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Aliases for ELOVL7 Gene

Aliases for ELOVL7 Gene

  • ELOVL Fatty Acid Elongase 7 2 3 4 5
  • ELOVL Family Member 7, Elongation Of Long Chain Fatty Acids (Yeast) 2
  • Very Long Chain 3-Ketoacyl-CoA Synthase 7 4
  • Very Long Chain 3-Oxoacyl-CoA Synthase 7 4
  • 3-Keto Acyl-CoA Synthase ELOVL7 4
  • ELOVL FA Elongase 7 4
  • EC 2.3.1.199 4

External Ids for ELOVL7 Gene

Previous GeneCards Identifiers for ELOVL7 Gene

  • GC05M060063
  • GC05M060083
  • GC05M060047
  • GC05M057005

Summaries for ELOVL7 Gene

GeneCards Summary for ELOVL7 Gene

ELOVL7 (ELOVL Fatty Acid Elongase 7) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include transferase activity. An important paralog of this gene is ELOVL6.

UniProtKB/Swiss-Prot for ELOVL7 Gene

  • Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELOVL7 Gene

Genomics for ELOVL7 Gene

Regulatory Elements for ELOVL7 Gene

Enhancers for ELOVL7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ELOVL7 on UCSC Golden Path with GeneCards custom track

Promoters for ELOVL7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ELOVL7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ELOVL7 Gene

Chromosome:
5
Start:
60,751,789 bp from pter
End:
60,844,389 bp from pter
Size:
92,601 bases
Orientation:
Minus strand

Genomic View for ELOVL7 Gene

Genes around ELOVL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOVL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOVL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOVL7 Gene

Proteins for ELOVL7 Gene

  • Protein details for ELOVL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L3X0-ELOV7_HUMAN
    Recommended name:
    Elongation of very long chain fatty acids protein 7
    Protein Accession:
    A1L3X0
    Secondary Accessions:
    • Q589T3
    • Q9H5D0
    • Q9NT66

    Protein attributes for ELOVL7 Gene

    Size:
    281 amino acids
    Molecular mass:
    33356 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15697.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15697.1; Type=Erroneous termination; Positions=52; Note=Translated as Gly.; Evidence={ECO:0000305}; Sequence=BAB15697.1; Type=Frameshift; Positions=138; Evidence={ECO:0000305};

neXtProt entry for ELOVL7 Gene

Proteomics data for ELOVL7 Gene at MOPED

Post-translational modifications for ELOVL7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ELOVL7 Gene

Domains & Families for ELOVL7 Gene

Protein Domains for ELOVL7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ELOVL7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1L3X0

UniProtKB/Swiss-Prot:

ELOV7_HUMAN :
  • The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
  • Belongs to the ELO family. ELOVL7 subfamily.
Domain:
  • The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
Family:
  • Belongs to the ELO family. ELOVL7 subfamily.
genes like me logo Genes that share domains with ELOVL7: view

No data available for Gene Families for ELOVL7 Gene

Function for ELOVL7 Gene

Molecular function for ELOVL7 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.6 uM for C18:3(n-3)-CoA {ECO:0000269 PubMed:21959040}; KM=11.7 uM for malonyl-CoA {ECO:0000269 PubMed:21959040}; Vmax=0.33 pmol/min/ug enzyme toward C18:3(n-3)-CoA {ECO:0000269 PubMed:21959040}; Vmax=0.31 pmol/min/ug enzyme toward malonyl-CoA {ECO:0000269 PubMed:21959040};
UniProtKB/Swiss-Prot CatalyticActivity:
A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Enzyme Numbers (IUBMB) for ELOVL7 Gene

Gene Ontology (GO) - Molecular Function for ELOVL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20937905
genes like me logo Genes that share ontologies with ELOVL7: view

Phenotypes for ELOVL7 Gene

GenomeRNAi human phenotypes for ELOVL7:
genes like me logo Genes that share phenotypes with ELOVL7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ELOVL7

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ELOVL7 Gene

Localization for ELOVL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOVL7 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELOVL7 Gene COMPARTMENTS Subcellular localization image for ELOVL7 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ELOVL7 Gene

Pathways & Interactions for ELOVL7 Gene

genes like me logo Genes that share pathways with ELOVL7: view

UniProtKB/Swiss-Prot A1L3X0-ELOV7_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis.

Gene Ontology (GO) - Biological Process for ELOVL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
GO:0042761 very long-chain fatty acid biosynthetic process IDA 19826053
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ELOVL7: view

No data available for SIGNOR curated interactions for ELOVL7 Gene

Drugs & Compounds for ELOVL7 Gene

(2) Drugs for ELOVL7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
malonyl-coa Experimental Pharma 0
Coenzyme A Nutra 0

(1) Additional Compounds for ELOVL7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
124-38-9
genes like me logo Genes that share compounds with ELOVL7: view

Transcripts for ELOVL7 Gene

Unigene Clusters for ELOVL7 Gene

ELOVL fatty acid elongase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELOVL7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for ELOVL7 Gene

GeneLoc Exon Structure for
ELOVL7
ECgene alternative splicing isoforms for
ELOVL7

Expression for ELOVL7 Gene

mRNA expression in normal human tissues for ELOVL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ELOVL7 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.8).

