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Aliases for ELP2 Gene

Aliases for ELP2 Gene

  • Elongator Acetyltransferase Complex Subunit 2 2 3
  • Signal Transducer And Activator Of Transcription 3 Interacting Protein 1 2 3
  • STAT3-Interacting Protein 1 3 4
  • STATIP1 3 4
  • SHINC-2 3 4
  • StIP1 3 4
  • Signal Transducer And Activator Of Transcription Interacting Protein 1 3
  • Elongation Protein 2 Homolog (S. Cerevisiae) 2
  • Elongation Protein 2 Homolog 3
  • Elongator Complex Protein 2 3
  • Elongator Protein 2 3
  • StIP 3

External Ids for ELP2 Gene

Previous Symbols for ELP2 Gene

  • STATIP1

Summaries for ELP2 Gene

GeneCards Summary for ELP2 Gene

ELP2 (Elongator Acetyltransferase Complex Subunit 2) is a Protein Coding gene. Diseases associated with ELP2 include eastern equine encephalitis. Among its related pathways are TGF-Beta Pathway and RNA Polymerase I Promoter Opening. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for ELP2 Gene

  • Regulates the ligand-dependent activation of STAT3.

  • Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.

Gene Wiki entry for ELP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELP2 Gene

Genomics for ELP2 Gene

Genomic Location for ELP2 Gene

Start:
36,129,444 bp from pter
End:
36,180,556 bp from pter
Size:
51,113 bases
Orientation:
Plus strand

Genomic View for ELP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELP2 Gene

Regulatory Elements for ELP2 Gene

Proteins for ELP2 Gene

  • Protein details for ELP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IA86-ELP2_HUMAN
    Recommended name:
    Elongator complex protein 2
    Protein Accession:
    Q6IA86
    Secondary Accessions:
    • A8KAI6
    • B4DTG0
    • B4DXP0
    • E7EP23
    • E9PCX0
    • Q53GZ0
    • Q687Y8
    • Q8N5C2
    • Q96GV4
    • Q96PI7
    • Q9H9N0
    • Q9NV81

    Protein attributes for ELP2 Gene

    Size:
    826 amino acids
    Molecular mass:
    92500 Da
    Quaternary structure:
    • Interacts with STAT3 and JAKs (By similarity). Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit.

    Alternative splice isoforms for ELP2 Gene

neXtProt entry for ELP2 Gene

Proteomics data for ELP2 Gene at MOPED

Post-translational modifications for ELP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys419, Lys459, and Lys682

No data available for DME Specific Peptides for ELP2 Gene

Domains for ELP2 Gene

Gene Families for ELP2 Gene

HGNC:
  • WDR :WD repeat domain containing
  • ELP :Elongator acetyltransferase complex subunits

Protein Domains for ELP2 Gene

UniProtKB/Swiss-Prot:

ELP2_HUMAN
Family:
  • Belongs to the WD repeat ELP2 family.:
    • Q6IA86
Similarity:
  • Contains 14 WD repeats.:
    • Q6IA86
genes like me logo Genes that share domains with ELP2: view

Function for ELP2 Gene

Molecular function for ELP2 Gene

UniProtKB/Swiss-Prot Function: Regulates the ligand-dependent activation of STAT3.
UniProtKB/Swiss-Prot Function: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.

Gene Ontology (GO) - Molecular Function for ELP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 contributes_to RNA polymerase II core binding IDA 11714725
GO:0003677 DNA binding --
GO:0005515 protein binding --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with ELP2: view

miRNA for ELP2 Gene

miRTarBase miRNAs that target ELP2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ELP2 Gene

Localization for ELP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELP2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELP2 Gene COMPARTMENTS Subcellular localization image for ELP2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ELP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 11714725
GO:0005730 nucleolus --
GO:0005737 cytoplasm NAS 11714725
GO:0008023 transcription elongation factor complex IDA 11714725
GO:0016591 DNA-directed RNA polymerase II, holoenzyme --
genes like me logo Genes that share ontologies with ELP2: view

Pathways for ELP2 Gene

genes like me logo Genes that share pathways with ELP2: view

Pathways by source for ELP2 Gene

1 Qiagen pathway for ELP2 Gene

Gene Ontology (GO) - Biological Process for ELP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 11714725
GO:0006368 transcription elongation from RNA polymerase II promoter TAS 11714725
GO:0046425 regulation of JAK-STAT cascade IEA --
genes like me logo Genes that share ontologies with ELP2: view

