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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EMP1 Gene

protein-coding   GIFtS: 52
GCID: GC12P013349

Epithelial Membrane Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Epithelial Membrane Protein 11 2     EMP-12 3
TMP2 3 5     B4B3
Tumor-Associated Membrane Protein2 3     Protein B4B3
CL-202 3     

External Ids:    HGNC: 33331   Entrez Gene: 20122   Ensembl: ENSG000001345317   OMIM: 6023335   UniProtKB: P548493   

Export aliases for EMP1 gene to outside databases

Previous GC identifers: GC12P013091 GC12P013494 GC12P013249 GC12P013240 GC12P013210 GC12P013119


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for EMP1 Gene: 
EMP1 (epithelial membrane protein 1) is a protein-coding gene. Diseases associated with EMP1 include x-linked hypophosphatemia, and hypophosphatemia. An important paralog of this gene is EMP2.

Gene Wiki entry for EMP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EMP1 gene promoter:
         COUP-TF1   SRF   AP-1   SRF (504 AA)   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEMP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for EMP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p13.1   HGNC cytogenetic band: 12p12.3

EMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EMP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P013349:  view genomic region     (about GC identifiers)

Start:
13,349,602 bp from pter      End:
13,369,708 bp from pter
Size:
20,107 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EMP1_HUMAN, P54849 (See protein sequence)
Recommended Name: Epithelial membrane protein 1  
Size: 157 amino acids; 17563 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B2R5N1 O00681 Q13481 Q13834

Explore the universe of human proteins at neXtProt for EMP1: NX_P54849

Explore proteomics data for EMP1 at MOPED 

EMP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

EMP1 Protein Expression

REFSEQ proteins: NP_001414.1  
ENSEMBL proteins: 
 ENSP00000256951   ENSP00000410755   ENSP00000445553   ENSP00000445497   ENSP00000441223  
 ENSP00000379595   ENSP00000445319  

Human Recombinant Protein Products for EMP1: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for EMP1
OriGene Protein Over-expression Lysate for EMP1
OriGene MassSpec for EMP1 
OriGene Custom Protein Services for EMP1
GenScript Custom Purified and Recombinant Proteins Services for EMP1
Novus Biologicals EMP1 Protein
Novus Biologicals EMP1 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for EMP1 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016020membrane TAS8996089
GO:0016021integral to membrane IEA--

EMP1 for ontologies           About GeneDecksing



EMP1 Antibody Products: 
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Novus Biologicals EMP1 Antibody
Search for Antibodies for EMP1 at Abcam
Cloud-Clone Corp. Antibodies for EMP1 
Search ThermoFisher Antibodies for EMP1
LSBio Antibodies in human, mouse, rat for EMP1 

Assay Products for EMP1: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for EMP1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for EMP1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for EMP1 
Cloud-Clone Corp. CLIAs for EMP1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR004032 PMP22_EMP_MP20
 IPR004031 PMP22/EMP/MP20/Claudin
 IPR003932 EMP_1

Graphical View of Domain Structure for InterPro Entry P54849

ProtoNet protein and cluster: P54849

2 Blocks protein domains:
IPB003932 Epithelial membrane protein EMP-1 signature
IPB004032 PMP-22/EMP/MP20 family


UniProtKB/Swiss-Prot: EMP1_HUMAN, P54849
Similarity: Belongs to the PMP-22/EMP/MP20 family


EMP1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for EMP1:
epithelial membrane protein 1,rabbit CL-20 homolog,tumor associated membrane protein,expressed in mammary tumor
and T cell lymphoma,c-Myc target

Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Emp1):
 normal 

EMP1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Emp1tm1Lex for EMP1

   inGenious Targeting Laboratory - Custom generated mouse model solutions for EMP1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EMP1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EMP1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EMP1 

miRNA
Products:
    
miRTarBase miRNAs that target EMP1:
hsa-mir-34a (MIRT005075)

QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EMP1
8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate EMP1 (see all 37):
hsa-miR-642a hsa-miR-188-5p hsa-miR-429 hsa-miR-29a hsa-miR-10b* hsa-miR-374c hsa-miR-3150b-3p hsa-miR-4330
SwitchGear 3'UTR luciferase reporter plasmidEMP1 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for EMP1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EMP1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for EMP1
Sirion Biotech Customized adenovirus for overexpression of EMP1

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for EMP1 (see all 7)
OriGene ORF clones in mouse, rat for EMP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: EMP1 (NM_001423)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for EMP1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EMP1
Sirion Biotech Customized lentivirus for stable overexpression of EMP1 
                     Customized lentivirus expression plasmids for stable overexpression of EMP1 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for EMP1
Search LifeMap BioReagents cell lines for EMP1
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EMP1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EMP1

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007275multicellular organismal development TAS8996089
GO:0008283cell proliferation TAS8996089
GO:0008544epidermis development TAS7499420
GO:0016049cell growth IEA--

EMP1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMP1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for EMP1

