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Aliases for ELP5 Gene

Aliases for ELP5 Gene

  • Elongator Acetyltransferase Complex Subunit 5 2 3 5
  • S-Phase 2 Protein 2 3 4
  • Dermal Papilla Derived Protein 6 2 3
  • C17orf81 3 4
  • DERP6 3 4
  • Chromosome 17 Open Reading Frame 81 2
  • Dermal Papilla-Derived Protein 6 4
  • Elongator Complex Protein 5 3
  • HSPC002 3
  • MSTP071 3
  • MST071 3

External Ids for ELP5 Gene

Previous HGNC Symbols for ELP5 Gene

  • C17orf81

Previous GeneCards Identifiers for ELP5 Gene

  • GC17P007154

Summaries for ELP5 Gene

GeneCards Summary for ELP5 Gene

ELP5 (Elongator Acetyltransferase Complex Subunit 5) is a Protein Coding gene. Among its related pathways are Chromatin organization.

UniProtKB/Swiss-Prot for ELP5 Gene

  • Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation.

Gene Wiki entry for ELP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELP5 Gene

Genomics for ELP5 Gene

Regulatory Elements for ELP5 Gene

Enhancers for ELP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F007247 1 ENCODE 38.1 -0.7 -738 6.0 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ELP5 YBX2 CLDN7 DLG4 ENSG00000262526
GH17F007256 0.7 ENCODE 37.8 +9.4 9382 8.7 HDGF ARNT MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS ELP5 YBX2 CLDN7 GABARAP SLC2A4 DLG4 ENSG00000262302 PIR33341
GH17F007233 0.4 ENCODE 37.8 -12.7 -12736 11.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 DVL2 CNTROB SNORD10 SNORA48 KIAA0753 ELP5 SENP3 MIR6883 NEURL4 ZBTB4
GH17F007279 0.2 ENCODE 31.2 +29.9 29922 4.3 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 YBX2 ELP5 SNORD10 DVL2 PFAS SNORA48 CTC1 MIR6883 ENSG00000262089 SLC2A4
GH17F007213 1 FANTOM5 ENCODE 29.2 -32.7 -32727 10.6 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 ELP5 CLDN7 SENP3 ZBTB4 LOC100996842 NEURL4 DVL2 MIR6883 KIAA0753 MIR324
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ELP5 on UCSC Golden Path with GeneCards custom track

Promoters for ELP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001340138 484 3001 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for ELP5 Gene

Chromosome:
17
Start:
7,251,416 bp from pter
End:
7,259,940 bp from pter
Size:
8,525 bases
Orientation:
Plus strand

Genomic View for ELP5 Gene

Genes around ELP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELP5 Gene

Proteins for ELP5 Gene

  • Protein details for ELP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE02-ELP5_HUMAN
    Recommended name:
    Elongator complex protein 5
    Protein Accession:
    Q8TE02
    Secondary Accessions:
    • A8K1M5
    • D3DTN9
    • Q659B6
    • Q7Z2T4
    • Q8TDR9
    • Q9BUB2
    • Q9Y2Q4

    Protein attributes for ELP5 Gene

    Size:
    316 amino acids
    Molecular mass:
    34841 Da
    Quaternary structure:
    • Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6; in the complex, is required for optimal binding of ELP3 to ELP4.
    SequenceCaution:
    • Sequence=AAD20964.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ13591.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ELP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELP5 Gene

Post-translational modifications for ELP5 Gene

  • Ubiquitination at Lys 43 and Lys 94
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ELP5 Gene

Domains & Families for ELP5 Gene

Gene Families for ELP5 Gene

Protein Domains for ELP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ELP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TE02

UniProtKB/Swiss-Prot:

ELP5_HUMAN :
  • Belongs to the ELP5 family.
Family:
  • Belongs to the ELP5 family.
genes like me logo Genes that share domains with ELP5: view

Function for ELP5 Gene

Molecular function for ELP5 Gene

UniProtKB/Swiss-Prot Function:
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ELP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16713569
genes like me logo Genes that share ontologies with ELP5: view

