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Aliases for EMID1 Gene

Aliases for EMID1 Gene

  • EMI Domain Containing 1 2 3 5
  • Emilin And Multimerin Domain-Containing Protein 1 3 4
  • EMU1 3 4
  • Emilin And Multimerin-Domain Containing Protein 1 2
  • EMI Domain-Containing Protein 1 3
  • Putative Emu1 2
  • EMI5 3

External Ids for EMID1 Gene

Previous GeneCards Identifiers for EMID1 Gene

  • GC22P027927
  • GC22P027928
  • GC22P029601
  • GC22P012566

Summaries for EMID1 Gene

GeneCards Summary for EMID1 Gene

EMID1 (EMI Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is COL26A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMID1 Gene

Genomics for EMID1 Gene

Regulatory Elements for EMID1 Gene

Enhancers for EMID1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around EMID1 on UCSC Golden Path with GeneCards custom track

Promoters for EMID1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EMID1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EMID1 Gene

29,205,851 bp from pter
29,259,597 bp from pter
53,747 bases
Plus strand

Genomic View for EMID1 Gene

Genes around EMID1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMID1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMID1 Gene

Proteins for EMID1 Gene

  • Protein details for EMID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    EMI domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B0QYK6
    • Q6ICG1
    • Q86SS7

    Protein attributes for EMID1 Gene

    441 amino acids
    Molecular mass:
    45292 Da
    Quaternary structure:
    • Homo- or heteromers.

    Alternative splice isoforms for EMID1 Gene


neXtProt entry for EMID1 Gene

Post-translational modifications for EMID1 Gene

  • Glycosylation at Asn 51 and Asn 136

No data available for DME Specific Peptides for EMID1 Gene

Domains & Families for EMID1 Gene

Gene Families for EMID1 Gene

Protein Domains for EMID1 Gene

Suggested Antigen Peptide Sequences for EMID1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 collagen-like domain.
  • Contains 1 collagen-like domain.
  • Contains 1 EMI domain.
genes like me logo Genes that share domains with EMID1: view

Function for EMID1 Gene

genes like me logo Genes that share phenotypes with EMID1: view

Animal Models for EMID1 Gene

MGI Knock Outs for EMID1:

Animal Model Products

  • Taconic Biosciences Mouse Models for EMID1

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EMID1 Gene

Localization for EMID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMID1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for EMID1 Gene COMPARTMENTS Subcellular localization image for EMID1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
golgi apparatus 2
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for EMID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005581 collagen trimer IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with EMID1: view

Pathways & Interactions for EMID1 Gene

SuperPathways for EMID1 Gene

No Data Available

Interacting Proteins for EMID1 Gene

Gene Ontology (GO) - Biological Process for EMID1 Gene


No data available for Pathways by source and SIGNOR curated interactions for EMID1 Gene

Drugs & Compounds for EMID1 Gene

No Compound Related Data Available

Transcripts for EMID1 Gene

Unigene Clusters for EMID1 Gene

EMI domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EMID1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -

Relevant External Links for EMID1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EMID1 Gene

mRNA expression in normal human tissues for EMID1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EMID1 Gene

This gene is overexpressed in Spleen (x7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EMID1 Gene

NURSA nuclear receptor signaling pathways regulating expression of EMID1 Gene:


SOURCE GeneReport for Unigene cluster for EMID1 Gene:

genes like me logo Genes that share expression patterns with EMID1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for EMID1 Gene

Orthologs for EMID1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EMID1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Emid1 34
  • 83.33 (n)
  • 80 (a)
Emid1 16
Emid1 35
  • 80 (a)
(Rattus norvegicus)
Mammalia Emid1 34
  • 87.97 (n)
  • 86.83 (a)
(Bos Taurus)
Mammalia EMID1 35
  • 80 (a)
(Canis familiaris)
Mammalia EMID1 35
  • 80 (a)
(Monodelphis domestica)
Mammalia EMID1 35
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia EMID1 35
  • 56 (a)
(Pan troglodytes)
Mammalia EMID1 35
  • 99 (a)
(Gallus gallus)
Aves EMID1 35
  • 57 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 3 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia emid1 34
  • 57.52 (n)
  • 52.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68894 34
(Danio rerio)
Actinopterygii emid1 35
  • 46 (a)
Species where no ortholog for EMID1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EMID1 Gene

Gene Tree for EMID1 (if available)
Gene Tree for EMID1 (if available)

Paralogs for EMID1 Gene

Paralogs for EMID1 Gene

(2) SIMAP similar genes for EMID1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with EMID1: view

Variants for EMID1 Gene

Sequence variations from dbSNP and Humsavar for EMID1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_019803 -
rs713886 -- 29,234,575(+) CTGTA(C/T)GTCTG intron-variant
rs713992 -- 29,229,922(+) CCTCA(A/G)CAGCT intron-variant
rs738435 -- 29,245,750(+) AACTG(A/G)AGTGA intron-variant
rs738436 -- 29,246,008(+) AGGTG(A/G)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EMID1 Gene

Variant ID Type Subtype PubMed ID
esv1772608 CNV deletion 17803354
esv22026 CNV loss 19812545
esv2673780 CNV deletion 23128226
esv2724121 CNV deletion 23290073
esv2724122 CNV deletion 23290073
esv275243 CNV gain+loss 21479260
esv3558040 CNV deletion 23714750
esv3647527 CNV loss 21293372
nsv1072208 CNV deletion 25765185
nsv1132574 CNV duplication 24896259
nsv436349 CNV deletion 17901297
nsv519651 CNV loss 19592680
nsv522714 CNV loss 19592680
nsv524483 CNV loss 19592680
nsv829154 CNV gain 20364138
nsv834171 CNV loss 17160897

Variation tolerance for EMID1 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.94; 87.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EMID1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EMID1 Gene

Disorders for EMID1 Gene

Relevant External Links for EMID1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EMID1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EMID1 Gene

Publications for EMID1 Gene

  1. Developmental expression and biochemical characterization of Emu family members. (PMID: 12221002) Leimeister C. … Gessler M. (Dev. Biol. 2002) 2 3 4 65
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for EMID1 Gene

Sources for EMID1 Gene