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Aliases for EMC4 Gene

Aliases for EMC4 Gene

  • ER Membrane Protein Complex Subunit 4 2 3 5
  • Transmembrane Protein 85 2 3 4
  • Cell Proliferation-Inducing Gene 17 Protein 3 4
  • TMEM85 3 4
  • PIG17 3

External Ids for EMC4 Gene

Previous HGNC Symbols for EMC4 Gene

  • TMEM85

Previous GeneCards Identifiers for EMC4 Gene

  • GC15P034519

Summaries for EMC4 Gene

GeneCards Summary for EMC4 Gene

EMC4 (ER Membrane Protein Complex Subunit 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for EMC4 Gene

  • May mediate anti-apoptotic activity.

Additional gene information for EMC4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMC4 Gene

Genomics for EMC4 Gene

Regulatory Elements for EMC4 Gene

Enhancers for EMC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H034100 1.1 ENCODE 10.7 -123.3 -123275 2 PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF207 ZNF143 AVEN KATNBL1 EMC4 PGBD4 EMC7 RPL32P2
GH15H034317 1.2 ENCODE dbSUPER 8.8 +93.8 93802 3 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ATF7 RUNX3 SP5 REST NOP10 SLC12A6 GOLGA8A AQR ENSG00000259287 LOC101929988 EMC4 ENSG00000207091
GH15H034055 0.7 Ensembl ENCODE 10.9 -168.5 -168462 2 JUND JUN AVEN KATNBL1 EMC4 GC15M034069 ENSG00000259505
GH15H034303 0.6 dbSUPER 10.6 +80.2 80207 4 SOX5 SOX13 FOXA2 CEBPG ATF2 MAFK NOP10 SLC12A6 NUTM1 KATNBL1 EMC4 GC15P034315 ENSG00000259468
GH15H034435 1 ENCODE 5 +212.1 212135 2 ATF1 ARNT ARID4B DMAP1 SLC30A9 GLIS2 RUNX3 MXD4 ZNF592 KAT8 GOLGA8A ACTG1P15 FSCN1P1 EMC4 ENSG00000279092
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EMC4 on UCSC Golden Path with GeneCards custom track

Promoters for EMC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000074779 -97 1801 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF302

Genomic Location for EMC4 Gene

Chromosome:
15
Start:
34,224,997 bp from pter
End:
34,230,165 bp from pter
Size:
5,169 bases
Orientation:
Plus strand

Genomic View for EMC4 Gene

Genes around EMC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC4 Gene

Proteins for EMC4 Gene

  • Protein details for EMC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5J8M3-EMC4_HUMAN
    Recommended name:
    ER membrane protein complex subunit 4
    Protein Accession:
    Q5J8M3
    Secondary Accessions:
    • A8K3A9
    • B4DJQ4
    • Q96KX9
    • Q9BUI5
    • Q9P0T9

    Protein attributes for EMC4 Gene

    Size:
    183 amino acids
    Molecular mass:
    20087 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).

    Alternative splice isoforms for EMC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EMC4 Gene

Post-translational modifications for EMC4 Gene

  • Ubiquitination at posLast=1616 and isoforms=2, 350
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EMC4 Gene

Domains & Families for EMC4 Gene

Gene Families for EMC4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for EMC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EMC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5J8M3

UniProtKB/Swiss-Prot:

EMC4_HUMAN :
  • Belongs to the EMC4 family.
Family:
  • Belongs to the EMC4 family.
genes like me logo Genes that share domains with EMC4: view

Function for EMC4 Gene

Molecular function for EMC4 Gene

UniProtKB/Swiss-Prot Function:
May mediate anti-apoptotic activity.

