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Aliases for EMCN Gene

Aliases for EMCN Gene

  • Endomucin 2 3 3 5
  • Gastric Cancer Antigen Ga34 3 4
  • Endomucin-2 3 4
  • Mucin-14 3 4
  • MUC-14 3 4
  • EMCN2 3 4
  • MUC14 3 4

External Ids for EMCN Gene

Previous GeneCards Identifiers for EMCN Gene

  • GC04M101629
  • GC04M101777
  • GC04M101676
  • GC04M101316
  • GC04M097054

Summaries for EMCN Gene

Entrez Gene Summary for EMCN Gene

  • EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001 [PubMed 11418125]).[supplied by OMIM, Mar 2008]

GeneCards Summary for EMCN Gene

EMCN (Endomucin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for EMCN Gene

  • Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.

Gene Wiki entry for EMCN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMCN Gene

Genomics for EMCN Gene

Regulatory Elements for EMCN Gene

Enhancers for EMCN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G100408 0.3 FANTOM5 2.4 +471.5 471519 0.2 EMCN GC04M100396 LOC105377345
GH04G100868 0.8 ENCODE 0.4 +10.7 10713 1.1 SIN3A BMI1 ZNF48 CBX5 ZNF143 ETV6 RELB CREM IKZF2 SP5 EMCN LINC01218
GH04G100882 0.4 FANTOM5 0.7 -2.5 -2492 0.2 MTA2 EMCN MIR8066
GH04G100893 0.7 Ensembl ENCODE 0.4 -15.1 -15060 2.6 ARID3A YY1 EMCN MIR8066
GH04G100869 0.6 ENCODE 0.4 +11.7 11658 0.5 CTBP1 FOXA2 FOXA3 MNT DPF2 FOXA1 EMCN LINC01218
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EMCN on UCSC Golden Path with GeneCards custom track

Genomic Location for EMCN Gene

Chromosome:
4
Start:
100,395,341 bp from pter
End:
100,880,126 bp from pter
Size:
484,786 bases
Orientation:
Minus strand

Genomic View for EMCN Gene

Genes around EMCN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMCN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMCN Gene

Proteins for EMCN Gene

  • Protein details for EMCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULC0-MUCEN_HUMAN
    Recommended name:
    Endomucin
    Protein Accession:
    Q9ULC0
    Secondary Accessions:
    • A8K716
    • B4E347
    • Q8NEY5
    • Q8WWE7
    • Q9NRM8

    Protein attributes for EMCN Gene

    Size:
    261 amino acids
    Molecular mass:
    27452 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EMCN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EMCN Gene

Post-translational modifications for EMCN Gene

  • Highly O-glycosylated. Sialic acid-rich glycoprotein.
  • Glycosylation at Asn19, isoforms=2, 328, Asn98, Asn104, Asn164, and isoforms=3178
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EMCN Gene

Domains & Families for EMCN Gene

Gene Families for EMCN Gene

HGNC:

Protein Domains for EMCN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EMCN Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EMCN: view

No data available for UniProtKB/Swiss-Prot for EMCN Gene

Function for EMCN Gene

Molecular function for EMCN Gene

UniProtKB/Swiss-Prot Function:
Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.

Gene Ontology (GO) - Molecular Function for EMCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IDA --
genes like me logo Genes that share ontologies with EMCN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EMCN

miRNA for EMCN Gene

miRTarBase miRNAs that target EMCN

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EMCN Gene

Localization for EMCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMCN Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Consistently localized to the plasma membrane and less abundantly to Golgi-like perinuclear stacks.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EMCN gene
Compartment Confidence
plasma membrane 5
extracellular 4
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for EMCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0009897 external side of plasma membrane IC --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EMCN: view

Pathways & Interactions for EMCN Gene

No Data Available

Interacting Proteins for EMCN Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296420%0d%0a9606.ENSP00000236147%0d%0a9606.ENSP00000206542%0d%0a
Selected Interacting proteins: ENSP00000296420 Q9ULC0-MUCEN_HUMAN for EMCN Gene via STRING IID

Gene Ontology (GO) - Biological Process for EMCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016337 single organismal cell-cell adhesion IDA --
GO:0030155 regulation of cell adhesion IMP --
genes like me logo Genes that share ontologies with EMCN: view

