Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ELOVL7 Gene

Aliases for ELOVL7 Gene

  • ELOVL Fatty Acid Elongase 7 2 3 4 5
  • ELOVL Family Member 7, Elongation Of Long Chain Fatty Acids (Yeast) 2
  • Very Long Chain 3-Ketoacyl-CoA Synthase 7 4
  • Very Long Chain 3-Oxoacyl-CoA Synthase 7 4
  • 3-Keto Acyl-CoA Synthase ELOVL7 4
  • ELOVL FA Elongase 7 4
  • EC 2.3.1.199 4

External Ids for ELOVL7 Gene

Previous GeneCards Identifiers for ELOVL7 Gene

  • GC05M060063
  • GC05M060083
  • GC05M060047
  • GC05M057005

Summaries for ELOVL7 Gene

GeneCards Summary for ELOVL7 Gene

ELOVL7 (ELOVL Fatty Acid Elongase 7) is a Protein Coding gene. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity. An important paralog of this gene is ELOVL1.

UniProtKB/Swiss-Prot for ELOVL7 Gene

  • Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Additional gene information for ELOVL7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELOVL7 Gene

Genomics for ELOVL7 Gene

GeneHancer (GH) Regulatory Elements for ELOVL7 Gene

Promoters and enhancers for ELOVL7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I060842 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 556.9 +0.3 321 2.4 ATF1 ZFP64 ARID4B SIN3A ZNF2 ZNF121 GLIS2 ZNF143 FOS ATF7 ELOVL7 ERCC8 NDUFAF2 KRT8P31
GH05I060698 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.4 +144.1 144060 4 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B POLR2B DEPDC1B ELOVL7 KRT8P31
GH05I060943 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 13.1 -100.6 -100639 3.2 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF548 FOS ERCC8 NDUFAF2 ZSWIM6 ELOVL7 LOC105378991
GH05I060820 Enhancer 0.9 ENCODE 19.5 +23.4 23351 2 HDGF PKNOX1 ATF1 ARNT NCOA2 TCF12 E2F8 ATF7 CAVIN1 NCOA1 ELOVL7 ERCC8 KRT8P31
GH05I060540 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +302.8 302758 1.7 FOXA2 SMAD1 BMI1 BATF RAD21 IRF4 RARA ZNF143 ATF7 ETV6 ELOVL7 RPL31P8 ERCC8 DEPDC1B ENSG00000276233 PDE4D PART1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ELOVL7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ELOVL7 gene promoter:

Genomic Locations for ELOVL7 Gene

Genomic Locations for ELOVL7 Gene
chr5:60,751,789-60,844,389
(GRCh38/hg38)
Size:
92,601 bases
Orientation:
Minus strand
chr5:60,047,616-60,140,216
(GRCh37/hg19)

Genomic View for ELOVL7 Gene

Genes around ELOVL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOVL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOVL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOVL7 Gene

Proteins for ELOVL7 Gene

  • Protein details for ELOVL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L3X0-ELOV7_HUMAN
    Recommended name:
    Elongation of very long chain fatty acids protein 7
    Protein Accession:
    A1L3X0
    Secondary Accessions:
    • Q589T3
    • Q9H5D0
    • Q9NT66

    Protein attributes for ELOVL7 Gene

    Size:
    281 amino acids
    Molecular mass:
    33356 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15697.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15697.1; Type=Erroneous termination; Positions=52; Note=Translated as Gly.; Evidence={ECO:0000305}; Sequence=BAB15697.1; Type=Frameshift; Positions=138; Evidence={ECO:0000305};

neXtProt entry for ELOVL7 Gene

Post-translational modifications for ELOVL7 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ELOVL7 Gene

Domains & Families for ELOVL7 Gene

Gene Families for ELOVL7 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ELOVL7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ELOVL7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1L3X0

UniProtKB/Swiss-Prot:

