Aliases for ELOA3 Gene
External Ids for ELOA3 Gene
Previous HGNC Symbols for ELOA3 Gene
The SIII (or elongin) transcription elongation factor complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. This complex is a heterotrimer, composed of the transcriptionally active subunit A, A2 or A3 (or elongin A, A2 or A3) and two regulatory subunits, B and C (or elongin B and C). This gene encodes subunit A3. A3 and A are ubiquitously expressed, whereas A2 is specifically expressed in the testis. [provided by RefSeq, Mar 2010]
GeneCards Summary for ELOA3 Gene
ELOA3 (Elongin A3) is a Protein Coding gene. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and HIV Life Cycle. An important paralog of this gene is ELOA3B.
UniProtKB/Swiss-Prot for ELOA3 Gene
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).