2 Novoseek inferred chemical compound relationships for EMP1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gefitinib 43.3 9 16087880 (6)
alanine 2.98 2 10318834 (1)

Search CenterWatch for drugs/clinical trials and news about EMP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for EMP1 gene: 
NM_001423.2  

Unigene Cluster for EMP1:

Epithelial membrane protein 1
Hs.719042  [show with all ESTs]
Unigene Representative Sequence: NM_001423
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000256951(uc010shr.1 uc001rbr.3 uc009zhy.3) ENST00000431267
ENST00000542474 ENST00000544053 ENST00000542289 ENST00000538364 ENST00000535134
ENST00000541935 ENST00000396301 ENST00000537612 ENST00000536383 ENST00000546357

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EMP1
8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate EMP1 (see all 37):
hsa-miR-642a hsa-miR-188-5p hsa-miR-429 hsa-miR-29a hsa-miR-10b* hsa-miR-374c hsa-miR-3150b-3p hsa-miR-4330
SwitchGear 3'UTR luciferase reporter plasmidEMP1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for EMP1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EMP1
Clone
Products:
     
OriGene clones in human, mouse for EMP1 (see all 7)
OriGene ORF clones in mouse, rat for EMP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: EMP1 (NM_001423)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for EMP1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EMP1
Sirion Biotech Customized lentivirus for stable overexpression of EMP1 
                     Customized lentivirus expression plasmids for stable overexpression of EMP1 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for EMP1
OriGene qSTAR qPCR primer pairs in human, mouse for EMP1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EMP1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EMP1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EMP1

Additional mRNA sequence: 

AK299388.1 AK308505.1 AK310798.1 AK312246.1 BC017854.1 BC047300.1 U43916.1 U77085.1 
Y07909.1 Z50751.1 

23 DOTS entries:

DT.118516  DT.100882920  DT.209718  DT.121183529  DT.121183498  DT.100705808  DT.100882919  DT.100882907 
DT.453065  DT.95356869  DT.121183540  DT.40268524  DT.97769860  DT.121183424  DT.121183435  DT.121183439 
DT.121183491  DT.121183515  DT.95292525  DT.95356894  DT.121183520  DT.70102025  DT.91764028 

24/519 AceView cDNA sequences (see all 519):

BE742343 CB269864 BU150998 AW305313 BQ575747 CD364356 AI379651 AA370297 
CA441779 F10534 AW316812 CB054682 AI129735 BQ575560 AI285570 BQ083517 
CA941777 BQ003032 AU118827 F13094 BQ007019 AL541218 BI858135 AA314702 

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for EMP1 (see all 8)    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d
SP1:                          -     -                 -     -     -                           
SP2:              -     -     -     -                 -     -     -                           
SP3:                          -     -                                                         
SP4:                                                  -     -     -                           
SP5:              -     -     -     -     -           -     -     -                           


ECgene alternative splicing isoforms for EMP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EMP1 expression in normal human tissues (normalized intensities)      EMP1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAATTTGCAT
EMP1 Expression
About this image


EMP1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/18 selected tissues (see all 18) fully expand
 
 Brain (Nervous System)    fully expand to see all 18 entries
         Postnatal Endothelial Cells Blood Brain Barrier
         Thalamus
         Septum   
 
 Endothelium (Cardiovascular System)    fully expand to see all 4 entries
         Postnatal Endothelial Cells Blood Brain Barrier
         Human umbilical vein endothelial cells (HUVEC)
         Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
 
 Adipose (Muscoskeletal System)    fully expand to see all 2 entries
         Visceral White Adipose
         omental adipose tissue   
 
 Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
         Pro-myelinating Schwann Cells Peripheral Nerve Domain
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
         Line H7 (WA07)

See EMP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EMP1

SOURCE GeneReport for Unigene cluster: Hs.719042
    SABiosciences Expression via Pathway-Focused PCR Arrays including EMP1: 
          TGFB/BMP Signaling Pathway in human mouse rat
          TGFB Signaling Targets in human mouse rat
          Signal Transduction PathwayFinder in human mouse rat

Primer
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EMP1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EMP1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EMP1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for EMP1 gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Emp11 , 5 epithelial membrane protein 11, 5 79.83(n)1
77.07(a)1
  6 (66.25 cM)5
137301  NM_010128.41  NP_034258.11 
 1353629315 
chicken
(Gallus gallus)
Aves EMP11 epithelial membrane protein 1 67.73(n)
68.79(a)
  417964  XM_416203.3  XP_416203.1 
lizard
(Anolis carolinensis)
Reptilia EMP16
Uncharacterized protein
64(a)
1 ↔ 1
GL343397.1(763272-774591)
African clawed frog
(Xenopus laevis)
Amphibia Xl.55052 Xenopus laevis transcribed sequence with weak similarity more 76.47(n)    CD328511.1 
zebrafish
(Danio rerio)
Actinopterygii emp16
epithelial membrane protein 1
32(a)
1 ↔ 1
1(45793835-45803328)


