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Aliases for EMC2 Gene

Aliases for EMC2 Gene

  • ER Membrane Protein Complex Subunit 2 2 3
  • KIAA0103 3 4 6
  • Tetratricopeptide Repeat Protein 35 3 4
  • Tetratricopeptide Repeat Domain 35 2 3
  • TPR Repeat Protein 35 3 4
  • TTC35 3 4

External Ids for EMC2 Gene

Previous HGNC Symbols for EMC2 Gene

  • KIAA0103
  • TTC35

Previous GeneCards Identifiers for EMC2 Gene

  • GC08P109455

Summaries for EMC2 Gene

GeneCards Summary for EMC2 Gene

EMC2 (ER Membrane Protein Complex Subunit 2) is a Protein Coding gene.

Gene Wiki entry for EMC2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMC2 Gene

Genomics for EMC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EMC2 Gene

Start:
108,443,601 bp from pter
End:
108,486,918 bp from pter
Size:
43,318 bases
Orientation:
Plus strand

Genomic View for EMC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC2 Gene

No data available for Regulatory Elements for EMC2 Gene

Proteins for EMC2 Gene

  • Protein details for EMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15006-EMC2_HUMAN
    Recommended name:
    ER membrane protein complex subunit 2
    Protein Accession:
    Q15006
    Secondary Accessions:
    • Q8WUE1

    Protein attributes for EMC2 Gene

    Size:
    297 amino acids
    Molecular mass:
    34834 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).

neXtProt entry for EMC2 Gene

Proteomics data for EMC2 Gene at MOPED

Post-translational modifications for EMC2 Gene

  • Ubiquitination at Lys220
  • Modification sites at PhosphoSitePlus

Other Protein References for EMC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EMC2 Gene

Domains for EMC2 Gene

Protein Domains for EMC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15006

UniProtKB/Swiss-Prot:

EMC2_HUMAN :
  • Q15006
Family:
  • Belongs to the EMC2 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with EMC2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for EMC2 Gene

Function for EMC2 Gene

Gene Ontology (GO) - Molecular Function for EMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with EMC2: view

Phenotypes for EMC2 Gene

GenomeRNAi human phenotypes for EMC2:
genes like me logo Genes that share phenotypes with EMC2: view

Animal Model Products

CRISPR Products

miRNA for EMC2 Gene

miRTarBase miRNAs that target EMC2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EMC2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EMC2 Gene

Localization for EMC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC2 Gene

Nucleus. Cytoplasm.

Gene Ontology (GO) - Cellular Components for EMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IDA 10942595
genes like me logo Genes that share ontologies with EMC2: view

No data available for Subcellular locations from COMPARTMENTS for EMC2 Gene

Pathways for EMC2 Gene

SuperPathways for EMC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EMC2 Gene

None

No data available for Pathways by source for EMC2 Gene

Transcripts for EMC2 Gene

Unigene Clusters for EMC2 Gene

ER membrane protein complex subunit 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EMC2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EMC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2:
SP3:

Relevant External Links for EMC2 Gene

GeneLoc Exon Structure for
EMC2
ECgene alternative splicing isoforms for
EMC2

Expression for EMC2 Gene

mRNA expression in normal human tissues for EMC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EMC2 Gene

SOURCE GeneReport for Unigene cluster for EMC2 Gene Hs.654351

genes like me logo Genes that share expressions with EMC2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EMC2 Gene

Orthologs for EMC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EMC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EMC2 35
  • 99.89 (n)
  • 100 (a)
TTC35 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EMC2 35
  • 95.17 (n)
  • 98.99 (a)
EMC2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 100 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
EMC2 35
  • 96.18 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Emc2 35
  • 92.03 (n)
  • 97.31 (a)
Emc2 16
Emc2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EMC2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EMC2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Emc2 35
  • 91.25 (n)
  • 96.63 (a)
chicken
(Gallus gallus)
Aves EMC2 35
  • 86.64 (n)
  • 96.3 (a)
EMC2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EMC2 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia kiaa0103-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia emc2 35
  • 80.47 (n)
  • 85.19 (a)
Str.11799 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10898 35
zebrafish
(Danio rerio)
Actinopterygii Dr.7383 35
emc2 35
  • 74.75 (n)
  • 85.19 (a)
emc2 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001136 35
  • 50.53 (n)
  • 44.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17556 36
  • 45 (a)
OneToMany
CG3678 35
  • 52.23 (n)
  • 48.03 (a)
CG3678 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea emc-2 36
  • 38 (a)
OneToOne
Y57G7A.10 35
  • 50 (n)
  • 39.93 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G28220 35
  • 51.28 (n)
  • 42.11 (a)
rice
(Oryza sativa)
Liliopsida Os02g0127000 35
  • 55.87 (n)
  • 48.3 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04651 35
  • 43.51 (n)
  • 32.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oca3 35
  • 46.96 (n)
  • 34.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for EMC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EMC2 Gene

ENSEMBL:
Gene Tree for EMC2 (if available)
TreeFam:
Gene Tree for EMC2 (if available)

Paralogs for EMC2 Gene

No data available for Paralogs for EMC2 Gene

Variants for EMC2 Gene

Sequence variations from dbSNP and Humsavar for EMC2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs981019 -- 108,468,541(+) TAAAC(A/G)TTGCT intron-variant
rs981020 -- 108,468,858(+) GTTTA(C/T)TTCAG intron-variant
rs1065243 -- 108,481,149(+) TGTCA(C/T)CTGTG intron-variant
rs1351401 -- 108,465,204(+) AAACA(A/G)ATTAT intron-variant
rs1351402 -- 108,465,220(+) TTTCC(A/G)TTTAT intron-variant

Relevant External Links for EMC2 Gene

HapMap Linkage Disequilibrium report
EMC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EMC2 Gene

Disorders for EMC2 Gene

No disorders were found for EMC2 Gene.

No data available for UniProtKB/Swiss-Prot for EMC2 Gene

Publications for EMC2 Gene

  1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  2. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (PMID: 17110338) Wang X. … Balch W.E. (Cell 2006) 3

Products for EMC2 Gene

Sources for EMC2 Gene

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