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Aliases for ELP6 Gene

Aliases for ELP6 Gene

  • Elongator Acetyltransferase Complex Subunit 6 2 3 5
  • Angiotonin-Transactivated Protein 1 3 4
  • Transmembrane Protein 103 2 3
  • C3orf75 3 4
  • TMEM103 3 4
  • Elongator Complex Protein 6 Homolog 3
  • Chromosome 3 Open Reading Frame 75 2
  • UPF0405 Protein C3orf75 3
  • Protein TMEM103 4
  • ATP1 4

External Ids for ELP6 Gene

Previous HGNC Symbols for ELP6 Gene

  • TMEM103
  • C3orf75

Previous GeneCards Identifiers for ELP6 Gene

  • GC03M047537

Summaries for ELP6 Gene

GeneCards Summary for ELP6 Gene

ELP6 (Elongator Acetyltransferase Complex Subunit 6) is a Protein Coding gene. Among its related pathways are Chromatin organization.

UniProtKB/Swiss-Prot for ELP6 Gene

  • Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELP6 Gene

Genomics for ELP6 Gene

Regulatory Elements for ELP6 Gene

Enhancers for ELP6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ELP6 on UCSC Golden Path with GeneCards custom track

Promoters for ELP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ELP6 on UCSC Golden Path with GeneCards custom track

Genomic Location for ELP6 Gene

Chromosome:
3
Start:
47,495,640 bp from pter
End:
47,513,761 bp from pter
Size:
18,122 bases
Orientation:
Minus strand

Genomic View for ELP6 Gene

Genes around ELP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELP6 Gene

Proteins for ELP6 Gene

  • Protein details for ELP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0PNE2-ELP6_HUMAN
    Recommended name:
    Elongator complex protein 6
    Protein Accession:
    Q0PNE2
    Secondary Accessions:
    • Q9BW57
    • Q9NXJ3

    Protein attributes for ELP6 Gene

    Size:
    266 amino acids
    Molecular mass:
    29793 Da
    Quaternary structure:
    • Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6.
    SequenceCaution:
    • Sequence=AAH00623.1; Type=Frameshift; Positions=256; Evidence={ECO:0000305}; Sequence=AAH14204.1; Type=Frameshift; Positions=256; Evidence={ECO:0000305};

    Alternative splice isoforms for ELP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELP6 Gene

Proteomics data for ELP6 Gene at MOPED

Post-translational modifications for ELP6 Gene

  • Ubiquitination at Lys 99, Lys 116, Lys 248, and Lys 259
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ELP6 Gene

Domains & Families for ELP6 Gene

Gene Families for ELP6 Gene

Protein Domains for ELP6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ELP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0PNE2

UniProtKB/Swiss-Prot:

ELP6_HUMAN :
  • Belongs to the ELP6 family.
Family:
  • Belongs to the ELP6 family.
genes like me logo Genes that share domains with ELP6: view

Function for ELP6 Gene

Molecular function for ELP6 Gene

UniProtKB/Swiss-Prot Function:
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.
genes like me logo Genes that share phenotypes with ELP6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ELP6 Gene

Localization for ELP6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELP6 Gene COMPARTMENTS Subcellular localization image for ELP6 gene
Compartment Confidence
chloroplast 2
mitochondrion 2
nucleus 2
plasma membrane 2
cytosol 1
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ELP6 Gene

Pathways & Interactions for ELP6 Gene

genes like me logo Genes that share pathways with ELP6: view

Pathways by source for ELP6 Gene

Interacting Proteins for ELP6 Gene

Gene Ontology (GO) - Biological Process for ELP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0030335 positive regulation of cell migration IEA,ISS --
genes like me logo Genes that share ontologies with ELP6: view

No data available for SIGNOR curated interactions for ELP6 Gene

Drugs & Compounds for ELP6 Gene

No Compound Related Data Available

Transcripts for ELP6 Gene

Unigene Clusters for ELP6 Gene

Elongator acetyltransferase complex subunit 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELP6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - -
SP11: - - - -
SP12: - - - - - - - - -
SP13: - -
SP14: - - - - - - - - - - - - - -
SP15: - - -

ExUns: 11b ^ 12a · 12b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ELP6 Gene

GeneLoc Exon Structure for
ELP6
ECgene alternative splicing isoforms for
ELP6

Expression for ELP6 Gene

mRNA expression in normal human tissues for ELP6 Gene

Protein differential expression in normal tissues from HIPED for ELP6 Gene

This gene is overexpressed in Breast (50.5) and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ELP6 Gene



SOURCE GeneReport for Unigene cluster for ELP6 Gene Hs.311100

genes like me logo Genes that share expression patterns with ELP6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ELP6 Gene

Orthologs for ELP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELP6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C22H3orf75 35
  • 85.34 (n)
  • 85.34 (a)
C22H3orf75 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELP6 35
  • 88.04 (n)
  • 89.52 (a)
ELP6 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elp6 35
  • 83.33 (n)
  • 80.08 (a)
Elp6 16
Elp6 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ELP6 35
  • 99.5 (n)
  • 99.25 (a)
TMEM103 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elp6 35
  • 82.96 (n)
  • 80.83 (a)
oppossum
(Monodelphis domestica)
Mammalia ELP6 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELP6 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H3ORF75 35
  • 67.68 (n)
  • 64.5 (a)
C2H3ORF75 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia elp6 35
  • 64.24 (n)
  • 60.54 (a)
Str.11120 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15185 35
zebrafish
(Danio rerio)
Actinopterygii elp6 35
  • 58.53 (n)
  • 56.59 (a)
elp6 36
  • 54 (a)
OneToOne
Species with no ortholog for ELP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELP6 Gene

ENSEMBL:
Gene Tree for ELP6 (if available)
TreeFam:
Gene Tree for ELP6 (if available)

Paralogs for ELP6 Gene

(1) SIMAP similar genes for ELP6 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ELP6: view

No data available for Paralogs for ELP6 Gene

Variants for ELP6 Gene

Sequence variations from dbSNP and Humsavar for ELP6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3192 -- 47,495,874(+) GTGGT(C/T)CCTTG utr-variant-3-prime
rs2291298 -- 47,513,652(-) CTCCA(C/G/T)CCTCC upstream-variant-2KB, utr-variant-5-prime
rs1138330 -- 47,509,150(+) agaga(C/T)ggggt intron-variant
rs1138331 -- 47,509,161(+) tttgc(C/T)atgct intron-variant
rs2351030 -- 47,506,576(+) ctttt(C/G)aaaga intron-variant

Variation tolerance for ELP6 Gene

Residual Variation Intolerance Score: 69.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELP6 Gene

HapMap Linkage Disequilibrium report
ELP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ELP6 Gene

Disorders for ELP6 Gene

Relevant External Links for ELP6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELP6

No disorders were found for ELP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELP6 Gene

Publications for ELP6 Gene

  1. DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. (PMID: 22854966) Close P. … Chariot A. (J. Biol. Chem. 2012) 2 3 4 67
  2. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Dimerization of elongator protein 1 is essential for Elongator complex assembly. (PMID: 26261306) Xu H. … Long J. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for ELP6 Gene

Sources for ELP6 Gene

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