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Aliases for EMC8 Gene

Aliases for EMC8 Gene

  • ER Membrane Protein Complex Subunit 8 2 3 5
  • Neighbor Of COX4 2 3 4
  • COX4 Neighbor 2 3
  • C16orf2 3 4
  • C16orf4 3 4
  • FAM158B 3 4
  • COX4NB 3 4
  • NOC4 3 4
  • Family With Sequence Similarity 158, Member B 3
  • Family With Sequence Similarity 158 2
  • Chromosome 16 Open Reading Frame 4 2
  • Chromosome 16 Open Reading Frame 2 2
  • Protein FAM158B 4
  • Member B 2
  • COX4AL 4

External Ids for EMC8 Gene

Previous HGNC Symbols for EMC8 Gene

  • C16orf4
  • NOC4
  • C16orf2
  • COX4NB

Previous GeneCards Identifiers for EMC8 Gene

  • GC16M085813

Summaries for EMC8 Gene

GeneCards Summary for EMC8 Gene

EMC8 (ER Membrane Protein Complex Subunit 8) is a Protein Coding gene. An important paralog of this gene is EMC9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMC8 Gene

Genomics for EMC8 Gene

Regulatory Elements for EMC8 Gene

Promoters for EMC8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EMC8 on UCSC Golden Path with GeneCards custom track

Genomic Location for EMC8 Gene

85,771,758 bp from pter
85,799,608 bp from pter
27,851 bases
Minus strand

Genomic View for EMC8 Gene

Genes around EMC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC8 Gene

Proteins for EMC8 Gene

  • Protein details for EMC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ER membrane protein complex subunit 8
    Protein Accession:
    Secondary Accessions:
    • C9JB21

    Protein attributes for EMC8 Gene

    210 amino acids
    Molecular mass:
    23773 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).

    Alternative splice isoforms for EMC8 Gene


neXtProt entry for EMC8 Gene

Proteomics data for EMC8 Gene at MOPED

Post-translational modifications for EMC8 Gene

  • Ubiquitination at Lys 100 and Lys 110
  • Modification sites at PhosphoSitePlus

Other Protein References for EMC8 Gene

No data available for DME Specific Peptides for EMC8 Gene

Domains & Families for EMC8 Gene

Protein Domains for EMC8 Gene


Suggested Antigen Peptide Sequences for EMC8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EMC8/EMC9 family.
  • Belongs to the EMC8/EMC9 family.
genes like me logo Genes that share domains with EMC8: view

No data available for Gene Families for EMC8 Gene

Function for EMC8 Gene

genes like me logo Genes that share phenotypes with EMC8: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EMC8 Gene

Localization for EMC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC8 Gene


Subcellular locations from

Jensen Localization Image for EMC8 Gene COMPARTMENTS Subcellular localization image for EMC8 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for EMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22119785
GO:0005739 mitochondrion IEA,TAS --
GO:0016020 membrane IDA 19946888
GO:0072546 ER membrane protein complex IDA 22119785
genes like me logo Genes that share ontologies with EMC8: view

Pathways & Interactions for EMC8 Gene

SuperPathways for EMC8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EMC8 Gene


No data available for Pathways by source and SIGNOR curated interactions for EMC8 Gene

Drugs & Compounds for EMC8 Gene

No Compound Related Data Available

Transcripts for EMC8 Gene

Unigene Clusters for EMC8 Gene

ER membrane protein complex subunit 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EMC8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: -
SP3: - - -
SP4: -
SP5: - -

Relevant External Links for EMC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EMC8 Gene

mRNA expression in normal human tissues for EMC8 Gene

Protein differential expression in normal tissues from HIPED for EMC8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.1), Bone (7.3), and Bone marrow stromal cell (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EMC8 Gene

SOURCE GeneReport for Unigene cluster for EMC8 Gene Hs.173162

mRNA Expression by UniProt/SwissProt for EMC8 Gene

Tissue specificity: Expressed in liver, pancreas, heart, lung, kidney, brain, skeletal muscle, and placenta. Expression levels are highest in pancreas and moderate in heart, skeletal muscle, and placenta.
genes like me logo Genes that share expression patterns with EMC8: view

Protein tissue co-expression partners for EMC8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EMC8 Gene

Orthologs for EMC8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EMC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EMC8 35
  • 92.7 (n)
  • 97.62 (a)
EMC8 36
  • 98 (a)
(Canis familiaris)
Mammalia EMC8 35
  • 93.33 (n)
  • 98.57 (a)
EMC8 36
  • 99 (a)
(Mus musculus)
Mammalia Emc8 35
  • 87.6 (n)
  • 93.24 (a)
Emc8 16
Emc8 36
  • 92 (a)
(Pan troglodytes)
Mammalia COX4NB 35
  • 98.73 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Emc8 35
  • 87.28 (n)
  • 93.72 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
-- 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia EMC8 36
  • 90 (a)
(Gallus gallus)
Aves EMC8 35
  • 79.97 (n)
  • 85.22 (a)
EMC8 36
  • 84 (a)
(Anolis carolinensis)
Reptilia EMC8 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia emc8 35
  • 71.45 (n)
  • 76.73 (a)
MGC75783 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4449 35
(Danio rerio)
Actinopterygii Dr.3514 35
emc8 35
  • 72.14 (n)
  • 70.65 (a)
emc8 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3501 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea F25H2.4 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons emb2731 35
  • 43.26 (n)
  • 30.32 (a)
(Oryza sativa)
Liliopsida Os04g0270200 35
  • 51.97 (n)
  • 34.95 (a)
Species with no ortholog for EMC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EMC8 Gene

Gene Tree for EMC8 (if available)
Gene Tree for EMC8 (if available)

Paralogs for EMC8 Gene

Paralogs for EMC8 Gene

(2) SIMAP similar genes for EMC8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EMC8: view

Variants for EMC8 Gene

Sequence variations from dbSNP and Humsavar for EMC8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs8587 -- 85,779,625(+) GCTAC(A/C)AGATA downstream-variant-500B, utr-variant-3-prime
rs9354 -- 85,779,727(-) TAAAG(C/T)TGTCC downstream-variant-500B, reference, missense, utr-variant-3-prime
rs437786 -- 85,785,767(+) GCCAA(C/T)TGAAA intron-variant
rs96603 -- 85,781,491(+) AGTGA(C/T)GCAAT intron-variant
rs100812 -- 85,782,598(+) CCTCC(C/G)TTCCA intron-variant

Variation tolerance for EMC8 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EMC8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EMC8 Gene

Disorders for EMC8 Gene

Relevant External Links for EMC8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EMC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EMC8 Gene

Publications for EMC8 Gene

  1. The 5-prime region of the COX4 gene contains a novel overlapping gene, NOC4. (PMID: 10337626) Bachman N.J. … Lomax M.I. (Mamm. Genome 1999) 2 3 4 23 67
  2. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for EMC8 Gene

Sources for EMC8 Gene

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