Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ELP3 Gene

protein-coding   GIFtS: 54
GCID: GC08P028006

elongator acetyltransferase complex subunit 3

(Previous name: elongation protein 3 homolog (S. cerevisiae) )
 Explore 4 diseases affiliated with
ELP3 via our new
 Human Malady Compendium 
Biological research products
for ELP3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Elongator Acetyltransferase Complex Subunit 31 2     FLJ104221
KAT91 2 5     Elongation Protein 3 Homolog (S. Cerevisiae)1
HELP31     Elongation Protein 3 Homolog2
EC 2.3.1.483 8     Elongator Complex Protein 32

External Ids:    HGNC: 206961   Entrez Gene: 551402   Ensembl: ENSG000001340147   OMIM: 6127225   UniProtKB: Q9H9T33   

Export aliases for ELP3 gene to outside databases

Previous GC identifers: GC08P027733 GC08P028455 GC08P027972 GC08P026496


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ELP3:
ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript
elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 (PubMed 19185337)).(supplied
by OMIM, Apr 2009)

UniProtKB/Swiss-Prot: ELP3_HUMAN, Q9H9T3
Function: Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component
of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role
in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a
methyltransferase activity. Involved in cell migration

Gene Wiki entry for ELP3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ELP3 gene promoter:
         USF1   HOXA3   IRF-1   HNF-3beta   IRF-2   POU2F1   POU2F1a   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ELP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.1   Ensembl cytogenetic band:  8p21.1   HGNC cytogenetic band: 8p21.1

ELP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELP3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P028006:  view genomic region     (about GC identifiers)

Start:
27,947,190 bp from pter      End:
28,048,673 bp from pter
Size:
101,484 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ELP3_HUMAN, Q9H9T3 (See protein sequence)
Recommended Name: Elongator complex protein 3  
Size: 547 amino acids; 62259 Da
Cofactor: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable
S-adenosyl-L-methionine (By similarity)
Subunit: Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2,
ELP3, ELP4, ELP5 and ELP6. IKBKAP/ELP1, STIP1/ELP2 and ELP3 form the Elongator core complex. Elongator associates with
the C-terminal domain (CTD) of Pol II largest subunit. Interacts with IKBKAP/ELP1
Subcellular location: Isoform 1: Nucleus
Subcellular location: Isoform 2: Cytoplasm. Nucleus
Sequence caution: Sequence=BAA91600.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=CAH10573.1;
Type=Frameshift; Positions=279;
Secondary accessions: Q53G84 Q6AWB0 Q9BVF7 Q9NVZ1
Alternative splicing: 2 isoforms:  Q9H9T3-1   Q9H9T3-2   

Explore the universe of human proteins at neXtProt for ELP3: NX_Q9H9T3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H9T3

  • 4/23 DME Specific Peptides for ELP3 (Q9H9T3) (see all 23)
     FENPAFR  PKLKAKP  ERDIEQF  KRHLSDML 

    ELP3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060561.3  
    ENSEMBL proteins: 
     ENSP00000429446   ENSP00000428449   ENSP00000428532   ENSP00000256398   ENSP00000430253  
     ENSP00000429180   ENSP00000429465   ENSP00000428357   ENSP00000430681   ENSP00000429248  
     ENSP00000429573   ENSP00000427833   ENSP00000430942   ENSP00000369711   ENSP00000445558  
     ENSP00000439242  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ELP3
    OriGene Custom Protein Services for ELP3 
    GenScript Custom Purified and Recombinant Proteins Services for ELP3
    Novus Biologicals ELP3 Protein
    Novus Biologicals ELP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ELP3

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA11714725
    GO:0005737cytoplasm IDA--
    GO:0008023transcription elongation factor complex IDA11714725
    GO:0016591DNA-directed RNA polymerase II, holoenzyme IDA11714725
    GO:0033588Elongator holoenzyme complex IDA--


    ELP3 for ontologies           About GeneDecksing



    ELP3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ELP3
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ELP3 
    OriGene Antibodies: ELP3
    OriGene Custom Antibody Services for ELP3 
    GenScript Custom Superior Antibodies Services for ELP3
    Novus Biologicals ELP3 Antibodies
    Abcam antibodies for ELP3 
    Uscn Antibodies for ELP3
    ThermoFisher Antibodies for ELP3

    Assay Products for ELP3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ELP3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ELP3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ELP3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR000182 GNAT_dom
     IPR007197 rSAM
     IPR016181 Acyl_CoA_acyltransferase
     IPR006638 Elp3/MiaB/NifB
     IPR005910 Hist_AcTrfase_ELP3

    Graphical View of Domain Structure for InterPro Entry Q9H9T3

    ProtoNet protein and cluster: Q9H9T3

    2 Blocks protein families:
    IPB000182 GCN5-related N-acetyltransferase
    IPB006638 Elongator protein 3/MiaB/NifB


    UniProtKB/Swiss-Prot: ELP3_HUMAN, Q9H9T3
    Similarity: Belongs to the ELP3 family
    Similarity: Contains 1 N-acetyltransferase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ELP3_HUMAN, Q9H9T3
    Function: Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component
    of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role
    in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a
    methyltransferase activity. Involved in cell migration
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

