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Aliases for EMC7 Gene

Aliases for EMC7 Gene

  • ER Membrane Protein Complex Subunit 7 2 3
  • C15orf24 3 4
  • C11orf3 3 4
  • Chromosome 15 Hypothetical ATG/GTP Binding Protein 3
  • Chromosome 15 Open Reading Frame 24 2
  • UPF0480 Protein C15orf24 3
  • ORF1-FL1 3
  • HT022 3

External Ids for EMC7 Gene

Previous HGNC Symbols for EMC7 Gene

  • C15orf24

Previous GeneCards Identifiers for EMC7 Gene

  • GC15M034377

Summaries for EMC7 Gene

GeneCards Summary for EMC7 Gene

EMC7 (ER Membrane Protein Complex Subunit 7) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMC7 Gene

Genomics for EMC7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EMC7 Gene

Chromosome:
15
Start:
34,084,017 bp from pter
End:
34,101,948 bp from pter
Size:
17,932 bases
Orientation:
Minus strand

Genomic View for EMC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EMC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC7 Gene

No data available for Regulatory Elements for EMC7 Gene

Proteins for EMC7 Gene

  • Protein details for EMC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA0-EMC7_HUMAN
    Recommended name:
    ER membrane protein complex subunit 7
    Protein Accession:
    Q9NPA0
    Secondary Accessions:
    • B2RC00
    • Q96ED5

    Protein attributes for EMC7 Gene

    Size:
    242 amino acids
    Molecular mass:
    26471 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).

    Three dimensional structures from OCA and Proteopedia for EMC7 Gene

neXtProt entry for EMC7 Gene

Proteomics data for EMC7 Gene at MOPED

Post-translational modifications for EMC7 Gene

  • Ubiquitination at Lys 57, Lys 115, Lys 127, and Lys 141
  • Glycosylation at Thr 113
  • Modification sites at PhosphoSitePlus

Other Protein References for EMC7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EMC7 Gene

Domains & Families for EMC7 Gene

Protein Domains for EMC7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EMC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPA0

UniProtKB/Swiss-Prot:

EMC7_HUMAN :
  • Belongs to the EMC7 family.
Family:
  • Belongs to the EMC7 family.
genes like me logo Genes that share domains with EMC7: view

No data available for Gene Families for EMC7 Gene

Function for EMC7 Gene

Gene Ontology (GO) - Molecular Function for EMC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with EMC7: view
genes like me logo Genes that share phenotypes with EMC7: view

Animal Model Products

miRNA for EMC7 Gene

miRTarBase miRNAs that target EMC7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EMC7

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EMC7 Gene

Localization for EMC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EMC7 Gene COMPARTMENTS Subcellular localization image for EMC7 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EMC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 12975309
GO:0072546 ER membrane protein complex IDA 22119785
genes like me logo Genes that share ontologies with EMC7: view

Pathways & Interactions for EMC7 Gene

SuperPathways for EMC7 Gene

No Data Available

Interacting Proteins for EMC7 Gene

Gene Ontology (GO) - Biological Process for EMC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with EMC7: view

No data available for Pathways by source and SIGNOR curated interactions for EMC7 Gene

Drugs & Compounds for EMC7 Gene

No Compound Related Data Available

Transcripts for EMC7 Gene

mRNA/cDNA for EMC7 Gene

Unigene Clusters for EMC7 Gene

ER membrane protein complex subunit 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EMC7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EMC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2:
SP3: -

Relevant External Links for EMC7 Gene

GeneLoc Exon Structure for
EMC7
ECgene alternative splicing isoforms for
EMC7

Expression for EMC7 Gene

mRNA expression in normal human tissues for EMC7 Gene

Protein differential expression in normal tissues from HIPED for EMC7 Gene

This gene is overexpressed in Brain (12.5), Islet of Langerhans (10.3), and Placenta (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EMC7 Gene



SOURCE GeneReport for Unigene cluster for EMC7 Gene Hs.160565

genes like me logo Genes that share expression patterns with EMC7: view

Protein tissue co-expression partners for EMC7 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EMC7 Gene

Orthologs for EMC7 Gene

This gene was present in the common ancestor of animals.

Orthologs for EMC7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EMC7 35
  • 92.25 (n)
  • 94.61 (a)
C10H15ORF24 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EMC7 35
  • 92.39 (n)
  • 95.44 (a)
EMC7 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Emc7 35
  • 90.59 (n)
  • 96.68 (a)
Emc7 16
Emc7 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EMC7 35
  • 99.86 (n)
  • 100 (a)
EMC7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1305045 35
  • 91.46 (n)
  • 98.17 (a)
oppossum
(Monodelphis domestica)
Mammalia EMC7 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5H15ORF24 35
  • 84.17 (n)
  • 92 (a)
EMC7 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EMC7 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia emc7 35
  • 78.6 (n)
  • 90.91 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5547 35
zebrafish
(Danio rerio)
Actinopterygii emc7 35
  • 76.14 (n)
  • 82.95 (a)
emc7 36
  • 66 (a)
OneToMany
EMC7 (2 of 2) 36
  • 55 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9630 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004626 35
  • 53.1 (n)
  • 48.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8397 35
  • 49.46 (n)
  • 40.65 (a)
CG8397 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C35D10.1 35
  • 54.9 (n)
  • 41.76 (a)
C35D10.1 36
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10397 36
  • 42 (a)
OneToOne
Species with no ortholog for EMC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EMC7 Gene

ENSEMBL:
Gene Tree for EMC7 (if available)
TreeFam:
Gene Tree for EMC7 (if available)

Paralogs for EMC7 Gene

No data available for Paralogs for EMC7 Gene

Variants for EMC7 Gene

Sequence variations from dbSNP and Humsavar for EMC7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs721122 -- 34,087,404(+) ATCCT(C/T)TCCCT intron-variant
rs1865924 -- 34,085,179(+) TATAA(C/G)CCTCA intron-variant
rs1865925 -- 34,085,400(+) AGTGA(C/T)ATTCT intron-variant
rs2339373 -- 34,097,357(+) CAAAT(A/G)ATAAA intron-variant
rs2568532 -- 34,095,164(-) TGACT(A/G)TGTTG intron-variant

Variation tolerance for EMC7 Gene

Residual Variation Intolerance Score: 32.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EMC7 Gene

HapMap Linkage Disequilibrium report
EMC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EMC7 Gene

Disorders for EMC7 Gene

Relevant External Links for EMC7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EMC7
genes like me logo Genes that share disorders with EMC7: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EMC7 Gene

Publications for EMC7 Gene

  1. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 2 67
  2. Characterization of five novel human genes in the 11q13-q22 region. (PMID: 10873569) O'Brien K.P. … Dumanski J.P. (Biochem. Biophys. Res. Commun. 2000) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  5. Identification of novel ATP13A2 interactors and their role in I+-synuclein misfolding and toxicity. (PMID: 22645275) Usenovic M. … Krainc D. (Hum. Mol. Genet. 2012) 67

Products for EMC7 Gene

Sources for EMC7 Gene

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