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Aliases for ELOA3D Gene

Aliases for ELOA3D Gene

  • Elongin A3 Family Member D 2 3 5
  • RNA Polymerase II Transcription Factor SIII Subunit A3-Like-2 3 4
  • Transcription Elongation Factor B Polypeptide 3C-Like-2 3 4
  • EloA3-Like-2 3 4
  • TCEB3CL2 3 4
  • Transcription Elongation Factor B Polypeptide 3C-Like 2 2
  • Transcription Elongation Factor B Subunit 3C Like 2 3
  • Elongin-A3 Member D 3
  • Elongin A3 Like 2 3
  • Elongin-A3-Like-2 4
  • ELOA3L2 3
  • EloA3D 4

External Ids for ELOA3D Gene

Previous HGNC Symbols for ELOA3D Gene

  • TCEB3CL2

Summaries for ELOA3D Gene

GeneCards Summary for ELOA3D Gene

ELOA3D (Elongin A3 Family Member D) is a Protein Coding gene. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and HIV Life Cycle. An important paralog of this gene is ELOA3.

UniProtKB/Swiss-Prot for ELOA3D Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Additional gene information for ELOA3D Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELOA3D Gene

Genomics for ELOA3D Gene

Regulatory Elements for ELOA3D Gene

Enhancers for ELOA3D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H046946 0.8 ENCODE 0.4 +17.9 17892 1 MXI1 PKNOX1 DDX20 MAX SIN3A BMI1 RFX5 POLR2A ZNF366 NFYB HAUS1 EPG5 HDHD2 ELOA3D GC18P046926
GH18H046939 0.6 ENCODE 0.3 +24.6 24595 2 MXI1 PKNOX1 JUN ZFP37 CEBPB JUND POLR2A FOS PRDM1 KATNAL2 ELOA3 ELOA2 IER3IP1 HDHD2 GC18P046926 ELOA3D
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ELOA3D on UCSC Golden Path with GeneCards custom track

Genomic Location for ELOA3D Gene

Chromosome:
18
Start:
46,962,768 bp from pter
End:
46,964,644 bp from pter
Size:
1,877 bases
Orientation:
Minus strand

Genomic View for ELOA3D Gene

Genes around ELOA3D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOA3D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOA3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOA3D Gene

Proteins for ELOA3D Gene

  • Protein details for ELOA3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLF2-ELB3D_HUMAN
    Recommended name:
    Elongin-A3 member D
    Protein Accession:
    A6NLF2

    Protein attributes for ELOA3D Gene

    Size:
    546 amino acids
    Molecular mass:
    59772 Da
    Quaternary structure:
    • Heterotrimer of an A (ELOA3, ELOA2, ELOA3, ELOA3B, ELOA3C or ELOA3D), ELOB and ELOC subunit.

neXtProt entry for ELOA3D Gene

Post-translational modifications for ELOA3D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELOA3D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ELOA3D Gene

Domains & Families for ELOA3D Gene

Gene Families for ELOA3D Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ELOA3D Gene

Suggested Antigen Peptide Sequences for ELOA3D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NLF2

UniProtKB/Swiss-Prot:

ELB3D_HUMAN :
  • The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x(3)-C-x(3)-[AILV].
Domain:
  • The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x(3)-C-x(3)-[AILV].
genes like me logo Genes that share domains with ELOA3D: view

Function for ELOA3D Gene

Molecular function for ELOA3D Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for ELOA3D
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ELOA3D Gene

Localization for ELOA3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOA3D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELOA3D gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ELOA3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070449 elongin complex IBA --
genes like me logo Genes that share ontologies with ELOA3D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ELOA3D Gene

Pathways & Interactions for ELOA3D Gene

genes like me logo Genes that share pathways with ELOA3D: view

Interacting Proteins for ELOA3D Gene

Gene Ontology (GO) - Biological Process for ELOA3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006368 transcription elongation from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ELOA3D: view

No data available for SIGNOR curated interactions for ELOA3D Gene

Drugs & Compounds for ELOA3D Gene

No Compound Related Data Available

Transcripts for ELOA3D Gene

mRNA/cDNA for ELOA3D Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for ELOA3D
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ELOA3D Gene

No ASD Table

Relevant External Links for ELOA3D Gene

GeneLoc Exon Structure for
ELOA3D
ECgene alternative splicing isoforms for
ELOA3D

Expression for ELOA3D Gene

NURSA nuclear receptor signaling pathways regulating expression of ELOA3D Gene:

ELOA3D
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELOA3D Gene

Orthologs for ELOA3D Gene

Evolution for ELOA3D Gene

ENSEMBL:
Gene Tree for ELOA3D (if available)
TreeFam:
Gene Tree for ELOA3D (if available)

No data available for Orthologs for ELOA3D Gene

Paralogs for ELOA3D Gene

Paralogs for ELOA3D Gene

genes like me logo Genes that share paralogs with ELOA3D: view

Variants for ELOA3D Gene

Sequence variations from dbSNP and Humsavar for ELOA3D Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs111713826 -- 46,963,651(+) CAGCG(A/C)CGGCC intron-variant, reference, missense
rs112278899 -- 46,966,129(+) GTGCA(A/G)AGAAA intron-variant, upstream-variant-2KB
rs113029175 -- 46,962,864(+) GCGGG(C/G)GCCGC intron-variant, reference, synonymous-codon
rs113214992 -- 46,965,595(+) CCCCC(C/G)CCCCC intron-variant, upstream-variant-2KB
rs117153245 -- 46,963,324(+) CAAGA(A/G)CCGAG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ELOA3D Gene

Variant ID Type Subtype PubMed ID
esv3583040 CNV loss 25503493
nsv1056744 CNV gain 25217958
nsv2280 CNV insertion 18451855
nsv509693 CNV insertion 20534489
nsv833639 CNV loss 17160897
nsv9629 CNV gain+loss 18304495

Variation tolerance for ELOA3D Gene

Gene Damage Index Score: 0.18; 3.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELOA3D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOA3D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELOA3D Gene

Disorders for ELOA3D Gene

Relevant External Links for ELOA3D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELOA3D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELOA3D

No disorders were found for ELOA3D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELOA3D Gene

Publications for ELOA3D Gene

  1. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 3 4 60

Products for ELOA3D Gene

Sources for ELOA3D Gene

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