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Aliases for ELSPBP1 Gene

Aliases for ELSPBP1 Gene

  • Epididymal Sperm Binding Protein 1 2 3
  • Epididymal Secretory Protein 12 3 4
  • Epididymal Protein 12 2 3
  • HE12 3 4
  • E12 3 4
  • Epididymis Luminal Secretory Protein 149 3
  • Epididymal Sperm-Binding Protein 1 3
  • EDDM12 3
  • EL149 3

External Ids for ELSPBP1 Gene

Summaries for ELSPBP1 Gene

Entrez Gene Summary for ELSPBP1 Gene

  • The protein encoded by this gene belongs to the sperm-coating protein family of epididymal origin. This protein and its canine homolog are the first known examples of proteins with four tandemly arranged fibronectin type 2 (Fn2) domains in the Fn2-module protein family. [provided by RefSeq, Jul 2008]

GeneCards Summary for ELSPBP1 Gene

ELSPBP1 (Epididymal Sperm Binding Protein 1) is a Protein Coding gene. Among its related pathways are NFAT and Cardiac Hypertrophy and NFAT and Cardiac Hypertrophy. An important paralog of this gene is MMP2.

UniProtKB/Swiss-Prot for ELSPBP1 Gene

  • Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELSPBP1 Gene

Genomics for ELSPBP1 Gene

Genomic Location for ELSPBP1 Gene

47,994,651 bp from pter
48,025,156 bp from pter
30,506 bases
Plus strand

Genomic View for ELSPBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELSPBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELSPBP1 Gene

Regulatory Elements for ELSPBP1 Gene

Proteins for ELSPBP1 Gene

  • Protein details for ELSPBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Epididymal sperm-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • Q96RT0
    • Q9H4C8

    Protein attributes for ELSPBP1 Gene

    223 amino acids
    Molecular mass:
    26106 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAC14267.1; Type=Frameshift; Positions=9; Evidence={ECO:0000305};

neXtProt entry for ELSPBP1 Gene

Proteomics data for ELSPBP1 Gene at MOPED

Post-translational modifications for ELSPBP1 Gene

Other Protein References for ELSPBP1 Gene

No data available for DME Specific Peptides for ELSPBP1 Gene

Domains for ELSPBP1 Gene

Protein Domains for ELSPBP1 Gene


  • Contains 4 fibronectin type-II domains.:
    • Q96BH3
  • Belongs to the seminal plasma protein family.:
    • Q96BH3
genes like me logo Genes that share domains with ELSPBP1: view

No data available for Gene Families for ELSPBP1 Gene

Function for ELSPBP1 Gene

Molecular function for ELSPBP1 Gene

UniProtKB/Swiss-Prot Function: Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity (By similarity).

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ELSPBP1 Gene

Localization for ELSPBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELSPBP1 Gene


Subcellular locations from

Jensen Localization Image for ELSPBP1 Gene COMPARTMENTS Subcellular localization image for ELSPBP1 gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ELSPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ELSPBP1: view

Pathways for ELSPBP1 Gene

genes like me logo Genes that share pathways with ELSPBP1: view

Pathways by source for ELSPBP1 Gene

1 BioSystems pathway for ELSPBP1 Gene

Gene Ontology (GO) - Biological Process for ELSPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization IEA --
genes like me logo Genes that share ontologies with ELSPBP1: view

Compounds for ELSPBP1 Gene

(1) HMDB Compounds for ELSPBP1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Choline phosphate

(1) Drugbank Compounds for ELSPBP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
107-73-3 target
genes like me logo Genes that share compounds with ELSPBP1: view

Transcripts for ELSPBP1 Gene

mRNA/cDNA for ELSPBP1 Gene

Unigene Clusters for ELSPBP1 Gene

Epididymal sperm binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELSPBP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP2: - - -
SP3: -

Relevant External Links for ELSPBP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ELSPBP1 Gene

mRNA expression in normal human tissues for ELSPBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELSPBP1 Gene

This gene is overexpressed in Testis (34.6) and Brain - Hypothalamus (7.8).

