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Aliases for EML2 Gene

Aliases for EML2 Gene

  • Echinoderm Microtubule Associated Protein Like 2 2 3
  • Echinoderm MT-Associated Protein (EMAP)-Like Protein 70 2 3
  • Microtubule-Associated Protein Like Echinoderm EMAP 2 3
  • EMAP-2 3 4
  • EMAP2 3 4
  • Echinoderm Microtubule-Associated Protein-Like 2 3
  • HuEMAP-2 4
  • TRTLT2 6
  • EMAPL2 4
  • ELP70 3

External Ids for EML2 Gene

Previous GeneCards Identifiers for EML2 Gene

  • GC19M046756
  • GC19M046503
  • GC19M050788
  • GC19M050804
  • GC19M046112
  • GC19M042541

Summaries for EML2 Gene

GeneCards Summary for EML2 Gene

EML2 (Echinoderm Microtubule Associated Protein Like 2) is a Protein Coding gene. An important paralog of this gene is EML5.

UniProtKB/Swiss-Prot for EML2 Gene

  • Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EML2 Gene

Genomics for EML2 Gene

Regulatory Elements for EML2 Gene

Genomic Location for EML2 Gene

Start:
45,606,994 bp from pter
End:
45,645,629 bp from pter
Size:
38,636 bases
Orientation:
Minus strand

Genomic View for EML2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EML2 Gene

Proteins for EML2 Gene

  • Protein details for EML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95834-EMAL2_HUMAN
    Recommended name:
    Echinoderm microtubule-associated protein-like 2
    Protein Accession:
    O95834
    Secondary Accessions:
    • B7Z3I2
    • B7Z3Q9
    • K7ERL7
    • Q59EN8
    • Q8N5A2
    • Q9UG50

    Protein attributes for EML2 Gene

    Size:
    649 amino acids
    Molecular mass:
    70679 Da
    Quaternary structure:
    • Interacts with GRID2 and may also interact with GRID1 (By similarity). Binds unpolymerized tubulins via its WD repeat region.

    Three dimensional structures from OCA and Proteopedia for EML2 Gene

    Alternative splice isoforms for EML2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EML2 Gene

Proteomics data for EML2 Gene at MOPED

Post-translational modifications for EML2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EML2 Gene

Domains for EML2 Gene

Gene Families for EML2 Gene

HGNC:
  • WDR :WD repeat domain containing

Graphical View of Domain Structure for InterPro Entry

O95834

UniProtKB/Swiss-Prot:

EMAL2_HUMAN :
  • O95834
Domain:
  • Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain (By similarity).
Family:
  • Belongs to the WD repeat EMAP family.
Similarity:
  • Contains 11 WD repeats.
genes like me logo Genes that share domains with EML2: view

Function for EML2 Gene

Molecular function for EML2 Gene

UniProtKB/Swiss-Prot Function: Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.

Gene Ontology (GO) - Molecular Function for EML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IDA 11694528
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with EML2: view

Phenotypes for EML2 Gene

GenomeRNAi human phenotypes for EML2:
genes like me logo Genes that share phenotypes with EML2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for EML2 Gene

Localization for EML2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EML2 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with the microtubule cytoskeleton. Colocalizes with the mitotic spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EML2 Gene COMPARTMENTS Subcellular localization image for EML2 gene
Compartment Confidence
cytoskeleton 4
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 10521658
GO:0072686 colocalizes_with mitotic spindle IDA 11694528
genes like me logo Genes that share ontologies with EML2: view

Pathways for EML2 Gene

SuperPathways for EML2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception TAS 10521658
GO:0007605 sensory perception of sound TAS 10521658
GO:0010968 regulation of microtubule nucleation IDA 11694528
GO:0031115 negative regulation of microtubule polymerization IDA 11694528
genes like me logo Genes that share ontologies with EML2: view

No data available for Pathways by source for EML2 Gene

Transcripts for EML2 Gene

Unigene Clusters for EML2 Gene

Echinoderm microtubule associated protein like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EML2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: - -
SP6: - -
SP7: -
SP8:

ExUns: 21 ^ 22a · 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for EML2 Gene

GeneLoc Exon Structure for
EML2
ECgene alternative splicing isoforms for
EML2

Expression for EML2 Gene

mRNA expression in normal human tissues for EML2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EML2 Gene

SOURCE GeneReport for Unigene cluster for EML2 Gene Hs.24178

mRNA Expression by UniProt/SwissProt for EML2 Gene

O95834-EMAL2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with EML2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EML2 Gene

Orthologs for EML2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EML2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EML2 35
  • 92.16 (n)
  • 96.71 (a)
EML2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EML2 35
  • 92.07 (n)
  • 97.17 (a)
EML2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eml2 35
  • 88.27 (n)
  • 95.17 (a)
Eml2 16
Eml2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EML2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EML2 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eml2 35
  • 88.15 (n)
  • 93.52 (a)
lizard
(Anolis carolinensis)
Reptilia EML2 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8866 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.206 35
zebrafish
(Danio rerio)
Actinopterygii eml2 35
  • 65.83 (n)
  • 68.22 (a)
eml2 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012350 35
  • 57.25 (n)
  • 50.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta DCX-EMAP 36
  • 25 (a)
OneToMany
CG13466 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea elp-1 35
  • 41.29 (n)
  • 30.46 (a)
elp-1 36
  • 24 (a)
OneToMany
elp-1 37
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10048 36
  • 50 (a)
OneToMany
Species with no ortholog for EML2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EML2 Gene

ENSEMBL:
Gene Tree for EML2 (if available)
TreeFam:
Gene Tree for EML2 (if available)

Paralogs for EML2 Gene

Paralogs for EML2 Gene

genes like me logo Genes that share paralogs with EML2: view

Variants for EML2 Gene

Sequence variations from dbSNP and Humsavar for EML2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs751598 -- 45,633,865(-) TGGGA(G/T)GCCAA intron-variant
rs1029846 -- 45,646,360(+) AACGA(C/G)GGTAA upstream-variant-2KB
rs1529723 -- 45,620,865(-) GGGGA(A/G)GGTCC intron-variant
rs1529724 -- 45,620,862(-) GAAGG(G/T)CCTGC intron-variant
rs1529725 -- 45,620,798(-) GGCCT(C/T)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EML2 Gene

Variant ID Type Subtype PubMed ID
nsv833848 CNV Loss 17160897
nsv912159 CNV Loss 21882294

Relevant External Links for EML2 Gene

HapMap Linkage Disequilibrium report
EML2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EML2 Gene

Disorders for EML2 Gene

(1) University of Copenhagen DISEASES for EML2 Gene

genes like me logo Genes that share disorders with EML2: view

No data available for UniProtKB/Swiss-Prot for EML2 Gene

Publications for EML2 Gene

  1. Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2). (PMID: 10521658) Lepley D.M. … Suprenant K.A. (Gene 1999) 2 3 4 23
  2. The human EMAP-like protein-70 (ELP70) is a microtubule destabilizer that localizes to the mitotic apparatus. (PMID: 11694528) Eichenmuller B. … Suprenant K.A. (J. Biol. Chem. 2002) 2 3 4 23
  3. Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical ?-propeller domain. (PMID: 24706829) Richards M.W. … Bayliss R. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for EML2 Gene

Sources for EML2 Gene

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