Aliases for ELOVL6 Gene
- ELOVL Fatty Acid Elongase 6 2 3 4 5
- ELOVL Family Member 6, Elongation Of Long Chain Fatty Acids (FEN1/Elo2, SUR4/Elo3-Like, Yeast) 2 3
- Very Long Chain 3-Ketoacyl-CoA Synthase 6 3 4
- Very Long Chain 3-Oxoacyl-CoA Synthase 6 3 4
- 3-Keto Acyl-CoA Synthase ELOVL6 3 4
- Long-Chain Fatty-Acyl Elongase 3 4
- Fatty Acyl-CoA Elongase 3 4
- Fatty Acid Elongase 2 3 4
External Ids for ELOVL6 Gene
Previous GeneCards Identifiers for ELOVL6 Gene
Fatty acid elongases (EC 18.104.22.168), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ELOVL6 Gene
ELOVL6 (ELOVL Fatty Acid Elongase 6) is a Protein Coding gene. Diseases associated with ELOVL6 include Common Bile Duct Disease. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include transferase activity and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is ELOVL7.
UniProtKB/Swiss-Prot for ELOVL6 Gene
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.