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Aliases for EMC4 Gene

Aliases for EMC4 Gene

  • ER Membrane Protein Complex Subunit 4 2 3
  • Transmembrane Protein 85 2 3 4
  • Cell Proliferation-Inducing Gene 17 Protein 3 4
  • TMEM85 3 4
  • PIG17 3

External Ids for EMC4 Gene

Previous HGNC Symbols for EMC4 Gene

  • TMEM85

Previous GeneCards Identifiers for EMC4 Gene

  • GC15P034519

Summaries for EMC4 Gene

GeneCards Summary for EMC4 Gene

EMC4 (ER Membrane Protein Complex Subunit 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for EMC4 Gene

  • May mediate anti-apoptotic activity

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMC4 Gene

Genomics for EMC4 Gene

Genomic Location for EMC4 Gene

Start:
34,224,997 bp from pter
End:
34,230,165 bp from pter
Size:
5,169 bases
Orientation:
Plus strand

Genomic View for EMC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EMC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC4 Gene

No data available for Regulatory Elements for EMC4 Gene

Proteins for EMC4 Gene

  • Protein details for EMC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5J8M3-EMC4_HUMAN
    Recommended name:
    ER membrane protein complex subunit 4
    Protein Accession:
    Q5J8M3
    Secondary Accessions:
    • A8K3A9
    • B4DJQ4
    • Q96KX9
    • Q9BUI5
    • Q9P0T9

    Protein attributes for EMC4 Gene

    Size:
    183 amino acids
    Molecular mass:
    20087 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).

    Alternative splice isoforms for EMC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EMC4 Gene

Proteomics data for EMC4 Gene at MOPED

Post-translational modifications for EMC4 Gene

  • Ubiquitination at Lys16 and Lys50
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EMC4 Gene

Domains for EMC4 Gene

Protein Domains for EMC4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5J8M3

UniProtKB/Swiss-Prot:

EMC4_HUMAN :
  • Q5J8M3
Family:
  • Belongs to the EMC4 family.
genes like me logo Genes that share domains with EMC4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for EMC4 Gene

Function for EMC4 Gene

Molecular function for EMC4 Gene

UniProtKB/Swiss-Prot Function: May mediate anti-apoptotic activity

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EMC4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for EMC4 Gene

Localization for EMC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC4 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for EMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IDA 22119785
GO:0072546 ER membrane protein complex IDA 22119785
genes like me logo Genes that share ontologies with EMC4: view

No data available for Subcellular locations from COMPARTMENTS for EMC4 Gene

Pathways for EMC4 Gene

SuperPathways for EMC4 Gene

No Data Available

Interacting Proteins for EMC4 Gene

Gene Ontology (GO) - Biological Process for EMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with EMC4: view

No data available for Pathways by source for EMC4 Gene

Transcripts for EMC4 Gene

Unigene Clusters for EMC4 Gene

ER membrane protein complex subunit 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EMC4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EMC4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - - -
SP9:
SP10: - -

Relevant External Links for EMC4 Gene

GeneLoc Exon Structure for
EMC4
ECgene alternative splicing isoforms for
EMC4

Expression for EMC4 Gene

mRNA expression in normal human tissues for EMC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EMC4 Gene

SOURCE GeneReport for Unigene cluster for EMC4 Gene Hs.250905

mRNA Expression by UniProt/SwissProt for EMC4 Gene

Q5J8M3-EMC4_HUMAN
Tissue specificity: Isoform 1 is expressed in brain and heart. Isoform 2 is expressed in heart.
genes like me logo Genes that share expressions with EMC4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for EMC4 Gene

Orthologs for EMC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EMC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EMC4 35
  • 96.36 (n)
  • 94.54 (a)
EMC4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EMC4 35
  • 94.72 (n)
  • 98.91 (a)
EMC4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EMC4 35
  • 94.17 (n)
  • 97.81 (a)
EMC4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Emc4 35
  • 93.44 (n)
  • 99.45 (a)
Emc4 16
Emc4 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EMC4 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EMC4 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Emc4 35
  • 93.62 (n)
  • 99.45 (a)
chicken
(Gallus gallus)
Aves EMC4 35
  • 65.69 (n)
  • 68.82 (a)
EMC4 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EMC4 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8318 35
tropical clawed frog
(Silurana tropicalis)
Amphibia emc4 35
  • 75.56 (n)
  • 83.89 (a)
MGC75691 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11082 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11020 35
emc4 35
  • 70.81 (n)
  • 76.27 (a)
emc4 36
  • 77 (a)
OneToMany
emc4 36
  • 77 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010558 35
  • 55.76 (n)
  • 53.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11137 35
  • 56.84 (n)
  • 55.77 (a)
CG11137 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea perm-3 35
  • 51.74 (n)
  • 49.25 (a)
perm-3 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMC4 36
  • 26 (a)
OneToOne
EMC4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10780 35
  • 45.29 (n)
  • 38.82 (a)
rice
(Oryza sativa)
Liliopsida Os03g0360500 35
  • 45.86 (n)
  • 30.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1875 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3102 36
  • 54 (a)
OneToOne
Species with no ortholog for EMC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EMC4 Gene

ENSEMBL:
Gene Tree for EMC4 (if available)
TreeFam:
Gene Tree for EMC4 (if available)

Paralogs for EMC4 Gene

No data available for Paralogs for EMC4 Gene

Variants for EMC4 Gene

Sequence variations from dbSNP and Humsavar for EMC4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1132869 -- 34,225,136(+) CTGTG(G/T)TGGCT reference, missense
rs2705105 -- 34,228,601(+) CAAAA(A/G)AAAAG intron-variant
rs2705116 -- 34,224,545(+) tttga(A/G)acaga upstream-variant-2KB
rs2705328 -- 34,224,510(+) GTTAA(A/G)AAGCT upstream-variant-2KB
rs7165280 -- 34,228,980(+) actgc(A/G)cctgg intron-variant

Relevant External Links for EMC4 Gene

HapMap Linkage Disequilibrium report
EMC4
Human Gene Mutation Database (HGMD)
EMC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EMC4 Gene

Disorders for EMC4 Gene

No disorders were found for EMC4 Gene.

No data available for UniProtKB/Swiss-Prot for EMC4 Gene

Publications for EMC4 Gene

  1. Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast. (PMID: 18586032) Ring G. … Greenwood M.T. (FEBS Lett. 2008) 2 3 4 23
  2. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4

Products for EMC4 Gene

Sources for EMC4 Gene

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