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Aliases for EMC9 Gene

Aliases for EMC9 Gene

  • ER Membrane Protein Complex Subunit 9 2 3
  • Family With Sequence Similarity 158, Member A 2 3
  • C14orf122 3 4
  • FAM158A 3 4
  • Chromosome 14 Open Reading Frame 122 2
  • UPF0172 Protein FAM158A 3
  • Protein FAM158A 4
  • CGI-112 3

External Ids for EMC9 Gene

Previous HGNC Symbols for EMC9 Gene

  • C14orf122
  • FAM158A

Previous GeneCards Identifiers for EMC9 Gene

  • GC14M024609

Summaries for EMC9 Gene

GeneCards Summary for EMC9 Gene

EMC9 (ER Membrane Protein Complex Subunit 9) is a Protein Coding gene. An important paralog of this gene is EMC8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMC9 Gene

Genomics for EMC9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EMC9 Gene

24,138,872 bp from pter
24,141,629 bp from pter
2,758 bases
Minus strand

Genomic View for EMC9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EMC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC9 Gene

No data available for Regulatory Elements for EMC9 Gene

Proteins for EMC9 Gene

  • Protein details for EMC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ER membrane protein complex subunit 9
    Protein Accession:
    Secondary Accessions:
    • D3DS60
    • Q9BUM3

    Protein attributes for EMC9 Gene

    208 amino acids
    Molecular mass:
    23061 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).

neXtProt entry for EMC9 Gene

Proteomics data for EMC9 Gene at MOPED

Post-translational modifications for EMC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EMC9 Gene

No data available for DME Specific Peptides for EMC9 Gene

Domains for EMC9 Gene

Protein Domains for EMC9 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EMC8/EMC9 family.
  • Belongs to the EMC8/EMC9 family.
genes like me logo Genes that share domains with EMC9: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for EMC9 Gene

Function for EMC9 Gene

Gene Ontology (GO) - Molecular Function for EMC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with EMC9: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EMC9

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for EMC9 Gene

Localization for EMC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC9 Gene


Gene Ontology (GO) - Cellular Components for EMC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22119785
GO:0072546 ER membrane protein complex IDA 22119785
genes like me logo Genes that share ontologies with EMC9: view

No data available for Subcellular locations from COMPARTMENTS for EMC9 Gene

Pathways for EMC9 Gene

SuperPathways for EMC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EMC9 Gene


No data available for Pathways by source for EMC9 Gene

Transcripts for EMC9 Gene

Unigene Clusters for EMC9 Gene

ER membrane protein complex subunit 9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EMC9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EMC9 Gene

No ASD Table

Relevant External Links for EMC9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EMC9 Gene

mRNA expression in normal human tissues for EMC9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for EMC9 Gene

This gene is overexpressed in Tonsil (53.0) and Platelet (16.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EMC9 Gene

SOURCE GeneReport for Unigene cluster for EMC9 Gene Hs.271614

genes like me logo Genes that share expressions with EMC9: view

Expression partners for EMC9 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EMC9 Gene

Orthologs for EMC9 Gene

This gene was present in the common ancestor of animals.

Orthologs for EMC9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EMC9 35
  • 91.38 (n)
  • 94.15 (a)
EMC9 36
  • 93 (a)
(Canis familiaris)
Mammalia EMC9 35
  • 91.87 (n)
  • 93.17 (a)
EMC9 36
  • 93 (a)
(Mus musculus)
Mammalia Emc9 35
  • 86.83 (n)
  • 91.22 (a)
Emc9 16
Emc9 36
  • 91 (a)
(Pan troglodytes)
Mammalia EMC9 35
  • 99.68 (n)
  • 99.52 (a)
EMC9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Emc9 35
  • 87.7 (n)
  • 89.81 (a)
(Monodelphis domestica)
Mammalia EMC9 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia emc9 35
  • 56.54 (n)
  • 50.49 (a)
(Danio rerio)
Actinopterygii emc9 35
  • 56.21 (n)
  • 52.45 (a)
emc9 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010320 35
  • 46.28 (n)
  • 37.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3501 35
  • 48.5 (n)
  • 40.21 (a)
CG3501 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea F25H2.4 36
  • 27 (a)
Species with no ortholog for EMC9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EMC9 Gene

Gene Tree for EMC9 (if available)
Gene Tree for EMC9 (if available)

Paralogs for EMC9 Gene

Paralogs for EMC9 Gene

(2) SIMAP similar genes for EMC9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EMC9: view

Variants for EMC9 Gene

Sequence variations from dbSNP and Humsavar for EMC9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2236352 -- 24,141,524(-) CCTGG(A/G)CTGGG utr-variant-5-prime, nc-transcript-variant
rs3742500 -- 24,142,769(+) CCAGT(G/T)AAACC upstream-variant-2KB
rs8006173 -- 24,142,126(+) TCGCA(C/G)CACAT upstream-variant-2KB
rs8010715 -- 24,139,938(+) ATTTA(C/T)GGTAA intron-variant
rs10151187 -- 24,141,580(+) CTGGC(C/G)GCCGC utr-variant-5-prime, nc-transcript-variant

Relevant External Links for EMC9 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EMC9 Gene

Disorders for EMC9 Gene

No disorders were found for EMC9 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for EMC9 Gene

Publications for EMC9 Gene

  1. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 2 3 4
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for EMC9 Gene

Sources for EMC9 Gene

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