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Aliases for ELOC Gene

Aliases for ELOC Gene

  • Elongin C 2 3 5
  • Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, Elongin C) 2 3
  • RNA Polymerase II Transcription Factor SIII Subunit C 3 4
  • Transcription Elongation Factor B Polypeptide 1 3 4
  • Transcription Elongation Factor B Subunit 1 2 3
  • Elongin 15 KDa Subunit 3 4
  • SIII P15 3 4
  • TCEB1 3 4
  • Transcription Elongation Factor B (SIII), Polypeptide 1 (15kD, Elongin C) 2
  • Elongin-C 3
  • SIII 3
  • EloC 4

External Ids for ELOC Gene

Previous HGNC Symbols for ELOC Gene

  • TCEB1

Summaries for ELOC Gene

Entrez Gene Summary for ELOC Gene

  • This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for ELOC Gene

ELOC (Elongin C) is a Protein Coding gene. Diseases associated with ELOC include Renal Cell Carcinoma and Hiv-1. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Formation of HIV elongation complex in the absence of HIV Tat.

UniProtKB/Swiss-Prot for ELOC Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).

  • The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Gene Wiki entry for ELOC Gene

Additional gene information for ELOC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELOC Gene

Genomics for ELOC Gene

Regulatory Elements for ELOC Gene

Enhancers for ELOC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H073876 1.1 ENCODE 10.4 +93.6 93586 3 HDGF PKNOX1 ARNT ARID4B SIN3A ZBTB7B YY1 ZNF143 SP3 SP5 ELOC TMEM70 UBE2W ENSG00000258677 RN7SL760P
GH08H073892 0.9 FANTOM5 ENCODE 10.5 +79.3 79256 0 HDAC1 GATA3 CTBP1 IKZF1 BHLHE40 CREB1 USF2 ELOC TMEM70 STAU2 ENSG00000253596 GDAP1 UBE2W PIR51756 LINC01617
GH08H073887 0.5 ENCODE 10.5 +84.0 84026 0 PKNOX1 ESRRA GATA3 MNT PAX8 ELOC TMEM70 STAU2 UBE2W LINC01617 PIR51756
GH08H073994 0.2 Ensembl 11.9 -23.0 -23034 1 TMEM70 ELOC LY96 GC08M074003
GH08H074033 0.2 ENCODE 10.5 -60.3 -60334 0 LY96 ELOC TMEM70 GDAP1 GC08M074003 RNU6-1300P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ELOC on UCSC Golden Path with GeneCards custom track

Promoters for ELOC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000225937 287 2401 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for ELOC Gene

Chromosome:
8
Start:
73,939,169 bp from pter
End:
73,972,287 bp from pter
Size:
33,119 bases
Orientation:
Minus strand

Genomic View for ELOC Gene

Genes around ELOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOC Gene

Proteins for ELOC Gene

  • Protein details for ELOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15369-ELOC_HUMAN
    Recommended name:
    Elongin-C
    Protein Accession:
    Q15369
    Secondary Accessions:
    • E5RGD9
    • Q567Q6

    Protein attributes for ELOC Gene

    Size:
    112 amino acids
    Molecular mass:
    12473 Da
    Quaternary structure:
    • Heterotrimer of an A (ELOA, ELOA2 or ELOA3), ELOB and ELOC subunit (PubMed:17997974). The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex (By similarity). Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, ELOA, VHL or WSB1 (PubMed:15590694). The elongin BC complex is part of a complex with hydroxylated HIF1A (PubMed:12050673, PubMed:12004076). Interacts with VHL (PubMed:10205047, PubMed:12050673). Interacts with TMF1 (PubMed:15467733). Interacts with SPSB1 (PubMed:17189197). posed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2 (PubMed:11006129, PubMed:10205047, PubMed:12050673). Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component (PubMed:23102700).
    • (Microbial infection) Substrate adapter protein can be a viral protein such as HIV Vif.
    • (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein NS1.

    Three dimensional structures from OCA and Proteopedia for ELOC Gene

    Alternative splice isoforms for ELOC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELOC Gene

Post-translational modifications for ELOC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ELOC Gene

Domains & Families for ELOC Gene

Gene Families for ELOC Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ELOC Gene

Suggested Antigen Peptide Sequences for ELOC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15369

UniProtKB/Swiss-Prot:

ELOC_HUMAN :
  • Belongs to the SKP1 family.
Family:
  • Belongs to the SKP1 family.
genes like me logo Genes that share domains with ELOC: view

Function for ELOC Gene

Molecular function for ELOC Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).
UniProtKB/Swiss-Prot Function:
The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Phenotypes From GWAS Catalog for ELOC Gene

Gene Ontology (GO) - Molecular Function for ELOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 10205047
genes like me logo Genes that share ontologies with ELOC: view
genes like me logo Genes that share phenotypes with ELOC: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ELOC Gene

Localization for ELOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELOC gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ELOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0070449 elongin complex IBA --
genes like me logo Genes that share ontologies with ELOC: view

Pathways & Interactions for ELOC Gene

genes like me logo Genes that share pathways with ELOC: view

SIGNOR curated interactions for ELOC Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for ELOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 7660129
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with ELOC: view

Drugs & Compounds for ELOC Gene

(1) Drugs for ELOC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ELOC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELOC: view

Transcripts for ELOC Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELOC Gene

No ASD Table

Relevant External Links for ELOC Gene

GeneLoc Exon Structure for
ELOC
ECgene alternative splicing isoforms for
ELOC

Expression for ELOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ELOC Gene:

ELOC

mRNA Expression by UniProt/SwissProt for ELOC Gene:

Q15369-ELOC_HUMAN
Tissue specificity: Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.

