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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ELP2 Gene

protein-coding   GIFtS: 53
GCID: GC18P033709

Elongator Acetyltransferase Complex Subunit 2

(Previous names: signal transducer and activator of transcription 3 interacting...)
(Previous symbol: STATIP1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Elongator Acetyltransferase Complex Subunit 21 2     Elongation Protein 2 Homolog2
STATIP11 2 3     Elongator Complex Protein 22
Signal Transducer And Activator Of Transcription 3 Interacting Protein 11 2     Elongator Protein 22
SHINC-22 3     Signal Transducer And Activator Of Transcription Interacting Protein 12
STAT3-Interacting Protein 12 3     stIP12
Elongation Protein 2 Homolog (S. Cerevisiae)1     StIP13
StIP2     

External Ids:    HGNC: 182481   Entrez Gene: 552502   Ensembl: ENSG000001347597   UniProtKB: Q6IA863   

Export aliases for ELP2 gene to outside databases

Previous GC identifers: GC18P033739 GC18P031964 GC18P030568


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ELP2 Gene: 
ELP2 (elongator acetyltransferase complex subunit 2) is a protein-coding gene. Diseases associated with ELP2 include acute disseminated encephalomyelitis, and spinal stenosis. GO annotations related to this gene include DNA binding.

UniProtKB/Swiss-Prot: ELP2_HUMAN, Q6IA86
Function: Regulates the ligand-dependent activation of STAT3 (By similarity)
Function: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase
component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator
may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4

Gene Wiki entry for ELP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.2  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ELP2 gene promoter:
         NCX/Ncx   C/EBPalpha   GATA-1   Gfi-1   AREB6   CP2   FOXO4   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidELP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ELP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.2   Ensembl cytogenetic band:  18q12.2   HGNC cytogenetic band: 18q12.1

ELP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELP2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P033709:  view genomic region     (about GC identifiers)

Start:
33,709,407 bp from pter      End:
33,757,909 bp from pter
Size:
48,503 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ELP2_HUMAN, Q6IA86 (See protein sequence)
Recommended Name: Elongator complex protein 2  
Size: 826 amino acids; 92500 Da
Subunit: Interacts with STAT3 and JAKs (By similarity). Component of the RNA polymerase II elongator complex
(Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and
p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: A8KAI6 B4DTG0 B4DXP0 E7EP23 E9PCX0 Q53GZ0 Q687Y8 Q8N5C2 Q96GV4 Q96PI7
Q9H9N0 Q9NV81
Alternative splicing: 7 isoforms:  Q6IA86-1   Q6IA86-2   Q6IA86-3   Q6IA86-4   Q6IA86-5   Q6IA86-6   Q6IA86-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ELP2: NX_Q6IA86

Explore proteomics data for ELP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6IA86

  • ELP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ELP2 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001229804.1  NP_001229805.1  NP_001229806.1  NP_001229807.1  NP_001229808.1  NP_060725.1  

    ENSEMBL proteins: 
     ENSP00000440426   ENSP00000350967   ENSP00000440516   ENSP00000257191   ENSP00000438533  
     ENSP00000414851   ENSP00000391202   ENSP00000443555   ENSP00000440774   ENSP00000316051  
     ENSP00000443800   ENSP00000468091   ENSP00000440651  

    Human Recombinant Protein Products for ELP2: 
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    Novus Biologicals ELP2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for ELP2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IC11714725
    GO:0005737cytoplasm NAS11714725
    GO:0008023transcription elongation factor complex IDA11714725
    GO:0016591DNA-directed RNA polymerase II, holoenzyme IC11714725
    GO:0033588Elongator holoenzyme complex IDA--

    ELP2 for ontologies           About GeneDecksing



    ELP2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ELP: Elongator acetyltransferase complex subunits
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6IA86

    ProtoNet protein and cluster: Q6IA86

    UniProtKB/Swiss-Prot: ELP2_HUMAN, Q6IA86
    Similarity: Belongs to the WD repeat ELP2 family
    Similarity: Contains 14 WD repeats


    ELP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELP2_HUMAN, Q6IA86
    Function: Regulates the ligand-dependent activation of STAT3 (By similarity)
    Function: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase
    component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator
    may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677contributes to DNA binding IDA11714725
    GO:0005515protein binding ----
    GO:0019901protein kinase binding IEA--
         
