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ELTD1 Gene

protein-coding   GIFtS: 50
GCID: GC01M079355

EGF, Latrophilin And Seven Transmembrane Domain Containing...

  Search for ELTD1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EGF, Latrophilin And Seven Transmembrane Domain Containing 11 2
ETL2 3
EGF-TM7-Latrophilin-Related Protein2 3
KPG_0032
EGF, Latrophilin And Seven Transmembrane Domain-Containing Protein 12
ETL Protein3

External Ids:    HGNC: 208221   Entrez Gene: 641232   Ensembl: ENSG000001626187   UniProtKB: Q9HBW93   

Export aliases for ELTD1 gene to outside databases

Previous GC identifers: GC01M078746 GC01M078778 GC01M079067 GC01M077487


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ELTD1 Gene:
ELTD1 (EGF, latrophilin and seven transmembrane domain containing 1) is a protein-coding gene. GO annotations related to this gene include protein dimerization activity and calcium ion binding. An important paralog of this gene is GPR97.

UniProtKB/Swiss-Prot: ELTD1_HUMAN, Q9HBW9
Function: Could be involved in cardiac development

Gene Wiki entry for ELTD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELTD1 gene promoter:
         Nkx3-1   LHX3b/Lhx3b   Pax-6   Nkx3-1 v1   FOXL1   Nkx3-1 v2   MEF-2A   Nkx3-1 v3   LHX3a/Lhx3a   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ELTD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELTD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33-p32   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p33-p32

ELTD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELTD1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M079355:  view genomic region     (about GC identifiers)

Start:
79,355,449 bp from pter      End:
79,472,495 bp from pter
Size:
117,047 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ELTD1_HUMAN, Q9HBW9 (See protein sequence)
Recommended Name: EGF, latrophilin and seven transmembrane domain-containing protein 1 precursor  
Size: 690 amino acids; 77811 Da
Subunit: Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to
a seven-transmembrane moiety (beta subunit). Forms stable dimer at the cells surface (By similarity)
Developmental stage: Up-regulated in the adult heart
Sequence caution: Sequence=AAG33021.1; Type=Erroneous initiation; Sequence=AAH25721.1; Type=Erroneous initiation;
Secondary accessions: B1AR71 Q5KU34

Explore the universe of human proteins at neXtProt for ELTD1: NX_Q9HBW9

Explore proteomics data for ELTD1 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit (By
    similarity)1
  • Glycosylation2 at Asn21, Asn64, Asn74, Asn127, Asn177, Asn188, Asn249, Asn381, Asn395

  • See ELTD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071442.2  
    ENSEMBL proteins: 
     ENSP00000383813   ENSP00000359778  

    ELTD1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ELTD1
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ELTD1

     
    Search eBioscience for Proteins for ELTD1 

    ELTD1 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRBO: GPCR / Class B : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: ELTD1
    Adhesion Class GPCRs

    Selected InterPro protein domains (see all 11):
     IPR017983 GPCR_2_secretin-like_CS
     IPR001881 EGF-like_Ca-bd_dom
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry Q9HBW9

    ProtoNet protein and cluster: Q9HBW9

    3 Blocks protein domains:
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: ELTD1_HUMAN, Q9HBW9
    Domain: The transmembrane domain is not required for cleavage, but it is required for dimer formation (By
    similarity)
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 GPS domain


    Find genes that share domains with ELTD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELTD1_HUMAN, Q9HBW9
    Function: Could be involved in cardiac development

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with ELTD1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Eltd1):
     normal 

    Find genes that share phenotypes with ELTD1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Eltd1tm1Lex for ELTD1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELTD1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ELTD1

    miRNA
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    Block miRNA regulation of human, mouse, rat ELTD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ELTD1 (see all 11):
    hsa-miR-3689b hsa-miR-4324 hsa-miR-607 hsa-miR-144* hsa-miR-196a* hsa-miR-589* hsa-miR-3689a-5p hsa-miR-4275
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ELTD1

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELTD1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELTD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ELTD1_HUMAN, Q9HBW9: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ELTD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ELTD1 About    
    See pathways by source

    SuperPathContained pathways About
    1GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like


    1 BioSystems Pathway for ELTD1
        GPCRs, Class B Secretin-like


        Pathway & Disease-focused RT2 Profiler PCR Array including ELTD1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ELTD1

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS15203201
    GO:0007218neuropeptide signaling pathway IEA--

    Find genes that share ontologies with ELTD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELTD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ELTD1 gene: 
    NM_022159.3  

    Unigene Cluster for ELTD1:

    EGF, latrophilin and seven transmembrane domain containing 1
    Hs.132314  [show with all ESTs]
    Unigene Representative Sequence: NM_022159
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401034 ENST00000370742(uc001diq.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ELTD1 (see all 11):
    hsa-miR-3689b hsa-miR-4324 hsa-miR-607 hsa-miR-144* hsa-miR-196a* hsa-miR-589* hsa-miR-3689a-5p hsa-miR-4275
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ELTD1
    Predesigned siRNA for gene silencing in human, mouse, rat ELTD1
    Clone
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    OriGene clones in human, mouse for ELTD1 (see all 7)
    OriGene ORF clones in mouse, rat for ELTD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ELTD1 (NM_022159)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELTD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELTD1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ELTD1
    OriGene qSTAR qPCR primer pairs in human, mouse for ELTD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ELTD1
      QuantiTect SYBR Green Assays in human, mouse, rat ELTD1
      QuantiFast Probe-based Assays in human, mouse, rat ELTD1

    Additional mRNA sequence: 

