Aliases for EML4 Gene
External Ids for EML4 Gene
Previous HGNC Symbols for EML4 Gene
Previous GeneCards Identifiers for EML4 Gene
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for EML4 Gene
EML4 (Echinoderm Microtubule Associated Protein Like 4) is a Protein Coding gene. Diseases associated with EML4 include Selection Of Therapeutic Option In Non-Small Cell Lung Carcinoma and Lung Cancer. Among its related pathways are Glioma and Cytoskeletal Signaling. An important paralog of this gene is EML2.
UniProtKB/Swiss-Prot for EML4 Gene
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.