    ELP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Elp2 (no phenotypes)

    ELP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ELP2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ELP2 
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                         Customized lentivirus expression plasmids for stable overexpression of ELP2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ELP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/154 Interacting proteins for ELP2 (Q6IA863 ENSP000003509674) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS11714725
    GO:0006368transcription elongation from RNA polymerase II promoter IC11714725
    GO:0046425regulation of JAK-STAT cascade IEA--

    ELP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ELP2

    Search CenterWatch for drugs/clinical trials and news about ELP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ELP2 gene (6 alternative transcripts): 
    NM_001242875.1  NM_001242876.1  NM_001242877.1  NM_001242878.1  NM_001242879.1  NM_018255.2  

    Unigene Cluster for ELP2:

    Elongator acetyltransferase complex subunit 2
    Hs.8739  [show with all ESTs]
    Unigene Representative Sequence: NM_001242875
    18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000543127 ENST00000358232(uc002kzk.2 uc002kzl.2 uc002kzm.2 uc002kzn.2 uc002kzo.2)
    ENST00000544267 ENST00000351393 ENST00000541190 ENST00000545632 ENST00000442325(uc010xcg.2 uc010xch.2)
    ENST00000423854 ENST00000539560 ENST00000535488 ENST00000540135 ENST00000542430
    ENST00000350494 ENST00000542824 ENST00000540799 ENST00000543439 ENST00000540730
    ENST00000540323
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ELP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELP2
    Clone
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    GenScript: all cDNA clones in your preferred vector: ELP2 (NM_018255)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELP2
    Sirion Biotech Customized lentivirus for stable overexpression of ELP2 
                         Customized lentivirus expression plasmids for stable overexpression of ELP2 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELP2

    Additional mRNA sequence: 

    AF332505.1 AF403223.1 AK001741.1 AK022709.1 AK222791.1 AK293051.1 AK300201.1 AK302062.1 
    BC007098.1 BC009211.2 BC032553.1 CR457269.1 NR_040110.1 

    24/25 DOTS entries (see all 25):

    DT.86848188  DT.91757129  DT.415381  DT.97849981  DT.91908315  DT.97849985  DT.121088573  DT.425717 
    DT.97849982  DT.97849983  DT.100783688  DT.415384  DT.87015740  DT.100783686  DT.121088624  DT.121088697 
    DT.99965735  DT.121088627  DT.121088737  DT.95303579  DT.95303589  DT.97813350  DT.99983684  DT.121088582 

    24/321 AceView cDNA sequences (see all 321):

    BC009211 AA916037 BG481002 W23625 AW991222 BM832249 AU125685 AI675062 
    AA587433 AW193945 BM465788 BQ669977 AA773533 AA936121 AV727294 BQ184416 
    AI565120 BQ936457 BM676415 BE740104 NM_018255 AA972982 BU183296 Z43743 

    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for ELP2 (see all 20)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^
    SP1:                                      -     -     -                 -                 -                 -                                         -         
    SP2:                                      -     -     -                 -                 -                 -                                         -         
    SP3:                                      -     -     -                 -     -     -     -                 -                                         -         
    SP4:                                      -     -     -                 -     -     -     -     -     -     -     -     -                             -         
    SP5:        -     -     -                 -     -     -                 -                 -                 -                                                   

    ExUns: 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d
    SP1:                                -                                                           -                                             
    SP2:                                -                                                                                                         
    SP3:  -                             -                                                                                                         
    SP4:                                -                                                                                                         
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for ELP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ELP2 expression in normal human tissues (normalized intensities)      ELP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAACAGGTC
    ELP2 Expression
    About this image


    ELP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             retinal progenitor cell e12.5   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             medial temporal gyrus   
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle

