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Aliases for EML3 Gene

Aliases for EML3 Gene

  • Echinoderm Microtubule Associated Protein Like 3 2 3 5
  • EMAP-3 3 4
  • Echinoderm Microtubule-Associated Protein-Like 3 3
  • ELP95 3

External Ids for EML3 Gene

Previous GeneCards Identifiers for EML3 Gene

  • GC11M062127
  • GC11M062370
  • GC11M058698

Summaries for EML3 Gene

GeneCards Summary for EML3 Gene

EML3 (Echinoderm Microtubule Associated Protein Like 3) is a Protein Coding gene. An important paralog of this gene is EML4.

UniProtKB/Swiss-Prot for EML3 Gene

  • May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

Additional gene information for EML3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EML3 Gene

Genomics for EML3 Gene

Regulatory Elements for EML3 Gene

Enhancers for EML3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H062551 2.1 FANTOM5 Ensembl ENCODE dbSUPER 58.6 +55.6 55589 12 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF207 EML3 TUT1 MTA2 TAF6L NXF1 LOC105369332 WDR74 STX5 INTS5 TTC9C
GH11H062852 1.7 FANTOM5 ENCODE dbSUPER 44.7 -243.1 -243073 5 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 SNHG1 METTL12 NXF1 MTA2 GANAB INTS5 UBXN1 EML3 STX5 LOC105369332
GH11H062669 1.1 ENCODE 68.9 -58.7 -58724 4 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 EML3 WDR74 LOC105369332 GANAB MTA2 STX5 INTS5 METTL12 NXF1 SNHG1
GH11H062537 1.8 FANTOM5 ENCODE dbSUPER 38.1 +68.9 68853 11 HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B EML3 NXF1 TAF6L TUT1 STX5 WDR74 B3GAT3 AHNAK SLC3A2 UBXN1
GH11H062838 1.5 ENCODE dbSUPER 44.7 -228.1 -228081 4 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC UBXN1 METTL12 WDR74 NXF1 SNHG1 INTS5 LOC105369332 STX5 MTA2 GANAB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EML3 on UCSC Golden Path with GeneCards custom track

Promoters for EML3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040452 265 1401 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 GLIS2 ELK1 ZNF143

Genomic Location for EML3 Gene

Chromosome:
11
Start:
62,602,218 bp from pter
End:
62,612,765 bp from pter
Size:
10,548 bases
Orientation:
Minus strand

Genomic View for EML3 Gene

Genes around EML3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EML3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EML3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EML3 Gene

Proteins for EML3 Gene

  • Protein details for EML3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q32P44-EMAL3_HUMAN
    Recommended name:
    Echinoderm microtubule-associated protein-like 3
    Protein Accession:
    Q32P44
    Secondary Accessions:
    • Q6ZQW7
    • Q8NA55

    Protein attributes for EML3 Gene

    Size:
    896 amino acids
    Molecular mass:
    95197 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC87566.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for EML3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EML3 Gene

Post-translational modifications for EML3 Gene

  • Ubiquitination at isoforms=2, 334 and posLast=577577
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EML3 Gene

Domains & Families for EML3 Gene

Gene Families for EML3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for EML3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q32P44

UniProtKB/Swiss-Prot:

EMAL3_HUMAN :
  • Belongs to the WD repeat EMAP family.
Family:
  • Belongs to the WD repeat EMAP family.
genes like me logo Genes that share domains with EML3: view

Function for EML3 Gene

Molecular function for EML3 Gene

UniProtKB/Swiss-Prot Function:
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

Phenotypes From GWAS Catalog for EML3 Gene

Gene Ontology (GO) - Molecular Function for EML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15324660
GO:0008017 microtubule binding IBA --
genes like me logo Genes that share ontologies with EML3: view
genes like me logo Genes that share phenotypes with EML3: view

Animal Model Products

CRISPR Products

miRNA for EML3 Gene

miRTarBase miRNAs that target EML3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EML3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EML3 Gene

