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Aliases for ELOA3B Gene

Aliases for ELOA3B Gene

  • Elongin A3 Family Member B 2 3 5
  • RNA Polymerase II Transcription Factor SIII Subunit A3-Like-1 3 4
  • Transcription Elongation Factor B Polypeptide 3C-Like-1 3 4
  • Transcription Elongation Factor B Subunit 3C Like 2 3
  • EloA3-Like-1 3 4
  • TCEB3CL 3 4
  • Transcription Elongation Factor B Polypeptide 3C-Like 2
  • Elongin-A3 Member B 3
  • Elongin A3 Like 1 3
  • Elongin-A3-Like-1 4
  • ELOA3L1 3
  • EloA3C 3
  • HsT828 3
  • EloA3B 4

External Ids for ELOA3B Gene

Previous HGNC Symbols for ELOA3B Gene

  • TCEB3CL

Summaries for ELOA3B Gene

GeneCards Summary for ELOA3B Gene

ELOA3B (Elongin A3 Family Member B) is a Protein Coding gene. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and HIV Life Cycle. An important paralog of this gene is ELOA3D.

UniProtKB/Swiss-Prot for ELOA3B Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Additional gene information for ELOA3B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELOA3B Gene

Genomics for ELOA3B Gene

Genomic Location for ELOA3B Gene

Chromosome:
18
Start:
46,968,695 bp from pter
End:
46,969,912 bp from pter
Size:
1,218 bases
Orientation:
Minus strand

Genomic View for ELOA3B Gene

Genes around ELOA3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOA3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOA3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOA3B Gene

No data available for Regulatory Elements for ELOA3B Gene

Proteins for ELOA3B Gene

  • Protein details for ELOA3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SY89-ELB3B_HUMAN
    Recommended name:
    Elongin-A3 member B
    Protein Accession:
    Q3SY89
    Secondary Accessions:
    • A0A0B4J2C8
    • Q3MI93

    Protein attributes for ELOA3B Gene

    Size:
    546 amino acids
    Molecular mass:
    59760 Da
    Quaternary structure:
    • Heterotrimer of an A (ELOA3, ELOA2, ELOA3, ELOA3B, ELOA3C or ELOA3D), ELOB and ELOC subunit.

neXtProt entry for ELOA3B Gene

Post-translational modifications for ELOA3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELOA3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ELOA3B Gene

Domains & Families for ELOA3B Gene

Gene Families for ELOA3B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ELOA3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3SY89

UniProtKB/Swiss-Prot:

ELB3B_HUMAN :
  • The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x(3)-C-x(3)-[AILV].
Domain:
  • The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x(3)-C-x(3)-[AILV].
genes like me logo Genes that share domains with ELOA3B: view

Function for ELOA3B Gene

Molecular function for ELOA3B Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Phenotypes for ELOA3B Gene

genes like me logo Genes that share phenotypes with ELOA3B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ELOA3B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ELOA3B Gene

Localization for ELOA3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOA3B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELOA3B gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ELOA3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070449 elongin complex IBA --
genes like me logo Genes that share ontologies with ELOA3B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ELOA3B Gene

Pathways & Interactions for ELOA3B Gene

genes like me logo Genes that share pathways with ELOA3B: view

Interacting Proteins for ELOA3B Gene

Gene Ontology (GO) - Biological Process for ELOA3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006368 transcription elongation from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ELOA3B: view

No data available for SIGNOR curated interactions for ELOA3B Gene

Drugs & Compounds for ELOA3B Gene

No Compound Related Data Available

Transcripts for ELOA3B Gene

mRNA/cDNA for ELOA3B Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ELOA3B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ELOA3B Gene

No ASD Table

Relevant External Links for ELOA3B Gene

GeneLoc Exon Structure for
ELOA3B
ECgene alternative splicing isoforms for
ELOA3B

Expression for ELOA3B Gene

NURSA nuclear receptor signaling pathways regulating expression of ELOA3B Gene:

ELOA3B

Evidence on tissue expression from TISSUES for ELOA3B Gene

  • Liver(5)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELOA3B Gene

Orthologs for ELOA3B Gene

Evolution for ELOA3B Gene

ENSEMBL:
Gene Tree for ELOA3B (if available)
TreeFam:
Gene Tree for ELOA3B (if available)

No data available for Orthologs for ELOA3B Gene

Paralogs for ELOA3B Gene

Paralogs for ELOA3B Gene

genes like me logo Genes that share paralogs with ELOA3B: view

Variants for ELOA3B Gene

Sequence variations from dbSNP and Humsavar for ELOA3B Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1054530408 -- 47,024,882(+) TCAGG(C/T)GGACG intron-variant, upstream-variant-2KB
rs138564494 -- 47,025,510(+) TGTGT(-/TGTG)GTGTG intron-variant, upstream-variant-2KB
rs139200050 -- 47,025,503(+) TCTCA(-/GT)GTGTG intron-variant, upstream-variant-2KB
rs139462441 -- 47,025,403(+) ACAGA(A/C)CCATT intron-variant, upstream-variant-2KB
rs139532054 -- 47,025,502(+) CTCTC(A/T)GTGTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ELOA3B Gene

Variant ID Type Subtype PubMed ID
esv2717039 CNV deletion 23290073
esv3583040 CNV loss 25503493
nsv1056744 CNV gain 25217958
nsv1149591 CNV duplication 26484159
nsv2284 CNV insertion 18451855
nsv471406 CNV gain 19718026
nsv509693 CNV insertion 20534489
nsv576818 CNV loss 21841781
nsv833639 CNV loss 17160897
nsv833640 CNV loss 17160897
nsv9629 CNV gain+loss 18304495

Variation tolerance for ELOA3B Gene

Gene Damage Index Score: 0.05; 1.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELOA3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOA3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELOA3B Gene

Disorders for ELOA3B Gene

Relevant External Links for ELOA3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELOA3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELOA3B

No disorders were found for ELOA3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELOA3B Gene

Publications for ELOA3B Gene

  1. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60
  4. Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3. (PMID: 11994304) Yamazaki K … Aso T (The Journal of biological chemistry 2002) 3 60

Products for ELOA3B Gene

Sources for ELOA3B Gene

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