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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ELP2 Gene

protein-coding GIFtS: 50
GCID: GC18P033709

elongator acetyltransferase complex subunit 2

(Previous names: signal transducer and activator of transcription 3 interacting...)
(Previous symbol: STATIP1)

Explore 3 diseases affiliated with
ELP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Elongator Acetyltransferase Complex Subunit 2¹ ²		Elongation Protein 2 Homolog (S. Cerevisiae)¹
STATIP1¹ ² ³		Elongation Protein 2 Homolog²
StIP¹ ²		Elongator Complex Protein 2²
Signal Transducer And Activator Of Transcription 3 Interacting Protein 1¹ ²		Elongator Protein 2²
SHINC-2² ³		Signal Transducer And Activator Of Transcription Interacting Protein 1²
STAT3-Interacting Protein 1² ³		StIP1³
FLJ10879¹		StIP1³

External Ids:	HGNC: 18248¹	Entrez Gene: 55250²	Ensembl: ENSG00000134759⁷	UniProtKB: Q6IA86³

Export aliases for ELP2 gene to outside databases

Previous GC identifers: GC18P033739 GC18P031964 GC18P030568

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ELP2_HUMAN, Q6IA86

Function: Regulates the ligand-dependent activation of STAT3 (By similarity)

Function: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of

the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in

chromatin remodeling and is involved in acetylation of histones H3 and probably H4

Gene Wiki entry for ELP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_010966.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ELP2 gene promoter:
NCX/Ncx C/EBPalpha GATA-1 Gfi-1 AREB6 CP2 FOXO4 FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ELP2 promoter sequence

Search SABiosciences Chromatin IP Primers for ELP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ELP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.2 Ensembl cytogenetic band: 18q12.2 HGNC cytogenetic band: 18q12.1

ELP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ELP2 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P033709: view genomic region (about GC identifiers)

Start:	33,709,407 bp from pter	End:	33,757,909 bp from pter
Size:	48,503 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ELP2_HUMAN, Q6IA86 (See protein sequence)

Recommended Name: Elongator complex protein 2

Size: 826 amino acids; 92500 Da

Subunit: Interacts with STAT3 and JAKs (By similarity). Component of the RNA polymerase II elongator complex

(Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38.

Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit

Subcellular location: Cytoplasm. Nucleus

Secondary accessions: A8KAI6 B4DTG0 B4DXP0 E7EP23 E9PCX0 Q53GZ0 Q687Y8 Q8N5C2 Q96GV4 Q96PI7 Q9H9N0

Q9NV81

Alternative splicing: 7 isoforms: Q6IA86-1 Q6IA86-2 Q6IA86-3 Q6IA86-4 Q6IA86-5 Q6IA86-6 Q6IA86-7 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ELP2: NX_Q6IA86

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6IA86

ELP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001229804.1 NP_001229805.1 NP_001229806.1 NP_001229807.1 NP_001229808.1 NP_060725.1

ENSEMBL proteins:

ENSP00000440426 ENSP00000350967 ENSP00000440516 ENSP00000257191 ENSP00000438533

ENSP00000414851 ENSP00000391202 ENSP00000443555 ENSP00000440774 ENSP00000316051

ENSP00000443800 ENSP00000468091 ENSP00000440651

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ELP2 OriGene Protein Over-expression Lysate: ELP2 OriGene Custom Protein Services for ELP2
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	Novus Biologicals ELP2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ELP2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IC	11714725
GO:0005737	cytoplasm	NAS	11714725
GO:0005794	Golgi apparatus	--	--
GO:0008023	transcription elongation factor complex	IDA	11714725
GO:0016591	DNA-directed RNA polymerase II, holoenzyme	IC	11714725

ELP2 for ontologies About GeneDecksing

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	ThermoFisher Antibody for ELP2

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	GenScript Custom Assay Services for ELP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ELP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ELP2 for domains About GeneDecksing

3 InterPro domains/families:

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q6IA86

ProtoNet protein and cluster: Q6IA86

UniProtKB/Swiss-Prot: ELP2_HUMAN, Q6IA86

Similarity: Belongs to the WD repeat ELP2 family

Similarity: Contains 14 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ELP2_HUMAN, Q6IA86

Function: Regulates the ligand-dependent activation of STAT3 (By similarity)

Function: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of

the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in

chromatin remodeling and is involved in acetylation of histones H3 and probably H4

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELP2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ELP2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ELP2 (see all 4) OriGene shRNA RFP: ELP2 OriGene siRNA: ELP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELP2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ELP2