Phenotypes for EMC4 Gene

genes like me logo Genes that share phenotypes with EMC4: view

Animal Models for EMC4 Gene

MGI Knock Outs for EMC4:
  • Emc4 tm1(KOMP)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EMC4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EMC4 Gene

Localization for EMC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EMC4 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
mitochondrion 2
peroxisome 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IDA 22119785
GO:0072546 ER membrane protein complex IDA 22119785
genes like me logo Genes that share ontologies with EMC4: view

Pathways & Interactions for EMC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0034975 protein folding in endoplasmic reticulum IBA --
genes like me logo Genes that share ontologies with EMC4: view

No data available for Pathways by source and SIGNOR curated interactions for EMC4 Gene

Drugs & Compounds for EMC4 Gene

No Compound Related Data Available

Transcripts for EMC4 Gene

Unigene Clusters for EMC4 Gene

ER membrane protein complex subunit 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EMC4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for EMC4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - - -
SP9:
SP10: - -

Relevant External Links for EMC4 Gene

GeneLoc Exon Structure for
EMC4
ECgene alternative splicing isoforms for
EMC4

Expression for EMC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EMC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EMC4 Gene

This gene is overexpressed in Bone (25.1) and Peripheral blood mononuclear cells (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EMC4 Gene



Protein tissue co-expression partners for EMC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EMC4 Gene:

EMC4

SOURCE GeneReport for Unigene cluster for EMC4 Gene:

Hs.250905

mRNA Expression by UniProt/SwissProt for EMC4 Gene:

Q5J8M3-EMC4_HUMAN
Tissue specificity: Isoform 1 is expressed in brain and heart. Isoform 2 is expressed in heart.

Evidence on tissue expression from TISSUES for EMC4 Gene

  • Liver(4.3)
  • Nervous system(4.3)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with EMC4: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EMC4 Gene

Orthologs for EMC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EMC4 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia EMC4 34
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EMC4 33 34
  • 96.36 (n)
cow
(Bos Taurus)
Mammalia EMC4 33 34
  • 94.72 (n)
dog
(Canis familiaris)
Mammalia EMC4 33 34
  • 94.17 (n)
rat
(Rattus norvegicus)
Mammalia Emc4 33
  • 93.62 (n)
mouse
(Mus musculus)
Mammalia Emc4 16 34 33
  • 93.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EMC4 34
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves EMC4 34 33
  • 65.69 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EMC4 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia emc4 33
  • 75.56 (n)
MGC75691 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8318 33
zebrafish
(Danio rerio)
Actinopterygii emc4 33 34 34
  • 70.81 (n)
Dr.11020 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11082 33
fruit fly
(Drosophila melanogaster)
Insecta CG11137 33 34
  • 56.84 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010558 33
  • 55.76 (n)
worm
(Caenorhabditis elegans)
Secernentea perm-3 33 34
  • 51.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMC4 34 36
  • 26 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10780 33
  • 45.29 (n)
rice
(Oryza sativa)
Liliopsida Os03g0360500 33
  • 45.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3102 34
  • 54 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1875 33
Species where no ortholog for EMC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EMC4 Gene

ENSEMBL:
Gene Tree for EMC4 (if available)
TreeFam:
Gene Tree for EMC4 (if available)

Paralogs for EMC4 Gene

No data available for Paralogs for EMC4 Gene

Variants for EMC4 Gene

Sequence variations from dbSNP and Humsavar for EMC4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1133154 Likely benign 34,230,356(+) CCCAC(A/G)ATAAG intron-variant, utr-variant-3-prime
rs11544435 Likely benign 34,230,213(+) CTGGG(A/T)CATAA intron-variant, utr-variant-3-prime
rs189231487 Uncertain significance 34,230,493(+) AGATG(A/C/G)TGCAG downstream-variant-500B, utr-variant-3-prime
rs549855456 Uncertain significance 34,230,301(+) CCAGA(A/C)AAAAG intron-variant, utr-variant-3-prime
rs552491692 Uncertain significance 34,230,039(+) CAGAG(A/C)AAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EMC4 Gene

Variant ID Type Subtype PubMed ID
dgv4456n54 CNV gain 21841781
esv33337 CNV gain+loss 17666407
esv3569431 CNV gain 25503493
nsv1052620 CNV gain 25217958

Variation tolerance for EMC4 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EMC4 Gene

Human Gene Mutation Database (HGMD)
EMC4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EMC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EMC4 Gene

Disorders for EMC4 Gene

Relevant External Links for EMC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EMC4

No disorders were found for EMC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EMC4 Gene

Publications for EMC4 Gene

  1. Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast. (PMID: 18586032) Ring G … Greenwood MT (FEBS letters 2008) 2 3 4 22 60
  2. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson JC … Kopito RR (Nature cell biology 2011) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 60

Products for EMC4 Gene

Sources for EMC4 Gene

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