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Aliases for ELOA3 Gene

Aliases for ELOA3 Gene

  • Elongin A3 2 5
  • Transcription Elongation Factor B Polypeptide 3C (Elongin A3) 2 3
  • RNA Polymerase II Transcription Factor SIII Subunit A3 3 4
  • Transcription Elongation Factor B Subunit 3C 2 3
  • TCEB3L2 3 4
  • TCEB3C 3 4
  • EloA3 3 4
  • Transcription Elongation Factor B Polypeptide 3C 4
  • Elongin A3 Family Member A 2
  • Elongin-A3 3
  • HsT829 3

External Ids for ELOA3 Gene

Previous HGNC Symbols for ELOA3 Gene

  • TCEB3C

Summaries for ELOA3 Gene

Entrez Gene Summary for ELOA3 Gene

  • The SIII (or elongin) transcription elongation factor complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. This complex is a heterotrimer, composed of the transcriptionally active subunit A, A2 or A3 (or elongin A, A2 or A3) and two regulatory subunits, B and C (or elongin B and C). This gene encodes subunit A3. A3 and A are ubiquitously expressed, whereas A2 is specifically expressed in the testis. [provided by RefSeq, Mar 2010]

GeneCards Summary for ELOA3 Gene

ELOA3 (Elongin A3) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Formation of HIV elongation complex in the absence of HIV Tat. An important paralog of this gene is ELOA3B.

UniProtKB/Swiss-Prot for ELOA3 Gene

  • SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELOA3 Gene

Genomics for ELOA3 Gene

Regulatory Elements for ELOA3 Gene

Enhancers for ELOA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G046939 0.7 ENCODE 10.9 +90.0 90029 2.1 MXI1 PKNOX1 JUN ZFP37 SIN3A CEBPB EP300 NR2F2 JUND GATA2 KATNAL2 ELOA3 ELOA2 IER3IP1 HDHD2 GC18P046926 ELOA3D
GH18G046898 0.5 ENCODE 10.4 +130.6 130627 1.3 EED TEAD4 PRDM1 ELOA3 ELOA2 IER3IP1 HDHD2 ENSG00000279354 LOC100421737
GH18G046692 0.4 dbSUPER 10.4 +336.2 336168 2.0 MAFK ELOA3 ELOA2 ST8SIA5 RPS21P6 LOC105372096
GH18G046694 0.4 dbSUPER 10.4 +336.2 336168 2.0 MAFK ELOA3 ELOA2 ST8SIA5 RPS21P6 LOC105372096
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ELOA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ELOA3 Gene

Chromosome:
18
Start:
47,028,202 bp from pter
End:
47,030,078 bp from pter
Size:
1,877 bases
Orientation:
Minus strand

Genomic View for ELOA3 Gene

Genes around ELOA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ELOA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ELOA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELOA3 Gene

Proteins for ELOA3 Gene

  • Protein details for ELOA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG57-ELOA3_HUMAN
    Recommended name:
    Elongin-A3
    Protein Accession:
    Q8NG57

    Protein attributes for ELOA3 Gene

    Size:
    546 amino acids
    Molecular mass:
    59744 Da
    Quaternary structure:
    • Heterotrimer of an A (ELOA, ELOA2 or ELOA3), ELOB and ELOC subunit.

neXtProt entry for ELOA3 Gene

Post-translational modifications for ELOA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ELOA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ELOA3 Gene

Domains & Families for ELOA3 Gene

Gene Families for ELOA3 Gene

Suggested Antigen Peptide Sequences for ELOA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG57

UniProtKB/Swiss-Prot:

ELOA3_HUMAN :
  • The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x(3)-C-x(3)-[AILV].
Domain:
  • The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x(3)-C-x(3)-[AILV].
genes like me logo Genes that share domains with ELOA3: view

Function for ELOA3 Gene

Molecular function for ELOA3 Gene

UniProtKB/Swiss-Prot Function:
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
genes like me logo Genes that share phenotypes with ELOA3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ELOA3 Gene

Localization for ELOA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELOA3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ELOA3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ELOA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0016021 integral component of membrane IEA --
GO:0070449 elongin complex IBA --
genes like me logo Genes that share ontologies with ELOA3: view

Pathways & Interactions for ELOA3 Gene

genes like me logo Genes that share pathways with ELOA3: view

Gene Ontology (GO) - Biological Process for ELOA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with ELOA3: view

No data available for SIGNOR curated interactions for ELOA3 Gene

Transcripts for ELOA3 Gene

mRNA/cDNA for ELOA3 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ELOA3 Gene

No ASD Table

Relevant External Links for ELOA3 Gene

GeneLoc Exon Structure for
ELOA3
ECgene alternative splicing isoforms for
ELOA3

Expression for ELOA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ELOA3 Gene:

ELOA3

mRNA Expression by UniProt/SwissProt for ELOA3 Gene:

Q8NG57-ELOA3_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for ELOA3 Gene

  • Liver(5)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ELOA3 Gene

Orthologs for ELOA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ELOA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 92 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 29 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 28 (a)
OneToMany
chicken
(Gallus gallus)
Aves TCEB3 35
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 28 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tceb3 35
  • 27 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta EloA 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R03D7.4 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for ELOA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ELOA3 Gene

ENSEMBL:
Gene Tree for ELOA3 (if available)
TreeFam:
Gene Tree for ELOA3 (if available)

Paralogs for ELOA3 Gene

Paralogs for ELOA3 Gene

genes like me logo Genes that share paralogs with ELOA3: view

Variants for ELOA3 Gene

Sequence variations from dbSNP and Humsavar for ELOA3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1005062675 -- 47,031,547(+) CCACA(C/G/T)TTTGT intron-variant, upstream-variant-2KB
rs1006496593 -- 47,030,797(+) TCAGG(C/T)GGACG intron-variant, upstream-variant-2KB
rs1006587146 -- 47,031,470(+) GCAGA(A/T)AGAAA intron-variant, upstream-variant-2KB
rs1007880302 -- 47,031,638(+) TCAGA(G/T)CTAGA intron-variant, upstream-variant-2KB
rs1009128879 -- 47,032,039(+) CTTTC(A/G)TGGTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ELOA3 Gene

Variant ID Type Subtype PubMed ID
esv2717039 CNV deletion 23290073
nsv1056744 CNV gain 25217958
nsv1149591 CNV duplication 26484159
nsv2284 CNV insertion 18451855
nsv471406 CNV gain 19718026
nsv509693 CNV insertion 20534489
nsv576818 CNV loss 21841781
nsv833639 CNV loss 17160897
nsv833640 CNV loss 17160897
nsv9629 CNV gain+loss 18304495

Variation tolerance for ELOA3 Gene

Gene Damage Index Score: 0.05; 1.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ELOA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ELOA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ELOA3 Gene

Disorders for ELOA3 Gene

Relevant External Links for ELOA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ELOA3

No disorders were found for ELOA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ELOA3 Gene

Publications for ELOA3 Gene

  1. A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. (PMID: 11932239) Strichman-Almashanu L.Z. … Feinberg A.P. (Genome Res. 2002) 2 3 22 64
  2. Identification and biochemical characterization of a novel transcription elongation factor, elongin A3. (PMID: 11994304) Yamazaki K. … Aso T. (J. Biol. Chem. 2002) 2 3 4 64
  3. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 4 64
  4. Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. (PMID: 15717329) Crockett D.K. … Lim M.S. (Proteomics 2005) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ELOA3 Gene

Sources for ELOA3 Gene

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