Evidence on tissue expression from TISSUES for ELOC Gene

  • Liver(4.4)
  • Blood(4.3)
  • Intestine(4.3)
  • Skin(4.3)
  • Nervous system(4.2)
  • Lung(2.7)
  • Kidney(2.4)
  • Heart(2.3)
genes like me logo Genes that share expression patterns with ELOC: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELOC Gene

Orthologs for ELOC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ELOC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEB1 34 33
  • 99.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TCEB1 34 33
  • 94.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TCEB1 34 33
  • 94.05 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCEB1 34
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tceb1 33
  • 93.75 (n)
mouse
(Mus musculus)
Mammalia Tceb1 33 34
  • 92.56 (n)
Eloc 16
oppossum
(Monodelphis domestica)
Mammalia TCEB1 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCEB1 34 33
  • 88.99 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCEB1 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tceb1 33
  • 85.42 (n)
Str.2774 33
African clawed frog
(Xenopus laevis)
Amphibia tceb1-prov 33
zebrafish
(Danio rerio)
Actinopterygii tceb1b 33 34
  • 80.95 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2905 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011535 33
  • 74.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta Elongin-C 33 34
  • 72.22 (n)
worm
(Caenorhabditis elegans)
Secernentea elc-1 33 34
  • 63.03 (n)
elc-2 34
  • 31 (a)
OneToMany
F54F7.10 34
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ELC1 34 36
  • 37 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G59140 33
  • 50.74 (n)
rice
(Oryza sativa)
Liliopsida Os11g0707700 33
  • 51.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2870 34
  • 82 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14780 33
Species where no ortholog for ELOC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELOC Gene

ENSEMBL:
Gene Tree for ELOC (if available)
TreeFam:
Gene Tree for ELOC (if available)

Paralogs for ELOC Gene

No data available for Paralogs for ELOC Gene

Variants for ELOC Gene

Sequence variations from dbSNP and Humsavar for ELOC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000063465 -- 73,956,440(+) TATTT(G/T)AAGAA intron-variant
rs1000114311 -- 73,949,926(+) AAGTA(C/G)TTCCT intron-variant
rs1000122974 -- 73,960,753(+) ACAAT(A/G)AGCAA intron-variant
rs1000328793 -- 73,954,978(+) GCAGT(A/G)AGCCG intron-variant
rs1000406209 -- 73,972,083(+) CGTCA(A/G)TCCCG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ELOC Gene

Variant ID Type Subtype PubMed ID
esv1009583 OTHER inversion 20482838
nsv510151 OTHER sequence alteration 20534489
nsv831355 CNV loss 17160897

Variation tolerance for ELOC Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELOC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELOC Gene

Disorders for ELOC Gene

MalaCards: The human disease database

(5) MalaCards diseases for ELOC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
hiv-1
  • aids, slow progression to
renal clear cell carcinoma
  • clear cell carcinoma of kidney
familial renal papillary carcinoma
  • hereditary papillary renal carcinoma
renal cell carcinoma, papillary
  • renal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search ELOC in MalaCards View complete list of genes associated with diseases

Relevant External Links for ELOC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELOC
genes like me logo Genes that share disorders with ELOC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELOC Gene

Publications for ELOC Gene

  1. Amplification and overexpression of Elongin C gene discovered in prostate cancer by cDNA microarrays. (PMID: 12004003) Porkka K … Visakorpi T (Laboratory investigation; a journal of technical methods and pathology 2002) 3 4 22 60
  2. Inhibition of transcription elongation by the VHL tumor suppressor protein. (PMID: 7660122) Duan DR … Klausner RD (Science (New York, N.Y.) 1995) 2 3 22 60
  3. A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII. (PMID: 7821821) Garrett KP … Conaway JW (Gene 1994) 2 3 4 60
  4. Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B. (PMID: 20086098) Li XS … Tanese N (Molecular and cellular biology 2010) 3 22 60
  5. Regulation of DNA topoisomerase IIalpha stability by the ECV ubiquitin ligase complex. (PMID: 19695223) Yun J … Choi CH (Biochemical and biophysical research communications 2009) 3 22 60

Products for ELOC Gene

  • Addgene plasmids for ELOC

Sources for ELOC Gene

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