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EMP1 Gene

protein-coding   GIFtS: 50
GCID: GC12P013349

Epithelial Membrane Protein 1

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Epithelial Membrane Protein 11 2     EMP-12 3
TMP2 3 5     B4B3
Tumor-Associated Membrane Protein2 3     Protein B4B3
CL-202 3     

External Ids:    HGNC: 33331   Entrez Gene: 20122   Ensembl: ENSG000001345317   OMIM: 6023335   UniProtKB: P548493   

Export aliases for EMP1 gene to outside databases

Previous GC identifers: GC12P013091 GC12P013494 GC12P013249 GC12P013240 GC12P013210 GC12P013119


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EMP1 Gene:
EMP1 (epithelial membrane protein 1) is a protein-coding gene. An important paralog of this gene is EMP2.

Gene Wiki entry for EMP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the EMP1 gene promoter:
         COUP-TF1   SRF   AP-1   SRF (504 AA)   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEMP1 promoter sequence
   Search Chromatin IP Primers for EMP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p13.1   HGNC cytogenetic band: 12p12.3

EMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EMP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P013349:  view genomic region     (about GC identifiers)

Start:
13,349,602 bp from pter      End:
13,369,708 bp from pter
Size:
20,107 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EMP1_HUMAN, P54849 (See protein sequence)
Recommended Name: Epithelial membrane protein 1  
Size: 157 amino acids; 17563 Da
Secondary accessions: B2R5N1 O00681 Q13481 Q13834

Explore the universe of human proteins at neXtProt for EMP1: NX_P54849

Explore proteomics data for EMP1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn43, Asn46

  • See EMP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001414.1  
    ENSEMBL proteins: 
     ENSP00000256951   ENSP00000410755   ENSP00000445553   ENSP00000445497   ENSP00000441223  
     ENSP00000379595   ENSP00000445319  

    EMP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for EMP1
    OriGene Protein Over-expression Lysate for EMP1
    OriGene MassSpec for EMP1
    OriGene Custom Protein Services for EMP1
    GenScript Custom Purified and Recombinant Proteins Services for EMP1
    Novus Biologicals EMP1 Protein
    Novus Biologicals EMP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EMP1

     
    Search eBioscience for Proteins for EMP1 

    EMP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for EMP1
    Novus Biologicals EMP1 Antibodies
    Search for Antibodies for EMP1 at Abcam
    Cloud-Clone Corp. Antibodies for EMP1
    Search ThermoFisher Antibodies for EMP1
    LSBio Antibodies in human, mouse, rat for EMP1

    EMP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EMP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EMP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EMP1
    Cloud-Clone Corp. CLIAs for EMP1
    Search eBioscience for ELISAs for EMP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004032 PMP22_EMP_MP20
     IPR004031 PMP22/EMP/MP20/Claudin
     IPR003932 EMP_1

    Graphical View of Domain Structure for InterPro Entry P54849

    ProtoNet protein and cluster: P54849

    2 Blocks protein domains:
    IPB003932 Epithelial membrane protein EMP-1 signature
    IPB004032 PMP-22/EMP/MP20 family


    UniProtKB/Swiss-Prot: EMP1_HUMAN, P54849
    Similarity: Belongs to the PMP-22/EMP/MP20 family


    Find genes that share domains with EMP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for EMP1:
    epithelial membrane protein 1,rabbit CL-20 homolog,tumor associated membrane protein,expressed in mammary tumor
    and T cell lymphoma,c-Myc target

    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Emp1):
     normal 

    Find genes that share phenotypes with EMP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Emp1tm1Lex for EMP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EMP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EMP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EMP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EMP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target EMP1:
    hsa-mir-124-3p (MIRT023169), hsa-mir-34a-5p (MIRT005075), hsa-mir-375 (MIRT019984), hsa-mir-335-5p (MIRT019100)

    Block miRNA regulation of human, mouse, rat EMP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EMP1 (see all 37):
    hsa-miR-642a hsa-miR-188-5p hsa-miR-429 hsa-miR-29a hsa-miR-10b* hsa-miR-374c hsa-miR-3150b-3p hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidEMP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EMP1
    Predesigned siRNA for gene silencing in human, mouse, rat EMP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EMP1

    Clone
    Products:
         
