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Aliases for ELP6 Gene

Aliases for ELP6 Gene

  • Elongator Acetyltransferase Complex Subunit 6 2 3
  • C3orf75 3 4 6
  • TMEM103 3 4 6
  • Angiotonin-Transactivated Protein 1 3 4
  • Transmembrane Protein 103 2 3
  • Elongator Complex Protein 6 Homolog 3
  • Chromosome 3 Open Reading Frame 75 2
  • Elongator Complex Protein 6 3
  • UPF0405 Protein C3orf75 3
  • Protein TMEM103 4
  • ATP1 4

External Ids for ELP6 Gene

Previous HGNC Symbols for ELP6 Gene

  • TMEM103
  • C3orf75

Previous GeneCards Identifiers for ELP6 Gene

  • GC03M047537

Summaries for ELP6 Gene

GeneCards Summary for ELP6 Gene

ELP6 (Elongator Acetyltransferase Complex Subunit 6) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening.

UniProtKB/Swiss-Prot for ELP6 Gene

  • Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELP6 Gene

Genomics for ELP6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ELP6 Gene

Start:
47,495,640 bp from pter
End:
47,513,761 bp from pter
Size:
18,122 bases
Orientation:
Minus strand

Genomic View for ELP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELP6 Gene

No data available for Regulatory Elements for ELP6 Gene

Proteins for ELP6 Gene

  • Protein details for ELP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0PNE2-ELP6_HUMAN
    Recommended name:
    Elongator complex protein 6
    Protein Accession:
    Q0PNE2
    Secondary Accessions:
    • Q9BW57
    • Q9NXJ3

    Protein attributes for ELP6 Gene

    Size:
    266 amino acids
    Molecular mass:
    29793 Da
    Quaternary structure:
    • Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6.
    SequenceCaution:
    • Sequence=AAH00623.1; Type=Frameshift; Positions=256; Evidence={ECO:0000305}; Sequence=AAH14204.1; Type=Frameshift; Positions=256; Evidence={ECO:0000305};

    Alternative splice isoforms for ELP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELP6 Gene

Proteomics data for ELP6 Gene at MOPED

Post-translational modifications for ELP6 Gene

  • Ubiquitination at Lys99, Lys116, Lys248, and Lys259
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ELP6 Gene

Domains for ELP6 Gene

Gene Families for ELP6 Gene

HGNC:
  • ELP :Elongator acetyltransferase complex subunits

Protein Domains for ELP6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q0PNE2

UniProtKB/Swiss-Prot:

ELP6_HUMAN :
  • Q0PNE2
Family:
  • Belongs to the ELP6 family.
genes like me logo Genes that share domains with ELP6: view

No data available for Suggested Antigen Peptide Sequences for ELP6 Gene

Function for ELP6 Gene

Molecular function for ELP6 Gene

UniProtKB/Swiss-Prot Function: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration

Gene Ontology (GO) - Molecular Function for ELP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with ELP6: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ELP6 Gene

Localization for ELP6 Gene

Gene Ontology (GO) - Cellular Components for ELP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033588 Elongator holoenzyme complex IDA 22854966
genes like me logo Genes that share ontologies with ELP6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for ELP6 Gene

Pathways for ELP6 Gene

genes like me logo Genes that share pathways with ELP6: view

Pathways by source for ELP6 Gene

Interacting Proteins for ELP6 Gene

Gene Ontology (GO) - Biological Process for ELP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
GO:0030335 positive regulation of cell migration ISS --
genes like me logo Genes that share ontologies with ELP6: view

Transcripts for ELP6 Gene

Unigene Clusters for ELP6 Gene

Elongator acetyltransferase complex subunit 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ELP6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELP6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - -
SP11: - - - -
SP12: - - - - - - - - -
SP13: - -
SP14: - - - - - - - - - - - - - -
SP15: - - -

ExUns: 11b ^ 12a · 12b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ELP6 Gene

GeneLoc Exon Structure for
ELP6
ECgene alternative splicing isoforms for
ELP6

Expression for ELP6 Gene

mRNA expression in normal human tissues for ELP6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ELP6 Gene

SOURCE GeneReport for Unigene cluster for ELP6 Gene Hs.311100

genes like me logo Genes that share expressions with ELP6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ELP6 Gene

Orthologs for ELP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELP6 35
  • 99.5 (n)
  • 99.25 (a)
TMEM103 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C22H3orf75 35
  • 85.34 (n)
  • 85.34 (a)
C22H3orf75 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELP6 35
  • 88.04 (n)
  • 89.52 (a)
ELP6 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elp6 35
  • 83.33 (n)
  • 80.08 (a)
Elp6 16
Elp6 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELP6 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELP6 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elp6 35
  • 82.96 (n)
  • 80.83 (a)
chicken
(Gallus gallus)
Aves C2H3ORF75 35
  • 67.68 (n)
  • 64.5 (a)
C2H3ORF75 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.15185 35
tropical clawed frog
(Silurana tropicalis)
Amphibia elp6 35
  • 64.24 (n)
  • 60.54 (a)
Str.11120 35
zebrafish
(Danio rerio)
Actinopterygii elp6 35
  • 58.53 (n)
  • 56.59 (a)
elp6 36
  • 54 (a)
OneToOne
Species with no ortholog for ELP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELP6 Gene

ENSEMBL:
Gene Tree for ELP6 (if available)
TreeFam:
Gene Tree for ELP6 (if available)

Paralogs for ELP6 Gene

Selected SIMAP similar genes for ELP6 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ELP6: view

No data available for Paralogs for ELP6 Gene

Variants for ELP6 Gene

Sequence variations from dbSNP and Humsavar for ELP6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3192 -- 47,495,874(+) GTGGT(C/T)CCTTG utr-variant-3-prime
rs1138330 -- 47,509,150(+) agaga(C/T)ggggt intron-variant
rs1138331 -- 47,509,161(+) tttgc(C/T)atgct intron-variant
rs1984882 -- 47,509,831(+) ATCTC(A/G)GCTCA intron-variant
rs1985505 -- 47,509,830(+) GATCT(C/T)GGCTC intron-variant

Relevant External Links for ELP6 Gene

HapMap Linkage Disequilibrium report
ELP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ELP6 Gene

Disorders for ELP6 Gene

No disorders were found for ELP6 Gene.

No data available for UniProtKB/Swiss-Prot for ELP6 Gene

Publications for ELP6 Gene

  1. DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. (PMID: 22854966) Close P. … Chariot A. (J. Biol. Chem. 2012) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1. (PMID: 20706999) Brieger A. … Trojan J. (Proteomics 2010) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for ELP6 Gene

Sources for ELP6 Gene

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