Localization for EML3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EML3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EML3 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0015630 microtubule cytoskeleton IBA --
genes like me logo Genes that share ontologies with EML3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EML3 Gene

Pathways & Interactions for EML3 Gene

No Data Available

Interacting Proteins for EML3 Gene

Gene Ontology (GO) - Biological Process for EML3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EML3 Gene

Drugs & Compounds for EML3 Gene

No Compound Related Data Available

Transcripts for EML3 Gene

Unigene Clusters for EML3 Gene

Echinoderm microtubule associated protein like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EML3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for EML3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - -
SP6: -
SP7:
SP8:
SP9:

ExUns: 21a · 21b · 21c ^ 22a · 22b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for EML3 Gene

GeneLoc Exon Structure for
EML3
ECgene alternative splicing isoforms for
EML3

Expression for EML3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EML3 Gene

Protein differential expression in normal tissues from HIPED for EML3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.1), Lymph node (17.5), and Tlymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EML3 Gene



Protein tissue co-expression partners for EML3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EML3 Gene:

EML3

SOURCE GeneReport for Unigene cluster for EML3 Gene:

Hs.379785

Evidence on tissue expression from TISSUES for EML3 Gene

  • Liver(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with EML3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EML3 Gene

Orthologs for EML3 Gene

This gene was present in the common ancestor of animals.

Orthologs for EML3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EML3 33 34
  • 99.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EML3 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EML3 33 34
  • 91.26 (n)
dog
(Canis familiaris)
Mammalia EML3 33 34
  • 89.83 (n)
mouse
(Mus musculus)
Mammalia Eml3 33 16 34
  • 87.95 (n)
rat
(Rattus norvegicus)
Mammalia LOC102551660 33
  • 87.83 (n)
oppossum
(Monodelphis domestica)
Mammalia EML3 34
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EML3 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eml3 33
  • 64.93 (n)
zebrafish
(Danio rerio)
Actinopterygii eml3 33 34
  • 67.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta DCX-EMAP 34
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea elp-1 34
  • 23 (a)
OneToMany
Species where no ortholog for EML3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EML3 Gene

ENSEMBL:
Gene Tree for EML3 (if available)
TreeFam:
Gene Tree for EML3 (if available)

Paralogs for EML3 Gene

Paralogs for EML3 Gene

genes like me logo Genes that share paralogs with EML3: view

Variants for EML3 Gene

Sequence variations from dbSNP and Humsavar for EML3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs527236104 Pathogenic 62,613,612(+) GTGGG(-/G)GGGGG upstream-variant-2KB, reference, frameshift-variant
rs137950927 Likely benign 62,614,479(+) TAGCA(A/C/T)GCTGG upstream-variant-2KB, reference, missense
rs150168119 Likely benign 62,614,353(+) AAACC(A/G)TCTTT upstream-variant-2KB, reference, missense
rs1801144 Likely benign 62,614,336(+) CCCCG(A/C/G)CCTTG upstream-variant-2KB, reference, synonymous-codon
rs3923805 Likely benign 62,612,953(+) GAAGG(G/T)AGCGC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for EML3 Gene

Variant ID Type Subtype PubMed ID
esv3579735 CNV loss 25503493
esv3584599 CNV gain 24956385
nsv476119 CNV novel sequence insertion 20440878
nsv555174 CNV gain 21841781
nsv825939 CNV gain 20364138
nsv832182 CNV gain+loss 17160897

Variation tolerance for EML3 Gene

Residual Variation Intolerance Score: 5.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EML3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EML3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EML3 Gene

Disorders for EML3 Gene

Relevant External Links for EML3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EML3

No disorders were found for EML3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EML3 Gene

Publications for EML3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. (PMID: 14744259) Pozuelo Rubio M … Mackintosh C (The Biochemical journal 2004) 2 3 60
  3. Eml5, a novel WD40 domain protein expressed in rat brain. (PMID: 15225882) O'Connor V … French PJ (Gene 2004) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for EML3 Gene

Sources for EML3 Gene

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