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Aliases for EMC4 Gene

Aliases for EMC4 Gene

  • ER Membrane Protein Complex Subunit 4 2 3 5
  • Transmembrane Protein 85 2 3 4
  • Cell Proliferation-Inducing Gene 17 Protein 3 4
  • TMEM85 3 4
  • PIG17 3

External Ids for EMC4 Gene

Previous HGNC Symbols for EMC4 Gene

  • TMEM85

Previous GeneCards Identifiers for EMC4 Gene

  • GC15P034519

Summaries for EMC4 Gene

GeneCards Summary for EMC4 Gene

EMC4 (ER Membrane Protein Complex Subunit 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for EMC4 Gene

  • May mediate anti-apoptotic activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMC4 Gene

Genomics for EMC4 Gene

Regulatory Elements for EMC4 Gene

Promoters for EMC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EMC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for EMC4 Gene

Chromosome:
15
Start:
34,224,997 bp from pter
End:
34,230,165 bp from pter
Size:
5,169 bases
Orientation:
Plus strand

Genomic View for EMC4 Gene

Genes around EMC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC4 Gene

Proteins for EMC4 Gene

  • Protein details for EMC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5J8M3-EMC4_HUMAN
    Recommended name:
    ER membrane protein complex subunit 4
    Protein Accession:
    Q5J8M3
    Secondary Accessions:
    • A8K3A9
    • B4DJQ4
    • Q96KX9
    • Q9BUI5
    • Q9P0T9

    Protein attributes for EMC4 Gene

    Size:
    183 amino acids
    Molecular mass:
    20087 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).

    Alternative splice isoforms for EMC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EMC4 Gene

Proteomics data for EMC4 Gene at MOPED

Post-translational modifications for EMC4 Gene

  • Ubiquitination at Lys 16 and Lys 50
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EMC4 Gene

Domains & Families for EMC4 Gene

Protein Domains for EMC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EMC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5J8M3

UniProtKB/Swiss-Prot:

EMC4_HUMAN :
  • Belongs to the EMC4 family.
Family:
  • Belongs to the EMC4 family.
genes like me logo Genes that share domains with EMC4: view

No data available for Gene Families for EMC4 Gene

Function for EMC4 Gene

Molecular function for EMC4 Gene

UniProtKB/Swiss-Prot Function:
May mediate anti-apoptotic activity.

Phenotypes for EMC4 Gene

MGI mutant phenotypes for EMC4:
inferred from 1 alleles
GenomeRNAi human phenotypes for EMC4:
genes like me logo Genes that share phenotypes with EMC4: view

Animal Models for EMC4 Gene

MGI Knock Outs for EMC4:
  • Emc4 tm1(KOMP)Wtsi

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EMC4 Gene

Localization for EMC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EMC4 Gene COMPARTMENTS Subcellular localization image for EMC4 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
cytosol 2
mitochondrion 2
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for EMC4 Gene

Pathways & Interactions for EMC4 Gene

SuperPathways for EMC4 Gene

No Data Available

Interacting Proteins for EMC4 Gene

Gene Ontology (GO) - Biological Process for EMC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EMC4 Gene

Drugs & Compounds for EMC4 Gene

No Compound Related Data Available

Transcripts for EMC4 Gene

Unigene Clusters for EMC4 Gene

ER membrane protein complex subunit 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EMC4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - - -
SP9:
SP10: - -

Relevant External Links for EMC4 Gene

GeneLoc Exon Structure for
EMC4
ECgene alternative splicing isoforms for
EMC4

Expression for EMC4 Gene

mRNA expression in normal human tissues for EMC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EMC4 Gene

This gene is overexpressed in Bone (25.1) and Peripheral blood mononuclear cells (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EMC4 Gene



SOURCE GeneReport for Unigene cluster for EMC4 Gene Hs.250905

mRNA Expression by UniProt/SwissProt for EMC4 Gene

Q5J8M3-EMC4_HUMAN
Tissue specificity: Isoform 1 is expressed in brain and heart. Isoform 2 is expressed in heart.
genes like me logo Genes that share expression patterns with EMC4: view

Protein tissue co-expression partners for EMC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for EMC4 Gene

Orthologs for EMC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EMC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EMC4 35
  • 94.72 (n)
  • 98.91 (a)
EMC4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EMC4 35
  • 94.17 (n)
  • 97.81 (a)
EMC4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Emc4 35
  • 93.44 (n)
  • 99.45 (a)
Emc4 16
Emc4 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EMC4 35
  • 96.36 (n)
  • 94.54 (a)
EMC4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Emc4 35
  • 93.62 (n)
  • 99.45 (a)
oppossum
(Monodelphis domestica)
Mammalia EMC4 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EMC4 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves EMC4 35
  • 65.69 (n)
  • 68.82 (a)
EMC4 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EMC4 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia emc4 35
  • 75.56 (n)
  • 83.89 (a)
MGC75691 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8318 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11020 35
emc4 35
  • 70.81 (n)
  • 76.27 (a)
emc4 36
  • 77 (a)
OneToMany
emc4 36
  • 77 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11082 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010558 35
  • 55.76 (n)
  • 53.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11137 35
  • 56.84 (n)
  • 55.77 (a)
CG11137 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea perm-3 35
  • 51.74 (n)
  • 49.25 (a)
perm-3 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMC4 36
  • 26 (a)
OneToOne
EMC4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10780 35
  • 45.29 (n)
  • 38.82 (a)
rice
(Oryza sativa)
Liliopsida Os03g0360500 35
  • 45.86 (n)
  • 30.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1875 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3102 36
  • 54 (a)
OneToOne
Species with no ortholog for EMC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EMC4 Gene

ENSEMBL:
Gene Tree for EMC4 (if available)
TreeFam:
Gene Tree for EMC4 (if available)

Paralogs for EMC4 Gene

No data available for Paralogs for EMC4 Gene

Variants for EMC4 Gene

Sequence variations from dbSNP and Humsavar for EMC4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11544437 - 34,227,783(-) AGTAG(G/T)GAAGA reference, missense
rs1132869 -- 34,225,136(+) CTGTG(G/T)TGGCT reference, missense
rs2705105 -- 34,228,601(+) CAAAA(A/G)AAAAG intron-variant
rs2705116 -- 34,224,545(+) tttga(A/G)acaga upstream-variant-2KB
rs2705328 -- 34,224,510(+) GTTAA(A/G)AAGCT upstream-variant-2KB

Variation tolerance for EMC4 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EMC4 Gene

HapMap Linkage Disequilibrium report
EMC4
Human Gene Mutation Database (HGMD)
EMC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EMC4 Gene

Disorders for EMC4 Gene

Relevant External Links for EMC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EMC4

No disorders were found for EMC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EMC4 Gene

Publications for EMC4 Gene

  1. Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast. (PMID: 18586032) Ring G. … Greenwood M.T. (FEBS Lett. 2008) 2 3 4 23 67
  2. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3

Products for EMC4 Gene

Sources for EMC4 Gene

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