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Aliases for EMC9 Gene

Aliases for EMC9 Gene

  • ER Membrane Protein Complex Subunit 9 2 3 5
  • Family With Sequence Similarity 158, Member A 2 3
  • C14orf122 3 4
  • FAM158A 3 4
  • Chromosome 14 Open Reading Frame 122 2
  • UPF0172 Protein FAM158A 3
  • Protein FAM158A 4
  • CGI-112 3

External Ids for EMC9 Gene

Previous HGNC Symbols for EMC9 Gene

  • C14orf122
  • FAM158A

Previous GeneCards Identifiers for EMC9 Gene

  • GC14M024609

Summaries for EMC9 Gene

GeneCards Summary for EMC9 Gene

EMC9 (ER Membrane Protein Complex Subunit 9) is a Protein Coding gene. An important paralog of this gene is EMC8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMC9 Gene

Genomics for EMC9 Gene

Regulatory Elements for EMC9 Gene

Enhancers for EMC9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around EMC9 on UCSC Golden Path with GeneCards custom track

Promoters for EMC9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EMC9 on UCSC Golden Path with GeneCards custom track

Genomic Location for EMC9 Gene

Chromosome:
14
Start:
24,138,959 bp from pter
End:
24,141,588 bp from pter
Size:
2,630 bases
Orientation:
Minus strand

Genomic View for EMC9 Gene

Genes around EMC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC9 Gene

Proteins for EMC9 Gene

  • Protein details for EMC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3B6-EMC9_HUMAN
    Recommended name:
    ER membrane protein complex subunit 9
    Protein Accession:
    Q9Y3B6
    Secondary Accessions:
    • D3DS60
    • Q9BUM3

    Protein attributes for EMC9 Gene

    Size:
    208 amino acids
    Molecular mass:
    23061 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).

neXtProt entry for EMC9 Gene

Post-translational modifications for EMC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EMC9 Gene

No data available for DME Specific Peptides for EMC9 Gene

Domains & Families for EMC9 Gene

Protein Domains for EMC9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EMC9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3B6

UniProtKB/Swiss-Prot:

EMC9_HUMAN :
  • Belongs to the EMC8/EMC9 family.
Family:
  • Belongs to the EMC8/EMC9 family.
genes like me logo Genes that share domains with EMC9: view

No data available for Gene Families for EMC9 Gene

Function for EMC9 Gene

Gene Ontology (GO) - Molecular Function for EMC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with EMC9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EMC9 Gene

Localization for EMC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EMC9 Gene COMPARTMENTS Subcellular localization image for EMC9 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for EMC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22119785
GO:0072546 ER membrane protein complex IDA 22119785
genes like me logo Genes that share ontologies with EMC9: view

Pathways & Interactions for EMC9 Gene

SuperPathways for EMC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EMC9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EMC9 Gene

Drugs & Compounds for EMC9 Gene

No Compound Related Data Available

Transcripts for EMC9 Gene

Unigene Clusters for EMC9 Gene

ER membrane protein complex subunit 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EMC9 Gene

No ASD Table

Relevant External Links for EMC9 Gene

GeneLoc Exon Structure for
EMC9
ECgene alternative splicing isoforms for
EMC9

Expression for EMC9 Gene

mRNA expression in normal human tissues for EMC9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EMC9 Gene

This gene is overexpressed in Tonsil (53.0) and Platelet (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EMC9 Gene



Protein tissue co-expression partners for EMC9 Gene

NURSA nuclear receptor signaling pathways regulating expression of EMC9 Gene:

EMC9

SOURCE GeneReport for Unigene cluster for EMC9 Gene:

Hs.271614
genes like me logo Genes that share expression patterns with EMC9: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EMC9 Gene

Orthologs for EMC9 Gene

This gene was present in the common ancestor of animals.

Orthologs for EMC9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EMC9 34
  • 91.38 (n)
  • 94.15 (a)
EMC9 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EMC9 34
  • 91.87 (n)
  • 93.17 (a)
EMC9 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Emc9 34
  • 86.83 (n)
  • 91.22 (a)
Emc9 16
Emc9 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EMC9 34
  • 99.68 (n)
  • 99.52 (a)
EMC9 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Emc9 34
  • 87.7 (n)
  • 89.81 (a)
oppossum
(Monodelphis domestica)
Mammalia EMC9 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia emc9 34
  • 56.54 (n)
  • 50.49 (a)
zebrafish
(Danio rerio)
Actinopterygii emc9 34
  • 56.21 (n)
  • 52.45 (a)
emc9 35
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010320 34
  • 46.28 (n)
  • 37.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3501 34
  • 48.5 (n)
  • 40.21 (a)
CG3501 35
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F25H2.4 35
  • 27 (a)
OneToMany
Species where no ortholog for EMC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EMC9 Gene

ENSEMBL:
Gene Tree for EMC9 (if available)
TreeFam:
Gene Tree for EMC9 (if available)

Paralogs for EMC9 Gene

Paralogs for EMC9 Gene

(2) SIMAP similar genes for EMC9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EMC9: view

Variants for EMC9 Gene

Sequence variations from dbSNP and Humsavar for EMC9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs11574512 - 24,139,600(+) TCAAG(A/G)CCAGG reference, missense
rs3742500 -- 24,142,769(+) CCAGT(G/T)AAACC upstream-variant-2KB
rs62001564 -- 24,140,196(+) ATAAG(A/G)AAACT intron-variant
rs35497840 -- 24,139,721(+) CCTTT(-/C)CCCTG intron-variant, utr-variant-5-prime
rs8006173 -- 24,142,126(+) TCGCA(C/G)CACAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EMC9 Gene

Variant ID Type Subtype PubMed ID
nsv564057 CNV loss 21841781

Variation tolerance for EMC9 Gene

Residual Variation Intolerance Score: 76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EMC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EMC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EMC9 Gene

Disorders for EMC9 Gene

Relevant External Links for EMC9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EMC9

No disorders were found for EMC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EMC9 Gene

Publications for EMC9 Gene

  1. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 2 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65

Products for EMC9 Gene

Sources for EMC9 Gene

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