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ELP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ELP2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ELP2 (NM_018255)
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		Search LifeMap BioReagents cell lines for ELP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELP2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	contributes to DNA binding	IDA	11714725
GO:0005515	protein binding	--	--
GO:0019901	protein kinase binding	--	--

ELP2 for ontologies About GeneDecksing

Animal Models:
1 MGI phenotypic allele

for Elp2 (no phenotypes)

ELP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ELP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/154 Interacting proteins for ELP2 (Q6IA86³ ENSP00000350967⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 154)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	11714725
GO:0006368	transcription elongation from RNA polymerase II promoter	IC	11714725
GO:0046425	regulation of JAK-STAT cascade	--	--

ELP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ELP2
Search CenterWatch for drugs/clinical trials and news about ELP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ELP2 gene (6 alternative transcripts):

NM_001242875.1 NM_001242876.1 NM_001242877.1 NM_001242878.1 NM_001242879.1 NM_018255.2

Unigene Cluster for ELP2:

Elongator acetyltransferase complex subunit 2

Hs.8739 [show with all ESTs]

Unigene Representative Sequence: NM_001242875

18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):

ENST00000543127 ENST00000358232(uc002kzk.2 uc002kzl.2 uc002kzm.2 uc002kzn.2 uc002kzo.2)

ENST00000544267 ENST00000351393 ENST00000541190 ENST00000545632 ENST00000442325(uc010xcg.2 uc010xch.2)

ENST00000423854 ENST00000539560 ENST00000535488 ENST00000540135 ENST00000542430

ENST00000350494 ENST00000542824 ENST00000540799 ENST00000543439 ENST00000540730

ENST00000540323

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ELP2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ELP2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ELP2 (see all 4) OriGene shRNA RFP: ELP2 OriGene siRNA: ELP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ELP2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ELP2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ELP2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ELP2 (NM_018255)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ELP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ELP2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ELP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELP2

Additional cDNA sequence:

AF332505.1 AF403223.1 AK001741.1 AK022709.1 AK222791.1 AK293051.1 AK300201.1 AK302062.1

BC007098.1 BC009211.2 BC032553.1 CR457269.1 NR_040110.1

24/25 DOTS entries (see all 25):

DT.86848188 DT.91757129 DT.415381 DT.97849981 DT.91908315 DT.97849985 DT.121088573 DT.425717

DT.97849982 DT.97849983 DT.100783688 DT.415384 DT.87015740 DT.100783686 DT.121088624 DT.121088697

DT.99965735 DT.121088627 DT.121088737 DT.95303579 DT.95303589 DT.97813350 DT.99983684 DT.121088582

24/321 AceView cDNA sequences (see all 321):

AA936121 AA587433 BQ955336 AA830115 AI675062 BM456404 AV727294 BQ217702

BM465788 BM450879 BM467463 BM676415 AU125685 AA916068 Z39803 CR602393

AU280507 NM_018255 W23625 BQ013254 BQ936457 BF036861 AI565120 AU133352

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for ELP2 (see all 20) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	·	12c	^	13a	·	13b	^	14	^
SP1:													-		-		-						-						-						-														-
SP2:													-		-		-						-						-						-														-
SP3:													-		-		-						-		-		-		-						-														-
SP4:													-		-		-						-		-		-		-		-		-		-		-		-										-
SP5:			-		-		-						-		-		-						-						-						-

ExUns:	15	^	16a	·	16b	^	17a	·	17b	^	18	^	19	^	20a	·	20b	^	21	^	22a	·	22b	^	23a	·	23b	·	23c	^	24a	·	24b	^	25	^	26	^	27a	·	27b	·	27c	·	27d
SP1:											-																				-
SP2:											-
SP3:	-										-
SP4:											-
SP5:

ECgene alternative splicing isoforms for ELP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ELP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAACAGGTC

About this image

ELP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Primary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ELP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ELP2