    Enzyme Number (IUBMB): EC 2.3.1.481 2

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: ELP3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELP3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ELP3:
    hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidELP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ELP3 (see all 4)
    OriGene shRNA RFP: ELP3
    OriGene siRNA: ELP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ELP3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ELP3 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ELP3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ELP3 (NM_018091)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELP3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ELP3
    Search LifeMap BioReagents cell lines for ELP3

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELP3

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677contributes to DNA binding IDA11714725
    GO:0004402histone acetyltransferase activity IEA--
    GO:0005515protein binding IPI19185337
    GO:0008080N-acetyltransferase activity ----
    GO:0008607phosphorylase kinase regulator activity IDA11818576


    ELP3 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Elp3 (no phenotypes)

    ELP3 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ELP3
        Chromatin Regulation / Acetylation



    ELP3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ELP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/163 Interacting proteins for ELP3 (Q9H9T31, 3 ENSP000002563984) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKAPO951631, 3, ENSP000003637794EBI-355217,EBI-347559 I2D: score=8 STRING: ENSP00000363779
    EEF1A1P681043, ENSP000003300544I2D: score=3 STRING: ENSP00000330054
    UTP18Q9Y5J13, ENSP000002252984I2D: score=3 STRING: ENSP00000225298
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    CTR9Q6PD623, ENSP000003550134I2D: score=1 STRING: ENSP00000355013
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS11714725
    GO:0006368transcription elongation from RNA polymerase II promoter IDA11714725
    GO:0030335positive regulation of cell migration ISS--


    ELP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ELP3

    3 HMDB Compounds for ELP3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Search CenterWatch for drugs/clinical trials and news about ELP3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ELP3 gene: 
    NM_018091.5  

    Unigene Cluster for ELP3:

    Elongator acetyltransferase complex subunit 3
    Hs.491336  [show with all ESTs]
    Unigene Representative Sequence: NM_018091
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000520270 ENST00000521015(uc003xgn.4) ENST00000521570 ENST00000256398(uc003xgo.4 uc011laq.2 uc011lar.2 uc011las.2 uc011lat.2)
    ENST00000523687 ENST00000523760 ENST00000524103 ENST00000518112 ENST00000519261
    ENST00000524024 ENST00000521938 ENST00000520288 ENST00000521099 ENST00000522063
    ENST00000520110 ENST00000520011 ENST00000523357 ENST00000517975

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: ELP3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELP3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ELP3:
    hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidELP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ELP3 (see all 4)
    OriGene shRNA RFP: ELP3
    OriGene siRNA: ELP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELP3
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ELP3 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ELP3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ELP3 (NM_018091)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELP3 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ELP3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ELP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELP3

    Additional cDNA sequence: 

    AK001284.1 AK022626.1 AK223047.1 AK293424.1 AK295574.1 AK296475.1 AK298265.1 AK302140.1 
    AK315985.1 AK316053.1 AL834273.1 BC001240.1 BX648011.1 

    13 DOTS entries:

    DT.454535  DT.100811712  DT.101983588  DT.100811719  DT.100802493  DT.121480432  DT.95288288  DT.97861876 
    DT.97776032  DT.86839177  DT.86855236  DT.97810312  DT.97822259 

    24/214 AceView cDNA sequences (see all 214):

    BP378418 AI810734 BQ064911 AA922599 BQ440313 AA580821 BP366303 BU632220 
    AA411348 CK725091 AU186102 AW439052 CR618264 AI288057 BX280249 BM930840 
    AA337527 BM824411 CB119076 BX390272 CB216924 BM663362 AI370380 AL834273 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ELP3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:                                                  -           -     -                                                                       -               
    SP2:                                                  -           -     -                                                     -     -           -               
    SP3:                                                                                                                                                            
    SP4:                                                                    -                                                                                       
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for ELP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ELP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAATAAAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ELP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ELP3

    SOURCE GeneReport for Unigene cluster: Hs.491336
        SABiosciences Custom PCR Arrays for ELP3
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ELP3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ELP3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELP3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ELP3 gene from 10/41 species (see all 41)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elp31 , 5 elongation protein 3 homolog (S. cerevisiae)5
    elongator acetyltransferase complex subunit 31
    88.06(n)1
    95.8(a)1
      14 (34.33 cM)5
    741951  NM_028811.31  NP_083087.11 
     655304465 
    chicken
    (Gallus gallus)
    Aves ELP31 elongation protein 3 homolog (S. cerevisiae) 79.24(n)
    91.58(a)
      422021  NM_001039293.1  NP_001034382.1 
    lizard
    (Anolis carolinensis)
    Reptilia ELP36
    --
    91(a)
    1 ↔ 1
    GL343529.1(139732-267657)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167502 Xenopus laevis transcribed sequence with moderate similarity more 77.43(n)    BU913269.1 
    zebrafish
    (Danio rerio)
    Actinopterygii elp31 elongation protein 3 homolog (S. cerevisiae) 75.84(n)
    90.46(a)
      541509  NM_001014322.2  NP_001014344.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Elp31 Elongator complex protein 3 67.4(n)
    82.63(a)
      33649  NM_134990.3  NP_608834.1 
    worm
    (Caenorhabditis elegans)
    Secernentea elpc-31 Protein ELPC-3 66.42(n)
    80.07(a)
      179669  NM_073654.3  NP_506055.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ELP3(YPL086C)4
    ELP31
    Subunit of Elongator complex, which is required for more4
    Elp3p1
    65.8(n)1
    75.23(a)1
      16(386446-384773)4
    8560191, 4  NP_015239.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ELO31 Elongator complex protein 3 65.55(n)
    73.98(a)
      835098  NM_124412.2  NP_568725.1 
    rice
    (Oryza sativa)
    Liliopsida Os.175162 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.94(n)    AK122179.1 


