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Aliases for ELOB Gene

Aliases for ELOB Gene

  • Elongin B 2 3
  • Transcription Elongation Factor B Subunit 2 2 3 5
  • TCEB2 3 4 5
  • Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) 2 3
  • RNA Polymerase II Transcription Factor SIII Subunit B 3 4
  • Elongin 18 KDa Subunit 3 4
  • SIII P18 3 4
  • RNA Polymerase II Transcription Factor SIII P18 Subunit 3
  • Transcription Elongation Factor B Polypeptide 2 3
  • Elongin, 18-KD Subunit 3
  • Elongin-B 4
  • SIII 3
  • EloB 4

External Ids for ELOB Gene

Previous HGNC Symbols for ELOB Gene

  • TCEB2

Summaries for ELOB Gene

Entrez Gene Summary for ELOB Gene

  • This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

GeneCards Summary for ELOB Gene

ELOB (Elongin B) is a Protein Coding gene. Diseases associated with ELOB include Renal Cell Carcinoma and Renal Clear Cell Carcinoma. Among its related pathways are Hypoxic and oxygen homeostasis regulation of HIF-1-alpha and Immune System.

UniProtKB/Swiss-Prot for ELOB Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

  • The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Gene Wiki entry for ELOB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELOB Gene

Genomics for ELOB Gene

Regulatory Elements for ELOB Gene

Enhancers for ELOB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F002750 0.8 ENCODE 12.5 +24.2 24225 4.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TIGD7 CLUAP1 ZNF213-AS1 ELOB PRSS33 ENSG00000221719 PRSS41 ZNF205 PRSS27 NME3
GH16F002756 0.5 ENCODE 12.5 +20.8 20773 0.1 HDGF ZNF263 ZFHX2 POLR2A ZBTB33 EGR2 ELOB PRSS33 PRSS41 ENSG00000221719 PRSS27 PRSS22 PKMYT1 GC16P002792 GC16M002769
GH16F002757 0.4 ENCODE 12.5 +21.1 21103 0.2 ZNF263 ZNF146 ELOB PRSS33 PRSS41 ENSG00000221719 PRSS27 PRSS22 PKMYT1 GC16P002792 GC16M002769
GH16F002867 0.2 ENCODE 11.3 -91.2 -91180 2.0 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 LOC101929566 ZNF263 ZNF597 ZNF213-AS1 ENSG00000200059 ENSG00000261240 ZNF598 THOC6 ENSG00000255513 FLYWCH2
GH16F002427 0.9 FANTOM5 ENCODE 3.1 +348.0 348049 2.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF766 CBX5 TIGD7 MEFV IFT140 MTCO1P28 CCNF LOC652276 KCTD5 DNASE1L2 ELOB MLST8
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ELOB on UCSC Golden Path with GeneCards custom track

Promoters for ELOB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000502612 97 2401 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS KLF13

Genomic Location for ELOB Gene

Chromosome:
16
Start:
2,771,414 bp from pter
End:
2,777,297 bp from pter
Size:
5,884 bases
Orientation:
Minus strand

Genomic View for ELOB Gene

Genes around ELOB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOB Gene

Proteins for ELOB Gene

  • Protein details for ELOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15370-ELOB_HUMAN
    Recommended name:
    Transcription elongation factor B polypeptide 2
    Protein Accession:
    Q15370
    Secondary Accessions:
    • B7WPD3

    Protein attributes for ELOB Gene

    Size:
    118 amino acids
    Molecular mass:
    13133 Da
    Quaternary structure:
    • Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1. Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component.
    SequenceCaution:
    • Sequence=AAC08452.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ELOB Gene

    Alternative splice isoforms for ELOB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELOB Gene

Post-translational modifications for ELOB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELOB Gene

No data available for DME Specific Peptides for ELOB Gene

Domains & Families for ELOB Gene

Protein Domains for ELOB Gene

Suggested Antigen Peptide Sequences for ELOB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15370

UniProtKB/Swiss-Prot:

ELOB_HUMAN :
  • Contains 1 ubiquitin-like domain.
Domain:
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with ELOB: view

No data available for Gene Families for ELOB Gene

Function for ELOB Gene

Molecular function for ELOB Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
UniProtKB/Swiss-Prot Function:
The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Gene Ontology (GO) - Molecular Function for ELOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10205047
GO:0031625 ubiquitin protein ligase binding IDA 17636018
genes like me logo Genes that share ontologies with ELOB: view
genes like me logo Genes that share phenotypes with ELOB: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ELOB