    OriGene clones in human, mouse for EMP1 (see all 6)
    OriGene ORF clones in mouse, rat for EMP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EMP1 (NM_001423)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EMP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EMP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for EMP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EMP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EMP1_HUMAN, P54849: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane TAS8996089
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with EMP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including EMP1: 
              TGFB/BMP Signaling Pathway in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for EMP1

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development TAS8996089
    GO:0008283cell proliferation TAS8996089
    GO:0008544epidermis development TAS7499420
    GO:0016049cell growth IEA--

    Find genes that share ontologies with EMP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EMP1

    2 Novoseek inferred chemical compound relationships for EMP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gefitinib 43.3 9 16087880 (6)
    alanine 2.98 2 10318834 (1)



    Find genes that share compounds with EMP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EMP1 gene: 
    NM_001423.2  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256951(uc010shr.1 uc001rbr.3 uc009zhy.3) ENST00000431267
    ENST00000542474 ENST00000544053 ENST00000542289 ENST00000538364 ENST00000535134
    ENST00000541935 ENST00000396301 ENST00000537612 ENST00000536383 ENST00000546357

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EMP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EMP1 (see all 37):
    hsa-miR-642a hsa-miR-188-5p hsa-miR-429 hsa-miR-29a hsa-miR-10b* hsa-miR-374c hsa-miR-3150b-3p hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidEMP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EMP1
    Predesigned siRNA for gene silencing in human, mouse, rat EMP1
    Clone
    Products:
         
    OriGene clones in human, mouse for EMP1 (see all 6)
    OriGene ORF clones in mouse, rat for EMP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EMP1 (NM_001423)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EMP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EMP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EMP1
    OriGene qSTAR qPCR primer pairs in human, mouse for EMP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EMP1
      QuantiTect SYBR Green Assays in human, mouse, rat EMP1
      QuantiFast Probe-based Assays in human, mouse, rat EMP1

    Selected AceView cDNA sequences (see all 519):

    AU118827 F13094 F12935 CA446854 BQ897579 BQ003032 Z42899 CA941777 
    AA913435 BU681388 CD365177 AW265287 BU735904 BU686836 BM718867 CA445291 
    U43916 AW469448 BP345443 AU131817 AA384452 BP346391 BQ878306 BQ007019 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EMP1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d
    SP1:                          -     -                 -     -     -                           
    SP2:              -     -     -     -                 -     -     -                           
    SP3:                          -     -                                                         
    SP4:                                                  -     -     -                           
    SP5:              -     -     -     -     -           -     -     -                           


    ECgene alternative splicing isoforms for EMP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EMP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTTGCAT
    EMP1 Expression
    About this image


    EMP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Mature Endothelial Cells Blood Brain Barrier
             Thalamus
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Mature Endothelial Cells Blood Brain Barrier
             Human umbilical vein endothelial cells (HUVEC)
             Endothelial-like cells
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Pro-myelinating Schwann Cells Peripheral Nerve Domain
    EMP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EMP1 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including EMP1: 
              TGFB/BMP Signaling Pathway in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EMP1
    OriGene qSTAR qPCR primer pairs in human, mouse for EMP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EMP1
    QuantiTect SYBR Green Assays in human, mouse, rat EMP1
    QuantiFast Probe-based Assays in human, mouse, rat EMP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EMP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EMP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Emp11 , 5 epithelial membrane protein 11, 5 79.83(n)1
    77.07(a)1
      6 (66.25 cM)5
    137301  NM_010128.41  NP_034258.11 
     1353629315 
    chicken
    (Gallus gallus)
    Aves EMP11 epithelial membrane protein 1 67.73(n)
    68.79(a)
      417964  NM_001277370.1  NP_001264299.1 
    lizard
    (Anolis carolinensis)
    Reptilia EMP16
    epithelial membrane protein 1
    61(a)
    1 ↔ 1
    GL343397.1(763272-774591)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55052 Xenopus laevis transcribed sequence with weak similarity more 76.47(n)    CD328511.1 
    zebrafish
    (Danio rerio)
    Actinopterygii emp16
    epithelial membrane protein 1
    31(a)
    1 ↔ 1
    1(45793835-45803328) ENSDARG00000069632


    ENSEMBL Gene Tree for EMP1 (if available)
    TreeFam Gene Tree for EMP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EMP1 gene
    EMP22  PMP222  EMP32  
    3 SIMAP similar genes for EMP1 using alignment to 7 protein entries:     EMP1_HUMAN (see all proteins):
    PMP22    EMP2    EMP3

