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Aliases for EML3 Gene

Aliases for EML3 Gene

  • Echinoderm Microtubule Associated Protein Like 3 2 3 5
  • EMAP-3 3 4
  • Echinoderm Microtubule-Associated Protein-Like 3 3
  • ELP95 3

External Ids for EML3 Gene

Previous GeneCards Identifiers for EML3 Gene

  • GC11M062127
  • GC11M062370
  • GC11M058698

Summaries for EML3 Gene

GeneCards Summary for EML3 Gene

EML3 (Echinoderm Microtubule Associated Protein Like 3) is a Protein Coding gene. An important paralog of this gene is EML4.

UniProtKB/Swiss-Prot for EML3 Gene

  • May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EML3 Gene

Genomics for EML3 Gene

Regulatory Elements for EML3 Gene

Enhancers for EML3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around EML3 on UCSC Golden Path with GeneCards custom track

Promoters for EML3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for EML3 Gene

62,602,218 bp from pter
62,612,765 bp from pter
10,548 bases
Minus strand

Genomic View for EML3 Gene

Genes around EML3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EML3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EML3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EML3 Gene

Proteins for EML3 Gene

  • Protein details for EML3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Echinoderm microtubule-associated protein-like 3
    Protein Accession:
    Secondary Accessions:
    • Q6ZQW7
    • Q8NA55

    Protein attributes for EML3 Gene

    896 amino acids
    Molecular mass:
    95197 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC87566.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for EML3 Gene


neXtProt entry for EML3 Gene

Post-translational modifications for EML3 Gene

  • Ubiquitination at Lys 34 and Lys 577
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EML3 Gene

Domains & Families for EML3 Gene

Gene Families for EML3 Gene

Suggested Antigen Peptide Sequences for EML3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat EMAP family.
  • Contains 9 WD repeats.
  • Belongs to the WD repeat EMAP family.
  • Contains 9 WD repeats.
genes like me logo Genes that share domains with EML3: view

Function for EML3 Gene

Molecular function for EML3 Gene

UniProtKB/Swiss-Prot Function:
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
genes like me logo Genes that share phenotypes with EML3: view

Animal Model Products

CRISPR Products

miRNA for EML3 Gene

miRTarBase miRNAs that target EML3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EML3 Gene

Localization for EML3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EML3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for EML3 Gene COMPARTMENTS Subcellular localization image for EML3 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for EML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with EML3: view

Pathways & Interactions for EML3 Gene

SuperPathways for EML3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EML3 Gene


No data available for Pathways by source and SIGNOR curated interactions for EML3 Gene

Drugs & Compounds for EML3 Gene

No Compound Related Data Available

Transcripts for EML3 Gene

Unigene Clusters for EML3 Gene

Echinoderm microtubule associated protein like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EML3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - -
SP6: -

ExUns: 21a · 21b · 21c ^ 22a · 22b
SP1: -
SP2: -

Relevant External Links for EML3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EML3 Gene

mRNA expression in normal human tissues for EML3 Gene

Protein differential expression in normal tissues from HIPED for EML3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.1), Lymph node (17.5), and Tlymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EML3 Gene

Protein tissue co-expression partners for EML3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EML3 Gene:


SOURCE GeneReport for Unigene cluster for EML3 Gene:

genes like me logo Genes that share expression patterns with EML3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EML3 Gene

Orthologs for EML3 Gene

This gene was present in the common ancestor of animals.

Orthologs for EML3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EML3 34
  • 91.26 (n)
  • 93.39 (a)
EML3 35
  • 94 (a)
(Canis familiaris)
Mammalia EML3 34
  • 89.83 (n)
  • 92.29 (a)
EML3 35
  • 93 (a)
(Mus musculus)
Mammalia Eml3 34
  • 87.95 (n)
  • 93.64 (a)
Eml3 16
Eml3 35
  • 94 (a)
(Pan troglodytes)
Mammalia EML3 34
  • 99.59 (n)
  • 99.89 (a)
EML3 35
  • 97 (a)
(Rattus norvegicus)
Mammalia LOC102551660 34
  • 87.83 (n)
  • 93.19 (a)
(Monodelphis domestica)
Mammalia EML3 35
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia EML3 35
  • 92 (a)
(Anolis carolinensis)
Reptilia EML3 35
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia eml3 34
  • 64.93 (n)
  • 69.68 (a)
(Danio rerio)
Actinopterygii eml3 34
  • 67.45 (n)
  • 69.11 (a)
eml3 35
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta DCX-EMAP 35
  • 24 (a)
(Caenorhabditis elegans)
Secernentea elp-1 35
  • 23 (a)
Species where no ortholog for EML3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EML3 Gene

Gene Tree for EML3 (if available)
Gene Tree for EML3 (if available)

Paralogs for EML3 Gene

Paralogs for EML3 Gene

genes like me logo Genes that share paralogs with EML3: view

Variants for EML3 Gene

Sequence variations from dbSNP and Humsavar for EML3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs34098002 - 62,605,698(+) GAGCT(G/T)CCGGT reference, missense
rs34065644 -- 62,604,466(+) TCCAC(C/T)TCCTG intron-variant
rs34894392 -- 62,607,349(+) CGGGC(A/G)TGATG intron-variant
rs34993735 -- 62,610,368(+) CCGGC(-/G)CACTA intron-variant
rs2512559 -- 62,606,784(+) CCTGG(A/G)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EML3 Gene

Variant ID Type Subtype PubMed ID
esv3579735 CNV loss 25503493
esv3584599 CNV gain 24956385
nsv476119 CNV novel sequence insertion 20440878
nsv555174 CNV gain 21841781
nsv825939 CNV gain 20364138
nsv832182 CNV gain+loss 17160897

Variation tolerance for EML3 Gene

Residual Variation Intolerance Score: 5.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EML3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EML3 Gene

Disorders for EML3 Gene

Relevant External Links for EML3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EML3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EML3 Gene

Publications for EML3 Gene

  1. 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. (PMID: 14744259) Pozuelo Rubio M. … Mackintosh C. (Biochem. J. 2004) 2 3 65
  2. Eml5, a novel WD40 domain protein expressed in rat brain. (PMID: 15225882) O'Connor V. … French P.J. (Gene 2004) 2 3 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain. (PMID: 25740311) Richards M.W. … Bayliss R. (Biochem. J. 2015) 3 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for EML3 Gene

Sources for EML3 Gene

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