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Aliases for EMB Gene

Aliases for EMB Gene

  • Embigin 2 3
  • Embigin Homolog (Mouse) 2
  • Embigin Homolog 3
  • GP70 3

External Ids for EMB Gene

Previous GeneCards Identifiers for EMB Gene

  • GC05M049731
  • GC05M046656
  • GC05M049693

Summaries for EMB Gene

Entrez Gene Summary for EMB Gene

  • This gene encodes a transmembrane glycoprotein that is a member of the immunoglobulin superfamily. The encoded protein may be involved in cell growth and development by mediating interactions between the cell and extracellular matrix. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Jan 2009]

GeneCards Summary for EMB Gene

EMB (Embigin) is a Protein Coding gene. An important paralog of this gene is NPTN.

UniProtKB/Swiss-Prot for EMB Gene

  • Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EMB Gene

Genomics for EMB Gene

Regulatory Elements for EMB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EMB Gene

Chromosome:
5
Start:
50,396,192 bp from pter
End:
50,443,307 bp from pter
Size:
47,116 bases
Orientation:
Minus strand

Genomic View for EMB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EMB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EMB Gene

Proteins for EMB Gene

  • Protein details for EMB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PCB8-EMB_HUMAN
    Recommended name:
    Embigin
    Protein Accession:
    Q6PCB8
    Secondary Accessions:
    • B7Z6S3
    • B7Z902

    Protein attributes for EMB Gene

    Size:
    327 amino acids
    Molecular mass:
    36881 Da
    Quaternary structure:
    • Interacts with SLC16A1 and SLC16A7.

    Alternative splice isoforms for EMB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EMB Gene

Proteomics data for EMB Gene at MOPED

Post-translational modifications for EMB Gene

  • Ubiquitination at Lys 135 and Lys 223
  • Glycosylation at Asn 54, Asn 61, Asn 75, Asn 85, Asn 100, Asn 189, Asn 196, Asn 213, and Asn 218
  • Modification sites at PhosphoSitePlus

Other Protein References for EMB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EMB Gene

Domains & Families for EMB Gene

Protein Domains for EMB Gene

Suggested Antigen Peptide Sequences for EMB Gene

Graphical View of Domain Structure for InterPro Entry

Q6PCB8

UniProtKB/Swiss-Prot:

EMB_HUMAN :
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with EMB: view

Function for EMB Gene

Molecular function for EMB Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity).

Gene Ontology (GO) - Molecular Function for EMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with EMB: view

Phenotypes for EMB Gene

GenomeRNAi human phenotypes for EMB:
genes like me logo Genes that share phenotypes with EMB: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EMB Gene

Localization for EMB Gene

Subcellular locations from UniProtKB/Swiss-Prot for EMB Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Localizes to the neuromuscular junctions. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EMB Gene COMPARTMENTS Subcellular localization image for EMB gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for EMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane ISS --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with EMB: view

Pathways & Interactions for EMB Gene

SuperPathways for EMB Gene

No Data Available

Interacting Proteins for EMB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000302289%0d%0a9606.ENSP00000263253%0d%0a
Selected Interacting proteins: ENSP00000302289 Q6PCB8-EMB_HUMAN for EMB Gene via STRING I2D

Gene Ontology (GO) - Biological Process for EMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035879 plasma membrane lactate transport ISS --
genes like me logo Genes that share ontologies with EMB: view

No data available for Pathways by source and SIGNOR curated interactions for EMB Gene

Drugs & Compounds for EMB Gene

(1) Drugs for EMB Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethambutol Approved Pharma 76

(1) Additional Compounds for EMB Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glutamate
genes like me logo Genes that share compounds with EMB: view

Transcripts for EMB Gene

Unigene Clusters for EMB Gene

Embigin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EMB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:
SP2: -

Relevant External Links for EMB Gene

GeneLoc Exon Structure for
EMB
ECgene alternative splicing isoforms for
EMB

Expression for EMB Gene

mRNA expression in normal human tissues for EMB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EMB Gene

This gene is overexpressed in Whole Blood (x18.4).

