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Aliases for EML3 Gene

Aliases for EML3 Gene

  • Echinoderm Microtubule Associated Protein Like 3 2 3
  • EMAP-3 3 4
  • ELP95 3

External Ids for EML3 Gene

Previous GeneCards Identifiers for EML3 Gene

  • GC11M062127
  • GC11M062370
  • GC11M058698

Summaries for EML3 Gene

GeneCards Summary for EML3 Gene

EML3 (Echinoderm Microtubule Associated Protein Like 3) is a Protein Coding gene. An important paralog of this gene is EML5.

UniProtKB/Swiss-Prot for EML3 Gene

  • May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EML3 Gene

Genomics for EML3 Gene

Regulatory Elements for EML3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EML3 Gene

Chromosome:
11
Start:
62,602,218 bp from pter
End:
62,612,765 bp from pter
Size:
10,548 bases
Orientation:
Minus strand

Genomic View for EML3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EML3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EML3 Gene

Proteins for EML3 Gene

  • Protein details for EML3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q32P44-EMAL3_HUMAN
    Recommended name:
    Echinoderm microtubule-associated protein-like 3
    Protein Accession:
    Q32P44
    Secondary Accessions:
    • Q6ZQW7
    • Q8NA55

    Protein attributes for EML3 Gene

    Size:
    896 amino acids
    Molecular mass:
    95197 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC87566.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for EML3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EML3 Gene

Proteomics data for EML3 Gene at MOPED

Post-translational modifications for EML3 Gene

  • Ubiquitination at Lys 34 and Lys 577
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EML3 Gene

Domains & Families for EML3 Gene

Gene Families for EML3 Gene

Suggested Antigen Peptide Sequences for EML3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q32P44

UniProtKB/Swiss-Prot:

EMAL3_HUMAN :
  • Belongs to the WD repeat EMAP family.
  • Contains 9 WD repeats.
Family:
  • Belongs to the WD repeat EMAP family.
Similarity:
  • Contains 9 WD repeats.
genes like me logo Genes that share domains with EML3: view

Function for EML3 Gene

Molecular function for EML3 Gene

UniProtKB/Swiss-Prot Function:
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

Gene Ontology (GO) - Molecular Function for EML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with EML3: view
genes like me logo Genes that share phenotypes with EML3: view

Animal Model Products

miRNA for EML3 Gene

miRTarBase miRNAs that target EML3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EML3 Gene

Localization for EML3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EML3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EML3 Gene COMPARTMENTS Subcellular localization image for EML3 gene
Compartment Confidence
cytoskeleton 3
nucleus 3

Gene Ontology (GO) - Cellular Components for EML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with EML3: view

Pathways & Interactions for EML3 Gene

SuperPathways for EML3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EML3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EML3 Gene

Drugs & Compounds for EML3 Gene

No Compound Related Data Available

Transcripts for EML3 Gene

Unigene Clusters for EML3 Gene

Echinoderm microtubule associated protein like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EML3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - -
SP6: -
SP7:
SP8:
SP9:

ExUns: 21a · 21b · 21c ^ 22a · 22b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for EML3 Gene

GeneLoc Exon Structure for
EML3
ECgene alternative splicing isoforms for
EML3

Expression for EML3 Gene

mRNA expression in normal human tissues for EML3 Gene

Protein differential expression in normal tissues from HIPED for EML3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.1), Lymph node (17.5), and Tlymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EML3 Gene



SOURCE GeneReport for Unigene cluster for EML3 Gene Hs.379785

genes like me logo Genes that share expression patterns with EML3: view

Protein tissue co-expression partners for EML3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EML3 Gene

Orthologs for EML3 Gene

This gene was present in the common ancestor of animals.

Orthologs for EML3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EML3 35
  • 91.26 (n)
  • 93.39 (a)
EML3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EML3 35
  • 89.83 (n)
  • 92.29 (a)
EML3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eml3 35
  • 87.95 (n)
  • 93.64 (a)
Eml3 16
Eml3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EML3 35
  • 99.59 (n)
  • 99.89 (a)
EML3 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102551660 35
  • 87.83 (n)
  • 93.19 (a)
oppossum
(Monodelphis domestica)
Mammalia EML3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EML3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EML3 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eml3 35
  • 64.93 (n)
  • 69.68 (a)
zebrafish
(Danio rerio)
Actinopterygii eml3 35
  • 67.45 (n)
  • 69.11 (a)
eml3 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta DCX-EMAP 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea elp-1 36
  • 23 (a)
OneToMany
Species with no ortholog for EML3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EML3 Gene

ENSEMBL:
Gene Tree for EML3 (if available)
TreeFam:
Gene Tree for EML3 (if available)

Paralogs for EML3 Gene

Paralogs for EML3 Gene

genes like me logo Genes that share paralogs with EML3: view

Variants for EML3 Gene

Sequence variations from dbSNP and Humsavar for EML3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2512559 -- 62,606,784(+) CCTGG(A/G)AGGCA intron-variant
rs2516633 -- 62,604,301(-) TCTCT(G/T)ATTTG intron-variant
rs7939473 -- 62,607,337(+) acaaa(A/C)aaaaa intron-variant
rs12281020 -- 62,608,333(+) GTGAA(A/C/T)CCTGG intron-variant
rs12281309 -- 62,609,732(+) GGGTC(A/G)GGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EML3 Gene

Variant ID Type Subtype PubMed ID
nsv832182 CNV Gain+Loss 17160897
nsv825939 CNV Gain 20364138
nsv897622 CNV Loss 21882294

Variation tolerance for EML3 Gene

Residual Variation Intolerance Score: 5.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EML3 Gene

HapMap Linkage Disequilibrium report
EML3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EML3 Gene

Disorders for EML3 Gene

Relevant External Links for EML3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EML3
genes like me logo Genes that share disorders with EML3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EML3 Gene

Publications for EML3 Gene

  1. 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. (PMID: 14744259) Pozuelo Rubio M. … Mackintosh C. (Biochem. J. 2004) 2 67
  2. Eml5, a novel WD40 domain protein expressed in rat brain. (PMID: 15225882) O'Connor V. … French P.J. (Gene 2004) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 67

Products for EML3 Gene

Sources for EML3 Gene

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