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ELSPBP1 Gene

protein-coding   GIFtS: 52
GCID: GC19P048497

Epididymal Sperm Binding Protein 1

  Search for ELSPBP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Epididymal Sperm Binding Protein 11 2     EL1492
Epididymal Protein 121 2     HE122
Epididymal Secretory Protein 122 3     Epididymal Sperm-Binding Protein 12
E122 3     Epididymis Luminal Secretory Protein 1492
EDDM122     hE123

External Ids:    HGNC: 144171   Entrez Gene: 641002   Ensembl: ENSG000001693937   OMIM: 6074435   UniProtKB: Q96BH33   

Export aliases for ELSPBP1 gene to outside databases

Previous GC identifers: GC19P049144 GC19P048866 GC19P053173 GC19P053189 GC19P044879


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ELSPBP1 Gene:
The protein encoded by this gene belongs to the sperm-coating protein family of epididymal origin. This protein
and its canine homolog are the first known examples of proteins with four tandemly arranged fibronectin type 2
(Fn2) domains in the Fn2-module protein family. (provided by RefSeq, Jul 2008)

GeneCards Summary for ELSPBP1 Gene:
ELSPBP1 (epididymal sperm binding protein 1) is a protein-coding gene. An important paralog of this gene is MMP21.

UniProtKB/Swiss-Prot: ESPB1_HUMAN, Q96BH3
Function: Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has
phosphorylcholine-binding activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ELSPBP1 gene promoter:
         C/EBPbeta   SRF (504 AA)   p300   NF-kappaB   POU2F1   POU2F1a   FOXJ2 (long isoform)   Cart-1   FOXJ2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELSPBP1 promoter sequence
   Search Chromatin IP Primers for ELSPBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ELSPBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

ELSPBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELSPBP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P048497:  view genomic region     (about GC identifiers)

Start:
48,497,908 bp from pter      End:
48,528,410 bp from pter
Size:
30,503 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ESPB1_HUMAN, Q96BH3 (See protein sequence)
Recommended Name: Epididymal sperm-binding protein 1 precursor  
Size: 223 amino acids; 26106 Da
Sequence caution: Sequence=CAC14267.1; Type=Frameshift; Positions=9;
Secondary accessions: Q96RT0 Q9H4C8

Explore the universe of human proteins at neXtProt for ELSPBP1: NX_Q96BH3

Explore proteomics data for ELSPBP1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn195

  • See ELSPBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071425.3  
    ENSEMBL proteins: 
     ENSP00000340660   ENSP00000470903   ENSP00000471690   ENSP00000472960   ENSP00000470551  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013806 Kringle-like
     IPR000562 FN_type2_col-bd

    Graphical View of Domain Structure for InterPro Entry Q96BH3

    ProtoNet protein and cluster: Q96BH3

    1 Blocks protein domain: IPB000562 Type II fibronectin collagen-binding domain

    UniProtKB/Swiss-Prot: ESPB1_HUMAN, Q96BH3
    Similarity: Belongs to the seminal plasma protein family
    Similarity: Contains 4 fibronectin type-II domains


    Find genes that share domains with ELSPBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ESPB1_HUMAN, Q96BH3
    Function: Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has
    phosphorylcholine-binding activity (By similarity)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ELSPBP1
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    1 qRT-PCR Assays for microRNA that regulate ELSPBP1:
    hsa-miR-100*
    SwitchGear 3'UTR luciferase reporter plasmidELSPBP1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ESPB1_HUMAN, Q96BH3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with ELSPBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ELSPBP1 About    
    See pathways by source

    SuperPathContained pathways About
    1NFAT and Cardiac Hypertrophy
    NFAT and Cardiac Hypertrophy0.42
    Signaling Involved in Cardiac Hypertrophy0.42
    2miRs in Muscle Cell Differentiation
    miRs in Muscle Cell Differentiation

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ELSPBP1
        NFAT and Cardiac Hypertrophy
    Signaling Involved in Cardiac Hypertrophy

    1 BioSystems Pathway for ELSPBP1
        miRs in Muscle Cell Differentiation



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ELSPBP1
    Interactions:

        GeneGlobe Interaction Network for ELSPBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for ELSPBP1 (Q96BH33 ENSP000003406604) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ID3Q025353, ENSP000003636894I2D: score=1 STRING: ENSP00000363689
    MYF6P234093, ENSP000002286414I2D: score=1 STRING: ENSP00000228641
    MYOD1P151723, ENSP000002500034I2D: score=1 STRING: ENSP00000250003
    NEDD9Q145113, ENSP000003687594I2D: score=1 STRING: ENSP00000368759
    MYF5P133493, ENSP000002286444I2D: score=1 STRING: ENSP00000228644
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007338single fertilization IEA--

    Find genes that share ontologies with ELSPBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ELSPBP1 (ESPB1)

    1 HMDB Compound for ELSPBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphorylcholineCholine phosphate (see all 5)3616-04-4--

    1 DrugBank Compound for ELSPBP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphocholine-- 107-73-3target--17139284 17016423 10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ELSPBP1 gene: 
    NM_022142.4  

    Unigene Cluster for ELSPBP1:

    Epididymal sperm binding protein 1
    Hs.104894  [show with all ESTs]
    Unigene Representative Sequence: NM_022142
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339841(uc002pht.3) ENST00000596043 ENST00000597519 ENST00000593782
    ENST00000593413
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ELSPBP1:
    hsa-miR-100*
    SwitchGear 3'UTR luciferase reporter plasmidELSPBP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ELSPBP1
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      QuantiTect SYBR Green Assays in human, mouse, rat ELSPBP1
      QuantiFast Probe-based Assays in human, mouse, rat ELSPBP1