SOURCE GeneReport for Unigene cluster: Hs.8739

SABiosciences Custom PCR Arrays for ELP2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ELP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ELP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ELP2 gene from 10/32 species (see all 32) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Elp2^{1 , 5}	elongation protein 2 homolog (S. cerevisiae)⁵ elongator acetyltransferase complex subunit 2¹	81.5(n)¹ 79.76(a)¹		18 (13.18 cM)⁵ 58523¹ NM_021448.2¹ NP_067423.2¹ 24603961⁵
chicken (Gallus gallus)	Aves	ELP2¹	elongation protein 2 homolog (S. cerevisiae)	69.28(n) 65.36(a)		420980 XM_419067.3 XP_419067.3
lizard (Anolis carolinensis)	Reptilia	ELP2⁶	--	58(a)	1 ↔ 1	4(67376341-67469228)
African clawed frog (Xenopus laevis)	Amphibia	AW641334.1²	--	77.71(n)		AW641334.1
zebrafish (Danio rerio)	Actinopterygii	elp2¹	elongation protein 2 homolog (S. cerevisiae)	61.21(n) 58.37(a)		560338 NM_001044925.1 NP_001038390.1
fruit fly (Drosophila melanogaster)	Insecta	CG11887³ Elp2¹	Elongator complex protein 2¹	40(a)³ 50.83(n)¹ 44.87(a)¹		36123¹ NM_136756.3¹ NP_610600.1¹
worm (Caenorhabditis elegans)	Secernentea	Y111B2A.17³	--	34(a)		III(12745328-12757810) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ELP2(YGR200C)⁴ ELP2¹	Subunit of Elongator complex, which is required for more⁴ Elp2p¹	48.96(n)¹ 36.09(a)¹		7(902270-899904)⁴ 853114^{1, 4} NP_011716.3¹ NP_011716.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	ELP2¹	elongator protein 2	49.26(n) 39.43(a)		841378 NM_001198251.1 NP_001185180.1
rice (Oryza sativa)	Liliopsida	Os.19179²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	73.16(n)		AK101284.1

ENSEMBL Gene Tree for ELP2 (if available)
TreeFam Gene Tree for ELP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74896245^1,2	F,	--	33711389(+)	`CCAGCG/ACCGTG`	7	--	int¹		1		WA	118
rs146874958^1,2		--	33711466(+)	`GGGCGC/GCCATA`	7	--	int¹		0	--	--	--	--
rs948418^1,2	C,F,H,	--	33711524(+)	`ACCCTT/GTTAAA`	7	--	int¹		6		NS EA WA	536
rs75345653^1,2		--	33711570(+)	`TTGCCA/GGTCAA`	7	--	int¹		0	--	--	--	--
rs74534794^1,2		--	33711575(+)	`AGTCAA/CCCCAC`	7	--	int¹		0	--	--	--	--
rs1785903^1,2	C,F,A,H,	--	33711642(+)	`TTGCCG/CCTATA`	7	--	int¹		18		EA NA NS WA CSA	910
rs117644908^1,2		--	33711664(+)	`GATCTG/ACTTTT`	7	--	int¹		1		NA	120
rs72886880^1,2	C,F,	--	33711679(+)	`TGATTA/GTACTC`	7	--	int¹		2		NA EA	240
rs138380488^1,2		--	33711887(+)	`TGCTGA/GTCGGG`	7	--	int¹		0	--	--	--	--
rs142970376^1,2		--	33711929(+)	`AGTGAA/CAGTAA`	7	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ELP2 (33709407 - 33757909 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ELP2: --
Human Gene Mutation Database (HGMD): ELP2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ELP2 for disorders About GeneDecksing

3 diseases for ELP2: About MalaCards

spinal stenosis acute disseminated encephalomyelitis encephalomyelitis

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ELP2 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with ELP2)

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Purification and characterization of the human elongator complex. (PubMed id 11714725)^{1, 2, 3} Hawkes N.A.... Svejstrup J.Q. (2002)
A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. (PubMed id 10954736)^{1, 3, 9} Collum R.G....Schindler C. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human Elongator facilitates RNA polymerase II transcription through chromatin. (PubMed id 11818576)^{1, 2} Kim J.H.... Reinberg D. (2002)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicit y and migration of melanoma cells as subunits of Elongator. (PubMed id 22854966)² Close P....Chariot A. (2012)
4-Phenylbutyrate stimulates Hsp70 expression through t he Elp2 component of elongator and STAT-3 in cystic fibrosis epithelial cells. (PubMed id 22069317)¹ Suaud L....Rubenstein R.C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55250	HGNC: 18248	AceView: STATIP1	Ensembl:ENSG00000134759	euGenes: HUgn55250
ECgene: ELP2	H-InvDB: ELP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ELP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ELP2 gene
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Patent Information for ELP2 gene:
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ELP2 Gene

elongator acetyltransferase complex subunit 2

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ELP2 Gene

elongator acetyltransferase complex subunit 2

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