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Aliases for EML4 Gene

Aliases for EML4 Gene

  • Echinoderm Microtubule Associated Protein Like 4 2 3 5
  • Restrictedly Overexpressed Proliferation-Associated Protein 3 4
  • Ropp 120 3 4
  • C2orf2 3 4
  • EMAP-4 3 4
  • EMAPL4 3 4
  • Echinoderm Microtubule-Associated Protein-Like 4 3
  • ROPP120 3
  • ELP120 3

External Ids for EML4 Gene

Previous HGNC Symbols for EML4 Gene

  • C2orf2

Previous GeneCards Identifiers for EML4 Gene

  • GC02P042385
  • GC02P042565
  • GC02P042371
  • GC02P042308
  • GC02P042397

Summaries for EML4 Gene

Entrez Gene Summary for EML4 Gene

  • This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for EML4 Gene

EML4 (Echinoderm Microtubule Associated Protein Like 4) is a Protein Coding gene. Diseases associated with EML4 include Lung Cancer and Congenital Pulmonary Airway Malformation. Among its related pathways are Glioma and Cytoskeletal Signaling. An important paralog of this gene is EML1.

UniProtKB/Swiss-Prot for EML4 Gene

  • May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

Gene Wiki entry for EML4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EML4 Gene

Genomics for EML4 Gene

Regulatory Elements for EML4 Gene

Enhancers for EML4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F042123 1.1 FANTOM5 Ensembl ENCODE 56.2 -35.8 -35835 20.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC EML4 ENSG00000226398 VDAC1P13 COX7A2L LOC102723824 LINC01914 OXER1 HAAO LOC105374531
GH02F042095 1.3 FANTOM5 Ensembl ENCODE 35.7 -65.7 -65747 15.6 HDGF MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 ZNF207 FOS PAF1 EML4 PKDCC LOC102723824 COX7A2L HAAO LOC105374531
GH02F042335 1.1 FANTOM5 Ensembl ENCODE 32 +171.0 170990 9.5 PKNOX1 SIN3A ARID4B DMAP1 ZNF48 ZNF143 FOS PAF1 ZNF263 JUNB COX7A2L EML4 LOC102723824 OXER1 GC02M042355 GC02P042307
GH02F042189 1.2 Ensembl ENCODE 31.2 +25.9 25896 11.9 PKNOX1 ARNT MLX SIN3A ARID4B FEZF1 DMAP1 YY1 SLC30A9 CBX5 COX7A2L EML4 LOC102723824 HAAO GC02M042233
GH02F042256 1 Ensembl ENCODE 29.8 +87.4 87432 1.5 PAF1 PKNOX1 ETV6 TBX21 SPI1 COX7A2L EML4 LOC102723824 GC02P042259 GC02M042239
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EML4 on UCSC Golden Path with GeneCards custom track

Promoters for EML4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000012672 1662 4001 HDGF WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for EML4 Gene

42,169,338 bp from pter
42,332,548 bp from pter
163,211 bases
Plus strand

Genomic View for EML4 Gene

Genes around EML4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EML4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EML4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EML4 Gene

Proteins for EML4 Gene

  • Protein details for EML4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Echinoderm microtubule-associated protein-like 4
    Protein Accession:
    Secondary Accessions:
    • A6H8Y6
    • B2RBK3
    • B2RTW7
    • B5MCW9
    • Q3SWW0
    • Q53R29
    • Q53TW8
    • Q6PJ45
    • Q9NV40

    Protein attributes for EML4 Gene

    981 amino acids
    Molecular mass:
    108916 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI04648.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91919.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EML4 Gene

    Alternative splice isoforms for EML4 Gene


neXtProt entry for EML4 Gene

Post-translational modifications for EML4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EML4 Gene

No data available for DME Specific Peptides for EML4 Gene

Domains & Families for EML4 Gene

Gene Families for EML4 Gene

Suggested Antigen Peptide Sequences for EML4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat EMAP family.
  • Contains 9 WD repeats.
  • Belongs to the WD repeat EMAP family.
  • Contains 9 WD repeats.
genes like me logo Genes that share domains with EML4: view

Function for EML4 Gene

Molecular function for EML4 Gene

UniProtKB/Swiss-Prot Function:
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

Gene Ontology (GO) - Molecular Function for EML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008017 microtubule binding IBA --
genes like me logo Genes that share ontologies with EML4: view

Phenotypes for EML4 Gene

genes like me logo Genes that share phenotypes with EML4: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EML4 Gene

Localization for EML4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EML4 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for EML4 Gene COMPARTMENTS Subcellular localization image for EML4 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
plasma membrane 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for EML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 10995578
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0015630 microtubule cytoskeleton IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EML4: view

Pathways & Interactions for EML4 Gene

SuperPathways for EML4 Gene

genes like me logo Genes that share pathways with EML4: view

Pathways by source for EML4 Gene

1 Cell Signaling Technology pathway for EML4 Gene
1 KEGG pathway for EML4 Gene

Gene Ontology (GO) - Biological Process for EML4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0007017 microtubule-based process NAS 10995578
GO:0007067 mitotic nuclear division NAS 10995578
genes like me logo Genes that share ontologies with EML4: view

