Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EMC2 Gene

Aliases for EMC2 Gene

  • ER Membrane Protein Complex Subunit 2 2 3 5
  • Tetratricopeptide Repeat Protein 35 3 4
  • Tetratricopeptide Repeat Domain 35 2 3
  • TPR Repeat Protein 35 3 4
  • KIAA0103 3 4
  • TTC35 3 4

External Ids for EMC2 Gene

Previous HGNC Symbols for EMC2 Gene

  • KIAA0103
  • TTC35

Previous GeneCards Identifiers for EMC2 Gene

  • GC08P109455

Summaries for EMC2 Gene

GeneCards Summary for EMC2 Gene

EMC2 (ER Membrane Protein Complex Subunit 2) is a Protein Coding gene.

Gene Wiki entry for EMC2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMC2 Gene

Genomics for EMC2 Gene

Regulatory Elements for EMC2 Gene

Enhancers for EMC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EMC2 on UCSC Golden Path with GeneCards custom track

Promoters for EMC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EMC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for EMC2 Gene

Chromosome:
8
Start:
108,443,601 bp from pter
End:
108,486,918 bp from pter
Size:
43,318 bases
Orientation:
Plus strand

Genomic View for EMC2 Gene

Genes around EMC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EMC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMC2 Gene

Proteins for EMC2 Gene

  • Protein details for EMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15006-EMC2_HUMAN
    Recommended name:
    ER membrane protein complex subunit 2
    Protein Accession:
    Q15006
    Secondary Accessions:
    • Q8WUE1

    Protein attributes for EMC2 Gene

    Size:
    297 amino acids
    Molecular mass:
    34834 Da
    Quaternary structure:
    • Component of the ER membrane protein complex (EMC).

neXtProt entry for EMC2 Gene

Proteomics data for EMC2 Gene at MOPED

Post-translational modifications for EMC2 Gene

  • Ubiquitination at Lys 220
  • Modification sites at PhosphoSitePlus

Other Protein References for EMC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EMC2 Gene

Domains & Families for EMC2 Gene

Gene Families for EMC2 Gene

Protein Domains for EMC2 Gene

Suggested Antigen Peptide Sequences for EMC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15006

UniProtKB/Swiss-Prot:

EMC2_HUMAN :
  • Belongs to the EMC2 family.
  • Contains 3 TPR repeats.
Family:
  • Belongs to the EMC2 family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with EMC2: view

Function for EMC2 Gene

Phenotypes for EMC2 Gene

genes like me logo Genes that share phenotypes with EMC2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EMC2 Gene

Localization for EMC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMC2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EMC2 Gene COMPARTMENTS Subcellular localization image for EMC2 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 3
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for EMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22119785
GO:0005739 mitochondrion IEA --
GO:0072546 ER membrane protein complex IDA 22119785
genes like me logo Genes that share ontologies with EMC2: view

Pathways & Interactions for EMC2 Gene

SuperPathways for EMC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EMC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EMC2 Gene

Drugs & Compounds for EMC2 Gene

No Compound Related Data Available

Transcripts for EMC2 Gene

Unigene Clusters for EMC2 Gene

ER membrane protein complex subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EMC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2:
SP3:

Relevant External Links for EMC2 Gene

GeneLoc Exon Structure for
EMC2
ECgene alternative splicing isoforms for
EMC2

Expression for EMC2 Gene

mRNA expression in normal human tissues for EMC2 Gene

Protein differential expression in normal tissues from HIPED for EMC2 Gene

This gene is overexpressed in Bone (14.3) and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EMC2 Gene



SOURCE GeneReport for Unigene cluster for EMC2 Gene Hs.654351

genes like me logo Genes that share expression patterns with EMC2: view

Protein tissue co-expression partners for EMC2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EMC2 Gene

Orthologs for EMC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EMC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EMC2 35
  • 95.17 (n)
  • 98.99 (a)
EMC2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EMC2 35
  • 96.18 (n)
  • 100 (a)
-- 36
  • 100 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Emc2 35
  • 92.03 (n)
  • 97.31 (a)
Emc2 16
Emc2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EMC2 35
  • 99.89 (n)
  • 100 (a)
TTC35 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Emc2 35
  • 91.25 (n)
  • 96.63 (a)
oppossum
(Monodelphis domestica)
Mammalia EMC2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EMC2 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves EMC2 35
  • 86.64 (n)
  • 96.3 (a)
EMC2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EMC2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia emc2 35
  • 80.47 (n)
  • 85.19 (a)
Str.11799 35
African clawed frog
(Xenopus laevis)
Amphibia kiaa0103-prov 35
zebrafish
(Danio rerio)
Actinopterygii emc2 35
  • 74.75 (n)
  • 85.19 (a)
emc2 36
  • 85 (a)
OneToOne
Dr.7383 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10898 35
fruit fly
(Drosophila melanogaster)
Insecta CG3678 35
  • 52.23 (n)
  • 48.03 (a)
CG17556 36
  • 45 (a)
OneToMany
CG3678 36
  • 45 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001136 35
  • 50.53 (n)
  • 44.84 (a)
worm
(Caenorhabditis elegans)
Secernentea Y57G7A.10 35
  • 50 (n)
  • 39.93 (a)
emc-2 36
  • 38 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G28220 35
  • 51.28 (n)
  • 42.11 (a)
rice
(Oryza sativa)
Liliopsida Os02g0127000 35
  • 55.87 (n)
  • 48.3 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04651 35
  • 43.51 (n)
  • 32.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oca3 35
  • 46.96 (n)
  • 34.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for EMC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EMC2 Gene

ENSEMBL:
Gene Tree for EMC2 (if available)
TreeFam:
Gene Tree for EMC2 (if available)

Paralogs for EMC2 Gene

No data available for Paralogs for EMC2 Gene

Variants for EMC2 Gene

Sequence variations from dbSNP and Humsavar for EMC2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2023103 -- 108,473,717(+) TTGGT(A/G)AAGTA intron-variant
rs2127733 -- 108,480,341(-) AACAT(C/T)GTCTC intron-variant
rs2127734 -- 108,480,192(-) ATACA(C/T)GTATT intron-variant
rs2156741 -- 108,447,132(+) AAACT(A/G)AAACC intron-variant
rs2156742 -- 108,451,375(+) ttatt(A/T)tattt intron-variant

Variation tolerance for EMC2 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EMC2 Gene

HapMap Linkage Disequilibrium report
EMC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EMC2 Gene

Disorders for EMC2 Gene

Relevant External Links for EMC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EMC2

No disorders were found for EMC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EMC2 Gene

Publications for EMC2 Gene

  1. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for EMC2 Gene

Sources for EMC2 Gene

Content