Aliases for EME1 Gene
- Essential Meiotic Structure-Specific Endonuclease 1 2 3 5
- MMS4 Homolog 3 4
- HMMS4 3 4
- SLX2 Structure-Specific Endonuclease Subunit Homolog A (S. Cerevisiae) 2
- SLX2 Structure-Specific Endonuclease Subunit Homolog A 3
- Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) 2
- Essential Meiotic Endonuclease 1 Homolog 1 3
- Essential Meiotic Endonuclease 1 Homolog 2 3
External Ids for EME1 Gene
Previous GeneCards Identifiers for EME1 Gene
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
GeneCards Summary for EME1 Gene
EME1 (Essential Meiotic Structure-Specific Endonuclease 1) is a Protein Coding gene. Among its related pathways are Fanconi anemia pathway and Homologous DNA Pairing and Strand Exchange. GO annotations related to this gene include endonuclease activity and nuclease activity. An important paralog of this gene is EME2.
UniProtKB/Swiss-Prot for EME1 Gene
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5-end at the branch nick. Typical substrates include 3-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.