SOURCE GeneReport for Unigene cluster for ELSPBP1 Gene Hs.104894

mRNA Expression by UniProt/SwissProt for ELSPBP1 Gene

Tissue specificity: Detected in cauda epididymidal fluid and on sperm membrane (at protein level).
genes like me logo Genes that share expressions with ELSPBP1: view

Orthologs for ELSPBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELSPBP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ELSPBP1 36
  • 98.49 (n)
  • 97.49 (a)
  • 98 (a)
(Bos Taurus)
Mammalia ELSPBP1 36
  • 81.91 (n)
  • 77.13 (a)
  • 77 (a)
(Canis familiaris)
Mammalia ELSPBP1 36
  • 84.3 (n)
  • 78.48 (a)
  • 68 (a)
(Mus musculus)
Mammalia Mmp28 37
  • 6 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 6 (a)
(Ornithorhynchus anatinus)
Mammalia ELSPBP1 37
  • 45 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 19 (a)
-- 37
  • 26 (a)
-- 37
  • 23 (a)
-- 37
  • 40 (a)
(Danio rerio)
Actinopterygii si:ch1073-408o3.1 37
  • 6 (a)
(Caenorhabditis elegans)
Secernentea T21D11.1 37
  • 4 (a)
Species with no ortholog for ELSPBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ELSPBP1 Gene

Gene Tree for ELSPBP1 (if available)
Gene Tree for ELSPBP1 (if available)

Paralogs for ELSPBP1 Gene

Paralogs for ELSPBP1 Gene

Selected SIMAP similar genes for ELSPBP1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ELSPBP1: view

Variants for ELSPBP1 Gene

Sequence variations from dbSNP and Humsavar for ELSPBP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs878054 -- 48,025,479(+) CTCAG(C/T)CCAGA downstream-variant-500B
rs2059814 -- 47,996,565(-) TCCAT(A/T)CATCC intron-variant
rs2099051 -- 48,001,373(-) aaacc(A/C)cgtct intron-variant
rs2115100 -- 48,019,637(-) GCCAC(C/G)CTTTA intron-variant
rs2278237 -- 48,024,645(-) CTGAA(A/C/G)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELSPBP1 Gene

Variant ID Type Subtype PubMed ID
nsv428367 CNV Gain+Loss 18775914
nsv9739 CNV Gain+Loss 18304495
nsv833853 CNV Loss 17160897
nsv912216 CNV Loss 21882294
esv34181 CNV Loss 18971310

Relevant External Links for ELSPBP1 Gene

HapMap Linkage Disequilibrium report

Disorders for ELSPBP1 Gene

Relevant External Links for ELSPBP1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ELSPBP1: view

No data available for UniProtKB/Swiss-Prot for ELSPBP1 Gene

Publications for ELSPBP1 Gene

  1. Sperm-binding fibronectin type II-module proteins are genetically linked and functionally related. (PMID: 17307309) Ekhlasi-Hundrieser M. … Toepfer-Petersen E. (Gene 2007) 3 4
  2. Genome-wide association study of intelligence: additive effects of novel brain expressed genes. (PMID: 22449649) Loo S.K. … Nelson S.F. (J Am Acad Child Adolesc Psychiatry 2012) 3 49
  3. Novel sperm-binding proteins of epididymal origin contain four fibronectin type II-modules. (PMID: 11144225) Saalmann A. … Kirchhoff C. (Mol. Reprod. Dev. 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an Atypical and versatile PDZ-domain motif interaction and identification of putative functional modules. (PMID: 25009770) Sangith N. … Venkatraman P. (FEBS Open Bio 2014) 3

Products for ELSPBP1 Gene

  • antibodies-online proteins for ELSPBP1
  • antibodies-online antibodies for ELSPBP1
  • antibodies-online kits for ELSPBP1

Sources for ELSPBP1 Gene

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