    Additional mRNA sequence: 

    AF279147.1 AJ278478.1 BC015598.2 GQ149084.1 

    3 DOTS entries:

    DT.408189  DT.92417588  DT.92417589 

    19 AceView cDNA sequences:

    BM690865 NM_022142 BM663735 BC015598 AW593247 AA913839 BG478994 AA429491 
    BX094593 AA868848 AF279147 BM661759 AA428554 AA336014 AA724454 AW592011 
    AJ278478 AI190145 AI125345 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ELSPBP1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                      
    SP2:                    -     -     -                     
    SP3:                    -                                 


    ECgene alternative splicing isoforms for ELSPBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ELSPBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATAAGGATG
    ELSPBP1 Expression
    About this image


    ELSPBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
    ELSPBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ELSPBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.104894

    UniProtKB/Swiss-Prot: ESPB1_HUMAN, Q96BH3
    Tissue specificity: Detected in cauda epididymidal fluid and on sperm membrane (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ELSPBP1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    40(a)
    26(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    GL343253.1(318758-332387)
    GL343253.1(263332-282200)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch1073-408o3.16
    si:ch1073-408o3.1
    6(a)
    many ↔ many
    15(1794129-1811472) ENSDARG00000059029
    worm
    (Caenorhabditis elegans)
    Secernentea T21D11.16
    Protein T21D11.1 (T21D11.1) mRNA, complete cds
    4(a)
    1 → many
    III(7245482-7247784) WBGene00020646
            Species with no ortholog for ELSPBP1

    ENSEMBL Gene Tree for ELSPBP1 (if available)
    TreeFam Gene Tree for ELSPBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ELSPBP1 gene
    MMP212  MMP23B2  MMP92  MMP22  MMP192  MMP262  
    3 SIMAP similar genes for ELSPBP1 using alignment to 5 protein entries:     ESPB1_HUMAN (see all proteins):
    EL149    MMP2    BSPH1

    Find genes that share paralogs with ELSPBP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ELSPBP1 (see all 948)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1118296051,2
    C--48496474(+) CTCCAT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs1117470031,2
    C,F--48497563(+) TGAACC/TCGGGA 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1443200141,2
    --48497612(+) TCCAGC/GCTGGG 1 -- us2k10--------
    rs1907846531,2
    --48497617(+) CCTGGC/GCAACA 1 -- us2k10--------
    rs1477603211,2
    --48497719(+) CCTCAC/TAGCTG 1 -- us2k10--------
    rs129741841,2
    C,F--48497795(+) GCCCCG/TTCTGT 1 -- us2k111Minor allele frequency- T:0.33NA WA CSA EA 372
    rs1488240711,2
    C--48497799(+) CTTCTA/GTGTAC 1 -- us2k10--------
    rs1826357501,2
    --48497868(+) AATTAA/GCCACA 1 -- us2k10--------
    rs1434687591,2
    C--48497893(+) GACTGC/TCTTCT 1 -- us2k10--------
    rs104092881,2
    C,F--48497941(+) CTGCCG/TTTGTG 1 -- ut5111Minor allele frequency- T:0.34NA WA CSA EA 372

    HapMap Linkage Disequilibrium report for ELSPBP1 (48497908 - 48528410 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ELSPBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833853CNV Loss17160897
    esv34181CNV Loss18971310
    nsv912216CNV Loss21882294
    nsv428367CNV Gain+Loss18775914
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ELSPBP1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607443    OMIM disorders: --


    Find genes that share disorders with ELSPBP1           About GenesLikeMe

    Genetic Association Database (GAD): ELSPBP1

    Export disorders for ELSPBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ELSPBP1 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with ELSPBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of intelligence: additive effects of novel brain expressed genes. (PubMed id 22449649)1, 4 Loo S.K....Nelson S.F. (J Am Acad Child Adolesc Psychiatry 2012)
    2. Sperm-binding fibronectin type II-module proteins are genetically linked and functionally related. (PubMed id 17307309)1, 2 Ekhlasi-Hundrieser M.... Toepfer-Petersen E. (Gene 2007)
    3. Novel sperm-binding proteins of epididymal origin contain four fibronectin type II-modules. (PubMed id 11144225)1, 2 Saalmann A.... Kirchhoff C. (Mol. Reprod. Dev. 2001)
    4. The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis. (PubMed id 20714342)1 Fu J....Xu J. (Cell Res. 2011)
    5. Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12. (PubMed id 20503194)1 Lee J.H....Smas C.M. (J. Cell. Biochem. 2010)
    6. Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription. (PubMed id 19828133)1 Furumatsu T....Ozaki T. (amp 2010)
    7. The core binding factor CBF negatively regulates skeletal muscle terminal differentiation. (PubMed id 20195544)1 Philipot O....Ait-Si-Ali S. (PLoS ONE 2010)
    8. Oxidative stress drives disulfide bond formation between basic helix-loop-helix transcription factors. (PubMed id 19950203)1 Danciu T.E. and Whitman M. (J. Cell. Biochem. 2010)
    9. Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12. (PubMed id 17910069)1 Ryan D.P....Matthews J.M. (Proteins 2008)
    10. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64100 HGNC: 14417 AceView: ELSPBP1 Ensembl:ENSG00000169393 euGenes: HUgn64100
    ECgene: ELSPBP1 H-InvDB: ELSPBP1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ELSPBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ELSPBP1 gene:
    Search GeneIP for patents involving ELSPBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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