No data available for SIGNOR curated interactions for EML4 Gene

Drugs & Compounds for EML4 Gene

(1) Drugs for EML4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ceritinib Approved Pharma 36
genes like me logo Genes that share compounds with EML4: view

Transcripts for EML4 Gene

Unigene Clusters for EML4 Gene

Echinoderm microtubule associated protein like 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EML4 Gene

No ASD Table

Relevant External Links for EML4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EML4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EML4 Gene

Protein differential expression in normal tissues from HIPED for EML4 Gene

This gene is overexpressed in Lymph node (16.5) and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EML4 Gene

Protein tissue co-expression partners for EML4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EML4 Gene:


SOURCE GeneReport for Unigene cluster for EML4 Gene:

genes like me logo Genes that share expression patterns with EML4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EML4 Gene

Orthologs for EML4 Gene

This gene was present in the common ancestor of animals.

Orthologs for EML4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EML4 34 35
  • 97.9 (n)
(Canis familiaris)
Mammalia EML4 34 35
  • 92.73 (n)
(Bos Taurus)
Mammalia EML4 34 35
  • 92.65 (n)
(Mus musculus)
Mammalia Eml4 34 16 35
  • 88 (n)
(Rattus norvegicus)
Mammalia Eml4 34
  • 87.32 (n)
(Monodelphis domestica)
Mammalia EML4 35
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
-- 35
  • 54 (a)
(Gallus gallus)
Aves EML4 34 35
  • 80.74 (n)
(Anolis carolinensis)
Reptilia EML4 35
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia eml4 34
  • 74.05 (n)
Str.7603 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14971 34
(Danio rerio)
Actinopterygii EML4 (2 of 2) 35
  • 72 (a)
EML4 (1 of 2) 35
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13466 36
  • 34 (a)
  • 24 (a)
(Caenorhabditis elegans)
Secernentea elp-1 36 35
  • 28 (a)
Species where no ortholog for EML4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EML4 Gene

Gene Tree for EML4 (if available)
Gene Tree for EML4 (if available)

Paralogs for EML4 Gene

Paralogs for EML4 Gene

(8) SIMAP similar genes for EML4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EML4: view

Variants for EML4 Gene

Sequence variations from dbSNP and Humsavar for EML4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10084442 -- 42,196,032(+) ATATA(A/G)TATTT intron-variant
rs10164865 -- 42,178,603(+) GTGTG(A/G)TGCCT intron-variant
rs10165230 -- 42,203,041(+) AATAA(G/T)AAGAA intron-variant
rs10166619 -- 42,191,443(+) GTTAC(A/G)TCAAA intron-variant
rs10169492 -- 42,174,821(+) ttttt(G/T)tttgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EML4 Gene

Variant ID Type Subtype PubMed ID
dgv1117e212 CNV loss 25503493
dgv6825n54 CNV loss 21841781
dgv6826n54 CNV loss 21841781
esv2533393 CNV deletion 19546169
esv2763299 CNV gain+loss 21179565
esv3555555 CNV deletion 23714750
esv3583755 CNV loss 25503493
esv3583756 CNV loss 25503493
esv3590499 CNV loss 21293372
esv3590500 CNV loss 21293372
esv3590501 CNV loss 21293372
esv3891982 CNV loss 25118596
esv8006 CNV gain 19470904
nsv1005165 CNV loss 25217958
nsv2705 CNV insertion 18451855
nsv2706 CNV deletion 18451855
nsv441755 CNV loss 18776908
nsv521335 CNV gain 19592680
nsv525133 CNV gain 19592680
nsv581635 CNV loss 21841781
nsv581640 CNV loss 21841781
nsv581642 CNV loss 21841781

Variation tolerance for EML4 Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.17; 87.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EML4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EML4 Gene

Disorders for EML4 Gene

MalaCards: The human disease database

(6) MalaCards diseases for EML4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
congenital pulmonary airway malformation
  • ccam
inflammatory myofibroblastic tumor
  • inflammatory fibrosarcoma
lung papillary adenocarcinoma
  • papillary adenocarcinoma of the lung
childhood kidney cell carcinoma
  • pediatric renal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search EML4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EML4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with EML4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EML4 Gene

Publications for EML4 Gene

  1. Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene. (PMID: 20183914) Takahashi T. … Date H. (Ann. Surg. Oncol. 2010) 3 22 64
  2. Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression. (PMID: 20624322) Zhang X. … Wu Y.L. (Mol. Cancer 2010) 3 46 64
  3. EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. (PMID: 18166835) Inamura K. … Ishikawa Y. (J Thorac Oncol 2008) 3 22 64
  4. EML4-ALK fusion transcript is not found in gastrointestinal and breast cancers. (PMID: 18414414) Fukuyoshi Y. … Mori M. (Br. J. Cancer 2008) 3 22 64
  5. Identification of the transforming EML4-ALK fusion gene in non-small- cell lung cancer. (PMID: 17625570) Soda M. … Mano H. (Nature 2007) 3 22 64

Products for EML4 Gene

Sources for EML4 Gene

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