    See ELP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ELP2

    SOURCE GeneReport for Unigene cluster: Hs.8739
        SABiosciences Custom PCR Arrays for ELP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ELP2 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Elp21 , 5 elongation protein 2 homolog (S. cerevisiae)5
    elongator acetyltransferase complex subunit 21
    81.5(n)1
    79.76(a)1
      18 (13.18 cM)5
    585231  NM_021448.21  NP_067423.21 
     246039615 
    chicken
    (Gallus gallus)
    Aves ELP21 elongation protein 2 homolog (S. cerevisiae) 69.28(n)
    65.36(a)
      420980  XM_419067.3  XP_419067.3 
    lizard
    (Anolis carolinensis)
    Reptilia ELP26
    Uncharacterized protein
    57(a)
    1 ↔ 1
    4(67376341-67469228)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW641334.12   -- 77.71(n)    AW641334.1 
    zebrafish
    (Danio rerio)
    Actinopterygii elp21 elongation protein 2 homolog (S. cerevisiae) 61.21(n)
    58.37(a)
      560338  NM_001044925.1  NP_001038390.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG118873
    Elp21
    Elongator complex protein 21 40(a)3
    50.83(n)1
    44.87(a)1
      361231  NM_136756.31  NP_610600.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y111B2A.173   -- 34(a)   III(12745328-12757810)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ELP2(YGR200C)4
    ELP21
    Subunit of Elongator complex, which is required for more4
    Elp2p1
    48.96(n)1
    36.09(a)1
      7(902270-899904)4
    8531141, 4  NP_011716.31  NP_011716.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ELP21 elongator protein 2 49.26(n)
    39.43(a)
      841378  NM_001198251.1  NP_001185180.1 
    rice
    (Oryza sativa)
    Liliopsida Os.191792 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.16(n)    AK101284.1 


    ENSEMBL Gene Tree for ELP2 (if available)
    TreeFam Gene Tree for ELP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/997 SNPs in ELP2 are shown (see all 997)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs588194791,2
    C--30576694(+) AAAAA-/AAA   
       
    /AAAA
    TTAAC
    13 -- int1 cds11NA 2
    rs748962451,2
    F--33711389(+) CCAGCG/ACCGTG 7 -- int11Minor allele frequency- A:0.06WA 118
    rs1468749581,2
    --33711466(+) GGGCGC/GCCATA 7 -- int10--------
    rs9484181,2
    C,F,H--33711524(+) ACCCTT/GTTAAA 7 -- int16Minor allele frequency- G:0.02NS EA WA 536
    rs753456531,2
    --33711570(+) TTGCCA/GGTCAA 7 -- int10--------
    rs745347941,2
    --33711575(+) AGTCAA/CCCCAC 7 -- int10--------
    rs17859031,2
    C,F,A,H--33711642(+) TTGCCG/CCTATA 7 -- int118Minor allele frequency- C:0.27EA NA NS WA CSA 910
    rs1176449081,2
    F--33711664(+) GATCTG/ACTTTT 7 -- int11Minor allele frequency- A:0.01NA 120
    rs728868801,2
    C,F--33711679(+) TGATTA/GTACTC 7 -- int12Minor allele frequency- G:0.15NA EA 240
    rs1383804881,2
    --33711887(+) TGCTGA/GTCGGG 7 -- int10--------

    HapMap Linkage Disequilibrium report for ELP2 (33709407 - 33757909 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ELP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv526055CNV Loss19592680


    Human Gene Mutation Database (HGMD): ELP2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ELP2
    DNA2.0 Custom Variant and Variant Library Synthesis for ELP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for ELP2:    About MalaCards
    acute disseminated encephalomyelitis    spinal stenosis    encephalomyelitis    cystic fibrosis
    melanoma

    1 disease from the University of Copenhagen DISEASES database for ELP2:
    Eastern equine encephalitis

    ELP2 for disorders           About GeneDecksing


    Export disorders for ELP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ELP2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with ELP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and characterization of the human elongator complex. (PubMed id 11714725)1, 2, 3 Hawkes N.A.... Svejstrup J.Q. (2002)
    2. A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. (PubMed id 10954736)1, 3, 9 Collum R.G....Schindler C. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Human Elongator facilitates RNA polymerase II transcription through chromatin. (PubMed id 11818576)1, 2 Kim J.H.... Reinberg D. (2002)
    6. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O....Lill R. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55250 HGNC: 18248 AceView: STATIP1 Ensembl:ENSG00000134759 euGenes: HUgn55250
    ECgene: ELP2 H-InvDB: ELP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ELP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ELP2 gene:
    Search GeneIP for patents involving ELP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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