    AB032017.1 AF192403.1 AK129766.1 AK172750.1 AK292894.1 AK313738.1 AY358360.1 BC025721.1 

    6 DOTS entries:

    DT.100744954  DT.455332  DT.95164922  DT.100691014  DT.97787036  DT.121351553 

    Selected AceView cDNA sequences (see all 111):

    AY358360 AW152154 AA700716 BM683811 AA487827 AW204065 AI241562 AA953110 
    AI024874 AA364110 BE503321 AA693670 BC025721 AI024852 AF192403 BP378283 
    CB995984 BG546368 BQ695256 CD631285 BF439602 R15824 CB960178 AK172750 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ELTD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAACTGTA
    ELTD1 Expression
    About this image


    ELTD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human umbilical vein endothelial cells (HUVEC)
             Endothelial-like cells
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Mesoderm (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
    ELTD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELTD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132314

    UniProtKB/Swiss-Prot: ELTD1_HUMAN, Q9HBW9
    Tissue specificity: Mainly expressed in smooth muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including ELTD1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat ELTD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELTD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ELTD1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eltd11 , 5 EGF, latrophilin seven transmembrane domain containing more1, 5 78.68(n)1
    78.05(a)1
      3 (76.76 cM)5
    1707571  NM_133222.31  NP_573485.21 
     1514378875 
    chicken
    (Gallus gallus)
    Aves ELTD11 EGF, latrophilin and seven transmembrane domain containing more 71.4(n)
    68.23(a)
      424546  XM_004936666.1  XP_004936723.1 
    lizard
    (Anolis carolinensis)
    Reptilia ELTD16
    EGF, latrophilin and seven transmembrane domain co...
    60(a)
    1 ↔ 1
    GL343194.1(5342234-5491169)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688192 ETL protein 78.97(n)    BC061675.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055171.12   -- 76.84(n)    BC055171.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lat-16
    Protein LAT-1, isoform b (lat-1) mRNA, complete cd...
    18(a)
    1 → many
    II(8896841-8908653) WBGene00002251


    ENSEMBL Gene Tree for ELTD1 (if available)
    TreeFam Gene Tree for ELTD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ELTD1 gene
    GPR972  CD972  LPHN22  LPHN12  GPR1142  EMR12  LPHN32  EMR22  
    GPR1332  GPR1122  GPR1442  EMR32  GPR562  GPR1262  GPR642  
    Selected SIMAP similar genes for ELTD1 using alignment to 3 protein entries:     ELTD1_HUMAN (see all proteins) (see all similar genes):
    LPHN3    FLJ00046    FLJ00015    EMR3    EMR4P    LPHN2
    GPR113    EMR2    GPR133    EMR1    BAI1    GPR64
    RESDA1    CELSR3    GPR116    BAI2    GPR112    GPR126

    Find genes that share paralogs with ELTD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ELTD1 (see all 2589)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs12484781,2
    C,F,A,H--79355059(+) CCACCT/CGGATA 1 -- ds500115Minor allele frequency- C:0.29NS EA NA WA CSA 792
    rs1411735511,2
    C--79355195(+) TTTTTA/GGGAGG 1 -- ds50010--------
    rs1432383881,2
    --79355201(+) GGAGGG/TGGCAT 1 -- ds50010--------
    rs1483236881,2
    --79355277(+) TTTCTA/GTAACA 1 -- ds50010--------
    rs1414875281,2
    --79355296(+) CAATGA/GCACTG 1 -- ds50010--------
    rs765510561,2
    C,F--79355325(+) CTTACC/TATGTA 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1872397331,2
    --79355356(+) AAGTTA/GTTATC 1 -- ds50010--------
    rs1916791271,2
    --79355446(+) GGAATG/TACTTC 1 -- ds50010--------
    rs1834571631,2
    --79355512(+) CTGGAA/GGAATT 1 -- ut310--------
    rs1501353221,2
    --79355581(+) TACCTA/GTTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ELTD1 (79355449 - 79472495 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ELTD1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750252CNV Deletion23290073
    esv2551231CNV Deletion19546169
    esv1001130CNV Deletion20482838
    esv2661629CNV Deletion23128226
    esv2750229CNV Deletion23290073
    esv2750240CNV Deletion23290073
    esv4207CNV Deletion18987735
    esv2156352CNV Deletion18987734
    esv9047CNV Loss19470904
    nsv526221CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ELTD1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ELTD1           About GenesLikeMe

    Genetic Association Database (GAD): ELTD1

    Export disorders for ELTD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ELTD1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ELTD1)
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    1. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. (PubMed id 11050079)1, 2, 3, 9 Nechiporuk T.... Keating M.T. (J. Biol. Chem. 2001)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. (PubMed id 23871637)1 Masiero M....Buffa F.M. (Cancer Cell 2013)
    6. ELTD1, a potential new biomarker for gliomas. (PubMed id 23096411)1 Towner R.A....Wren J.D. (Neurosurgery 2013)
    7. Microsatellite scanning of the immunogenome associates MAPK14 and ELTD1 with graft-versus-host disease in hematopoietic stem cell transplantation. (PubMed id 23474535)1 Harkensee C....Morishima Y. (Immunogenetics 2013)
    8. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PubMed id 23453885)1 (Lancet 2013)
    9. A genome-wide association study of aging. (PubMed id 21782286)1 Walter S....Franceschini N. (Neurobiol. Aging 2011)
    10. An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project. (PubMed id 18519829)1 Agrawal A....Madden P.A. (Arch. Gen. Psychiatry 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64123 HGNC: 20822 AceView: ELTD1 Ensembl:ENSG00000162618 euGenes: HUgn64123
    ECgene: ELTD1 H-InvDB: ELTD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ELTD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ELTD1 gene:
    Search GeneIP for patents involving ELTD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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