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EML2 Gene

protein-coding   GIFtS: 52
GCID: GC19M046112

Echinoderm Microtubule Associated Protein Like 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Echinoderm Microtubule Associated Protein Like 21 2     ELP702
Echinoderm MT-Associated Protein (EMAP)-Like Protein 701 2     Echinoderm Microtubule-Associated Protein-Like 22
Microtubule-Associated Protein Like Echinoderm EMAP1 2     EMAPL23
EMAP-22 3     HuEMAP-23
EMAP22 3     TRTLT25

External Ids:    HGNC: 180351   Entrez Gene: 241392   Ensembl: ENSG000001257467   OMIM: 6097155   UniProtKB: O958343   

Export aliases for EML2 gene to outside databases

Previous GC identifers: GC19M046756 GC19M046503 GC19M050788 GC19M050804 GC19M042541


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EML2 Gene:
EML2 (echinoderm microtubule associated protein like 2) is a protein-coding gene. An important paralog of this gene is EML3.

UniProtKB/Swiss-Prot: EMAL2_HUMAN, O95834
Function: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more
dynamic (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EML2 gene promoter:
         AhR   Max1   AML1a   AP-4   GATA-2   Arnt   C/EBPalpha   CREB   deltaCREB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEML2 promoter sequence
   Search Chromatin IP Primers for EML2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EML2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

EML2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EML2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M046112:  view genomic region     (about GC identifiers)

Start:
46,110,252 bp from pter      End:
46,148,887 bp from pter
Size:
38,636 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EMAL2_HUMAN, O95834 (See protein sequence)
Recommended Name: Echinoderm microtubule-associated protein-like 2  
Size: 649 amino acids; 70679 Da
Secondary accessions: B7Z3I2 B7Z3Q9 K7ERL7 Q59EN8 Q8N5A2 Q9UG50
Alternative splicing: 3 isoforms:  O95834-1   O95834-2   O95834-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EML2: NX_O95834

Explore proteomics data for EML2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See EML2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180197.1  NP_001180198.1  NP_036287.1  

    ENSEMBL proteins: 
     ENSP00000464789   ENSP00000468329   ENSP00000465339   ENSP00000245925   ENSP00000442365  
     ENSP00000468312   ENSP00000465885   ENSP00000465994   ENSP00000464950   ENSP00000382503  
     ENSP00000464764   ENSP00000466100   ENSP00000465607   ENSP00000468383   ENSP00000465786  
     ENSP00000468470   ENSP00000467941   ENSP00000464804   ENSP00000468373   ENSP00000468768  

    EML2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR005108 HELP
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR011047 Quinonprotein_ADH-like_supfam

    Graphical View of Domain Structure for InterPro Entry O95834

    ProtoNet protein and cluster: O95834

    1 Blocks protein domain: IPB005108 HELP domain

    UniProtKB/Swiss-Prot: EMAL2_HUMAN, O95834
    Similarity: Belongs to the WD repeat EMAP family
    Similarity: Contains 11 WD repeats


    Find genes that share domains with EML2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EMAL2_HUMAN, O95834
    Function: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more
    dynamic (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005102receptor binding IEA--
    GO:0005515protein binding ----
    GO:0008022protein C-terminus binding IEA--
         
    Find genes that share ontologies with EML2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for EML2:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EML2
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    hsa-miR-330-5p hsa-miR-326 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidEML2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): EML2 (NM_012155)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EML2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EMAL2_HUMAN, O95834: Cytoplasm, cytoskeleton (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    plasma membrane2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex TAS10521658
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with EML2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EML2
    Interactions:

        Search GeneGlobe Interaction Network for EML2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for EML2 (O958343 ENSP000002459254) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK6Q9HC983, ENSP000003627024I2D: score=2 STRING: ENSP00000362702
    GRID1Q9ULK03I2D: score=1 
    GRID2O434243I2D: score=1 
    NEK9Q8TD193I2D: score=1 
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007601visual perception TAS10521658
    GO:0007605sensory perception of sound TAS10521658

    Find genes that share ontologies with EML2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EML2 (EMAL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EML2 gene (3 alternative transcripts): 
    NM_001193268.1  NM_001193269.1  NM_012155.2  

    Unigene Cluster for EML2:

    Echinoderm microtubule associated protein like 2
    Hs.24178  [show with all ESTs]
    Unigene Representative Sequence: NM_001193268
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000589876 ENST00000588308 ENST00000586195 ENST00000245925(uc002pcn.3 uc002pcp.3 uc002pco.3 uc010xxo.2 uc010ekj.3)
    ENST00000536630(uc010xxl.2 uc010xxm.2) ENST00000587152 ENST00000592433
    ENST00000586405 ENST00000587484 ENST00000592482 ENST00000590819 ENST00000399594(uc010xxn.1 uc010ekk.1 uc010ekl.3)
    ENST00000590575 ENST00000588272 ENST00000588000 ENST00000588610 ENST00000588496
    ENST00000586902
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate EML2:
    hsa-miR-330-5p hsa-miR-326 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidEML2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EML2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): EML2 (NM_012155)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EML2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EML2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for EML2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EML2
      QuantiTect SYBR Green Assays in human, mouse, rat EML2
      QuantiFast Probe-based Assays in human, mouse, rat EML2

    Additional mRNA sequence: 

    AB209773.1 AF103939.1 AK024984.1 AK026616.1 AK225043.1 AK294668.1 AK295905.1 AK296258.1 
    AK304299.1 AK308403.1 AK308580.1 AL096717.1 BC029304.1 NR_034098.1 