ELOV7_HUMAN :
  • The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
  • Belongs to the ELO family. ELOVL7 subfamily.
Domain:
  • The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
Family:
  • Belongs to the ELO family. ELOVL7 subfamily.
genes like me logo Genes that share domains with ELOVL7: view

Function for ELOVL7 Gene

Molecular function for ELOVL7 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.6 uM for C18:3(n-3)-CoA {ECO:0000269 PubMed:21959040}; KM=11.7 uM for malonyl-CoA {ECO:0000269 PubMed:21959040}; Vmax=0.33 pmol/min/ug enzyme toward C18:3(n-3)-CoA {ECO:0000269 PubMed:21959040}; Vmax=0.31 pmol/min/ug enzyme toward malonyl-CoA {ECO:0000269 PubMed:21959040};
UniProtKB/Swiss-Prot CatalyticActivity:
A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Enzyme Numbers (IUBMB) for ELOVL7 Gene

Phenotypes From GWAS Catalog for ELOVL7 Gene

Gene Ontology (GO) - Molecular Function for ELOVL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20937905
GO:0009922 fatty acid elongase activity TAS --
GO:0016740 transferase activity IEA --
GO:0102336 3-oxo-arachidoyl-CoA synthase activity IEA --
GO:0102337 3-oxo-cerotoyl-CoA synthase activity IEA --
genes like me logo Genes that share ontologies with ELOVL7: view

Phenotypes for ELOVL7 Gene

GenomeRNAi human phenotypes for ELOVL7:
genes like me logo Genes that share phenotypes with ELOVL7: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ELOVL7 Gene

Localization for ELOVL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOVL7 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELOVL7 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ELOVL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 20937905
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with ELOVL7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ELOVL7 Gene

Pathways & Interactions for ELOVL7 Gene

genes like me logo Genes that share pathways with ELOVL7: view

UniProtKB/Swiss-Prot A1L3X0-ELOV7_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis.

Gene Ontology (GO) - Biological Process for ELOVL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0019367 fatty acid elongation, saturated fatty acid IDA 19826053
GO:0030148 sphingolipid biosynthetic process IBA --
genes like me logo Genes that share ontologies with ELOVL7: view

No data available for SIGNOR curated interactions for ELOVL7 Gene

Drugs & Compounds for ELOVL7 Gene

(3) Drugs for ELOVL7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0
Malonyl-CoA Experimental Pharma 0
Coenzyme A Investigational Nutra 0
genes like me logo Genes that share compounds with ELOVL7: view

Transcripts for ELOVL7 Gene

Unigene Clusters for ELOVL7 Gene

ELOVL fatty acid elongase 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELOVL7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for ELOVL7 Gene

GeneLoc Exon Structure for
ELOVL7
ECgene alternative splicing isoforms for
ELOVL7

Expression for ELOVL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ELOVL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELOVL7 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.8).

Protein differential expression in normal tissues from HIPED for ELOVL7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.7), Platelet (26.8), and Islet of Langerhans (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ELOVL7 Gene



Protein tissue co-expression partners for ELOVL7 Gene

NURSA nuclear receptor signaling pathways regulating expression of ELOVL7 Gene:

ELOVL7

SOURCE GeneReport for Unigene cluster for ELOVL7 Gene:

Hs.274256

mRNA Expression by UniProt/SwissProt for ELOVL7 Gene:

A1L3X0-ELOV7_HUMAN
Tissue specificity: Expressed in most tissues except heart and skeletal muscle.

