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Aliases for ELP5 Gene

Aliases for ELP5 Gene

  • Elongator Acetyltransferase Complex Subunit 5 2 3
  • S-Phase 2 Protein 2 3 4
  • C17orf81 3 4 6
  • DERP6 3 4 6
  • Dermal Papilla Derived Protein 6 2 3
  • Chromosome 17 Open Reading Frame 81 2
  • Dermal Papilla-Derived Protein 6 4
  • Elongator Complex Protein 5 3
  • HSPC002 3
  • MSTP071 3
  • MST071 3

External Ids for ELP5 Gene

Previous Symbols for ELP5 Gene

  • C17orf81

Summaries for ELP5 Gene

GeneCards Summary for ELP5 Gene

ELP5 (Elongator Acetyltransferase Complex Subunit 5) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening.

UniProtKB/Swiss-Prot for ELP5 Gene

  • Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation.

Gene Wiki entry for ELP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELP5 Gene

Genomics for ELP5 Gene

Genomic Location for ELP5 Gene

Start:
7,251,416 bp from pter
End:
7,259,940 bp from pter
Size:
8,525 bases
Orientation:
Plus strand

Genomic View for ELP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELP5 Gene

No data available for Regulatory Elements for ELP5 Gene

Proteins for ELP5 Gene

  • Protein details for ELP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE02-ELP5_HUMAN
    Recommended name:
    Elongator complex protein 5
    Protein Accession:
    Q8TE02
    Secondary Accessions:
    • A8K1M5
    • D3DTN9
    • Q659B6
    • Q7Z2T4
    • Q8TDR9
    • Q9BUB2
    • Q9Y2Q4

    Protein attributes for ELP5 Gene

    Size:
    316 amino acids
    Molecular mass:
    34841 Da
    Quaternary structure:
    • Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6; in the complex, is required for optimal binding of ELP3 to ELP4.
    SequenceCaution:
    • Sequence=AAD20964.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ13591.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ELP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELP5 Gene

Proteomics data for ELP5 Gene at MOPED

Post-translational modifications for ELP5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys43 and Lys94

No data available for DME Specific Peptides for ELP5 Gene

Domains for ELP5 Gene

Gene Families for ELP5 Gene

HGNC:
  • ELP :Elongator acetyltransferase complex subunits

Protein Domains for ELP5 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ELP5_HUMAN
Family:
  • Belongs to the ELP5 family.:
    • Q8TE02
genes like me logo Genes that share domains with ELP5: view

Function for ELP5 Gene

Molecular function for ELP5 Gene

UniProtKB/Swiss-Prot Function: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ELP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16713569
genes like me logo Genes that share ontologies with ELP5: view

Phenotypes for ELP5 Gene

GenomeRNAi human phenotypes for ELP5:
genes like me logo Genes that share phenotypes with ELP5: view

miRNA for ELP5 Gene

miRTarBase miRNAs that target ELP5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ELP5 Gene

Localization for ELP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELP5 Gene

Nucleus. Cytoplasm.

Gene Ontology (GO) - Cellular Components for ELP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22854966
GO:0005737 cytoplasm IDA --
GO:0033588 Elongator holoenzyme complex IDA 22854966
genes like me logo Genes that share ontologies with ELP5: view

Pathways for ELP5 Gene

genes like me logo Genes that share pathways with ELP5: view

Pathways by source for ELP5 Gene

Gene Ontology (GO) - Biological Process for ELP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030335 positive regulation of cell migration ISS --
genes like me logo Genes that share ontologies with ELP5: view

Transcripts for ELP5 Gene

Unigene Clusters for ELP5 Gene

Elongator acetyltransferase complex subunit 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELP5 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - - - - - - - - - -
SP6:
SP7:
SP8: - - - -
SP9: -

Relevant External Links for ELP5 Gene

GeneLoc Exon Structure for
ELP5
ECgene alternative splicing isoforms for
ELP5

Expression for ELP5 Gene

mRNA expression in normal human tissues for ELP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELP5 Gene

This gene is overexpressed in Testis (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELP5 Gene

SOURCE GeneReport for Unigene cluster for ELP5 Gene Hs.417029

mRNA Expression by UniProt/SwissProt for ELP5 Gene

Q8TE02-ELP5_HUMAN
Tissue specificity: Ubiquitously expressed with high levels in heart, brain, liver, skeletal muscle and testis
genes like me logo Genes that share expressions with ELP5: view

Orthologs for ELP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 98 (a)
OneToMany
-- 37
  • 99 (a)
OneToMany
LOC455799 36
  • 99.26 (n)
  • 98.73 (a)
cow
(Bos Taurus)
Mammalia ELP5 36
  • 85.78 (n)
  • 83.57 (a)
ELP5 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELP5 36
  • 84.44 (n)
  • 81.4 (a)
ELP5 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elp5 36
  • 78.55 (n)
  • 75.17 (a)
Elp5 16
Elp5 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELP5 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELP5 37
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elp5 36
  • 78.4 (n)
  • 74.91 (a)
lizard
(Anolis carolinensis)
Reptilia ELP5 37
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii elp5 36
  • 46.43 (n)
  • 36.58 (a)
elp5 37
  • 35 (a)
OneToOne
Species with no ortholog for ELP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELP5 Gene

ENSEMBL:
Gene Tree for ELP5 (if available)
TreeFam:
Gene Tree for ELP5 (if available)

Paralogs for ELP5 Gene

No data available for Paralogs for ELP5 Gene

Variants for ELP5 Gene

Sequence variations from dbSNP and Humsavar for ELP5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs367181 -- 7,257,205(+) ggctc(A/C)agtga intron-variant
rs402514 -- 7,254,884(+) TAGAA(G/T)AAACA intron-variant
rs427784 -- 7,254,197(+) TTTCA(C/T)CCAGG intron-variant
rs2106842 -- 7,259,132(+) CTTGG(A/G)TCACA intron-variant, utr-variant-3-prime
rs2521989 -- 7,258,309(+) CTGGG(C/T)GTGGT intron-variant

Relevant External Links for ELP5 Gene

HapMap Linkage Disequilibrium report
ELP5

No data available for Structural Variations from Database of Genomic Variants (DGV) for ELP5 Gene

Disorders for ELP5 Gene

No disorders were found for ELP5 Gene.

No data available for UniProtKB/Swiss-Prot for ELP5 Gene

Publications for ELP5 Gene

  1. DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. (PMID: 22854966) Close P. … Chariot A. (J. Biol. Chem. 2012) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53. (PMID: 16850183) Yuan J. … Yu L. (Mol. Biol. Rep. 2006) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ELP5 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ELP5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ELP5
    • Block miRNA regulation of ELP5 using miScript Target Protectors

    Sources for ELP5 Gene

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