    24 DOTS entries:

    DT.210578  DT.100703025  DT.91754596  DT.121495670  DT.97791555  DT.91959849  DT.100788533  DT.100788545 
    DT.91754598  DT.97778608  DT.100026111  DT.101983905  DT.70102261  DT.95290255  DT.100788548  DT.91715760 
    DT.121495695  DT.121495711  DT.92067947  DT.95102980  DT.97844331  DT.100026110  DT.100788544  DT.75152129 

    Selected AceView cDNA sequences (see all 196):

    BM543723 AF103939 BP368652 AI312515 BX377816 AA352385 AI369855 AI700239 
    BI063914 AI740707 BM674983 AI376302 BX356387 BM920766 NM_012155 BC029304 
    CB135263 BQ053860 AW593841 AW105193 BM717489 CD624285 BF000696 AI701494 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EML2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^
    SP1:                                -     -                                                                                               -           -         
    SP2:                                -     -                                                                       -           -     -     -           -         
    SP3:                          -     -     -     -     -                                                                                   -           -         
    SP4:                                                                                                                                      -                     
    SP5:                          -     -                                                                                                                           

    ExUns: 21 ^ 22a · 22b · 22c
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for EML2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EML2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTGACCA
    EML2 Expression
    About this image

    EML2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EML2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.24178

    UniProtKB/Swiss-Prot: EMAL2_HUMAN, O95834
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for EML2
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    QuantiFast Probe-based Assays in human, mouse, rat EML2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EML2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EML2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eml21 , 5 echinoderm microtubule associated protein like 21, 5 88.27(n)1
    95.17(a)1
      7 (9.46 cM)5
    722051  NM_001162996.11  NP_001156468.11 
     191764215 
    lizard
    (Anolis carolinensis)
    Reptilia EML26
    echinoderm microtubule associated protein like 2
    77(a)
    1 ↔ 1
    GL343870.1(25204-89133)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.88662 Xenopus laevis transcribed sequence with weak similarity more 73.09(n)    CD519805.1 
    zebrafish
    (Danio rerio)
    Actinopterygii eml21 echinoderm microtubule associated protein like 2 65.83(n)
    68.22(a)
      569375  NM_001030235.1  NP_001025406.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG134663 microtubule-based process microtubule
    binding
    36(a)   71A2   --
    worm
    (Caenorhabditis elegans)
    Secernentea elp-11 , 3 WD domain, G-beta repeat3
    elp-11
    29(a)3
    41.29(n)1
    30.46(a)1
      V(20757166-20762289)3
    1803581  NM_001270022.11  NP_001256951.11 


    ENSEMBL Gene Tree for EML2 (if available)
    TreeFam Gene Tree for EML2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EML2 gene
    EML32  EML52  EML62  EML42  EML12  
    Selected SIMAP similar genes for EML2 using alignment to 17 protein entries:     EMAL2_HUMAN (see all proteins) (see all similar genes):
    AURA2    DCTN5    PKN1    PLA2G15    ZNF546    DNMT1
    FKBP3    TCF4    RNF217    NF2    UTY    ZNF212
    ZNF737    ZNF738    PLEKHH2    ZNF169    NSRP1    ZNF547

    Find genes that share paralogs with EML2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EML2 (see all 760)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358794
    A colorectal cancer sample4--see VAR_0358792 V L mis40--------
    rs1453685131,2
    --46112207(+) TAACAA/GTGGTC 4 -- int10--------
    rs1161018431,2
    F--46112326(+) ATCACG/CGGGCA 4 -- int11Minor allele frequency- C:0.01WA 118
    rs785834041,2
    C,F--46112343(+) TCCCAT/CGCTGT 4 -- int11Minor allele frequency- C:0.03NA 120
    rs1861230701,2
    --46112358(+) GATAGC/TGAATG 4 -- int10--------
    rs1894029331,2
    --46112376(+) CAAGAG/TCTGAT 4 -- int10--------
    rs1139004971,2
    C,F--46112398(+) GTGGCG/ATTTCT 4 -- int13Minor allele frequency- A:0.05CSA WA 121
    rs72590831,2
    C,F,A--46112463(+) CCACCA/GTGATT 4 -- int14Minor allele frequency- G:0.37WA CSA 123
    rs1813754591,2
    --46112569(+) GAAAAC/TGGGCT 4 -- int10--------
    rs1472363811,2
    --46112572(+) AACGGA/GCTAAT 4 -- int10--------

    HapMap Linkage Disequilibrium report for EML2 (46110252 - 46148887 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EML2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912159CNV Loss21882294
    nsv833848CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EML2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609715    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for EML2:
    Usher syndrome

    Find genes that share disorders with EML2           About GenesLikeMe


    Export disorders for EML2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EML2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with EML2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2). (PubMed id 10521658)1, 2, 3, 9 Lepley D.M.... Suprenant K.A. (Gene 1999)
    2. The human EMAP-like protein-70 (ELP70) is a microtubule destabilizer that localizes to the mitotic apparatus. (PubMed id 11694528)1, 3, 9 Eichenmuller B....Suprenant K.A. (J. Biol. Chem. 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 24139 HGNC: 18035 AceView: EML2 Ensembl:ENSG00000125746 euGenes: HUgn24139
    ECgene: EML2 H-InvDB: EML2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EML2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EML2 gene:
    Search GeneIP for patents involving EML2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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