Phenotypes for ELP5 Gene

genes like me logo Genes that share phenotypes with ELP5: view

Animal Model Products

miRNA for ELP5 Gene

miRTarBase miRNAs that target ELP5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ELP5 Gene

Localization for ELP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELP5 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELP5 Gene COMPARTMENTS Subcellular localization image for ELP5 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for ELP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22854966
GO:0005737 cytoplasm IEA,IDA 22854966
GO:0033588 Elongator holoenzyme complex IDA 22854966
genes like me logo Genes that share ontologies with ELP5: view

Pathways & Interactions for ELP5 Gene

genes like me logo Genes that share pathways with ELP5: view

Pathways by source for ELP5 Gene

Gene Ontology (GO) - Biological Process for ELP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030335 positive regulation of cell migration ISS --
genes like me logo Genes that share ontologies with ELP5: view

No data available for SIGNOR curated interactions for ELP5 Gene

Transcripts for ELP5 Gene

Unigene Clusters for ELP5 Gene

Elongator acetyltransferase complex subunit 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELP5 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5: - - - - - - - - - -
SP6:
SP7:
SP8: - - - -
SP9: -

Relevant External Links for ELP5 Gene

GeneLoc Exon Structure for
ELP5
ECgene alternative splicing isoforms for
ELP5

Expression for ELP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ELP5 Gene

mRNA differential expression in normal tissues according to GTEx for ELP5 Gene

This gene is overexpressed in Testis (x4.8).

Protein differential expression in normal tissues from HIPED for ELP5 Gene

This gene is overexpressed in Breast (29.6), Bone (13.7), Cerebrospinal fluid (13.1), and Pancreas (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ELP5 Gene



NURSA nuclear receptor signaling pathways regulating expression of ELP5 Gene:

ELP5

SOURCE GeneReport for Unigene cluster for ELP5 Gene:

Hs.417029

mRNA Expression by UniProt/SwissProt for ELP5 Gene:

Q8TE02-ELP5_HUMAN
Tissue specificity: Ubiquitously expressed with high levels in heart, brain, liver, skeletal muscle and testis.
genes like me logo Genes that share expression patterns with ELP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for ELP5 Gene

Orthologs for ELP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ELP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC455799 34
  • 99.26 (n)
-- 35
  • 99 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ELP5 35 34
  • 85.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ELP5 35 34
  • 84.44 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Elp5 34 16 35
  • 78.55 (n)
rat
(Rattus norvegicus)
Mammalia Elp5 34
  • 78.4 (n)
oppossum
(Monodelphis domestica)
Mammalia ELP5 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELP5 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELP5 35
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii elp5 34 35
  • 46.43 (n)
Species where no ortholog for ELP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELP5 Gene

ENSEMBL:
Gene Tree for ELP5 (if available)
TreeFam:
Gene Tree for ELP5 (if available)

Paralogs for ELP5 Gene

No data available for Paralogs for ELP5 Gene

Variants for ELP5 Gene

Sequence variations from dbSNP and Humsavar for ELP5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1050097 -- 7,259,753(+) TCTTT(C/T)TATTG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111401163 -- 7,252,031(+) GTGGT(A/G)ACGTG upstream-variant-2KB
rs111507663 -- 7,254,449(+) TCTCT(C/T)AGTAA intron-variant
rs111599214 -- 7,253,000(+) ATCGG(C/T)AAGTA upstream-variant-2KB, splice-donor-variant
rs112150023 -- 7,257,071(+) GAAAC(-/GG)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELP5 Gene

Variant ID Type Subtype PubMed ID
dgv885e212 CNV loss 25503493
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv3639861 CNV loss 21293372
nsv1963 CNV deletion 18451855
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for ELP5 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELP5 Gene

Disorders for ELP5 Gene

Relevant External Links for ELP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELP5

No disorders were found for ELP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELP5 Gene

Publications for ELP5 Gene

  1. DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. (PMID: 22854966) Close P. … Chariot A. (J. Biol. Chem. 2012) 2 3 4 64
  2. Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53. (PMID: 16850183) Yuan J. … Yu L. (Mol. Biol. Rep. 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ELP5 Gene

Sources for ELP5 Gene

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