Protein differential expression in normal tissues from HIPED for ELOVL7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.7), Platelet (26.8), and Islet of Langerhans (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELOVL7 Gene



SOURCE GeneReport for Unigene cluster for ELOVL7 Gene Hs.274256

mRNA Expression by UniProt/SwissProt for ELOVL7 Gene

A1L3X0-ELOV7_HUMAN
Tissue specificity: Expressed in most tissues except heart and skeletal muscle.
genes like me logo Genes that share expression patterns with ELOVL7: view

Protein tissue co-expression partners for ELOVL7 Gene

Primer Products

Orthologs for ELOVL7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ELOVL7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ELOVL7 35
  • 91.7 (n)
  • 91.1 (a)
ELOVL7 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELOVL7 35
  • 92.17 (n)
  • 92.17 (a)
ELOVL7 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elovl7 35
  • 88.73 (n)
  • 88.61 (a)
Elovl7 16
Elovl7 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ELOVL7 35
  • 99.64 (n)
  • 99.29 (a)
ELOVL7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elovl7 35
  • 87.54 (n)
  • 87.9 (a)
oppossum
(Monodelphis domestica)
Mammalia ELOVL7 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ELOVL7 35
  • 72.16 (n)
  • 73.84 (a)
ELOVL7 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELOVL7 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia elovl7 35
  • 73.19 (n)
  • 75.8 (a)
Str.4776 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398440 35
zebrafish
(Danio rerio)
Actinopterygii elovl7b 35
  • 66.3 (n)
  • 72.89 (a)
wufd20a06 35
elovl7a 36
  • 64 (a)
OneToMany
elovl7b 36
  • 69 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5317 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003600 35
  • 55.51 (n)
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2781 35
  • 55.13 (n)
  • 53.85 (a)
bond 36
  • 34 (a)
ManyToMany
CG16904 36
  • 33 (a)
ManyToMany
CG17821 36
  • 32 (a)
ManyToMany
CG18609 36
  • 31 (a)
ManyToMany
CG2781 36
  • 42 (a)
ManyToMany
CG30008 36
  • 27 (a)
ManyToMany
CG31141 36
  • 31 (a)
ManyToMany
CG31522 36
  • 38 (a)
ManyToMany
CG31523 36
  • 36 (a)
ManyToMany
CG33110 36
  • 34 (a)
ManyToMany
CG5278 36
  • 43 (a)
ManyToMany
CG5326 36
  • 42 (a)
ManyToMany
CG6660 36
  • 32 (a)
ManyToMany
CG8534 36
  • 34 (a)
ManyToMany
CG9458 36
  • 34 (a)
ManyToMany
CG9459 36
  • 31 (a)
ManyToMany
eloF 36
  • 37 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ELO1 36
  • 22 (a)
ManyToMany
FEN1 36
  • 18 (a)
ManyToMany
SUR4 36
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for ELOVL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ELOVL7 Gene

ENSEMBL:
Gene Tree for ELOVL7 (if available)
TreeFam:
Gene Tree for ELOVL7 (if available)

Paralogs for ELOVL7 Gene

Paralogs for ELOVL7 Gene

(4) SIMAP similar genes for ELOVL7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ELOVL7: view

Variants for ELOVL7 Gene

Sequence variations from dbSNP and Humsavar for ELOVL7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs898622 -- 60,784,354(+) CAAAC(A/G)CAAGG intron-variant
rs921897 -- 60,793,310(+) CTACA(A/G)TTTTT intron-variant
rs921898 -- 60,793,609(+) GCTGC(G/T)AAGGG intron-variant
rs2898298 -- 60,756,816(+) GAAAT(A/G)CAAGG intron-variant
rs1031744 -- 60,756,742(-) AATTT(G/T)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELOVL7 Gene

Variant ID Type Subtype PubMed ID
nsv508362 CNV Loss 20534489
esv2752073 CNV Loss 17911159
nsv4851 CNV Insertion 18451855
nsv4852 CNV Insertion 18451855
esv2730243 CNV Deletion 23290073
esv2730244 CNV Deletion 23290073
dgv6076n71 CNV Loss 21882294
dgv6077n71 CNV Loss 21882294
nsv462199 CNV Gain 19166990
esv29921 CNV Loss 19812545
nsv462200 CNV Loss 19166990

Variation tolerance for ELOVL7 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ELOVL7 Gene

Disorders for ELOVL7 Gene

Relevant External Links for ELOVL7

Genetic Association Database (GAD)
ELOVL7
Human Genome Epidemiology (HuGE) Navigator
ELOVL7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELOVL7

No disorders were found for ELOVL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELOVL7 Gene

Publications for ELOVL7 Gene

  1. Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism. (PMID: 19826053) Tamura K. … Nakagawa H. (Cancer Res. 2009) 2 3 4 67
  2. Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. (PMID: 25732827) Purdy J.G. … Rabinowitz J.D. (Cell Rep 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PMID: 22751105) Chu L. … Tomasson M.H. (J. Clin. Invest. 2012) 3
  5. Biochemical characterization of the very long-chain fatty acid elongase ELOVL7. (PMID: 21959040) Naganuma T. … Kihara A. (FEBS Lett. 2011) 3

Products for ELOVL7 Gene

Sources for ELOVL7 Gene

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