Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EME2 Gene

Aliases for EME2 Gene

  • Essential Meiotic Structure-Specific Endonuclease Subunit 2 2 3 5
  • SLX2 Structure-Specific Endonuclease Subunit Homolog B (S. Cerevisiae) 2
  • SLX2 Structure-Specific Endonuclease Subunit Homolog B 3
  • Essential Meiotic Endonuclease 1 Homolog 2 (S. Pombe) 2
  • Probable Crossover Junction Endonuclease EME2 3
  • Essential Meiotic Endonuclease 1 Homolog 2 3
  • Homolog Of Yeast EME1 Endonuclease 2 3
  • EC 3.1.22.- 4
  • SLX2B 3
  • Gs125 3

External Ids for EME2 Gene

Previous GeneCards Identifiers for EME2 Gene

  • GC16P001763
  • GC16U900464
  • GC16P001823

Summaries for EME2 Gene

Entrez Gene Summary for EME2 Gene

  • EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]

GeneCards Summary for EME2 Gene

EME2 (Essential Meiotic Structure-Specific Endonuclease Subunit 2) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA). GO annotations related to this gene include endonuclease activity and nuclease activity. An important paralog of this gene is EME1.

UniProtKB/Swiss-Prot for EME2 Gene

  • Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3-flap structures.

Additional gene information for EME2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EME2 Gene

Genomics for EME2 Gene

Regulatory Elements for EME2 Gene

Enhancers for EME2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H001769 1.4 ENCODE dbSUPER 38.8 -0.7 -656 6 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000261505 EME2 ENSG00000260051 CRAMP1 TELO2 SRRM2 UNKL UBE2I ENSG00000260954 ENSG00000255513
GH16H001271 1.1 ENCODE 33.4 -501.4 -501381 1 PKNOX1 SIN3A FEZF1 ZNF2 ZNF302 ZNF416 SP3 REST ZNF662 ZNF592 CRAMP1 WDR90 TELO2 IFT140 ENSG00000261505 TSC2 E4F1 WDR24 ENSG00000260646 UBE2I
GH16H001308 1.4 ENCODE dbSUPER 20.5 -462.5 -462453 5 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 MCM3 NFYC WDR90 CRAMP1 ENSG00000261505 TELO2 UBE2I E4F1 TSC2 ENSG00000260051 JMJD8 RHOT2
GH16H001793 0.9 ENCODE 31.7 +21.1 21086 2 FOXA2 ARID4B THRB RAD21 RARA YY1 SLC30A9 THAP11 KLF11 HMG20B EME2 HAGH IGFALS JPT2 SPSB3
GH16H001781 1.1 ENCODE 23.1 +9.3 9265 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 TBL3 CRAMP1 FAHD1 EME2 ENSG00000261207 ENSG00000260051 UNKL UBE2I TELO2 CHTF18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EME2 on UCSC Golden Path with GeneCards custom track

Promoters for EME2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082385 -807 3201 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for EME2 Gene

Chromosome:
16
Start:
1,773,207 bp from pter
End:
1,781,708 bp from pter
Size:
8,502 bases
Orientation:
Plus strand

Genomic View for EME2 Gene

Genes around EME2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EME2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EME2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EME2 Gene

Proteins for EME2 Gene

  • Protein details for EME2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4GXA9-EME2_HUMAN
    Recommended name:
    Probable crossover junction endonuclease EME2
    Protein Accession:
    A4GXA9
    Secondary Accessions:
    • Q8TEP2
    • Q96RY3

    Protein attributes for EME2 Gene

    Size:
    379 amino acids
    Molecular mass:
    41178 Da
    Quaternary structure:
    • Interacts with MUS81.
    SequenceCaution:
    • Sequence=AAK61292.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB84906.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for EME2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EME2 Gene

Post-translational modifications for EME2 Gene

No Post-translational modifications

Other Protein References for EME2 Gene

No data available for DME Specific Peptides for EME2 Gene

Domains & Families for EME2 Gene

Gene Families for EME2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EME2 Gene

Suggested Antigen Peptide Sequences for EME2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4GXA9

UniProtKB/Swiss-Prot:

EME2_HUMAN :
  • Belongs to the EME1/MMS4 family.
Family:
  • Belongs to the EME1/MMS4 family.
genes like me logo Genes that share domains with EME2: view

Function for EME2 Gene

Molecular function for EME2 Gene

UniProtKB/Swiss-Prot Function:
Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3-flap structures.