Protein differential expression in normal tissues from HIPED for EMB Gene

This gene is overexpressed in Monocytes (22.6), Testis (10.3), Heart (10.2), Peripheral blood mononuclear cells (8.3), and Blymphocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EMB Gene



SOURCE GeneReport for Unigene cluster for EMB Gene Hs.561411

genes like me logo Genes that share expression patterns with EMB: view

Protein tissue co-expression partners for EMB Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for EMB Gene

Orthologs for EMB Gene

This gene was present in the common ancestor of animals.

Orthologs for EMB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EMB 35
  • 83.05 (n)
  • 72.7 (a)
EMB 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EMB 35
  • 84.37 (n)
  • 73.61 (a)
EMB 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Emb 35
  • 75.59 (n)
  • 65.89 (a)
Emb 16
Emb 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EMB 35
  • 99.69 (n)
  • 99.39 (a)
EMB 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Emb 35
  • 76.99 (n)
  • 69.02 (a)
oppossum
(Monodelphis domestica)
Mammalia EMB 36
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
chicken
(Gallus gallus)
Aves EMB 35
  • 57.48 (n)
  • 39.93 (a)
ZOV3 36
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EMB 36
  • 32 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia emb 35
  • 51.22 (n)
  • 36.24 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-261c8.5 35
  • 53.4 (n)
  • 43.52 (a)
EMB 36
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Bsg 36
  • 7 (a)
OneToMany
Species with no ortholog for EMB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EMB Gene

ENSEMBL:
Gene Tree for EMB (if available)
TreeFam:
Gene Tree for EMB (if available)

Paralogs for EMB Gene

Paralogs for EMB Gene

Pseudogenes.org Pseudogenes for EMB Gene

genes like me logo Genes that share paralogs with EMB: view

Variants for EMB Gene

Structural Variations from Database of Genomic Variants (DGV) for EMB Gene

Variant ID Type Subtype PubMed ID
nsv523212 CNV Gain 19592680
nsv4819 CNV Insertion 18451855

Variation tolerance for EMB Gene

Residual Variation Intolerance Score: 47.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EMB Gene

HapMap Linkage Disequilibrium report
EMB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for EMB Gene

Disorders for EMB Gene

Relevant External Links for EMB

Genetic Association Database (GAD)
EMB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EMB
genes like me logo Genes that share disorders with EMB: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EMB Gene

Publications for EMB Gene

  1. Embigin, a developmentally expressed member of the immunoglobulin super family, is also expressed during regression of prostate and mammary gland. (PMID: 9438341) Guenette R.S. … Tenniswood M. (Dev. Genet. 1997) 2 23 67
  2. emb nucleotide polymorphisms and the role of embB306 mutations in Mycobacterium tuberculosis resistance to ethambutol. (PMID: 19010731) Srivastava S. … Dwivedi S.K. (Int. J. Med. Microbiol. 2009) 23 67
  3. Analysis of isoniazid, streptomycin and ethambutol resistance in Mycobacterium tuberculosis isolates from Morocco. (PMID: 19759491) Chaoui I. … El Mzibri M. (J Infect Dev Ctries 2009) 23 67
  4. Evidence for a homodimeric structure of human monocarboxylate transporter 8. (PMID: 19797118) Visser W.E. … Visser T.J. (Endocrinology 2009) 23 67
  5. Minor contribution of mutations at iniA codon 501 and embC-embA intergenic region in ethambutol-resistant clinical Mycobacterium tuberculosis isolates in Kuwait. (PMID: 19146672) Jaber A.A. … Mokaddas E. (Ann. Clin. Microbiol. Antimicrob. 2009) 23 67

Products for EMB Gene

Sources for EMB Gene

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