PubMed id 9066625)3, 4 Schiemann S....Weidle U.H. (1997)
- B4B, a novel growth-arrest gene, is expressed by a subset of progenitor/pre-B lymphocytes negative for cytoplasmic mu-chain. (PubMed id 8683158)3, 4 Ruegg C.L.... Laus R. (1996)
- Analysis of gene expression profile induced by EMP-1 in esophageal cancer cells using cDNA Microarray. (PubMed id 12632483)1, 3 Wang H.T....Liu Z.H. (2003)
- Epithelial membrane protein-1 is a biomarker of gefitinib resistance. (PubMed id 16087880)1, 3 Jain A....Agus D.B. (2005)
- [Effect of EMP-1 gene on human esophageal cancer cell line] (PubMed id 12451984)1, 3 Wang H.T....Wu M. (2002)
- Regional localization of the human epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, EMP3) to 12p12.3, 16p13.2, and 19q13.3. (PubMed id 10331954)1, 3 Liehr T....Rautenstrauss B. (1999)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for EMP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing EMP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing EMP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EMP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for EMP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for EMP1:

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Incremental update: 13 Oct 2009
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