ELP4 Gene
protein-coding GIFtS: 53
GCID: GC11P031487
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elongator acetyltransferase complex subunit 4(Previous names: chromosome 11 open reading frame 19, elongation protein...)
(Previous symbol: C11orf19)
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Aliases
for ELP4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Elongator Acetyltransferase Complex Subunit 41 2 | | Chromosome 11 Open Reading Frame 191 | | C11orf191 2 3 | | Elongation Protein 4 Homolog (S. Cerevisiae)1 | | PAXNEB1 2 3 | | DJ68P15A.11 | | HELP41 | | Elongation Protein 4 Homolog2 | | PAX6 Neighbor Gene Protein2 3 | | Elongator Complex Protein 42 | | PAX6NEB2 5 | | |
Export aliases for ELP4 gene to outside databasesPrevious GC identifers: GC11U990232 GC11P032306 GC11P031570 GC11P031495 GC11P031226 |
Summaries
for ELP4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ELP4:
This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associatesdirectly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivityphenotypes of yeast ELP4 deletion mutants. Alternatively spliced variants that encode different protein isoforms havebeen described but the full-length nature of only one has been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ELP4_HUMAN, Q96EB1Function: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component ofthe RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role inchromatin remodeling and is involved in acetylation of histones H3 and probably H4
Gene Wiki entry for ELP4
|
Genomic Views
for ELP4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ELP4 gene promoter:
E2F-3a E2F-4 E2F-5 E2F-2 E47 Egr-4 E2F E2F-1 Nkx6-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ELP4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELP4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13ELP4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P031487: view genomic region
(about GC identifiers)
Start:
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31,531,297 bp from pter |
End:
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31,805,546 bp from pter |
Size:
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274,250 bases |
Orientation:
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plus strand |
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Proteins
for ELP4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ELP4_HUMAN, Q96EB1 (See
protein sequence)Recommended Name: Elongator complex protein 4 Size: 424 amino acids; 46588 Da
Subunit: Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2,ELP3, ELP4, ELP5 and ELP6. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: Q9H4E8 Q9NX11Alternative splicing: 2 isoforms: Q96EB1-1 Q96EB1-2 Explore the universe of human proteins at neXtProt for ELP4: NX_Q96EB1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96EB1
ELP4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061913.3
ENSEMBL proteins: ENSP00000298937 ENSP00000368461 ENSP00000432642 ENSP00000379267
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ELP4 for ontologies About GeneDecksing
ELP4 Antibody Products:
Assay Products for ELP4: |
Protein
Domains /
Families
for ELP4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ELP4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96EB1ProtoNet protein and cluster: Q96EB1 UniProtKB/Swiss-Prot: ELP4_HUMAN, Q96EB1Similarity: Belongs to the ELP4 family |
Function
for ELP4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ELP4_HUMAN, Q96EB1Function: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component ofthe RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role inchromatin remodeling and is involved in acetylation of histones H3 and probably H4
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ELP4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ELP4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELP4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELP4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ELP4 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ELP4:
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Pathways & Interactions
for ELP4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ELP4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/28 Interacting proteins for ELP4 (Q96EB13 ENSP000002989374) via UniProtKB, MINT, STRING, and/or I2D (see all 28)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
ELP4 for ontologies About GeneDecksing
|
Drugs & Compounds
for ELP4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ELP4
Search CenterWatch for drugs/clinical trials and news about ELP4
|
Transcripts
for ELP4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ELP4 gene: NM_019040.3 Unigene Cluster for ELP4: Elongator acetyltransferase complex subunit 4 Hs.175534 [show with all ESTs]Unigene Representative Sequence: BC0125144 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000350638(uc001mtb.3) ENST00000379163(uc010rdz.2) ENST00000474374
ENST00000395934(uc001mtc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ELP4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ELP4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ELP4 (NM_019040) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ELP4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELP4 |
Additional cDNA sequence: AK000505.1 AK304885.1 AL136677.1 BC012514.1 6 DOTS entries: DT.100777720 DT.120706892 DT.441601 DT.91740075 DT.91740058 DT.97836474 24/148 AceView cDNA sequences (see all 148): AI671784 CR610736 AW627465 BG698097 CR611102 BQ215253 AI580174 BQ027134 BM785878 CR604657 BQ632507 BQ632794 BM768264 BQ431894 AL136677 CA866169 CA307545 CA941140 AI366838 AI949290 AI088062 BU619879 BU616566 AI695669
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ELP4 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | | |
ECgene alternative splicing isoforms for ELP4
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Expression
for ELP4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ELP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTAGAGAA
About this image
See ELP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ELP4
SOURCE GeneReport for Unigene cluster: Hs.175534
UniProtKB/Swiss-Prot: ELP4_HUMAN, Q96EB1Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for ELP4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ELP4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ELP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELP4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELP4 |
Orthologs
for ELP4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ELP4 gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for ELP4 (if available)
TreeFam Gene Tree for ELP4 (if available) |
Paralogs
for ELP4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ELP4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ELP4 (31531297 - 31781297 bp, first 250kb of ELP4)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ELP4
2 CNVs: 9180 39072
Human Gene Mutation Database (HGMD): ELP4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ELP4 |
|
Disorders
/ Diseases
for ELP4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ELP4 for disorders About GeneDecksing
OMIM gene information: 606985
OMIM disorders: --
3  diseases for ELP4: About MalaCardslandau-kleffner syndrome dysautonomia aniridia
5 diseases from the University of Copenhagen DISEASES database for ELP4:Benign epilepsy with centrotemporal spikes Aniridia Articulation disorder Developmental coordination disorder
Landau-Kleffner syndrome Export disorders for ELP4 gene to outside databases
|
Publications
for ELP4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ELP4 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with ELP4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a novel gene adjacent to PAX6, revealing synteny conservation with functional significance. (PubMed id 11889558)1, 2, 3, 9 Kleinjan D.A.... van Heyningen V. (2002)
- Human Elongator facilitates RNA polymerase II transcription through chromatin. (PubMed id 11818576)1, 2 Kim J.H.... Reinberg D. (2002)
- Purification and characterization of the human elongator complex. (PubMed id 11714725)1, 2 Hawkes N.A.... Svejstrup J.Q. (2002)
- RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes. (PubMed id 11435442)1, 3 Winkler G.S....Svejstrup J.Q. (2001)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicit y and migration of melanoma cells as subunits of Elongator. (PubMed id 22854966)2 Close P....Chariot A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for ELP4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ELP4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ELP4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ELP4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ELP4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ELP4 gene:
Search GeneIP for patents involving ELP4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ELP4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for ELP4 | | OriGene Custom Protein Services for ELP4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ELP4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ELP4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELP4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELP4 |
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 | | | ELP4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELP4 |
|  |  |  | | | | ThermoFisher Antibody for ELP4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELP4 |
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