Transcripts for ELP2 Gene

Unigene Clusters for ELP2 Gene

Elongator acetyltransferase complex subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELP2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: -
SP10:
SP11: - - - - - - - - -
SP12: - - - - -
SP13: - - - - - - -
SP14:
SP15:
SP16: - - -
SP17: - -
SP18:
SP19: - - -
SP20:

ExUns: 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15: - - - - -
SP16:
SP17:
SP18: - - -
SP19:
SP20:

Relevant External Links for ELP2 Gene

GeneLoc Exon Structure for
ELP2
ECgene alternative splicing isoforms for
ELP2

Expression for ELP2 Gene

mRNA expression in normal human tissues for ELP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ELP2 Gene

SOURCE GeneReport for Unigene cluster for ELP2 Gene Hs.8739

genes like me logo Genes that share expressions with ELP2: view

Orthologs for ELP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ELP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELP2 36
  • 99.56 (n)
  • 99.64 (a)
ELP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELP2 36
  • 89.31 (n)
  • 89.1 (a)
ELP2 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELP2 36
  • 91.04 (n)
  • 91.27 (a)
ELP2 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elp2 36
  • 81.5 (n)
  • 79.76 (a)
Elp2 16
Elp2 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELP2 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELP2 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elp2 36
  • 81.36 (n)
  • 80.15 (a)
chicken
(Gallus gallus)
Aves ELP2 36
  • 69.4 (n)
  • 65.36 (a)
ELP2 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELP2 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elp2 36
  • 65.16 (n)
  • 61.86 (a)
zebrafish
(Danio rerio)
Actinopterygii elp2 36
  • 61.04 (n)
  • 58.25 (a)
elp2 37
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006889 36
  • 47.57 (n)
  • 41.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Elp2 36
  • 50.9 (n)
  • 45.31 (a)
Elp2 37
  • 42 (a)
OneToOne
CG11887 38
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea elpc-2 37
  • 31 (a)
OneToOne
Y111B2A.17 38
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL116W 36
  • 45.86 (n)
  • 36.42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ELP2 36
  • 48.77 (n)
  • 36.28 (a)
ELP2 37
  • 29 (a)
OneToOne
ELP2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F22000g 36
  • 46.58 (n)
  • 34.69 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ELP2 36
  • 49.21 (n)
  • 39.5 (a)
rice
(Oryza sativa)
Liliopsida Os.19179 36
Os08g0493900 36
  • 50.66 (n)
  • 40.24 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04176 36
  • 43.84 (n)
  • 34.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes elp2 36
  • 46.49 (n)
  • 37.07 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14172 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
OneToOne
Species with no ortholog for ELP2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELP2 Gene

ENSEMBL:
Gene Tree for ELP2 (if available)
TreeFam:
Gene Tree for ELP2 (if available)

Paralogs for ELP2 Gene

No data available for Paralogs for ELP2 Gene

Variants for ELP2 Gene

Sequence variations from dbSNP and Humsavar for ELP2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs8299 -- 36,170,083(-) GAGTC(A/G)CACTC reference, synonymous-codon, nc-transcript-variant, intron-variant
rs12083 -- 36,171,049(-) CCACG(C/T)ATCGT reference, missense, nc-transcript-variant
rs471955 -- 36,165,467(+) CTCTT(G/T)GTTTC intron-variant
rs483641 -- 36,167,676(-) TGTTT(G/T)GACTT intron-variant
rs546575 -- 36,169,709(-) AAATG(A/C)TTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELP2 Gene

Variant ID Type Subtype PubMed ID
nsv526055 CNV Loss 19592680

Relevant External Links for ELP2 Gene

HapMap Linkage Disequilibrium report
ELP2
Human Gene Mutation Database (HGMD)
ELP2

Disorders for ELP2 Gene

(1) University of Copenhagen DISEASES for ELP2 Gene

genes like me logo Genes that share disorders with ELP2: view

No data available for UniProtKB/Swiss-Prot for ELP2 Gene

Publications for ELP2 Gene

  1. A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. (PMID: 10954736) Collum R.G. … Schindler C. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 23
  2. Purification and characterization of the human elongator complex. (PMID: 11714725) Hawkes N.A. … Svejstrup J.Q. (J. Biol. Chem. 2002) 2 3 4
  3. Human Elongator facilitates RNA polymerase II transcription through chromatin. (PMID: 11818576) Kim J.H. … Reinberg D. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ELP2 Gene

Sources for ELP2 Gene

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