Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EMP1 Gene

Aliases for EMP1 Gene

  • Epithelial Membrane Protein 1 2 3
  • TMP 3 4 6
  • Tumor-Associated Membrane Protein 3 4
  • CL-20 3 4
  • EMP-1 3 4
  • Protein B4B 4
  • B4B 4

External Ids for EMP1 Gene

Summaries for EMP1 Gene

GeneCards Summary for EMP1 Gene

EMP1 (Epithelial Membrane Protein 1) is a Protein Coding gene. Diseases associated with EMP1 include esophageal cancer. An important paralog of this gene is EMP3.

Gene Wiki entry for EMP1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMP1 Gene

Genomics for EMP1 Gene

Genomic Location for EMP1 Gene

Start:
13,196,668 bp from pter
End:
13,219,939 bp from pter
Size:
23,272 bases
Orientation:
Plus strand

Genomic View for EMP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMP1 Gene

Regulatory Elements for EMP1 Gene

Proteins for EMP1 Gene

  • Protein details for EMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54849-EMP1_HUMAN
    Recommended name:
    Epithelial membrane protein 1
    Protein Accession:
    P54849
    Secondary Accessions:
    • B2R5N1
    • B4DRR1
    • O00681
    • Q13481
    • Q13834

    Protein attributes for EMP1 Gene

    Size:
    157 amino acids
    Molecular mass:
    17563 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EMP1 Gene

Proteomics data for EMP1 Gene at MOPED

Post-translational modifications for EMP1 Gene

Other Protein References for EMP1 Gene

No data available for DME Specific Peptides for EMP1 Gene

Domains for EMP1 Gene

UniProtKB/Swiss-Prot:

EMP1_HUMAN
Family:
  • Belongs to the PMP-22/EMP/MP20 family.:
    • P54849
genes like me logo Genes that share domains with EMP1: view

No data available for Gene Families for EMP1 Gene

Function for EMP1 Gene

Molecular function for EMP1 Gene

GENATLAS Biochemistry: epithelial membrane protein 1,rabbit CL-20 homolog,tumor associated membrane protein,expressed in mammary tumor and T cell lymphoma,c-Myc target

Gene Ontology (GO) - Molecular Function for EMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12107182
genes like me logo Genes that share ontologies with EMP1: view

Phenotypes for EMP1 Gene

MGI mutant phenotypes for EMP1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with EMP1: view

Animal Models for EMP1 Gene

MGI Knock Outs for EMP1:

miRNA for EMP1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EMP1 Gene

Localization for EMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMP1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EMP1 Gene COMPARTMENTS Subcellular localization image for EMP1 gene
Compartment Confidence
plasma membrane 3
extracellular 2

Gene Ontology (GO) - Cellular Components for EMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 12107182
GO:0016020 membrane TAS 8996089
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EMP1: view

Pathways for EMP1 Gene

SuperPathways for EMP1 Gene

No Data Available

Interacting Proteins for EMP1 Gene

Gene Ontology (GO) - Biological Process for EMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development TAS 8996089
GO:0008219 cell death IDA 12107182
GO:0008283 cell proliferation TAS 8996089
GO:0008544 epidermis development TAS 7499420
GO:0016049 cell growth IEA --
genes like me logo Genes that share ontologies with EMP1: view

No data available for Pathways by source for EMP1 Gene

Compounds for EMP1 Gene

(2) Novoseek inferred chemical compound relationships for EMP1 Gene

Compound -log(P) Hits PubMed IDs
gefitinib 43.3 6
alanine 2.98 1
genes like me logo Genes that share compounds with EMP1: view

Transcripts for EMP1 Gene

Unigene Clusters for EMP1 Gene

Epithelial membrane protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EMP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - -
SP7:
SP8:

Relevant External Links for EMP1 Gene

GeneLoc Exon Structure for
EMP1
ECgene alternative splicing isoforms for
EMP1

Expression for EMP1 Gene

mRNA expression in normal human tissues for EMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EMP1 Gene

This gene is overexpressed in Esophagus - Mucosa (16.6), Vagina (5.1), Cervix - Ectocervix (4.2), and Minor Salivary Gland (4.1).

SOURCE GeneReport for Unigene cluster for EMP1 Gene Hs.719042

genes like me logo Genes that share expressions with EMP1: view

Orthologs for EMP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EMP1 36
  • 99.15 (n)
  • 97.45 (a)
EMP1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EMP1 36
  • 82.17 (n)
  • 80.89 (a)
EMP1 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EMP1 36
  • 85.35 (n)
  • 86.62 (a)
EMP1 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Emp1 36
  • 79.83 (n)
  • 77.07 (a)
Emp1 16
Emp1 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EMP1 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EMP1 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Emp1 36
  • 77.28 (n)
  • 75.8 (a)
chicken
(Gallus gallus)
Aves EMP1 36
  • 67.73 (n)
  • 68.79 (a)
EMP1 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EMP1 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5505 36
tropical clawed frog
(Silurana tropicalis)
Amphibia emp1 36
  • 62.82 (n)
  • 60.26 (a)
zebrafish
(Danio rerio)
Actinopterygii emp1 37
  • 31 (a)
OneToOne
Species with no ortholog for EMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EMP1 Gene

ENSEMBL:
Gene Tree for EMP1 (if available)
TreeFam:
Gene Tree for EMP1 (if available)

Paralogs for EMP1 Gene

Paralogs for EMP1 Gene

Selected SIMAP similar genes for EMP1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with EMP1: view

Variants for EMP1 Gene

Sequence variations from dbSNP and Humsavar for EMP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8885 -- 13,216,262(+) CTCAT(C/T)CATTT utr-variant-3-prime
rs1131273 -- 13,196,772(+) GAGGC(A/G)GGTCC utr-variant-5-prime
rs1804761 -- 13,215,526(+) GTCTT(A/G)CAACA utr-variant-3-prime
rs2069086 -- 13,215,388(+) CCTCA(A/G/T)GGAGA utr-variant-3-prime
rs2277395 -- 13,213,665(-) AGGAC(A/G)AGGAG intron-variant

Relevant External Links for EMP1 Gene

HapMap Linkage Disequilibrium report
EMP1

No data available for Structural Variations from Database of Genomic Variants (DGV) for EMP1 Gene

Disorders for EMP1 Gene

(1) MalaCards Diseases for EMP1 Gene

Search for EMP1 Gene in MalaCards »

(4) Novoseek inferred disease relationships for EMP1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 19.2 1
glioma 12.1 1
tumors 7.2 3
cancer 0 1

Relevant External Links for EMP1

Genetic Association Database (GAD)
EMP1
Human Genome Epidemiology (HuGE) Navigator
EMP1
genes like me logo Genes that share disorders with EMP1: view

No data available for UniProtKB/Swiss-Prot for EMP1 Gene

Publications for EMP1 Gene

  1. cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family. (PMID: 9126480) Chen Y. … Jetten A.M. (Genomics 1997) 2 3 4 23
  2. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. (PMID: 8996089) Ben-Porath I. … Benvenisty N. (Gene 1996) 2 3 4
  3. Differential gene expression in human mammary carcinoma cells: identification of a new member of a receptor family. (PMID: 9066625) Schiemann S. … Weidle U.H. (Anticancer Res. 1997) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 49

Products for EMP1 Gene

Sources for EMP1 Gene

Back to Top

Content