Enzyme Numbers (IUBMB) for EME2 Gene

Gene Ontology (GO) - Molecular Function for EME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0008821 contributes_to crossover junction endodeoxyribonuclease activity IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with EME2: view

Phenotypes for EME2 Gene

genes like me logo Genes that share phenotypes with EME2: view

Animal Model Products

CRISPR Products

miRNA for EME2 Gene

miRTarBase miRNAs that target EME2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EME2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EME2 Gene

Localization for EME2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EME2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EME2 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for EME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IBA --
GO:0005634 nucleus IEA --
GO:0048476 Holliday junction resolvase complex IEA,IBA --
genes like me logo Genes that share ontologies with EME2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EME2 Gene

Pathways & Interactions for EME2 Gene

genes like me logo Genes that share pathways with EME2: view

Interacting Proteins for EME2 Gene

Selected Interacting proteins: A4GXA9-EME2_HUMAN for EME2 Gene via IID MINT

Gene Ontology (GO) - Biological Process for EME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates IBA --
GO:0006281 DNA repair IEA --
GO:0006302 double-strand break repair IBA --
GO:0006310 DNA recombination IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with EME2: view

No data available for SIGNOR curated interactions for EME2 Gene

Drugs & Compounds for EME2 Gene

No Compound Related Data Available

Transcripts for EME2 Gene

Unigene Clusters for EME2 Gene

Essential meiotic endonuclease 1 homolog 2 (S. pombe):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EME2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for EME2 Gene

No ASD Table

Relevant External Links for EME2 Gene

GeneLoc Exon Structure for
EME2
ECgene alternative splicing isoforms for
EME2

Expression for EME2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EME2 Gene

Protein differential expression in normal tissues from HIPED for EME2 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EME2 Gene



Protein tissue co-expression partners for EME2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EME2 Gene:

EME2

SOURCE GeneReport for Unigene cluster for EME2 Gene:

Hs.7247

Evidence on tissue expression from TISSUES for EME2 Gene

  • Spleen(4.2)
genes like me logo Genes that share expression patterns with EME2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EME2 Gene

Orthologs for EME2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EME2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EME2 33 34
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia EME2 33
  • 79.5 (n)
cow
(Bos Taurus)
Mammalia EME2 33 34
  • 78.49 (n)
rat
(Rattus norvegicus)
Mammalia Eme2 33
  • 74.21 (n)
mouse
(Mus musculus)
Mammalia Eme2 16 34 33
  • 73.64 (n)
oppossum
(Monodelphis domestica)
Mammalia EME2 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves EME2 33 34
  • 57.99 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia eme2 33
  • 51.19 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01072828.1 34
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mms4 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToMany
Species where no ortholog for EME2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EME2 Gene

ENSEMBL:
Gene Tree for EME2 (if available)
TreeFam:
Gene Tree for EME2 (if available)

Paralogs for EME2 Gene

Paralogs for EME2 Gene

genes like me logo Genes that share paralogs with EME2: view

Variants for EME2 Gene

Sequence variations from dbSNP and Humsavar for EME2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000513546 -- 1,776,371(+) ACCTC(-/AG)GGGAA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000988298 -- 1,773,005(+) GGTCT(C/T)GTAGT upstream-variant-2KB, reference, missense
rs1002180875 -- 1,771,576(+) GGTGG(C/T)GCCCG intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1003213252 -- 1,772,269(+) GCAGG(A/G)TAATC upstream-variant-2KB, reference, synonymous-codon
rs1003222824 -- 1,774,798(+) ACCAG(A/G)ATGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EME2 Gene

Variant ID Type Subtype PubMed ID
dgv4856n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv3892756 CNV loss 25118596
nsv1051692 CNV loss 25217958
nsv1160328 CNV deletion 26073780
nsv457335 CNV loss 19166990
nsv457336 CNV loss 19166990
nsv471069 CNV loss 18288195
nsv517196 CNV gain+loss 19592680
nsv518641 CNV loss 19592680
nsv571169 CNV loss 21841781
nsv571170 CNV loss 21841781
nsv571171 CNV gain+loss 21841781
nsv571172 CNV loss 21841781
nsv571173 CNV loss 21841781
nsv827500 CNV gain 20364138
nsv952900 CNV deletion 24416366

Variation tolerance for EME2 Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EME2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EME2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EME2 Gene

Disorders for EME2 Gene

Relevant External Links for EME2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EME2

No disorders were found for EME2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EME2 Gene

Publications for EME2 Gene

  1. Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. (PMID: 17289582) Ciccia A … West SC (Molecular cell 2007) 3 4 60
  2. Identification and characterization of the human mus81-eme1 endonuclease. (PMID: 12721304) Ciccia A … West SC (The Journal of biological chemistry 2003) 2 3 60
  3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 60
  4. Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage. (PMID: 26804904) Técher H … Debatisse M (Cell reports 2016) 3 60
  5. Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex. (PMID: 24692662) Amangyeld T … Seo YS (Nucleic acids research 2014) 3 60

Products for EME2 Gene

Sources for EME2 Gene

Content
Loading form....