Evidence on tissue expression from TISSUES for ELOVL7 Gene

  • Nervous system(4.3)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ELOVL7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ELOVL7 Gene

Orthologs for ELOVL7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ELOVL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELOVL7 33 34
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia ELOVL7 33 34
  • 92.17 (n)
cow
(Bos Taurus)
Mammalia ELOVL7 34 33
  • 91.7 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Elovl7 16 34 33
  • 88.73 (n)
rat
(Rattus norvegicus)
Mammalia Elovl7 33
  • 87.54 (n)
oppossum
(Monodelphis domestica)
Mammalia ELOVL7 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELOVL7 34 33
  • 72.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELOVL7 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elovl7 33
  • 73.19 (n)
Str.4776 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398440 33
zebrafish
(Danio rerio)
Actinopterygii elovl7b 33 34
  • 66.3 (n)
elovl7a 34
  • 64 (a)
OneToMany
wufd20a06 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5317 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003600 33
  • 55.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2781 33 34
  • 55.13 (n)
CG5278 34
  • 43 (a)
ManyToMany
CG5326 34
  • 42 (a)
ManyToMany
CG31522 34
  • 38 (a)
ManyToMany
eloF 34
  • 37 (a)
ManyToMany
CG31523 34
  • 36 (a)
ManyToMany
bond 34
  • 34 (a)
ManyToMany
CG33110 34
  • 34 (a)
ManyToMany
CG8534 34
  • 34 (a)
ManyToMany
CG9458 34
  • 34 (a)
ManyToMany
CG16904 34
  • 33 (a)
ManyToMany
CG17821 34
  • 32 (a)
ManyToMany
CG6660 34
  • 32 (a)
ManyToMany
CG18609 34
  • 31 (a)
ManyToMany
CG31141 34
  • 31 (a)
ManyToMany
CG9459 34
  • 31 (a)
ManyToMany
CG30008 34
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ELO1 34
  • 22 (a)
ManyToMany
FEN1 34
  • 18 (a)
ManyToMany
SUR4 34
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
OneToMany
Species where no ortholog for ELOVL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELOVL7 Gene

ENSEMBL:
Gene Tree for ELOVL7 (if available)
TreeFam:
Gene Tree for ELOVL7 (if available)

Paralogs for ELOVL7 Gene

Paralogs for ELOVL7 Gene

(4) SIMAP similar genes for ELOVL7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ELOVL7: view

Variants for ELOVL7 Gene

Sequence variations from dbSNP and Humsavar for ELOVL7 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000014093 -- 60,766,029(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000058101 -- 60,809,516(-) A/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000125302 -- 60,802,137(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000132835 -- 60,804,787(-) C/G genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000136242 -- 60,759,641(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ELOVL7 Gene

Variant ID Type Subtype PubMed ID
dgv9810n54 CNV loss 21841781
dgv9811n54 CNV loss 21841781
esv2730243 CNV deletion 23290073
esv2730244 CNV deletion 23290073
esv2752073 CNV loss 17911159
esv2763456 CNV loss 21179565
esv29921 CNV loss 19812545
esv3605196 CNV loss 21293372
esv3894195 CNV loss 25118596
nsv1023403 CNV gain 25217958
nsv1161250 CNV deletion 26073780
nsv462199 CNV gain 19166990
nsv462200 CNV loss 19166990
nsv4851 CNV insertion 18451855
nsv4852 CNV insertion 18451855
nsv508362 CNV deletion 20534489
nsv598298 CNV loss 21841781
nsv598308 CNV gain 21841781
nsv968918 CNV duplication 23825009

Variation tolerance for ELOVL7 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ELOVL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOVL7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELOVL7 Gene

Disorders for ELOVL7 Gene

Additional Disease Information for ELOVL7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ELOVL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELOVL7 Gene

Publications for ELOVL7 Gene

  1. Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism. (PMID: 19826053) Tamura K … Nakagawa H (Cancer research 2009) 2 3 4 58
  2. Biochemical characterization of the very long-chain fatty acid elongase ELOVL7. (PMID: 21959040) Naganuma T … Kihara A (FEBS letters 2011) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. (PMID: 20937905) Ohno Y … Kihara A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 58
  5. Gene expression signatures for phlegm-dampness constitution of Chinese medicine. (PMID: 27928700) Li L … Wang Q (Science China. Life sciences 2017) 3 58

Products for ELOVL7 Gene

Sources for ELOVL7 Gene

Content
Loading form....