    ENSEMBL Gene Tree for ELP3 (if available)
    TreeFam Gene Tree for ELP3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1693 NCBI SNPs in ELP3 are shown (see all 1693    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910493871,2
    --27948644(+) GGTCTC/TGATCT 1 -- us2k10--------
    rs1476018151,2
    --27948665(+) TGATCC/TGCCCA 1 -- us2k10--------
    rs1818017001,2
    --27948722(+) CCGGCC/TGTAAA 1 -- us2k10--------
    rs1861658241,2
    --27948894(+) AGTTTA/GACTTT 1 -- us2k10--------
    rs1917359661,2
    --27949027(+) TAGCAA/GGGCCA 1 -- us2k10--------
    rs791081531,2
    --27949049(+) ATAGTG/AGGGTC 1 -- us2k14Minor allele frequency- A:0.03CSA WA NA EA 359
    rs1171281371,2
    C,--27949095(+) ATATTC/ACTGTC 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs797200801,2
    F,--27949195(+) AAATTT/CTGCAA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs736691841,2
    C,--27949418(+) CAACTA/GTGCAT 1 -- us2k12Minor allele frequency- G:0.17WA 120
    rs285070201,2
    C,F,--27949459(+) CAGAAG/CACAAA 1 -- us2k11Minor allele frequency- C:0.18WA 118

    HapMap Linkage Disequilibrium report for ELP3 (27947190 - 28048673 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ELP3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ELP3
    DNA2.0 Custom Variant and Variant Library Synthesis for ELP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ELP3 for disorders           About GeneDecksing

    OMIM gene information: 612722    OMIM disorders: --

    4 diseases for ELP3:    About MalaCards
    riley-day syndrome    dysautonomia    neuronitis    malaria

    1 disease from the University of Copenhagen DISEASES database for ELP3:
    Riley-Day syndrome
    Human Genome Epidemiology (HuGE) Navigator: ELP3 (2 documents)

    Export disorders for ELP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ELP3 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with ELP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and characterization of the human elongator complex. (PubMed id 11714725)1, 2, 3 Hawkes N.A.... Svejstrup J.Q. (2002)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Human Elongator facilitates RNA polymerase II transcription through chromatin. (PubMed id 11818576)1, 2 Kim J.H.... Reinberg D. (2002)
    4. hELP3 subunit of the Elongator complex regulates the transcription of HSP70 gene in human cells. (PubMed id 17558451)1, 9 Han Q....Lu J. (2007)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicit y and migration of melanoma cells as subunits of Elongator. (PubMed id 22854966)2 Close P....Chariot A. (2012)
    8. Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization. (PubMed id 22002106)2 Ahmad Y.... Lamond A.I. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55140 HGNC: 20696 AceView: ELP3 Ensembl:ENSG00000134014 euGenes: HUgn55140
    ECgene: ELP3 H-InvDB: ELP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ELP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ELP3 gene:
    Search GeneIP for patents involving ELP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ELP3
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ELP3   OriGene shRNA RFP for ELP3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ELP3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ELP3  
     OriGene Protein Over-expression Lysate for ELP3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ELP3   OriGene 3'-UTR Clone for ELP3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ELP3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ELP3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ELP3   OriGene Custom Protein Services for ELP3  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ELP3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ELP3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELP3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELP3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELP3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELP3
     GenScript Custom Purified and Recombinant Proteins Services for ELP3 GenScript cDNA clones with any tag delivered in your preferred vector for ELP3
     GenScript Custom Assay Services for ELP3 GenScript Custom Superior Antibodies Services for ELP3
     GenScript Custom overexpressing Cell Line Services for ELP3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for ELP3 

     Regulatory tfbs in ELP3 promoter
     Search Chromatin IP Primers for ELP3
     RT2 qPCR Primer Assay in human, mouse, rat ELP3
     Search GNC Networks for ELP3
     SABiosciences Custom PCR Arrays for ELP3
     Search Tocris compounds for ELP3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ELP3 antibodies
     ELP3 proteins
     ELP3 lysates
     Antibodies for ELP3
     See all of Abcam's Antibodies, Kits and Proteins for ELP3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ELP3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ELP3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELP3
     SwitchGear 3'UTR luciferase reporter plasmids for ELP3
     SwitchGear Promoter luciferase reporter plasmids for ELP3
     ThermoFisher Antibodies for ELP3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELP3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ELP3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4