No data available for Pathways by source and SIGNOR curated interactions for EMCN Gene

Drugs & Compounds for EMCN Gene

No Compound Related Data Available

Transcripts for EMCN Gene

Unigene Clusters for EMCN Gene

Endomucin:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EMCN Gene

No ASD Table

Relevant External Links for EMCN Gene

GeneLoc Exon Structure for
EMCN
ECgene alternative splicing isoforms for
EMCN

Expression for EMCN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EMCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EMCN Gene

This gene is overexpressed in Serum (40.2) and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EMCN Gene



NURSA nuclear receptor signaling pathways regulating expression of EMCN Gene:

EMCN

SOURCE GeneReport for Unigene cluster for EMCN Gene:

Hs.152913

mRNA Expression by UniProt/SwissProt for EMCN Gene:

Q9ULC0-MUCEN_HUMAN
Tissue specificity: Expressed in heart, kidney and lung.

Evidence on tissue expression from TISSUES for EMCN Gene

  • Heart(4.5)
  • Lung(4.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with EMCN: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for EMCN Gene

Orthologs for EMCN Gene

This gene was present in the common ancestor of chordates.

Orthologs for EMCN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EMCN 34 35
  • 96.51 (n)
dog
(Canis familiaris)
Mammalia EMCN 34 35
  • 81.17 (n)
cow
(Bos Taurus)
Mammalia EMCN 34 35
  • 72.8 (n)
mouse
(Mus musculus)
Mammalia Emcn 34 16 35
  • 68.48 (n)
rat
(Rattus norvegicus)
Mammalia Emcn 34
  • 66.8 (n)
oppossum
(Monodelphis domestica)
Mammalia EMCN 35
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EMCN 35
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves EMCN 35
  • 23 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EMCN 35
  • 24 (a)
OneToOne
Species where no ortholog for EMCN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EMCN Gene

ENSEMBL:
Gene Tree for EMCN (if available)
TreeFam:
Gene Tree for EMCN (if available)

Paralogs for EMCN Gene

No data available for Paralogs for EMCN Gene

Variants for EMCN Gene

Sequence variations from dbSNP and Humsavar for EMCN Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000003635 -- 100,456,596(+) TACTG(A/C/T)AGTTT intron-variant
rs1000017266 -- 100,494,247(+) AAAGA(A/G)TTACT intron-variant
rs1000052444 -- 100,413,140(+) AGCTC(A/G)AATTT intron-variant
rs1000101714 -- 100,510,050(+) TCTGG(G/T)CCAAT intron-variant
rs1000102073 -- 100,418,982(+) ATAGT(A/G)GTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EMCN Gene

Variant ID Type Subtype PubMed ID
esv1322255 CNV deletion 17803354
esv2422310 CNV deletion 17116639
esv2434052 CNV deletion 19546169
esv2670161 CNV deletion 23128226
esv2728039 CNV deletion 23290073
esv2728041 CNV deletion 23290073
esv3055269 CNV deletion 24192839
esv3564335 CNV deletion 23714750
nsv1005010 CNV loss 25217958
nsv1073360 CNV deletion 25765185
nsv1139292 CNV deletion 24896259
nsv521801 CNV loss 19592680
nsv956397 CNV deletion 24416366
nsv997418 CNV loss 25217958

Variation tolerance for EMCN Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.87; 89.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EMCN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EMCN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EMCN Gene

Disorders for EMCN Gene

Relevant External Links for EMCN

Genetic Association Database (GAD)
EMCN
Human Genome Epidemiology (HuGE) Navigator
EMCN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EMCN

No disorders were found for EMCN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EMCN Gene

Publications for EMCN Gene

  1. Identification of human endomucin-1 and -2 as membrane-bound O- sialoglycoproteins with anti-adhesive activity. (PMID: 11418125) Kinoshita M. … Noda M. (FEBS Lett. 2001) 2 3 4 22 64
  2. Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin. (PMID: 12485444) Kuhn A. … Vestweber D. (J. Invest. Dermatol. 2002) 3 4 22 64
  3. Human endomucin is an endothelial marker. (PMID: 11594763) Liu C. … Nguyen M. (Biochem. Biophys. Res. Commun. 2001) 2 3 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for EMCN Gene

Sources for EMCN Gene

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