ENSEMBL Gene Tree for EMP1 (if available)
TreeFam Gene Tree for EMP1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for EMP1 gene
EMP22  PMP222  EMP32  
3 SIMAP similar genes for EMP1 using alignment to 7 protein entries:     EMP1_HUMAN (see all proteins):
PMP22    EMP2    EMP3

EMP1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/453 SNPs in EMP1 are shown (see all 453)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1484156011,2
--13347624(+) AGGCAC/GCTGAG 1 -- us2k10--------
rs1847409081,2
--13347688(+) AGAGTA/TGGAAA 1 -- us2k10--------
rs1425000481,2
--13347711(+) CAGGCC/TGATTC 1 -- us2k10--------
rs73157251,2
C,F,H--13347745(+) GGAGCG/ACCAGC 1 -- us2k18Minor allele frequency- A:0.17NS EA CSA WA NA 755
rs1509614811,2
--13348031(+) CAGCAG/TCATCA 1 -- us2k10--------
rs580786721,2
C--13348067(+) TGTGT-/G/GTGTGTGTGTGT/GTGTGTGTG
TGTGTGT
/GTGTGTGTGTGTGTGTGT
TGTGT
3 -- us2k1 cds11NA 2
rs1395004251,2
--13348153(+) CACATA/GCCAAC 1 -- us2k10--------
rs781383881,2
C,F--13348180(+) TATAGG/TTTCAT 1 -- us2k11Minor allele frequency- T:0.01WA 118
rs125813021,2
C,F,H--13348246(+) TAATTT/GTATCA 1 -- us2k1 tfbs324Minor allele frequency- G:0.19NS EA NA WA CSA 2766
rs604063571,2
C,F--13348430(+) CACACG/ACATAT 1 -- us2k12Minor allele frequency- A:0.10WA 120

HapMap Linkage Disequilibrium report for EMP1 (13349602 - 13369708 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for EMP1: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing EMP1
DNA2.0 Custom Variant and Variant Library Synthesis for EMP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 602333    OMIM disorders: --

20/23 diseases for EMP1 (see all 23):    About MalaCards
x-linked hypophosphatemia    hypophosphatemia    hyperphosphatemia    calcinosis
osteomalacia    nephrolithiasis    myoclonus    rickets
major depressive disorder    laryngeal carcinoma    hypercalcemia    esophageal cancer
hyperparathyroidism    leiomyoma    esophagitis    laryngitis
esophageal squamous cell carcinoma    bipolar disorder    nasopharyngitis    squamous cell carcinoma

7 diseases from the University of Copenhagen DISEASES database for EMP1:
X-linked hypophosphatemia     Hypophosphatemia     Rickets     Osteomalacia
Hyperparathyroidism     Calcinosis     Nephrolithiasis

EMP1 for disorders           About GeneDecksing

4 Novoseek inferred disease relationships for EMP1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer 19.2 1 17690741 (1)
glioma 12.1 1 16204036 (1)
tumors 7.2 8 17690741 (1), 19732125 (1), 19288191 (1)
cancer 0 1 17690741 (1)

Genetic Association Database (GAD): EMP1
Human Genome Epidemiology (HuGE) Navigator: EMP1 (2 documents)

Export disorders for EMP1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for EMP1 gene, integrated from 9 sources (see all 51):
(articles sorted by number of sources associating them with EMP1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family. (PubMed id 9126480)1, 2, 3, 9 Chen Y....Jetten A.M. (1997)
  2. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. (PubMed id 8996089)1, 2, 3 Ben-Porath I. and Benvenisty N. (1996)
  3. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Differential gene expression in human mammary carcinoma cells: identification of a new member of a receptor family. (PubMed id 9066625)1, 2 Schiemann S....Weidle U.H. (1997)
  6. B4B, a novel growth-arrest gene, is expressed by a subset of progenitor/pre-B lymphocytes negative for cytoplasmic mu-chain. (PubMed id 8683158)1, 2 Ruegg C.L.... Laus R. (1996)
  7. Up-regulation of epithelial membrane protein-1 in the temporal neocortex of patients with intractable epilepsy. (PubMed id 19288191)1, 9 Li Y.Q....Yao L. (2009)
  8. Analysis of gene expression profile induced by EMP-1 in esophageal cancer cells using cDNA Microarray. (PubMed id 12632483)1, 9 Wang H.T....Liu Z.H. (2003)
  9. Epithelial membrane protein-1 is a biomarker of gefitinib resistance. (PubMed id 16087880)1, 9 Jain A....Agus D.B. (2005)
  10. [Effect of EMP-1 gene on human esophageal cancer cell line] (PubMed id 12451984)1, 9 Wang H.T....Wu M. (2002)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2012 HGNC: 3333 AceView: EMP1 Ensembl:ENSG00000134531 euGenes: HUgn2012
ECgene: EMP1 H-InvDB: EMP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for EMP1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for EMP1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
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Patent Information for EMP1 gene:
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