Aliases for ELP4 Gene
External Ids for ELP4 Gene
Previous HGNC Symbols for ELP4 Gene
Previous GeneCards Identifiers for ELP4 Gene
This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
GeneCards Summary for ELP4 Gene
ELP4 (Elongator Acetyltransferase Complex Subunit 4) is a Protein Coding gene. Diseases associated with ELP4 include Aniridia 2 and Aniridia 1. Among its related pathways are Mesodermal Commitment Pathway and Chromatin organization. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity and phosphorylase kinase regulator activity.
UniProtKB/Swiss-Prot for ELP4 Gene
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.