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ELOB Gene

Localization for ELOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOB Gene

Gene Ontology (GO) - Cellular Components for ELOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0030891 VCB complex IBA --
GO:0031462 Cul2-RING ubiquitin ligase complex IDA 17636018
genes like me logo Genes that share ontologies with ELOB: view

No data available for Subcellular locations from COMPARTMENTS for ELOB Gene

Pathways & Interactions for ELOB Gene

SuperPathways for ELOB Gene

genes like me logo Genes that share pathways with ELOB: view

UniProtKB/Swiss-Prot Q15370-ELOB_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ELOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0006414 translational elongation IEA --
genes like me logo Genes that share ontologies with ELOB: view

No data available for SIGNOR curated interactions for ELOB Gene

Drugs & Compounds for ELOB Gene

(1) Drugs for ELOB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ELOB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ELOB: view

Transcripts for ELOB Gene

Unigene Clusters for ELOB Gene

Transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ELOB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELOB Gene

No ASD Table

Relevant External Links for ELOB Gene

GeneLoc Exon Structure for
ELOB
ECgene alternative splicing isoforms for
ELOB

Expression for ELOB Gene

NURSA nuclear receptor signaling pathways regulating expression of ELOB Gene:

ELOB

SOURCE GeneReport for Unigene cluster for ELOB Gene:

Hs.172772
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ELOB Gene

Orthologs for ELOB Gene

This gene was present in the common ancestor of animals.

Orthologs for ELOB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEB2 34
  • 99.38 (n)
-- 35
  • 98 (a)
OneToMany
-- 35
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tceb2 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 91 (a)
OneToMany
TCEB2 34 35
  • 88.42 (n)
-- 35
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TCEB2 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC479873 34
  • 89.77 (n)
TCEB2 35
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909963 34
  • 88.03 (n)
lizard
(Anolis carolinensis)
Reptilia TCEB2 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76322 34
African clawed frog
(Xenopus laevis)
Amphibia tceb2-prov 34
zebrafish
(Danio rerio)
Actinopterygii tceb2 34 35
  • 85 (a)
TCEB2 (2 of 2) 35
  • 64 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13460 34
fruit fly
(Drosophila melanogaster)
Insecta Elongin-B 35
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea elb-1 35
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4437 35
  • 55 (a)
OneToOne
Species where no ortholog for ELOB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELOB Gene

ENSEMBL:
Gene Tree for ELOB (if available)
TreeFam:
Gene Tree for ELOB (if available)

Paralogs for ELOB Gene

Pseudogenes.org Pseudogenes for ELOB Gene

genes like me logo Genes that share paralogs with ELOB: view

No data available for Paralogs for ELOB Gene

Variants for ELOB Gene

Sequence variations from dbSNP and Humsavar for ELOB Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1050195 -- 2,771,334(+) TGTTT(C/T)TTAAA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1058855 -- 2,771,762(-) GCCCT(C/G)AGACC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs111748580 -- 2,771,099(+) AGGGA(A/G)TGCAG intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111815759 -- 2,772,127(+) CTGCA(-/C/G)GGGGG intron-variant
rs111838652 -- 2,776,346(+) CTTGG(A/G)CGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ELOB Gene

Variant ID Type Subtype PubMed ID
esv2760067 CNV gain+loss 17122850
nsv471073 CNV loss 18288195
nsv827523 CNV gain 20364138

Variation tolerance for ELOB Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.98; 84.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELOB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELOB Gene

Disorders for ELOB Gene

MalaCards: The human disease database

(4) MalaCards diseases for ELOB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
renal clear cell carcinoma
  • clear cell carcinoma of kidney
kidney cancer
  • malignant neoplasm of kidney except pelvis
familial renal papillary carcinoma
  • hereditary papillary renal carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search ELOB in MalaCards View complete list of genes associated with diseases

Relevant External Links for ELOB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELOB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELOB
genes like me logo Genes that share disorders with ELOB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ELOB Gene

Publications for ELOB Gene

  1. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. (PMID: 15574592) Mehle A. … Gabuzda D. (Genes Dev. 2004) 3 4 22 64
  2. Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. (PMID: 11006129) Aso T. … Kitajima S. (Biochem. Biophys. Res. Commun. 2000) 3 4 22 64
  3. Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog. (PMID: 7638163) Garrett K.P. … Conaway J.W. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 64
  4. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PMID: 22286099) Foxler D.E. … Sharp T.V. (Nat. Cell Biol. 2012) 3 4 64
  5. NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL. (PMID: 18323857) Russell R.C. … Ohh M. (EMBO Rep. 2008) 3 22 64

Products for ELOB Gene

Sources for ELOB Gene

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