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Aliases for EMC3 Gene

Aliases for EMC3 Gene

  • ER Membrane Protein Complex Subunit 3 2 3
  • Transmembrane Protein 111 2 3 4
  • TMEM111 3 4
  • Partial Optokinetic Response B 3
  • 30 KDa Protein 3
  • POB 3

External Ids for EMC3 Gene

Previous HGNC Symbols for EMC3 Gene

  • TMEM111

Previous GeneCards Identifiers for EMC3 Gene

  • GC03M010007

Summaries for EMC3 Gene

GeneCards Summary for EMC3 Gene

EMC3 (ER Membrane Protein Complex Subunit 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMC3 Gene

Genomics for EMC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EMC3 Gene

Start:
9,962,537 bp from pter
End:
10,011,116 bp from pter
Size:
48,580 bases
Orientation:
Minus strand

Genomic View for EMC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EMC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC3 Gene

No data available for Regulatory Elements for EMC3 Gene

Proteins for EMC3 Gene

  • Protein details for EMC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0I2-EMC3_HUMAN
    Recommended name:
    ER membrane protein complex subunit 3
    Protein Accession:
    Q9P0I2
    Secondary Accessions:
    • B2R4Z9
    • Q53GH8
    • Q6ZMC2

    Protein attributes for EMC3 Gene

    Size:
    261 amino acids
    Molecular mass:
    29952 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).
    SequenceCaution:
    • Sequence=BAD18807.1; Type=Erroneous termination; Positions=222; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for EMC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EMC3 Gene

Proteomics data for EMC3 Gene at MOPED

Post-translational modifications for EMC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EMC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EMC3 Gene

Domains for EMC3 Gene

Protein Domains for EMC3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P0I2

UniProtKB/Swiss-Prot:

EMC3_HUMAN :
  • Q9P0I2
Family:
  • Belongs to the EMC3 family.
genes like me logo Genes that share domains with EMC3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for EMC3 Gene

Function for EMC3 Gene

Gene Ontology (GO) - Molecular Function for EMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with EMC3: view

Phenotypes for EMC3 Gene

GenomeRNAi human phenotypes for EMC3:
genes like me logo Genes that share phenotypes with EMC3: view

miRNA for EMC3 Gene

miRTarBase miRNAs that target EMC3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EMC3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EMC3 Gene

Localization for EMC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC3 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for EMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IDA 22119785
GO:0072546 ER membrane protein complex IDA 22119785
genes like me logo Genes that share ontologies with EMC3: view

No data available for Subcellular locations from COMPARTMENTS for EMC3 Gene

Pathways for EMC3 Gene

SuperPathways for EMC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0034975 protein folding in endoplasmic reticulum IBA --
genes like me logo Genes that share ontologies with EMC3: view

No data available for Pathways by source for EMC3 Gene

Transcripts for EMC3 Gene

Unigene Clusters for EMC3 Gene

ER membrane protein complex subunit 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EMC3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EMC3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
SP1: - -
SP2: -
SP3: - - - -
SP4:

Relevant External Links for EMC3 Gene

GeneLoc Exon Structure for
EMC3
ECgene alternative splicing isoforms for
EMC3

Expression for EMC3 Gene

mRNA expression in normal human tissues for EMC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for EMC3 Gene

This gene is overexpressed in Bone (11.5) and Placenta (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EMC3 Gene

SOURCE GeneReport for Unigene cluster for EMC3 Gene Hs.475392

genes like me logo Genes that share expressions with EMC3: view

Expression partners for EMC3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EMC3 Gene

Orthologs for EMC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EMC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EMC3 35
  • 93.49 (n)
  • 99.62 (a)
EMC3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EMC3 35
  • 94.89 (n)
  • 100 (a)
EMC3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Emc3 35
  • 91.44 (n)
  • 99.62 (a)
Emc3 16
Emc3 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EMC3 35
  • 100 (n)
  • 100 (a)
TMEM111 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Emc3 35
  • 89.53 (n)
  • 99.62 (a)
oppossum
(Monodelphis domestica)
Mammalia EMC3 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EMC3 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves EMC3 35
  • 83.27 (n)
  • 96.93 (a)
EMC3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EMC3 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia emc3 35
  • 80.59 (n)
  • 93.87 (a)
Str.1909 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.34728 35
zebrafish
(Danio rerio)
Actinopterygii emc3 35
  • 75.1 (n)
  • 89.66 (a)
wufi32f05 35
emc3 36
  • 90 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1284 35
fruit fly
(Drosophila melanogaster)
Insecta CG6750 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea emc-3 36
  • 58 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIM27 36
  • 30 (a)
OneToOne
AIM27 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G12590 35
  • 52.53 (n)
  • 43.72 (a)
rice
(Oryza sativa)
Liliopsida Os09g0497400 35
  • 56.03 (n)
  • 46.12 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4027 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9956 36
  • 65 (a)
OneToOne
Species with no ortholog for EMC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EMC3 Gene

ENSEMBL:
Gene Tree for EMC3 (if available)
TreeFam:
Gene Tree for EMC3 (if available)

Paralogs for EMC3 Gene

Pseudogenes.org Pseudogenes for EMC3 Gene

genes like me logo Genes that share paralogs with EMC3: view

No data available for Paralogs for EMC3 Gene

Variants for EMC3 Gene

Sequence variations from dbSNP and Humsavar for EMC3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs12087 -- 9,964,135(+) ATGAG(C/T)TCTTC synonymous-codon, reference
rs13237 -- 9,969,747(+) CGGGC(A/G)TGGCC missense, reference
rs398025 -- 9,974,098(+) GAAGT(C/G)AAAAT intron-variant
rs781866 -- 9,972,860(+) gtctc(A/G)ctctg intron-variant
rs781867 -- 9,972,907(+) cactg(C/T)aagct intron-variant

Relevant External Links for EMC3 Gene

HapMap Linkage Disequilibrium report
EMC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EMC3 Gene

Disorders for EMC3 Gene

No disorders were found for EMC3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for EMC3 Gene

Publications for EMC3 Gene

  1. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 2 3 4
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Coexpression network based on natural variation in human gene expression reveals gene interactions and functions. (PMID: 19797678) Nayak R.R. … Cheung V.G. (Genome Res. 2009) 2 3

Products for EMC3 Gene

Sources for EMC3 Gene

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