    Find genes that share paralogs with EMP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EMP1 (see all 453)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1484156011,2
    --13347624(+) AGGCAC/GCTGAG 1 -- us2k10--------
    rs1847409081,2
    --13347688(+) AGAGTA/TGGAAA 1 -- us2k10--------
    rs1425000481,2
    --13347711(+) CAGGCC/TGATTC 1 -- us2k10--------
    rs73157251,2
    C,F,H--13347745(+) GGAGCG/ACCAGC 1 -- us2k18Minor allele frequency- A:0.17NS EA CSA WA NA 755
    rs1509614811,2
    --13348031(+) CAGCAG/TCATCA 1 -- us2k10--------
    rs580786721,2
    C--13348067(+) TGTGT-/G/GTGTGTGTGTGT/GTGTGTGTG
    TGTGTGT
    /GTGTGTGTGTGTGTGTGT
    TGTGT
    3 -- us2k1 cds11NA 2
    rs1395004251,2
    --13348153(+) CACATA/GCCAAC 1 -- us2k10--------
    rs781383881,2
    C,F--13348180(+) TATAGG/TTTCAT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs125813021,2
    C,F,H--13348246(+) TAATTT/GTATCA 1 -- us2k1 tfbs324Minor allele frequency- G:0.19NS EA NA WA CSA 2766
    rs604063571,2
    C,F--13348430(+) CACACG/ACATAT 1 -- us2k12Minor allele frequency- A:0.10WA 120

    HapMap Linkage Disequilibrium report for EMP1 (13349602 - 13369708 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for EMP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EMP1
    DNA2.0 Custom Variant and Variant Library Synthesis for EMP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602333    OMIM disorders: --

    7 diseases from the University of Copenhagen DISEASES database for EMP1:
    X-linked hypophosphatemia     Hypophosphatemia     Rickets     Osteomalacia
    Hyperparathyroidism     Calcinosis     Nephrolithiasis

    Find genes that share disorders with EMP1           About GenesLikeMe

    4 Novoseek inferred disease relationships for EMP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 19.2 1 17690741 (1)
    glioma 12.1 1 16204036 (1)
    tumors 7.2 8 17690741 (1), 19732125 (1), 19288191 (1)
    cancer 0 1 17690741 (1)

    Genetic Association Database (GAD): EMP1
    Human Genome Epidemiology (HuGE) Navigator: EMP1 (2 documents)

    Export disorders for EMP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EMP1 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with EMP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family. (PubMed id 9126480)1, 2, 3, 9 Chen Y.... Jetten A.M. (Genomics 1997)
    2. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. (PubMed id 8996089)1, 2, 3 Ben-Porath I. and Benvenisty N. (Gene 1996)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Differential gene expression in human mammary carcinoma cells: identification of a new member of a receptor family. (PubMed id 9066625)1, 2 Schiemann S....Weidle U.H. (Anticancer Res. 1997)
    6. B4B, a novel growth-arrest gene, is expressed by a subset of progenitor/pre-B lymphocytes negative for cytoplasmic mu-chain. (PubMed id 8683158)1, 2 Ruegg C.L.... Laus R. (J. Immunol. 1996)
    7. Up-regulation of epithelial membrane protein-1 in the temporal neocortex of patients with intractable epilepsy. (PubMed id 19288191)1, 9 Li Y.Q....Yao L. (Neurochem. Res. 2009)
    8. Analysis of gene expression profile induced by EMP-1 in esophageal cancer cells using cDNA Microarray. (PubMed id 12632483)1, 9 Wang H.T....Liu Z.H. (World J. Gastroenterol. 2003)
    9. Epithelial membrane protein-1 is a biomarker of gefitinib resistance. (PubMed id 16087880)1, 9 Jain A....Agus D.B. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    10. [Effect of EMP-1 gene on human esophageal cancer cell line]. (PubMed id 12451984)1, 9 Wang H.T....Wu M. (Ai Zheng 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2012 HGNC: 3333 AceView: EMP1 Ensembl:ENSG00000134531 euGenes: HUgn2012
    ECgene: EMP1 H-InvDB: EMP1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EMP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EMP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EMP1 gene:
    Search GeneIP for patents involving EMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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