Aliases for ELOVL1 Gene
External Ids for ELOVL1 Gene
Previous GeneCards Identifiers for ELOVL1 Gene
GeneCards Summary for ELOVL1 Gene
ELOVL1 (ELOVL Fatty Acid Elongase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include fatty acid elongase activity. An important paralog of this gene is ELOVL7.
UniProtKB/Swiss-Prot for ELOVL1 Gene
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.